ketorolac has been researched along with Blood Loss, Postoperative in 30 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Determine the impact of ketorolac on post-tonsillectomy hemorrhage (PTH) and narcotic administration in children undergoing tonsillectomy." | 7.96 | Intraoperative ketorolac for pediatric tonsillectomy: Effect on post-tonsillectomy hemorrhage and perioperative analgesia. ( Dahl, JP; Gettelfinger, JD; Matt, BH; Pflum, ZE; Rabbani, CC; Sadhasivam, S; Ye, MJ, 2020) |
| " Ketorolac has well-documented opioid-sparing effects in the postoperative period; however, its use is limited because of concerns of postoperative bleeding and hematoma formation." | 7.88 | Perioperative Ketorolac Use and Postoperative Hematoma Formation in Reduction Mammaplasty: A Single-Surgeon Experience of 500 Consecutive Cases. ( Firriolo, JM; Labow, BI; Nuzzi, LC; Schmidtberg, LC, 2018) |
| " Secondary measures were morphine usage in the first 8 and 24h postoperatively, numeric rating scores (NRS) up to 24h, sedation, nausea, vomiting, respiratory depression, pruritus and bleeding complications." | 5.24 | Intraoperative ketorolac dose of 15mg versus the standard 30mg on early postoperative pain after spine surgery: A randomized, blinded, non-inferiority trial. ( Davis, M; De Guzman, C; Duttchen, KM; Lo, A; McLuckie, D; Roman-Smith, H; Walker, A, 2017) |
| "To compare the incidence of vomiting following codeine or ketorolac for tonsillectomy in children." | 5.08 | Preoperative ketorolac increases bleeding after tonsillectomy in children. ( MacNeill, HB; Reid, CW; Rhine, EJ; Roberts, DW; Splinter, WM, 1996) |
| "Determine the impact of ketorolac on post-tonsillectomy hemorrhage (PTH) and narcotic administration in children undergoing tonsillectomy." | 3.96 | Intraoperative ketorolac for pediatric tonsillectomy: Effect on post-tonsillectomy hemorrhage and perioperative analgesia. ( Dahl, JP; Gettelfinger, JD; Matt, BH; Pflum, ZE; Rabbani, CC; Sadhasivam, S; Ye, MJ, 2020) |
| " Ketorolac has well-documented opioid-sparing effects in the postoperative period; however, its use is limited because of concerns of postoperative bleeding and hematoma formation." | 3.88 | Perioperative Ketorolac Use and Postoperative Hematoma Formation in Reduction Mammaplasty: A Single-Surgeon Experience of 500 Consecutive Cases. ( Firriolo, JM; Labow, BI; Nuzzi, LC; Schmidtberg, LC, 2018) |
| "We conducted a retrospective review following concerns involving a suspected increase in the requirement for surgical re-exploration for hematoma evacuation when ketorolac was administered perioperatively in patients undergoing reduction mammoplasty." | 3.78 | Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty. ( Cawthorn, TR; Davidson, JS; Phelan, R; Turner, KE, 2012) |
| "Postoperative pain was assessed by self-report 1." | 2.69 | Analgesic efficacy and safety of preoperative versus postoperative ketorolac in paediatric tonsillectomy. ( Ostergaard, D; Rømsing, J; Valentin, N; Walther-Larsen, S, 1998) |
| "Ketorolac is an attractive alternative for achieving pain control postoperatively, but concerns over postoperative bleeding have limited its use." | 2.50 | Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials. ( Gobble, RM; Hoang, HLT; Kachniarz, B; Orgill, DP, 2014) |
| "Ketorolac is an effective adjunct in multimodal regimens for postoperative pain control." | 1.91 | Bleeding and ketorolac use in pediatric circumcision. ( Davis, RL; Lee, J; Lin, HM; Ouyang, Y; Yudkowitz, FS; Zhou, EP, 2023) |
