ketorolac has been researched along with Cancer of Esophagus in 6 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer." | 7.88 | Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients. ( Achiam, MP; Fjederholt, KT; Kirkegård, J; Mortensen, FV; Okholm, C; Svendsen, LB, 2018) |
| "The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer." | 3.88 | Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients. ( Achiam, MP; Fjederholt, KT; Kirkegård, J; Mortensen, FV; Okholm, C; Svendsen, LB, 2018) |
| "Ketorolac was administered to 686 patients (67%); use was observed to increase over the study period from 49% in 2006 to 92% in 2016." | 1.62 | Ketorolac use and anastomotic leak in patients with esophageal cancer. ( Corsini, EM; Hofstetter, WL, 2021) |
| "It has the potential to reduce postoperative pain and use of nonsteroidal anti-inflammatory drugs, and to enhance recovery from surgery." | 1.48 | Outcomes of Transhiatal and Intercostal Pleural Drain After Ivor Lewis Esophagectomy: Comparative Analysis of Two Consecutive Patient Cohorts. ( Asti, E; Bernardi, D; Bonavina, L; Bonitta, G, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kwon, JH | 1 |
| Denlinger, CE | 1 |
| Corsini, EM | 1 |
| Hofstetter, WL | 1 |
| Groth, SS | 1 |
| Fjederholt, KT | 1 |
| Okholm, C | 1 |
| Svendsen, LB | 1 |
| Achiam, MP | 1 |
| Kirkegård, J | 1 |
| Mortensen, FV | 1 |
| Asti, E | 1 |
| Bernardi, D | 1 |
| Bonitta, G | 1 |
| Bonavina, L | 1 |
| Jain, PN | 1 |
| Shah, SC | 1 |
6 other studies available for ketorolac and Cancer of Esophagus
| Article | Year |
|---|---|
Commentary: Don't fear the nonsteroidal anti-inflammatory drugs.
Topics: Anastomotic Leak; Anti-Inflammatory Agents; Esophageal Neoplasms; Humans; Ketorolac; Pharmaceutical | 2021 |
Ketorolac use and anastomotic leak in patients with esophageal cancer.
Topics: Adenocarcinoma; Aged; Anastomosis, Surgical; Anti-Inflammatory Agents, Non-Steroidal; Endoleak; Enha | 2021 |
Commentary: Enhanced recovery after surgery: Does ketorolac get in the WAE of anastomotic healing following esophagectomy?
Topics: Anastomosis, Surgical; Anastomotic Leak; Enhanced Recovery After Surgery; Esophageal Neoplasms; Esop | 2021 |
Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients.
Topics: Adult; Aged; Anastomosis, Surgical; Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Datab | 2018 |
Outcomes of Transhiatal and Intercostal Pleural Drain After Ivor Lewis Esophagectomy: Comparative Analysis of Two Consecutive Patient Cohorts.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chest Tubes; Drainage; Esophageal Neoplasms; Esophage | 2018 |
Respiratory depression following combination of epidural buprenorphine and intramuscular ketorolac.
Topics: Analgesia, Epidural; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Buprenorphine; Depression, | 1993 |