ketorolac has been researched along with Burns in 6 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Life-threatening acute respiratory distress syndrome (ARDS) complicates the recovery of patients with burn and inhalation injury." | 5.32 | Ketorolac may control more than pain. ( Isik, F, 2003) |
| "Primary and secondary hyperalgesia were produced by a first-degree burn injury on abdominal skin 45 min before injection of the test medicines." | 2.73 | Methylprednisolone and ketorolac rapidly reduce hyperalgesia around a skin burn injury and increase pressure pain thresholds. ( Breivik, H; Kaasa, T; Romundstad, L; Stubhaug, A, 2007) |
| "Treatment with ketorolac prevented all of these morbidities." | 1.32 | Ketorolac attenuates cardiopulmonary derangements in sheep with combined burn and smoke inhalation injury. ( Cox, R; Enkhbaatar, P; Hawkins, H; Herndon, D; Murakami, K; Salsbury, J; Shimoda, K; Traber, D; Traber, L, 2003) |
| "Life-threatening acute respiratory distress syndrome (ARDS) complicates the recovery of patients with burn and inhalation injury." | 1.32 | Ketorolac may control more than pain. ( Isik, F, 2003) |
| "Pretreatment with ketorolac had a selective effect on the postburn injury hyperalgesia, reducing the increase in pain intensity (P<0." | 1.29 | Reduction of postburn hyperalgesia after local injection of ketorolac in healthy volunteers. ( Brull, SJ; Collins, JG; Kitahata, LM; LaMotte, R; Lundell, JC; O'Connor, TZ; Silverman, DG, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fuzaylov, G | 1 |
| Kelly, TL | 1 |
| Bline, C | 1 |
| Dunaev, A | 1 |
| Dylewski, ML | 1 |
| Driscoll, DN | 1 |
| Enkhbaatar, P | 1 |
| Murakami, K | 1 |
| Shimoda, K | 1 |
| Salsbury, J | 1 |
| Cox, R | 1 |
| Hawkins, H | 1 |
| Traber, L | 1 |
| Herndon, D | 1 |
| Traber, D | 1 |
| Isik, F | 1 |
| Stubhaug, A | 1 |
| Romundstad, L | 1 |
| Kaasa, T | 1 |
| Breivik, H | 1 |
| Møiniche, S | 1 |
| Pedersen, JL | 1 |
| Kehlet, H | 1 |
| Lundell, JC | 1 |
| Silverman, DG | 1 |
| Brull, SJ | 1 |
| O'Connor, TZ | 1 |
| Kitahata, LM | 1 |
| Collins, JG | 1 |
| LaMotte, R | 1 |
3 trials available for ketorolac and Burns
| Article | Year |
|---|---|
Post-operative pain control for burn reconstructive surgery in a resource-restricted country with subcutaneous infusion of local anesthetics through a soaker catheter to the surgical site: Preliminary results.
Topics: Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Burns; Catheters; Di | 2015 |
Methylprednisolone and ketorolac rapidly reduce hyperalgesia around a skin burn injury and increase pressure pain thresholds.
Topics: Adult; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Burns; Cross-Over Studies; Double-Blind M | 2007 |
Topical ketorolac has no antinociceptive or anti-inflammatory effect in thermal injury.
Topics: Administration, Topical; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; B | 1994 |
3 other studies available for ketorolac and Burns
| Article | Year |
|---|---|
Ketorolac attenuates cardiopulmonary derangements in sheep with combined burn and smoke inhalation injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Female; Ketorolac; Lung; Models, Animal; Ni | 2003 |
Ketorolac may control more than pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Burns; Humans; Ketorolac; Pain; Respiratory Distress Syndro | 2003 |
Reduction of postburn hyperalgesia after local injection of ketorolac in healthy volunteers.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Burns; Humans; Hyperalgesia; Injections, Intrad | 1996 |