| "Ketorolac was given to 1549 (45%) of the women, with 922 women (60%) receiving 30 mg and 627 women (40%) receiving 15 mg." | 1.62 | Intraoperative Ketorolac is Associated with Risk of Reoperation After Mastectomy: A Single-Center Examination. ( Assel, M; McCormick, PJ; Morrow, M; Nelson, JA; Simon, BA; Tokita, HK; Twersky, RS; Van Zee, KJ; Vickers, AJ, 2021) |
| "Ketorolac-treated patients were younger, had better preoperative renal function, and underwent less complex operations compared with non-ketorolac patients." | 1.40 | Black box warning: is ketorolac safe for use after cardiac surgery? ( Jerzewski, K; Kulik, A; Oliveri, L, 2014) |
| "Ketorolac is a nonsteroidal antiinflammatory drug widely used as an adjunct to postoperative pain control in adult and pediatric patients." | 1.37 | Safety of ketorolac in surgical neonates and infants 0 to 3 months old. ( Aldrink, JH; Caniano, DA; Ma, M; Puthoff, T; Wang, W; Wispe, J, 2011) |
| "Ketorolac proved safe for short-term intravenous use in children more than 1 year of age when patients with known contraindications to the use of non-steroidal antiinflammatory drugs were excluded." | 1.29 | Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system. ( Berde, CB; Houck, CS; McDermott, JS; Sethna, NF; Wilder, RT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (30.00) | 18.2507 |
| 2000's | 4 (13.33) | 29.6817 |
| 2010's | 11 (36.67) | 24.3611 |
| 2020's | 6 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, J | 1 |
| Zhou, EP | 1 |
| Davis, RL | 1 |
| Ouyang, Y | 1 |
| Lin, HM | 1 |
| Yudkowitz, FS | 1 |
| Rabbani, CC | 1 |
| Pflum, ZE | 1 |
| Ye, MJ | 1 |
| Gettelfinger, JD | 1 |
| Sadhasivam, S | 1 |
| Matt, BH | 1 |
| Dahl, JP | 1 |
| Bongiovanni, T | 1 |
| Lancaster, E | 1 |
| Ledesma, Y | 1 |
| Whitaker, E | 1 |
| Steinman, MA | 1 |
| Allen, IE | 1 |
| Auerbach, A | 1 |
| Wick, E | 1 |
| McCormick, PJ | 1 |
| Assel, M | 1 |
| Van Zee, KJ | 1 |
| Vickers, AJ | 1 |
| Nelson, JA | 1 |
| Morrow, M | 1 |
| Tokita, HK | 1 |
| Simon, BA | 1 |
| Twersky, RS | 1 |
| Kolb, CM | 1 |
| Jain, N | 1 |
| Schillinger, K | 1 |
| Born, K | 1 |
| Banker, K | 1 |
| Aaronson, NL | 1 |
| Nardone, HC | 1 |
| Kopitkó, C | 1 |
| Czermann, R | 1 |
| Orosz, M | 1 |
| Hangody, G | 1 |
| Kiss, D | 1 |
| Szabó, Z | 1 |
| Hangody, L | 1 |
| Duttchen, KM | 1 |
| Lo, A | 1 |
| Walker, A | 1 |
| McLuckie, D | 1 |
| De Guzman, C | 1 |
| Roman-Smith, H | 1 |
| Davis, M | 1 |
| Firriolo, JM | 1 |
| Nuzzi, LC | 1 |
| Schmidtberg, LC | 1 |
| Labow, BI | 1 |
| Tabrizian, P | 1 |
| Giacca, M | 1 |
| Prigoff, J | 1 |
| Tran, B | 1 |
| Holzner, ML | 1 |
| Chin, E | 1 |
| Palese, M | 1 |
| Herron, D | 1 |
| Arvelakis, A | 1 |
| Rudow, DL | 1 |
| Florman, S | 1 |
| Shapiro, R | 1 |
| Oliveri, L | 1 |
| Jerzewski, K | 1 |
| Kulik, A | 1 |
| Chan, DK | 1 |
| Parikh, SR | 1 |
| Gobble, RM | 2 |
| Hoang, HLT | 1 |
| Kachniarz, B | 1 |
| Orgill, DP | 2 |
| Han, JB | 1 |
| Keller, EE | 1 |
| Grothe, RM | 1 |
| Davidson, JSD | 1 |
| Turner, K | 1 |
| Aldrink, JH | 1 |
| Ma, M | 1 |
| Wang, W | 1 |
| Caniano, DA | 1 |
| Wispe, J | 1 |
| Puthoff, T | 1 |
| Cawthorn, TR | 1 |
| Phelan, R | 1 |
| Davidson, JS | 1 |
| Turner, KE | 1 |
| Dsida, R | 1 |
| Coté, CJ | 1 |
| Gupta, A | 1 |
| Daggett, C | 1 |
| Ludwick, J | 1 |
| Wells, W | 1 |
| Lewis, A | 1 |
| Ignjatovic, D | 1 |
| Gunter, JB | 1 |
| Varughese, AM | 1 |
| Harrington, JF | 1 |
| Wittkugel, EP | 1 |
| Patankar, SS | 1 |
| Matar, MM | 1 |
| Lowe, EE | 1 |
| Myer, CM | 1 |
| Willging, JP | 1 |
| Etches, RC | 1 |
| Warriner, CB | 1 |
| Badner, N | 1 |
| Buckley, DN | 1 |
| Beattie, WS | 1 |
| Chan, VW | 1 |
| Parsons, D | 1 |
| Girard, M | 1 |
| Hubbell, K | 1 |
| Gumprecht, T | 1 |
| Houck, CS | 1 |
| Wilder, RT | 1 |
| McDermott, JS | 1 |
| Sethna, NF | 1 |
| Berde, CB | 1 |
