ketorolac has been researched along with Asthma in 8 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketorolac is an effective and popular long-lasting analgesic that is especially useful in the emergency department and postoperatively." | 5.29 | Ketorolac-precipitated asthma. ( Hebert, WG; Scopelitis, E, 1994) |
| "Aspirin-exacerbated respiratory disease (AERD) is a late onset condition characterized by the Samter triad (aspirin sensitivity [as well as sensitivity to any nonselective cyclooxygenase inhibitor], nasal polyps, asthma) and additional features, including eosinophilic chronic rhinosinusitis, hypereosinophilia, anosmia, frequent absence of atopy, and, intolerance to ingestion of red wine and other alcoholic beverages." | 4.93 | Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future. ( Borish, L; Kennedy, JL; Stoner, AN, 2016) |
| "Aspirin-exacerbated respiratory disease is characterized by asthma, nasal polyps, and intolerance to aspirin with overexpression of leukotriene (LT) C(4) synthase and cysteinyl leukotriene receptors." | 3.75 | Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization. ( Borish, L; Culp, JA; Kropf, E; Steinke, JW, 2009) |
| " In general, the adverse events associated with ketorolac are similar to other NSAIDs." | 2.39 | Side effects of NSAIDs and dosing recommendations for ketorolac. ( Camu, F; Lauwers, MH; Vanlersberghe, C, 1996) |
| ", its pharmacokinetic (PK) properties] and how these PK properties differ between individuals in a population (i." | 1.32 | An evaluation of population D-optimal designs via pharmacokinetic simulations. ( Dodds, MG; Foracchia, M; Hooker, AC; Vicini, P, 2003) |
| "Ketorolac is an effective and popular long-lasting analgesic that is especially useful in the emergency department and postoperatively." | 1.29 | Ketorolac-precipitated asthma. ( Hebert, WG; Scopelitis, E, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kennedy, JL | 1 |
| Stoner, AN | 1 |
| Borish, L | 2 |
| Steinke, JW | 1 |
| Culp, JA | 1 |
| Kropf, E | 1 |
| Hooker, AC | 1 |
| Foracchia, M | 1 |
| Dodds, MG | 1 |
| Vicini, P | 1 |
| Hebert, WG | 1 |
| Scopelitis, E | 1 |
| Gijsbers, AJ | 1 |
| Clarke, BG | 1 |
| Camu, F | 1 |
| Lauwers, MH | 1 |
| Vanlersberghe, C | 1 |
| Lilley, LL | 1 |
| Guanci, R | 1 |
2 reviews available for ketorolac and Asthma
| Article | Year |
|---|---|
Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future.
Topics: Animals; Anti-Allergic Agents; Aspirin; Asthma; Desensitization, Immunologic; Diagnosis, Differentia | 2016 |
Side effects of NSAIDs and dosing recommendations for ketorolac.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cyclooxygenase Inhibitors; Dose-Response Rela | 1996 |
6 other studies available for ketorolac and Asthma
| Article | Year |
|---|---|
Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cell Line; Cyclooxygenase 2; Desensitizati | 2009 |
An evaluation of population D-optimal designs via pharmacokinetic simulations.
Topics: AIDS Vaccines; Algorithms; Asthma; Clinical Trials as Topic; Computer Simulation; Dose-Response Rela | 2003 |
Ketorolac-precipitated asthma.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Drug Hypersensitivity; Emergencies; Female; | 1994 |
Ketorolac.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Apnea; Aspirin; Asthma; Drug Hypersensitivity; | 1993 |
Cross sensitivities. Medication errors waiting to happen.
Topics: Analgesics, Non-Narcotic; Aspirin; Asthma; Cross Reactions; Drug Hypersensitivity; Drug Interactions | 1999 |
Drugs for pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2000 |