ketorolac has been researched along with Appendicitis in 3 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Appendicitis: Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this pilot trial, we will assess the feasibility of a definitive trial comparing ketorolac with morphine in children with suspected appendicitis." | 9.51 | Intravenous ketorolac versus morphine in children presenting with suspected appendicitis: a pilot single-centre non-inferiority randomised controlled trial. ( Ali, S; Beattie, K; Busse, JW; Carciumaru, R; Eltorki, M; Freedman, SB; Serbanescu, C; Thabane, L; Thompson, G, 2022) |
| "Perioperative ketorolac alone is not associated with an increased risk of significant bleeding in children undergoing appendectomy for perforated appendicitis." | 8.12 | Ketorolac use and risk of bleeding after appendectomy in children with perforated appendicitis. ( Kelley-Quon, LI; Kim, E; Kingston, P; Lascano, D; Ourshalimian, S; Russell, CJ, 2022) |
| " In this pilot trial, we will assess the feasibility of a definitive trial comparing ketorolac with morphine in children with suspected appendicitis." | 5.51 | Intravenous ketorolac versus morphine in children presenting with suspected appendicitis: a pilot single-centre non-inferiority randomised controlled trial. ( Ali, S; Beattie, K; Busse, JW; Carciumaru, R; Eltorki, M; Freedman, SB; Serbanescu, C; Thabane, L; Thompson, G, 2022) |
| "Perioperative ketorolac alone is not associated with an increased risk of significant bleeding in children undergoing appendectomy for perforated appendicitis." | 4.12 | Ketorolac use and risk of bleeding after appendectomy in children with perforated appendicitis. ( Kelley-Quon, LI; Kim, E; Kingston, P; Lascano, D; Ourshalimian, S; Russell, CJ, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kingston, P | 1 |
| Lascano, D | 1 |
| Ourshalimian, S | 1 |
| Russell, CJ | 1 |
| Kim, E | 1 |
| Kelley-Quon, LI | 1 |
| Eltorki, M | 1 |
| Busse, JW | 1 |
| Freedman, SB | 1 |
| Thompson, G | 1 |
| Beattie, K | 1 |
| Serbanescu, C | 1 |
| Carciumaru, R | 1 |
| Thabane, L | 1 |
| Ali, S | 1 |
| Talha, A | 1 |
| El-Haddad, H | 1 |
| Ghazal, AE | 1 |
| Shehata, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravenous Ketorolac Vs. Morphine In Children Presenting With Suspected Appendicitis: A Pilot Single Center Non Inferiority Randomised Controlled Trial[NCT04528563] | Phase 3 | 105 participants (Actual) | Interventional | 2021-05-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for ketorolac and Appendicitis
| Article | Year |
|---|---|
Intravenous ketorolac versus morphine in children presenting with suspected appendicitis: a pilot single-centre non-inferiority randomised controlled trial.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Appendicitis; Child; Double-Blind Method; Human | 2022 |
Laparoscopic versus open appendectomy for perforated appendicitis in adults: randomized clinical trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Appendectomy; Appendicitis; Drug Utiliza | 2020 |
1 other study available for ketorolac and Appendicitis
| Article | Year |
|---|---|
Ketorolac use and risk of bleeding after appendectomy in children with perforated appendicitis.
Topics: Appendectomy; Appendicitis; Child; Hemorrhage; Humans; Ibuprofen; Ketorolac; Retrospective Studies | 2022 |