| Hall, SC | 1 |
| Splinter, WM | 1 |
| Rhine, EJ | 1 |
| Roberts, DW | 1 |
| Reid, CW | 1 |
| MacNeill, HB | 1 |
| Rømsing, J | 2 |
| Walther-Larsen, S | 2 |
| Ostergaard, D | 1 |
| Valentin, N | 1 |
| Sharma, S | 1 |
| Chang, DW | 1 |
| Koutz, C | 1 |
| Evans, GR | 1 |
| Robb, GL | 1 |
| Langstein, HN | 1 |
| Kroll, SS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Opioid-Free Versus Transitional Anesthetic With Opioids From Tonsillectomy[NCT04528173] | Phase 4 | 550 participants (Anticipated) | Interventional | 2020-07-22 | Recruiting | ||
| A Randomized, Double-blinded, Placebo-controlled Study of Ketorolac Use in Pediatric Patients Undergoing Tonsillectomy[NCT03453541] | Phase 4 | 600 participants (Anticipated) | Interventional | 2017-11-21 | Recruiting | ||
| Prospective Evaluation of the Effects of IV Ketorolac on Platelet Function Post-Cesarean Delivery[NCT03805607] | Phase 4 | 40 participants (Actual) | Interventional | 2021-01-18 | Active, not recruiting | ||
| A Randomized Blinded Placebo Controlled Trial Assessing Ketorolac (Toradol) at Oocyte Retrieval[NCT06026553] | Phase 1 | 400 participants (Anticipated) | Interventional | 2022-08-10 | Recruiting | ||
| A Prospective, Randomized, Control Trial of Ketorolac Versus Placebo on Opioid Analgesic Use, Estimated Blood Loss and Complications Following Cesarean Delivery With Epidural Morphine[NCT02509312] | Phase 4 | 70 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| Prospective, Randomized, Allocation-Concealed, Blinded Study Designed to Compare Ketorolac Sublingual and Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children[NCT02653742] | Phase 4 | 150 participants (Anticipated) | Interventional | 2015-05-31 | Recruiting | ||
| Perioperative Systemic Acetaminophen to Improve Postoperative Quality of Recovery After Ambulatory Breast Surgery[NCT01852955] | 70 participants (Actual) | Interventional | 2013-11-30 | Completed | |||
| Does Ketorolac Increase the Risk of Hematoma After Reduction Mammoplasty? A Case-control Study.[NCT03280043] | 80 participants (Actual) | Observational | 2015-09-01 | Completed | |||
| A Pilot Study Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT02973958] | Phase 1 | 30 participants (Actual) | Interventional | 2017-02-01 | Completed | ||
| A Randomized Control Trial Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT04646967] | Phase 2 | 100 participants (Anticipated) | Interventional | 2022-11-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total doses of medications to treat pruritus (opioid side-effect) including ondansetron and promethazine. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | doses (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0 |
Corrected change in Hct on POD1. Performed by subtracting POD1 Hct from POD0 Hct. Correction for transfusion by further subtracting 3 per unit of pRBC transfused to account for the typical change seen per unit transfused. (NCT02509312)
Timeframe: POD1
| Intervention | mg/dl (Mean) |
|---|---|
| Ketorolac | -5.1 |
| Placebo | -3.5 |
Estimation of blood loss during surgery (NCT02509312)
Timeframe: Immediately post-op
| Intervention | ml (Median) |
|---|---|
| Ketorolac | 900 |
| Placebo | 800 |
Rate of Post-Partum Hemorrhage between groups during the first 24 hours pst-partum. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketorolac | 7 |
| Placebo | 4 |
Total doses of medications to treat pruritus (opioid side-effect) including diphenhydramine, nalbuphine and naloxone. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | doses (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0 |
