Page last updated: 2024-10-29

ketorolac and Anasarca

ketorolac has been researched along with Anasarca in 16 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Research Excerpts

ExcerptRelevanceReference
"Treatment with morphine (1mg/kg, s."5.38Involvement of inflammation in severe post-operative pain demonstrated by pre-surgical and post-surgical treatment with piroxicam and ketorolac. ( Fujita, I; Kita, Y; Okumura, T; Sakakibara, A, 2012)
" All compounds were tested for their anti-inflammatory activity using the carrageenan-induced rat paw oedema model and exhibited weak to good activities compared to ketorolac as the reference drug."3.76Novel substituted and fused pyrrolizine derivatives: synthesis, anti-inflammatory and ulcerogenecity studies. ( Abbas, SE; Awadallah, FM; Gouda, AM; Ibrahim, NA, 2010)
") had no effect in two acute pain models, namely, the acetic acid-induced writhing (visceral pain) and the formalin test (tonic pain)."3.72Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. ( Jain, NK; Kulkarni, SK; Padi, SS; Singh, S, 2004)
"The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale."3.01Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. ( Araújo, FA; Barros, AM; Lucena, EE; Martins-de-Barros, AV; Sette de Souza, PH; Siqueira, AK, 2021)
"Pain, trismus, and swelling after lower third molar extraction, independent of surgical difficulty, were successfully controlled by sublingual ketorolac (10 mg 4 times daily) or sublingual piroxicam (20 mg once daily), and no significant differences were observed between the NSAIDs evaluated."2.77Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal. ( Brozoski, DT; Calvo, AM; Colombini-Ishikiriama, BL; Dionísio, TJ; Faria, FA; Giglio, FP; Lauris, JR; Modena, KC; Ribeiro, DA; Santos, CF; Trindade, PA, 2012)
" The selective COX-2 inhibitors hold promise for clinical efficacy with less toxicity from chronic administration and may prove advantageous for the relief of chronic orofacial pain."2.41Therapeutic uses of non-steroidal anti-inflammatory drugs in dentistry. ( Berthold, CW; Dionne, RA, 2001)
"Treatment with morphine (1mg/kg, s."1.38Involvement of inflammation in severe post-operative pain demonstrated by pre-surgical and post-surgical treatment with piroxicam and ketorolac. ( Fujita, I; Kita, Y; Okumura, T; Sakakibara, A, 2012)
" In a single dose study, its pharmacokinetic profile was compared with that of ketorolac."1.35Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations. ( Abignente, E; Boatto, G; Calignano, A; Curcio, A; Gavini, E; La Rana, G; Melisi, D; Nieddu, M; Rimoli, MG; Russo, R; Sasso, O, 2009)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19903 (18.75)18.7374
1990's0 (0.00)18.2507
2000's4 (25.00)29.6817
2010's8 (50.00)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Muchowski, JM2
Galeazzi, E1
Greenhouse, R1
Guzmán, A1
Peréz, V1
Ackerman, N1
Ballaron, SA1
Rovito, JR1
Tomolonis, AJ2
Young, JM1
Unger, SH1
Ackrell, J1
Cheung, P1
Cooper, GF1
Cook, J1
Gallegra, P1
Halpern, O1
Koehler, R1
Kluge, AF1
Curcio, A1
Sasso, O1
Melisi, D1
Nieddu, M1
La Rana, G1
Russo, R1
Gavini, E1
Boatto, G1
Abignente, E1
Calignano, A1
Rimoli, MG1
Abbas, SE1
Awadallah, FM1
Ibrahim, NA1
Gouda, AM1
Abdelazeem, AH1
Khan, SI1
White, SW1
Sufka, KJ1
McCurdy, CR1
Madrigal, DA1
Escalante, CH1
Gutiérrez-Rebolledo, GA1
Cristobal-Luna, JM1
Gómez-García, O1
Hernández-Benitez, RI1
Esquivel-Campos, AL1
Pérez-Gutiérrez, S1
Chamorro-Cevallos, GA1
Delgado, F1
Tamariz, J1
Martins-de-Barros, AV1
Barros, AM1
Siqueira, AK1
Lucena, EE1
Sette de Souza, PH1
Araújo, FA1
Brignardello-Petersen, R1
Lee, U1
Choi, YJ1
Choi, GJ1
Kang, H1
Isiordia-Espinoza, MA1
Sánchez-Prieto, M1
Tobías-Azúa, F1
Reyes-García, JG1
Fujita, I1
Okumura, T1
Sakakibara, A1
Kita, Y1
Trindade, PA1
Giglio, FP1
Colombini-Ishikiriama, BL1
Calvo, AM1
Modena, KC1
Ribeiro, DA1
Dionísio, TJ1
Brozoski, DT1
Lauris, JR1
Faria, FA1
Santos, CF1
Padi, SS1
Jain, NK1
Singh, S1
Kulkarni, SK1
Alsarra, IA1
Alanazi, FK1
Mahrous, GM1
Abdel Rahman, AA1
Al Hezaimi, KA1
Rooks, WH1
Maloney, PJ1
Wallach, MB1
Schuler, ME1
Dionne, RA1
Berthold, CW1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Preemptive Use of Etoricoxib and Dexamethasone: Effect on Early Bone Healing, Inflammatory Response, and Postoperative Parameters After Impacted Lower Third Molar Surgery[NCT05791721]Phase 490 participants (Actual)Interventional2021-10-11Completed
Preliminary Studies for Whole Genome Association Study (WGAS) in Acute Perioperative Pain[NCT01557751]156 participants (Actual)Interventional2010-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

