ketorolac has been researched along with Brain Ischemia in 2 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketorolac treatment did not affect basal prostanoid levels but completely prevented prostanoid induction upon global ischemia." | 1.56 | Blood-Brain Barrier Is the Major Site for a Rapid and Dramatic Prostanoid Increase upon Brain Global Ischemia. ( Golovko, MY; Golovko, SA; Seeger, DR, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seeger, DR | 1 |
| Golovko, SA | 1 |
| Golovko, MY | 1 |
| Schink, T | 1 |
| Kollhorst, B | 1 |
| Varas Lorenzo, C | 1 |
| Arfè, A | 1 |
| Herings, R | 1 |
| Lucchi, S | 1 |
| Romio, S | 1 |
| Schade, R | 1 |
| Schuemie, MJ | 1 |
| Straatman, H | 1 |
| Valkhoff, V | 1 |
| Villa, M | 1 |
| Sturkenboom, M | 1 |
| Garbe, E | 1 |
2 other studies available for ketorolac and Brain Ischemia
| Article | Year |
|---|---|
Blood-Brain Barrier Is the Major Site for a Rapid and Dramatic Prostanoid Increase upon Brain Global Ischemia.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Cyclooxygenase 1; Cyclooxygenase 2; Erythrocytes; Huma | 2020 |
Risk of ischemic stroke and the use of individual non-steroidal anti-inflammatory drugs: A multi-country European database study within the SOS Project.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Case-Control Studi | 2018 |