Total hydromorphone doses in mg in the first 24 hours post-partum. (NCT02509312)
Timeframe: 0 - 24 hours post-partum.
| Intervention | mg (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0.2 |
Total number of Units of Packed Reb Blood Cell Transfused in intra-op until 24 hours post-partum. (NCT02509312)
Timeframe: Intra-op until 24 hours post-partum.
| Intervention | units of pRBCs (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0 |
Total number of uterotonic doses including methylergonovine, carboprost and misoprostol. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | doses (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0 |
Pain score post-Cesarean Delivery using 11-point numerical rating scale (NRS): 0-10 where 0 is no pain and 10 is the worst pain imaginable (NCT02509312)
Timeframe: Up to 24 hours post-cesarean delivery
| Intervention | units on NRS (Median) | |||||
|---|---|---|---|---|---|---|
| Baseline | 15 mins | 1 hour | 6 hours | 12 hours | 24 hours | |
| Ketorolac | 0 | 0 | 0 | 1 | 2 | 4.5 |
| Placebo | 0 | 0 | 0 | 3 | 3.5 | 5.5 |
Percentile change in diastolic Blood Pressure at 6,12, and 24 hours for each patient's baseline defined by immediate post-op PACU vitals. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | Percent change (Mean) | ||
|---|---|---|---|
| 6 hours | 12 hours | 24 hours | |
| Ketorolac | 12.30 | 8.8 | 12.0 |
| Placebo | 7.6 | 8.8 | 11.1 |
Percentile change in Systolic Blood Pressure at 6,12, and 24 hours for each patient's baseline defined by immediate post-op PACU vitals. (NCT02509312)
Timeframe: 0 - 24 hours post-partum
| Intervention | Percent change (Mean) | ||
|---|---|---|---|
| 6 hours | 12 hours | 24 hours | |
| Ketorolac | -2.0 | -9.10 | -5.9 |
| Placebo | -0.6 | -2.85 | -3.5 |
Postoperative opioid consumption over 24 hours. Converted into oral mg of morpine equivalents. (NCT01852955)
Timeframe: 24 hour
| Intervention | oral mg of morpine equivalents (Median) |
|---|---|
| IV Acetaminophen | 20 |
| Placebo | 30 |
Postoperative pain within the post anesthesia care unit after surgery. Area under the numeric rating scale for pain versus time curve in the post anesthesia care unit (score * min).Numeric rating scale for pain on a scale of 0-10 (0 is no pain and 10 is high pain) versus time curve in the post anesthesia care unit ( score * min). Area under a curve units of the horizontal axis multiplied by the units of the vertical axis. A higher value indicates more pain and time in the Post Anesthesia Care Unit.The range is 0 pain to x time in minutes x 1 hour to 5 hour ( 60-300 minutes) . The pain scores were collected at 15 minute intervals from the time of admission to the PACU. The area under the NRS pain scale versus time curve was calculated using the trapezoidal method as an indicator of pain burden during early recovery (Graph Pad Prism ver 5.03, Graph Pad Software INC. (NCT01852955)
Timeframe: Time in the post anesthesia care unit after surgery (average of 5 hours)
| Intervention | (units on a scale * minutes (Median) |
|---|---|
| IV Acetaminophen | 255 |
| Placebo | 240 |
Quality of recovery score 24 hours after the surgical procedure. Total score range of 40 (poor recovery) and a score of 200 (good recovery). (NCT01852955)
Timeframe: 24 hours after the surgical procedure
| Intervention | units on a scale (Median) |
|---|---|
| IV Acetaminophen | 189 |
| Placebo | 183 |
4 reviews available for ketorolac and Blood Loss, Postoperative
| Article | Year |
|---|---|
Systematic Review and Meta-Analysis of the Association Between Non-Steroidal Anti-Inflammatory Drugs and Operative Bleeding in the Perioperative Period.
