ketorolac has been researched along with Anasarca in 16 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with morphine (1mg/kg, s." | 5.38 | Involvement of inflammation in severe post-operative pain demonstrated by pre-surgical and post-surgical treatment with piroxicam and ketorolac. ( Fujita, I; Kita, Y; Okumura, T; Sakakibara, A, 2012) |
| " All compounds were tested for their anti-inflammatory activity using the carrageenan-induced rat paw oedema model and exhibited weak to good activities compared to ketorolac as the reference drug." | 3.76 | Novel substituted and fused pyrrolizine derivatives: synthesis, anti-inflammatory and ulcerogenecity studies. ( Abbas, SE; Awadallah, FM; Gouda, AM; Ibrahim, NA, 2010) |
| ") had no effect in two acute pain models, namely, the acetic acid-induced writhing (visceral pain) and the formalin test (tonic pain)." | 3.72 | Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. ( Jain, NK; Kulkarni, SK; Padi, SS; Singh, S, 2004) |
| "The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale." | 3.01 | Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. ( Araújo, FA; Barros, AM; Lucena, EE; Martins-de-Barros, AV; Sette de Souza, PH; Siqueira, AK, 2021) |
| "Pain, trismus, and swelling after lower third molar extraction, independent of surgical difficulty, were successfully controlled by sublingual ketorolac (10 mg 4 times daily) or sublingual piroxicam (20 mg once daily), and no significant differences were observed between the NSAIDs evaluated." | 2.77 | Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal. ( Brozoski, DT; Calvo, AM; Colombini-Ishikiriama, BL; Dionísio, TJ; Faria, FA; Giglio, FP; Lauris, JR; Modena, KC; Ribeiro, DA; Santos, CF; Trindade, PA, 2012) |
| " The selective COX-2 inhibitors hold promise for clinical efficacy with less toxicity from chronic administration and may prove advantageous for the relief of chronic orofacial pain." | 2.41 | Therapeutic uses of non-steroidal anti-inflammatory drugs in dentistry. ( Berthold, CW; Dionne, RA, 2001) |
| "Treatment with morphine (1mg/kg, s." | 1.38 | Involvement of inflammation in severe post-operative pain demonstrated by pre-surgical and post-surgical treatment with piroxicam and ketorolac. ( Fujita, I; Kita, Y; Okumura, T; Sakakibara, A, 2012) |
| " In a single dose study, its pharmacokinetic profile was compared with that of ketorolac." | 1.35 | Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations. ( Abignente, E; Boatto, G; Calignano, A; Curcio, A; Gavini, E; La Rana, G; Melisi, D; Nieddu, M; Rimoli, MG; Russo, R; Sasso, O, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Muchowski, JM | 2 |
| Galeazzi, E | 1 |
| Greenhouse, R | 1 |
| Guzmán, A | 1 |
| Peréz, V | 1 |
| Ackerman, N | 1 |
| Ballaron, SA | 1 |
| Rovito, JR | 1 |
| Tomolonis, AJ | 2 |
| Young, JM | 1 |
| Unger, SH | 1 |
| Ackrell, J | 1 |
| Cheung, P | 1 |
| Cooper, GF | 1 |
| Cook, J | 1 |
| Gallegra, P | 1 |
| Halpern, O | 1 |
| Koehler, R | 1 |
| Kluge, AF | 1 |
| Curcio, A | 1 |
| Sasso, O | 1 |
| Melisi, D | 1 |
| Nieddu, M | 1 |
| La Rana, G | 1 |
| Russo, R | 1 |
| Gavini, E | 1 |
| Boatto, G | 1 |
| Abignente, E | 1 |
| Calignano, A | 1 |
| Rimoli, MG | 1 |
| Abbas, SE | 1 |
| Awadallah, FM | 1 |
| Ibrahim, NA | 1 |
| Gouda, AM | 1 |
| Abdelazeem, AH | 1 |
| Khan, SI | 1 |
| White, SW | 1 |
| Sufka, KJ | 1 |
| McCurdy, CR | 1 |
| Madrigal, DA | 1 |
| Escalante, CH | 1 |
| Gutiérrez-Rebolledo, GA | 1 |
| Cristobal-Luna, JM | 1 |
| Gómez-García, O | 1 |
| Hernández-Benitez, RI | 1 |
| Esquivel-Campos, AL | 1 |
| Pérez-Gutiérrez, S | 1 |
| Chamorro-Cevallos, GA | 1 |
| Delgado, F | 1 |
| Tamariz, J | 1 |
| Martins-de-Barros, AV | 1 |
| Barros, AM | 1 |
| Siqueira, AK | 1 |
| Lucena, EE | 1 |
| Sette de Souza, PH | 1 |
| Araújo, FA | 1 |
| Brignardello-Petersen, R | 1 |
| Lee, U | 1 |
| Choi, YJ | 1 |
| Choi, GJ | 1 |
| Kang, H | 1 |
| Isiordia-Espinoza, MA | 1 |
| Sánchez-Prieto, M | 1 |
| Tobías-Azúa, F | 1 |
| Reyes-García, JG | 1 |
| Fujita, I | 1 |
| Okumura, T | 1 |
| Sakakibara, A | 1 |
| Kita, Y | 1 |
| Trindade, PA | 1 |
| Giglio, FP | 1 |
| Colombini-Ishikiriama, BL | 1 |
| Calvo, AM | 1 |
| Modena, KC | 1 |
| Ribeiro, DA | 1 |
| Dionísio, TJ | 1 |
| Brozoski, DT | 1 |
| Lauris, JR | 1 |
| Faria, FA | 1 |
| Santos, CF | 1 |
| Padi, SS | 1 |
| Jain, NK | 1 |
| Singh, S | 1 |
| Kulkarni, SK | 1 |
| Alsarra, IA | 1 |
| Alanazi, FK | 1 |