NRS-Pain With Movement on POD 2

"The primary endpoint is the pain reported by subjects, using the NRS-Pain with movement on the second day after surgery.The assumption behind this study is that certain genetic variants (e.g. single-nucleotide polymorphism (SNP) are responsible for part of total variation of certain clinical phenotypes (e.g. post-operative pain here).~Numeric Rating Score Pain Assessment (0-10 scale where 0 indicates no pain at all and 10 indicates the worst pain imaginable) on Post Op Day 2, Pain with Movement" (NCT01557751)
Timeframe: Postoperative day (POD) 2

Interventionunits on a scale (Mean)
Total Knee Arthroplasty Subjects Who Are Genotyped2.83

Reviews

1 review available for ketorolac and Anasarca

ArticleYear
Therapeutic uses of non-steroidal anti-inflammatory drugs in dentistry.
    Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 2001, Volume: 12, Issue:4

    Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; beta-Endorphin; Cyclooxygenase 2; Cyclo

2001

Trials

5 trials available for ketorolac and Anasarca

ArticleYear
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial.
    Medicina oral, patologia oral y cirugia bucal, 2021, Mar-01, Volume: 26, Issue:2

    Topics: Dexamethasone; Double-Blind Method; Edema; Female; Humans; Ketorolac; Male; Molar, Third; Pain, Post

2021
Intravenous lidocaine for effective pain relief after bimaxillary surgery.
    Clinical oral investigations, 2017, Volume: 21, Issue:9

    Topics: Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Cone-Beam Computed T

2017
Pre-emptive analgesic effectiveness of meloxicam versus tramadol after mandibular third molar surgery: a pilot study.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2012, Volume: 70, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method;

2012
Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2012, Volume: 114, Issue:1

    Topics: Analysis of Variance; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Edema; Fem

2012
Clinical evaluation of novel buccoadhesive film containing ketorolac in dental and post-oral surgery pain management.
    Die Pharmazie, 2007, Volume: 62, Issue:10

    Topics: Adolescent; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Chemical Phen

2007

Other Studies

10 other studies available for ketorolac and Anasarca

ArticleYear
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-6-(methylthio)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-ca rboxyl ic acids and 1-methyl-4-(methylthio)-5-aroylpyrrole-2-acetic acids.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

    Topics: Acetates; Analgesia; Animals; Aspirin; Benzoquinones; Carboxylic Acids; Carrageenan; Chemical Phenom

1989
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and related compounds.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:8

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Male; Mice; Pain; Pyrroles; Rats; Structure-Ac

1985
Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations.
    Journal of medicinal chemistry, 2009, Jun-25, Volume: 52, Issue:12

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Edem

2009
Novel substituted and fused pyrrolizine derivatives: synthesis, anti-inflammatory and ulcerogenecity studies.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Female; Male; Mice; Pyrroles; Rats; Ulcer

2010
Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.
    Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Benzoxazoles; Carragee

2015
Synthesis and highly potent anti-inflammatory activity of licofelone- and ketorolac-based 1-arylpyrrolizin-3-ones.
    Bioorganic & medicinal chemistry, 2019, 10-15, Volume: 27, Issue:20

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Dose-Response Relationsh

2019
Betamethasone does not seem to provide benefits in postoperative pain and swelling when added to ketorolac after placement of multiple implants.
    Journal of the American Dental Association (1939), 2017, Volume: 148, Issue:7

    Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Double-Blind Method; Ede

2017
Involvement of inflammation in severe post-operative pain demonstrated by pre-surgical and post-surgical treatment with piroxicam and ketorolac.
    The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:5

    Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Hyperalgesia;

2012
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
    European journal of pharmacology, 2004, Apr-26, Volume: 491, Issue:1

    Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh

2004
The analgesic and anti-inflammatory profile of (+/-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619).
    Agents and actions, 1982, Volume: 12, Issue:5-6

    Topics: Adrenal Cortex Hormones; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, No

1982