Topics: Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Blood Loss, Surgical; Blood Transfusion; Diclofe | 2021 |
Perioperative ketorolac increases post-tonsillectomy hemorrhage in adults but not children.
Topics: Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Child; Humans; Ketorolac; Pain, Postope | 2014 |
Perioperative ketorolac increases post-tonsillectomy hemorrhage in adults but not children.
Topics: Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Child; Humans; Ketorolac; Pain, Postope | 2014 |
Perioperative ketorolac increases post-tonsillectomy hemorrhage in adults but not children.
Topics: Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Child; Humans; Ketorolac; Pain, Postope | 2014 |
Perioperative ketorolac increases post-tonsillectomy hemorrhage in adults but not children.
Topics: Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Child; Humans; Ketorolac; Pain, Postope | 2014 |
Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Male; Pain, Postoperative | 2014 |
Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Male; Pain, Postoperative | 2014 |
Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Male; Pain, Postoperative | 2014 |
Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Male; Pain, Postoperative | 2014 |
Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Male; Pain, Postoperative | 2014 |
Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Male; Pain, Postoperative | 2014 |
Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Male; Pain, Postoperative | 2014 |
Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Male; Pain, Postoperative | 2014 |
Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Male; Pain, Postoperative | 2014 |
Peri-operative use of nonsteroidal anti-inflammatory drugs in children: analgesic efficacy and bleeding.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Diclofenac; Drug Admin | 1997 |
6 trials available for ketorolac and Blood Loss, Postoperative
| Article | Year |
|---|---|
A randomized comparative evaluation of local infiltration analgesia, extended nerve blocks, and conventional analgesia in pain management after total knee arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia, Local; Anesthesia, Spinal; Anesthetics, Local | 2021 |
Intraoperative ketorolac dose of 15mg versus the standard 30mg on early postoperative pain after spine surgery: A randomized, blinded, non-inferiority trial.
Topics: Adult; Aged; Analgesics, Opioid; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double | 2017 |
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B | 1995 |
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B | 1995 |
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B | 1995 |
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B | 1995 |
Continuous intravenous administration of ketorolac reduces pain and morphine consumption after total hip or knee arthroplasty.
Topics: Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Antiem | 1995 |
Preoperative ketorolac increases bleeding after tonsillectomy in children.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anesthesia, Inhalation; Anesthet | 1996 |
Analgesic efficacy and safety of preoperative versus postoperative ketorolac in paediatric tonsillectomy.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; | 1998 |
20 other studies available for ketorolac and Blood Loss, Postoperative
| Article | Year |
|---|---|
Bleeding and ketorolac use in pediatric circumcision.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Humans; Ketorolac; Male; Pain, Postoperative; Postop | 2023 |
Intraoperative ketorolac for pediatric tonsillectomy: Effect on post-tonsillectomy hemorrhage and perioperative analgesia.
