ketorolac has been researched along with Bimalleolar Ankle Fractures in 4 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether postoperative ketorolac (1) reduces opioid consumption, (2) improves VAS pain control, and (3) affects fracture healing after open reduction and internal fixation of ankle fractures." | 3.96 | How Does Perioperative Ketorolac Affect Opioid Consumption and Pain Management After Ankle Fracture Surgery? ( Bilolikar, V; Daniel, JN; McDonald, EL; Nicholson, K; Pedowitz, DI; Raikin, SM; Rogero, RG; Shakked, RJ; Winters, BS, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Badin, D | 1 |
| Ortiz-Babilonia, CD | 1 |
| Gupta, A | 1 |
| Leland, CR | 1 |
| Musharbash, F | 1 |
| Parrish, JM | 1 |
| Aiyer, AA | 1 |
| McDonald, EL | 1 |
| Daniel, JN | 2 |
| Rogero, RG | 1 |
| Shakked, RJ | 1 |
| Nicholson, K | 2 |
| Pedowitz, DI | 2 |
| Raikin, SM | 1 |
| Bilolikar, V | 1 |
| Winters, BS | 1 |
| Barg, A | 1 |
| McDonald, E | 1 |
| Winters, B | 1 |
| Shakked, R | 1 |
| Raikin, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study[NCT04771741] | 72 participants (Actual) | Observational | 2020-12-01 | Completed | |||
| Effect of Toradol on Post-operative Foot and Ankle Healing[NCT03727048] | Phase 4 | 128 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketorolac and Bimalleolar Ankle Fractures
| Article | Year |
|---|---|
Prescription Patterns, Associated Factors, and Outcomes of Opioids for Operative Foot and Ankle Fractures: A Systematic Review.
Topics: Adult; Analgesics, Opioid; Ankle Fractures; Child; Humans; Ketorolac; Middle Aged; Morphine; Observa | 2022 |
3 other studies available for ketorolac and Bimalleolar Ankle Fractures
| Article | Year |
|---|---|
How Does Perioperative Ketorolac Affect Opioid Consumption and Pain Management After Ankle Fracture Surgery?
Topics: Adult; Analgesics, Opioid; Ankle Fractures; Ankle Joint; Anti-Inflammatory Agents, Non-Steroidal; Fe | 2020 |
CORR Insights®: How Does Perioperative Ketorolac Affect Opioid Consumption and Pain Management After Ankle Fracture Surgery?
Topics: Analgesics, Opioid; Ankle Fractures; Humans; Ketorolac; Pain Management; Pain, Postoperative | 2020 |
Effect of Postoperative Ketorolac Administration on Bone Healing in Ankle Fracture Surgery.
Topics: Adult; Ankle Fractures; Anti-Inflammatory Agents, Non-Steroidal; Female; Fracture Fixation, Internal | 2018 |