Page last updated: 2024-10-29

ketorolac and Anastomotic Leak

ketorolac has been researched along with Anastomotic Leak in 8 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Anastomotic Leak: Breakdown of the connection and subsequent leakage of effluent (fluids, secretions, air) from a SURGICAL ANASTOMOSIS of the digestive, respiratory, genitourinary, and cardiovascular systems. Most common leakages are from the breakdown of suture lines in gastrointestinal or bowel anastomosis.

Research Excerpts

ExcerptRelevanceReference
"The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer."7.88Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients. ( Achiam, MP; Fjederholt, KT; Kirkegård, J; Mortensen, FV; Okholm, C; Svendsen, LB, 2018)
"This study aims to assess the association between ketorolac and anastomotic leak."7.88Ketorolac Use and Anastomotic Leak in Elective Colorectal Surgery: A Detailed Analysis. ( Ford, MM; Geiger, TM; Hawkins, AT; Hopkins, MB; King, AB; Martin, BJ; McEvoy, MD; Muldoon, RL; Wanderer, JP, 2018)
" Our aim was, for the first time, to analyze the morpho-functional effects of postoperative administration of two commonly used NSAIDs, Diclofenac and Ketorolac, on the healing process of colo-colic anastomoses constructed under condition of fecal peritonitis in a rat model."3.96Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration. ( Casciani, F; Ghiselli, R; Guerrieri, M; Lucarini, G; Orlando, F; Ortenzi, M; Provinciali, M; Saccomanno, S; Salvolini, E, 2020)
"The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer."3.88Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients. ( Achiam, MP; Fjederholt, KT; Kirkegård, J; Mortensen, FV; Okholm, C; Svendsen, LB, 2018)
"This study aims to assess the association between ketorolac and anastomotic leak."3.88Ketorolac Use and Anastomotic Leak in Elective Colorectal Surgery: A Detailed Analysis. ( Ford, MM; Geiger, TM; Hawkins, AT; Hopkins, MB; King, AB; Martin, BJ; McEvoy, MD; Muldoon, RL; Wanderer, JP, 2018)
" The purpose of this retrospective cohort study was to investigate the relationship between perioperative ketorolac use and anastomotic leakage after colorectal surgery."3.80Perioperative nonselective non-steroidal anti-inflammatory drugs are not associated with anastomotic leakage after colorectal surgery. ( Ambrosini, L; Gnanasegaram, JJ; Jackson, TD; Kwong, J; Okrainec, A; Quereshy, F; Saleh, F, 2014)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (62.50)24.3611
2020's3 (37.50)2.80

Authors

AuthorsStudies
Ghiselli, R1
Lucarini, G1
Ortenzi, M1
Salvolini, E1
Saccomanno, S1
Orlando, F1
Provinciali, M1
Casciani, F1
Guerrieri, M1
Kwon, JH1
Denlinger, CE1
Groth, SS1
Fjederholt, KT1
Okholm, C1
Svendsen, LB1
Achiam, MP1
Kirkegård, J1
Mortensen, FV1
Hawkins, AT1
McEvoy, MD1
Wanderer, JP1
Ford, MM1
Hopkins, MB1
Muldoon, RL1
Martin, BJ1
King, AB1
Geiger, TM1
Saleh, F1
Jackson, TD1
Ambrosini, L1
Gnanasegaram, JJ1
Kwong, J1
Quereshy, F1
Okrainec, A1
Hassan, I1
Van Koughnett, JA1
Wexner, SD1

Other Studies

8 other studies available for ketorolac and Anastomotic Leak

ArticleYear
Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration.
    European journal of histochemistry : EJH, 2020, Jan-10, Volume: 64, Issue:1

    Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cecum; Di

2020
Commentary: Don't fear the nonsteroidal anti-inflammatory drugs.
    The Journal of thoracic and cardiovascular surgery, 2021, Volume: 161, Issue:2

    Topics: Anastomotic Leak; Anti-Inflammatory Agents; Esophageal Neoplasms; Humans; Ketorolac; Pharmaceutical

2021
Commentary: Enhanced recovery after surgery: Does ketorolac get in the WAE of anastomotic healing following esophagectomy?
    The Journal of thoracic and cardiovascular surgery, 2021, Volume: 161, Issue:2

    Topics: Anastomosis, Surgical; Anastomotic Leak; Enhanced Recovery After Surgery; Esophageal Neoplasms; Esop

2021
Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2018, Volume: 22, Issue:4

    Topics: Adult; Aged; Anastomosis, Surgical; Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Datab

2018
Ketorolac Use and Anastomotic Leak in Elective Colorectal Surgery: A Detailed Analysis.
    Diseases of the colon and rectum, 2018, Volume: 61, Issue:12

    Topics: Acute Kidney Injury; Adult; Aged; Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Electiv

2018
Perioperative nonselective non-steroidal anti-inflammatory drugs are not associated with anastomotic leakage after colorectal surgery.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2014, Volume: 18, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Anastomosis, Surgical; Anastomotic Leak; Anti-Inflammatory Agents, N

2014
NSAID use and colorectal anastomotic leaks. Caution and further investigation.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2014, Volume: 18, Issue:8

    Topics: Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Colon; Elective Surgical Procedures; Fema

2014
Surgery. NSAIDs and risk of anastomotic leaks after colorectal surgery.
    Nature reviews. Gastroenterology & hepatology, 2014, Volume: 11, Issue:9

    Topics: Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Colon; Elective Surgical Procedures; Fema

2014