Topics: Adenoidectomy; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; | 2020 |
Intraoperative Ketorolac is Associated with Risk of Reoperation After Mastectomy: A Single-Center Examination.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Female; Humans; Ketor | 2021 |
Does perioperative ketorolac increase bleeding risk after intracapsular tonsillectomy?
Topics: Child; Humans; Ketorolac; Male; Postoperative Hemorrhage; Retrospective Studies; Tonsillectomy; Tons | 2021 |
Perioperative Ketorolac Use and Postoperative Hematoma Formation in Reduction Mammaplasty: A Single-Surgeon Experience of 500 Consecutive Cases.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Administration Schedul | 2018 |
Renal Safety of Intravenous Ketorolac Use After Donor Nephrectomy.
Topics: Administration, Intravenous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Female; Hum | 2019 |
Black box warning: is ketorolac safe for use after cardiac surgery?
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Cohor | 2014 |
Postoperative gastrointestinal bleeding in orthognathic surgery patients: its estimated prevalence and possible association to known risk factors.
Topics: Adolescent; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Bone Transplantation; | 2014 |
Reply: Ketorolac does not increase postoperative bleeding: a meta-analysis of randomized controlled trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Male; Pain, Postoperative; Posto | 2015 |
Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Male; Pain, Postoperative; Posto | 2015 |
Safety of ketorolac in surgical neonates and infants 0 to 3 months old.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Dose-Response Relationship, Drug; Drug Admi | 2011 |
Safety of ketorolac in surgical neonates and infants 0 to 3 months old.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Dose-Response Relationship, Drug; Drug Admi | 2011 |
Safety of ketorolac in surgical neonates and infants 0 to 3 months old.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Dose-Response Relationship, Drug; Drug Admi | 2011 |
Safety of ketorolac in surgical neonates and infants 0 to 3 months old.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Dose-Response Relationship, Drug; Drug Admi | 2011 |
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K | 2012 |
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K | 2012 |
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K | 2012 |
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K | 2012 |
Nonsteroidal antiinflammatory drugs and hemorrhage following tonsillectomy: do we have the data?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Ketorolac; Postoperative Hemorrhage; Ton | 2004 |
Ketorolac after congenital heart surgery: does it increase the risk of significant bleeding complications?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Child; Heart Defects, Congenit | 2005 |
Ketorolac after congenital heart surgery: does it increase the risk of significant bleeding complications?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Child; Heart Defects, Congenit | 2005 |
Ketorolac after congenital heart surgery: does it increase the risk of significant bleeding complications?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Child; Heart Defects, Congenit | 2005 |
Ketorolac after congenital heart surgery: does it increase the risk of significant bleeding complications?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Child; Heart Defects, Congenit | 2005 |
Comment to: Vuilleumier H, Halkic N. Ruptured subcapsular hematoma after laparoscopic cholecystectomy attributed to ketorolac-induced coagulopathy. Surg Endosc 2006, online first.
Topics: Blood Coagulation; Cholecystectomy, Laparoscopic; Follow-Up Studies; Gastrointestinal Hemorrhage; He | 2007 |
Problems and pitfalls in providing acute and short-term pain relief with nonsteroidal anti-inflammatory agents.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Drug Int | 1996 |
Risk of operative site bleeding with parenteral ketorolac.
Topics: Analgesics, Non-Narcotic; Humans; Ketorolac; Postoperative Hemorrhage; Tolmetin | 1996 |
Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system.
Topics: Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Prescho | 1996 |
Tonsillectomies, ketorolac, and the march of progress.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Child; Contraind | 1996 |
Incidence of hematoma associated with ketorolac after TRAM flap breast reconstruction.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 2001 |