ketorolac has been researched along with Blood Loss, Surgical in 6 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Blood Loss, Surgical: Loss of blood during a surgical procedure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the incidence of vomiting following codeine or ketorolac for tonsillectomy in children." | 5.08 | Preoperative ketorolac increases bleeding after tonsillectomy in children. ( MacNeill, HB; Reid, CW; Rhine, EJ; Roberts, DW; Splinter, WM, 1996) |
| "Ketorolac, which may cause renal vasoconstriction by cyclooxygenase inhibition, is often administered to patients anesthetized with sevoflurane that is metabolized to inorganic fluoride (F(-)), another potential nephrotoxin." | 2.70 | Ketorolac is not nephrotoxic in connection with sevoflurane anesthesia in patients undergoing breast surgery. ( Eriksson, H; Koivusalo, AM; Laisalmi, M; Lindgren, L; Pere, P; Rosenberg, P, 2001) |
| "Ketorolac is approved for the relief of postoperative pain but concerns have been raised over a possible risk of serious adverse effects and death." | 2.70 | Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. ( Abdalla, M; Bianchi, PG; Bonnet, F; Camu, F; Ebrahim, S; Escolar, G; Forrest, JB; Greer, IA; Heitlinger, E; Jage, J; Kehlet, H; Langman, MJ; Pocock, S; Samama, MM; Velo, G, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Bongiovanni, T | 1 |
| Lancaster, E | 1 |
| Ledesma, Y | 1 |
| Whitaker, E | 1 |
| Steinman, MA | 1 |
| Allen, IE | 1 |
| Auerbach, A | 1 |
| Wick, E | 1 |
| Sutters, KA | 1 |
| Levine, JD | 1 |
| Dibble, S | 1 |
| Savedra, M | 1 |
| Miaskowski, C | 1 |
| Rogers, JE | 1 |
| Fleming, BG | 1 |
| Macintosh, KC | 1 |
| Johnston, B | 1 |
| Morgan-Hughes, JO | 1 |
| Splinter, WM | 1 |
| Rhine, EJ | 1 |
| Roberts, DW | 1 |
| Reid, CW | 1 |
| MacNeill, HB | 1 |
| Laisalmi, M | 1 |
| Eriksson, H | 1 |
| Koivusalo, AM | 1 |
| Pere, P | 1 |
| Rosenberg, P | 1 |
| Lindgren, L | 1 |
| Forrest, JB | 1 |
| Camu, F | 1 |
| Greer, IA | 1 |
| Kehlet, H | 1 |
| Abdalla, M | 1 |
| Bonnet, F | 1 |
| Ebrahim, S | 1 |
| Escolar, G | 1 |
| Jage, J | 1 |
| Pocock, S | 1 |
| Velo, G | 1 |
| Langman, MJ | 1 |
| Bianchi, PG | 1 |
| Samama, MM | 1 |
| Heitlinger, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT02973958] | Phase 1 | 30 participants (Actual) | Interventional | 2017-02-01 | Completed | ||
| A Randomized Control Trial Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT04646967] | Phase 2 | 100 participants (Anticipated) | Interventional | 2022-11-25 | Recruiting | ||
| Evaluation of Perioperative Usage of Ketorolac on Postoperative Pain Reduction in Pediatric Patients With Adenotonsillectom[NCT05074056] | Phase 4 | 200 participants (Anticipated) | Interventional | 2022-02-08 | Recruiting | ||
| Opioid-Free Versus Transitional Anesthetic With Opioids From Tonsillectomy[NCT04528173] | Phase 4 | 550 participants (Anticipated) | Interventional | 2020-07-22 | Recruiting | ||
| Acute Kidney Injury and Nonsteroidal Anti-inflammatory Drugs in Patients Undergoing High-risk Abdominal or Thoracic Surgery[NCT02553174] | 50 participants (Actual) | Observational | 2016-06-01 | Terminated (stopped due to unable to recruit sufficient patients to satisfy study protocols) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketorolac and Blood Loss, Surgical
| Article | Year |
|---|---|
Systematic Review and Meta-Analysis of the Association Between Non-Steroidal Anti-Inflammatory Drugs and Operative Bleeding in the Perioperative Period.
Topics: Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Blood Loss, Surgical; Blood Transfusion; Diclofe | 2021 |
5 trials available for ketorolac and Blood Loss, Surgical
| Article | Year |
|---|---|
Analgesic efficacy and safety of single-dose intramuscular ketorolac for postoperative pain management in children following tonsillectomy.
Topics: Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analysis of Variance; Blood Loss, Surgical | 1995 |
Analgesic efficacy and safety of single-dose intramuscular ketorolac for postoperative pain management in children following tonsillectomy.
Topics: Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analysis of Variance; Blood Loss, Surgical | 1995 |
Analgesic efficacy and safety of single-dose intramuscular ketorolac for postoperative pain management in children following tonsillectomy.
Topics: Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analysis of Variance; Blood Loss, Surgical | 1995 |
Analgesic efficacy and safety of single-dose intramuscular ketorolac for postoperative pain management in children following tonsillectomy.
Topics: Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analysis of Variance; Blood Loss, Surgical | 1995 |
Effect of timing of ketorolac administration on patient-controlled opioid use.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Blood Loss | 1995 |
Preoperative ketorolac increases bleeding after tonsillectomy in children.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anesthesia, Inhalation; Anesthet | 1996 |
Ketorolac is not nephrotoxic in connection with sevoflurane anesthesia in patients undergoing breast surgery.
Topics: Acetylglucosaminidase; Adult; Anesthetics, Inhalation; Anti-Inflammatory Agents, Non-Steroidal; Biom | 2001 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |