ketorolac has been researched along with Anastomotic Leak in 8 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Anastomotic Leak: Breakdown of the connection and subsequent leakage of effluent (fluids, secretions, air) from a SURGICAL ANASTOMOSIS of the digestive, respiratory, genitourinary, and cardiovascular systems. Most common leakages are from the breakdown of suture lines in gastrointestinal or bowel anastomosis.
Excerpt | Relevance | Reference |
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"The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer." | 7.88 | Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients. ( Achiam, MP; Fjederholt, KT; Kirkegård, J; Mortensen, FV; Okholm, C; Svendsen, LB, 2018) |
"This study aims to assess the association between ketorolac and anastomotic leak." | 7.88 | Ketorolac Use and Anastomotic Leak in Elective Colorectal Surgery: A Detailed Analysis. ( Ford, MM; Geiger, TM; Hawkins, AT; Hopkins, MB; King, AB; Martin, BJ; McEvoy, MD; Muldoon, RL; Wanderer, JP, 2018) |
" Our aim was, for the first time, to analyze the morpho-functional effects of postoperative administration of two commonly used NSAIDs, Diclofenac and Ketorolac, on the healing process of colo-colic anastomoses constructed under condition of fecal peritonitis in a rat model." | 3.96 | Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration. ( Casciani, F; Ghiselli, R; Guerrieri, M; Lucarini, G; Orlando, F; Ortenzi, M; Provinciali, M; Saccomanno, S; Salvolini, E, 2020) |
"The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer." | 3.88 | Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients. ( Achiam, MP; Fjederholt, KT; Kirkegård, J; Mortensen, FV; Okholm, C; Svendsen, LB, 2018) |
"This study aims to assess the association between ketorolac and anastomotic leak." | 3.88 | Ketorolac Use and Anastomotic Leak in Elective Colorectal Surgery: A Detailed Analysis. ( Ford, MM; Geiger, TM; Hawkins, AT; Hopkins, MB; King, AB; Martin, BJ; McEvoy, MD; Muldoon, RL; Wanderer, JP, 2018) |
" The purpose of this retrospective cohort study was to investigate the relationship between perioperative ketorolac use and anastomotic leakage after colorectal surgery." | 3.80 | Perioperative nonselective non-steroidal anti-inflammatory drugs are not associated with anastomotic leakage after colorectal surgery. ( Ambrosini, L; Gnanasegaram, JJ; Jackson, TD; Kwong, J; Okrainec, A; Quereshy, F; Saleh, F, 2014) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 5 (62.50) | 24.3611 |
2020's | 3 (37.50) | 2.80 |
Authors | Studies |
---|---|
Ghiselli, R | 1 |
Lucarini, G | 1 |
Ortenzi, M | 1 |
Salvolini, E | 1 |
Saccomanno, S | 1 |
Orlando, F | 1 |
Provinciali, M | 1 |
Casciani, F | 1 |
Guerrieri, M | 1 |
Kwon, JH | 1 |
Denlinger, CE | 1 |
Groth, SS | 1 |
Fjederholt, KT | 1 |
Okholm, C | 1 |
Svendsen, LB | 1 |
Achiam, MP | 1 |
Kirkegård, J | 1 |
Mortensen, FV | 1 |
Hawkins, AT | 1 |
McEvoy, MD | 1 |
Wanderer, JP | 1 |
Ford, MM | 1 |
Hopkins, MB | 1 |
Muldoon, RL | 1 |
Martin, BJ | 1 |
King, AB | 1 |
Geiger, TM | 1 |
Saleh, F | 1 |
Jackson, TD | 1 |
Ambrosini, L | 1 |
Gnanasegaram, JJ | 1 |
Kwong, J | 1 |
Quereshy, F | 1 |
Okrainec, A | 1 |
Hassan, I | 1 |
Van Koughnett, JA | 1 |
Wexner, SD | 1 |
8 other studies available for ketorolac and Anastomotic Leak
Article | Year |
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Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cecum; Di | 2020 |
Commentary: Don't fear the nonsteroidal anti-inflammatory drugs.
Topics: Anastomotic Leak; Anti-Inflammatory Agents; Esophageal Neoplasms; Humans; Ketorolac; Pharmaceutical | 2021 |
Commentary: Enhanced recovery after surgery: Does ketorolac get in the WAE of anastomotic healing following esophagectomy?
Topics: Anastomosis, Surgical; Anastomotic Leak; Enhanced Recovery After Surgery; Esophageal Neoplasms; Esop | 2021 |
Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients.
Topics: Adult; Aged; Anastomosis, Surgical; Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Datab | 2018 |
Ketorolac Use and Anastomotic Leak in Elective Colorectal Surgery: A Detailed Analysis.
Topics: Acute Kidney Injury; Adult; Aged; Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Electiv | 2018 |
Perioperative nonselective non-steroidal anti-inflammatory drugs are not associated with anastomotic leakage after colorectal surgery.
Topics: Adult; Aged; Aged, 80 and over; Anastomosis, Surgical; Anastomotic Leak; Anti-Inflammatory Agents, N | 2014 |
NSAID use and colorectal anastomotic leaks. Caution and further investigation.
Topics: Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Colon; Elective Surgical Procedures; Fema | 2014 |
Surgery. NSAIDs and risk of anastomotic leaks after colorectal surgery.
Topics: Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Colon; Elective Surgical Procedures; Fema | 2014 |