ketorolac has been researched along with Bone Cancer in 6 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "ketorolac (10mg q." | 6.71 | Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003) |
| " Ketorolac can be well tolerated in high-dose, long-term use even in this frail patient population." | 6.69 | The opioid-sparing effects of intravenous ketorolac as an adjuvant analgesic in cancer pain: application in bone metastases and the opioid bowel syndrome. ( Joishy, SK; Walsh, D, 1998) |
| "ketorolac (10mg q." | 2.71 | Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003) |
| " Ketorolac can be well tolerated in high-dose, long-term use even in this frail patient population." | 2.69 | The opioid-sparing effects of intravenous ketorolac as an adjuvant analgesic in cancer pain: application in bone metastases and the opioid bowel syndrome. ( Joishy, SK; Walsh, D, 1998) |
| "Bone cancer pain is mostly associated with an inflammatory response dominated by local activation of osteoclasts and by astrogliosis in the spinal cord." | 1.33 | The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception. ( Beitz, A; Eikmeier, L; Fike, JR; Jasmin, L; Ohara, PT; Tien, DA; Vit, JP; Wilcox, GL, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zuckerman, LM | 1 |
| Frames, WL | 1 |
| Elsissy, JG | 1 |
| Shields, TG | 1 |
| de Necochea-Campion, R | 1 |
| Mirshahidi, HR | 1 |
| Williams, NL | 1 |
| Mirshahidi, S | 1 |
| De Luna-Bertos, E | 1 |
| Ramos-Torrecillas, J | 1 |
| García-Martínez, O | 1 |
| Guildford, A | 1 |
| Santin, M | 1 |
| Ruiz, C | 1 |
| Rodríguez, MJ | 1 |
| Contreras, D | 1 |
| Gálvez, R | 1 |
| Castro, A | 1 |
| Camba, MA | 1 |
| Busquets, C | 1 |
| Herrera, J | 1 |
| Vit, JP | 1 |
| Ohara, PT | 1 |
| Tien, DA | 1 |
| Fike, JR | 1 |
| Eikmeier, L | 1 |
| Beitz, A | 1 |
| Wilcox, GL | 1 |
| Jasmin, L | 1 |
| Joishy, SK | 1 |
| Walsh, D | 1 |
| Long, TD | 1 |
| Twillman, RK | 1 |
| Cathers-Schiffman, TA | 1 |
| O'Donnell, T | 1 |
2 trials available for ketorolac and Bone Cancer
| Article | Year |
|---|---|
Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Ster | 2003 |
The opioid-sparing effects of intravenous ketorolac as an adjuvant analgesic in cancer pain: application in bone metastases and the opioid bowel syndrome.
Topics: Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Colonic Ps | 1998 |
4 other studies available for ketorolac and Bone Cancer
| Article | Year |
|---|---|
The effect of non-steroidal anti-inflammatory drugs on osteosarcoma cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Line, Tumor; Cell Proliferati | 2019 |
Therapeutic doses of nonsteroidal anti-inflammatory drugs inhibit osteosarcoma MG-63 osteoblast-like cells maturation, viability, and biomineralization potential.
Topics: Alkaline Phosphatase; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation; Aspirin; B | 2013 |
The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception.
Topics: Analgesia; Analgesics, Opioid; Animals; Antineoplastic Agents; Behavior, Animal; Bone Neoplasms; Che | 2006 |
Treatment of vinorelbine-associated tumor pain.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Bone Neoplasms; F | 2001 |