ketorolac has been researched along with Biliary Tract Diseases in 4 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Biliary Tract Diseases: Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketorolac tromethamine is a well-tolerated, effective medication in the treatment of acute biliary colic." | 2.70 | Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic. ( Henderson, SO; Newton, E; Swadron, S, 2002) |
| "Ketorolac is a nonsteroidal anti-inflammatory medication that is used widely for pain management." | 2.70 | A prospective study comparing i.m. ketorolac with i.m. meperidine in the treatment of acute biliary colic. ( Anderson, R; Dula, DJ; Wood, GC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Olsen, JC | 1 |
| McGrath, NA | 1 |
| Schwarz, DG | 1 |
| Cutcliffe, BJ | 1 |
| Stern, JL | 1 |
| Henderson, SO | 1 |
| Swadron, S | 1 |
| Newton, E | 1 |
| Meyers, D | 1 |
| Feldstein, DA | 1 |
| Dula, DJ | 1 |
| Anderson, R | 1 |
| Wood, GC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of the Analgesic Efficacy of Intravenous Ibuprofen in Biliary Colic[NCT02268955] | 22 participants (Actual) | Interventional | 2014-09-09 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Pain is measured on a visual analog scale 0=no pain and 10=worst pain imaginable. (NCT02268955)
Timeframe: 120 minutes post medication administration
| Intervention | score on a scale (Median) |
|---|---|
| Control Group: Adults Age 18-55 Years | 3.0 |
| IV Ibuprofen: Adults Age 18-55 Years | 0.3 |
3 trials available for ketorolac and Biliary Tract Diseases
| Article | Year |
|---|---|
A double-blind randomized clinical trial evaluating the analgesic efficacy of ketorolac versus butorphanol for patients with suspected biliary colic in the emergency department.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract Diseases; Butorpha | 2008 |
Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract Diseases; Colic; D | 2002 |
A prospective study comparing i.m. ketorolac with i.m. meperidine in the treatment of acute biliary colic.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract | 2001 |
1 other study available for ketorolac and Biliary Tract Diseases
| Article | Year |
|---|---|
Initial treatment of biliary colic: are NSAIDs better than opiates?
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract Diseases; Cholecystitis; | 2005 |