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ketorolac and Bone Cancer

ketorolac has been researched along with Bone Cancer in 6 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Research Excerpts

ExcerptRelevanceReference
"ketorolac (10mg q."6.71Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003)
" Ketorolac can be well tolerated in high-dose, long-term use even in this frail patient population."6.69The opioid-sparing effects of intravenous ketorolac as an adjuvant analgesic in cancer pain: application in bone metastases and the opioid bowel syndrome. ( Joishy, SK; Walsh, D, 1998)
"ketorolac (10mg q."2.71Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003)
" Ketorolac can be well tolerated in high-dose, long-term use even in this frail patient population."2.69The opioid-sparing effects of intravenous ketorolac as an adjuvant analgesic in cancer pain: application in bone metastases and the opioid bowel syndrome. ( Joishy, SK; Walsh, D, 1998)
"Bone cancer pain is mostly associated with an inflammatory response dominated by local activation of osteoclasts and by astrogliosis in the spinal cord."1.33The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception. ( Beitz, A; Eikmeier, L; Fike, JR; Jasmin, L; Ohara, PT; Tien, DA; Vit, JP; Wilcox, GL, 2006)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zuckerman, LM1
Frames, WL1
Elsissy, JG1
Shields, TG1
de Necochea-Campion, R1
Mirshahidi, HR1
Williams, NL1
Mirshahidi, S1
De Luna-Bertos, E1
Ramos-Torrecillas, J1
García-Martínez, O1
Guildford, A1
Santin, M1
Ruiz, C1
Rodríguez, MJ1
Contreras, D1
Gálvez, R1
Castro, A1
Camba, MA1
Busquets, C1
Herrera, J1
Vit, JP1
Ohara, PT1
Tien, DA1
Fike, JR1
Eikmeier, L1
Beitz, A1
Wilcox, GL1
Jasmin, L1
Joishy, SK1
Walsh, D1
Long, TD1
Twillman, RK1
Cathers-Schiffman, TA1
O'Donnell, T1

Trials

2 trials available for ketorolac and Bone Cancer

ArticleYear
Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain.
    Pain, 2003, Volume: 104, Issue:1-2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Ster

2003
The opioid-sparing effects of intravenous ketorolac as an adjuvant analgesic in cancer pain: application in bone metastases and the opioid bowel syndrome.
    Journal of pain and symptom management, 1998, Volume: 16, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Colonic Ps

1998

Other Studies

4 other studies available for ketorolac and Bone Cancer

ArticleYear
The effect of non-steroidal anti-inflammatory drugs on osteosarcoma cells.
    European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Line, Tumor; Cell Proliferati

2019
Therapeutic doses of nonsteroidal anti-inflammatory drugs inhibit osteosarcoma MG-63 osteoblast-like cells maturation, viability, and biomineralization potential.
    TheScientificWorldJournal, 2013, Volume: 2013

    Topics: Alkaline Phosphatase; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation; Aspirin; B

2013
The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception.
    Pain, 2006, Volume: 120, Issue:1-2

    Topics: Analgesia; Analgesics, Opioid; Animals; Antineoplastic Agents; Behavior, Animal; Bone Neoplasms; Che

2006
Treatment of vinorelbine-associated tumor pain.
    American journal of clinical oncology, 2001, Volume: 24, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Bone Neoplasms; F

2001