| Mahrous, GM | 1 |
| Abdel Rahman, AA | 1 |
| Al Hezaimi, KA | 1 |
| Rooks, WH | 1 |
| Maloney, PJ | 1 |
| Wallach, MB | 1 |
| Schuler, ME | 1 |
| Dionne, RA | 1 |
| Berthold, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preemptive Use of Etoricoxib and Dexamethasone: Effect on Early Bone Healing, Inflammatory Response, and Postoperative Parameters After Impacted Lower Third Molar Surgery[NCT05791721] | Phase 4 | 90 participants (Actual) | Interventional | 2021-10-11 | Completed | ||
| Preliminary Studies for Whole Genome Association Study (WGAS) in Acute Perioperative Pain[NCT01557751] | 156 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The primary endpoint is the pain reported by subjects, using the NRS-Pain with movement on the second day after surgery.The assumption behind this study is that certain genetic variants (e.g. single-nucleotide polymorphism (SNP) are responsible for part of total variation of certain clinical phenotypes (e.g. post-operative pain here).~Numeric Rating Score Pain Assessment (0-10 scale where 0 indicates no pain at all and 10 indicates the worst pain imaginable) on Post Op Day 2, Pain with Movement" (NCT01557751)
Timeframe: Postoperative day (POD) 2
| Intervention | units on a scale (Mean) |
|---|---|
| Total Knee Arthroplasty Subjects Who Are Genotyped | 2.83 |
1 review available for ketorolac and Anasarca
| Article | Year |
|---|---|
Therapeutic uses of non-steroidal anti-inflammatory drugs in dentistry.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; beta-Endorphin; Cyclooxygenase 2; Cyclo | 2001 |
5 trials available for ketorolac and Anasarca
| Article | Year |
|---|---|
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial.
Topics: Dexamethasone; Double-Blind Method; Edema; Female; Humans; Ketorolac; Male; Molar, Third; Pain, Post | 2021 |
Intravenous lidocaine for effective pain relief after bimaxillary surgery.
Topics: Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Cone-Beam Computed T | 2017 |
Pre-emptive analgesic effectiveness of meloxicam versus tramadol after mandibular third molar surgery: a pilot study.
Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; | 2012 |
Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal.
Topics: Analysis of Variance; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Edema; Fem | 2012 |
Clinical evaluation of novel buccoadhesive film containing ketorolac in dental and post-oral surgery pain management.
Topics: Adolescent; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Chemical Phen | 2007 |
10 other studies available for ketorolac and Anasarca
| Article | Year |
|---|---|
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-6-(methylthio)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-ca rboxyl ic acids and 1-methyl-4-(methylthio)-5-aroylpyrrole-2-acetic acids.
Topics: Acetates; Analgesia; Animals; Aspirin; Benzoquinones; Carboxylic Acids; Carrageenan; Chemical Phenom | 1989 |
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and related compounds.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Male; Mice; Pain; Pyrroles; Rats; Structure-Ac | 1985 |
Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Edem | 2009 |
Novel substituted and fused pyrrolizine derivatives: synthesis, anti-inflammatory and ulcerogenecity studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Female; Male; Mice; Pyrroles; Rats; Ulcer | 2010 |
Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Benzoxazoles; Carragee | 2015 |
Synthesis and highly potent anti-inflammatory activity of licofelone- and ketorolac-based 1-arylpyrrolizin-3-ones.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Dose-Response Relationsh | 2019 |
Betamethasone does not seem to provide benefits in postoperative pain and swelling when added to ketorolac after placement of multiple implants.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Double-Blind Method; Ede | 2017 |
Involvement of inflammation in severe post-operative pain demonstrated by pre-surgical and post-surgical treatment with piroxicam and ketorolac.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Hyperalgesia; | 2012 |
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2004 |
The analgesic and anti-inflammatory profile of (+/-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619).
Topics: Adrenal Cortex Hormones; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, No | 1982 |