Page last updated: 2024-10-29

ketorolac and Bimalleolar Ankle Fractures

ketorolac has been researched along with Bimalleolar Ankle Fractures in 4 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Research Excerpts

ExcerptRelevanceReference
"To determine whether postoperative ketorolac (1) reduces opioid consumption, (2) improves VAS pain control, and (3) affects fracture healing after open reduction and internal fixation of ankle fractures."3.96How Does Perioperative Ketorolac Affect Opioid Consumption and Pain Management After Ankle Fracture Surgery? ( Bilolikar, V; Daniel, JN; McDonald, EL; Nicholson, K; Pedowitz, DI; Raikin, SM; Rogero, RG; Shakked, RJ; Winters, BS, 2020)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (25.00)24.3611
2020's3 (75.00)2.80

Authors

AuthorsStudies
Badin, D1
Ortiz-Babilonia, CD1
Gupta, A1
Leland, CR1
Musharbash, F1
Parrish, JM1
Aiyer, AA1
McDonald, EL1
Daniel, JN2
Rogero, RG1
Shakked, RJ1
Nicholson, K2
Pedowitz, DI2
Raikin, SM1
Bilolikar, V1
Winters, BS1
Barg, A1
McDonald, E1
Winters, B1
Shakked, R1
Raikin, S1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study[NCT04771741]72 participants (Actual)Observational2020-12-01Completed
Effect of Toradol on Post-operative Foot and Ankle Healing[NCT03727048]Phase 4128 participants (Actual)Interventional2016-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for ketorolac and Bimalleolar Ankle Fractures

ArticleYear
Prescription Patterns, Associated Factors, and Outcomes of Opioids for Operative Foot and Ankle Fractures: A Systematic Review.
    Clinical orthopaedics and related research, 2022, 11-01, Volume: 480, Issue:11

    Topics: Adult; Analgesics, Opioid; Ankle Fractures; Child; Humans; Ketorolac; Middle Aged; Morphine; Observa

2022

Other Studies

3 other studies available for ketorolac and Bimalleolar Ankle Fractures

ArticleYear
How Does Perioperative Ketorolac Affect Opioid Consumption and Pain Management After Ankle Fracture Surgery?
    Clinical orthopaedics and related research, 2020, Volume: 478, Issue:1

    Topics: Adult; Analgesics, Opioid; Ankle Fractures; Ankle Joint; Anti-Inflammatory Agents, Non-Steroidal; Fe

2020
CORR Insights®: How Does Perioperative Ketorolac Affect Opioid Consumption and Pain Management After Ankle Fracture Surgery?
    Clinical orthopaedics and related research, 2020, Volume: 478, Issue:1

    Topics: Analgesics, Opioid; Ankle Fractures; Humans; Ketorolac; Pain Management; Pain, Postoperative

2020
Effect of Postoperative Ketorolac Administration on Bone Healing in Ankle Fracture Surgery.
    Foot & ankle international, 2018, Volume: 39, Issue:10

    Topics: Adult; Ankle Fractures; Anti-Inflammatory Agents, Non-Steroidal; Female; Fracture Fixation, Internal

2018