ketorolac has been researched along with Allergy, Drug in 13 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketorolac is a potent analgesic drug that has been restricted in dosage and use because of its potential adverse effects." | 5.33 | Report of an anaphylactoid and an anaphylactic reaction to ketorolac in two pediatric surgical patients. ( Castillo-Peralta, LA; Castillo-Zamora, C; Nava-Ocampo, AA, 2006) |
| "Ketorolac is an effective and popular long-lasting analgesic that is especially useful in the emergency department and postoperatively." | 5.29 | Ketorolac-precipitated asthma. ( Hebert, WG; Scopelitis, E, 1994) |
| "Aspirin-exacerbated respiratory disease (AERD) is a late onset condition characterized by the Samter triad (aspirin sensitivity [as well as sensitivity to any nonselective cyclooxygenase inhibitor], nasal polyps, asthma) and additional features, including eosinophilic chronic rhinosinusitis, hypereosinophilia, anosmia, frequent absence of atopy, and, intolerance to ingestion of red wine and other alcoholic beverages." | 4.93 | Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future. ( Borish, L; Kennedy, JL; Stoner, AN, 2016) |
| "Aspirin-exacerbated respiratory disease is characterized by asthma, nasal polyps, and intolerance to aspirin with overexpression of leukotriene (LT) C(4) synthase and cysteinyl leukotriene receptors." | 3.75 | Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization. ( Borish, L; Culp, JA; Kropf, E; Steinke, JW, 2009) |
| "Ketorolac is approved for the relief of postoperative pain but concerns have been raised over a possible risk of serious adverse effects and death." | 2.70 | Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. ( Abdalla, M; Bianchi, PG; Bonnet, F; Camu, F; Ebrahim, S; Escolar, G; Forrest, JB; Greer, IA; Heitlinger, E; Jage, J; Kehlet, H; Langman, MJ; Pocock, S; Samama, MM; Velo, G, 2002) |
| "Ketorolac is a potent analgesic drug that has been restricted in dosage and use because of its potential adverse effects." | 1.33 | Report of an anaphylactoid and an anaphylactic reaction to ketorolac in two pediatric surgical patients. ( Castillo-Peralta, LA; Castillo-Zamora, C; Nava-Ocampo, AA, 2006) |
| "Ketorolac is an effective and popular long-lasting analgesic that is especially useful in the emergency department and postoperatively." | 1.29 | Ketorolac-precipitated asthma. ( Hebert, WG; Scopelitis, E, 1994) |
| "Ketorolac proved safe for short-term intravenous use in children more than 1 year of age when patients with known contraindications to the use of non-steroidal antiinflammatory drugs were excluded." | 1.29 | Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system. ( Berde, CB; Houck, CS; McDermott, JS; Sethna, NF; Wilder, RT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pal, K | 1 |
| Ramsden, M | 1 |
| Shim, YM | 1 |
| Borish, L | 3 |
| Payne, SC | 1 |
| Steinke, JW | 2 |
| Kennedy, JL | 1 |
| Stoner, AN | 1 |
| Culp, JA | 1 |
| Kropf, E | 1 |
| Kang, YJ | 1 |
| Vincler, M | 1 |
| Li, X | 1 |
| Conklin, D | 1 |
| Eisenach, JC | 1 |
| Castillo-Zamora, C | 1 |
| Castillo-Peralta, LA | 1 |
| Nava-Ocampo, AA | 1 |
| White, A | 1 |
| Bigby, T | 1 |
| Stevenson, D | 1 |
| Hebert, WG | 1 |
| Scopelitis, E | 1 |
| Shapiro, N | 1 |
| Gijsbers, AJ | 1 |
| Clarke, BG | 1 |
| Hubbell, K | 1 |
| Houck, CS | 1 |
| Wilder, RT | 1 |
| McDermott, JS | 1 |
| Sethna, NF | 1 |
| Berde, CB | 1 |
| Lilley, LL | 1 |
| Guanci, R | 1 |
| Forrest, JB | 1 |
| Camu, F | 1 |
| Greer, IA | 1 |
| Kehlet, H | 1 |
| Abdalla, M | 1 |
| Bonnet, F | 1 |
| Ebrahim, S | 1 |
| Escolar, G | 1 |
| Jage, J | 1 |
| Pocock, S | 1 |
| Velo, G | 1 |
| Langman, MJ | 1 |
| Bianchi, PG | 1 |
| Samama, MM | 1 |
| Heitlinger, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Perioperative Usage of Ketorolac on Postoperative Pain Reduction in Pediatric Patients With Adenotonsillectom[NCT05074056] | Phase 4 | 200 participants (Anticipated) | Interventional | 2022-02-08 | Recruiting | ||
| Opioid-Free Versus Transitional Anesthetic With Opioids From Tonsillectomy[NCT04528173] | Phase 4 | 550 participants (Anticipated) | Interventional | 2020-07-22 | Recruiting | ||
| Acute Kidney Injury and Nonsteroidal Anti-inflammatory Drugs in Patients Undergoing High-risk Abdominal or Thoracic Surgery[NCT02553174] | 50 participants (Actual) | Observational | 2016-06-01 | Terminated (stopped due to unable to recruit sufficient patients to satisfy study protocols) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketorolac and Allergy, Drug
| Article | Year |
|---|---|
Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future.
Topics: Animals; Anti-Allergic Agents; Aspirin; Asthma; Desensitization, Immunologic; Diagnosis, Differentia | 2016 |
2 trials available for ketorolac and Allergy, Drug
| Article | Year |
|---|---|
Intranasal ketorolac challenge for the diagnosis of aspirin-exacerbated respiratory disease.
Topics: Administration, Intranasal; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Dr | 2006 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2002 |
10 other studies available for ketorolac and Allergy, Drug
| Article | Year |
|---|---|
Suppression of aspirin-mediated eosinophil activation by prostaglandin E
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Cysteine; Dinoprostone; Drug Hype | 2019 |
Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cell Line; Cyclooxygenase 2; Desensitizati | 2009 |
Intrathecal ketorolac reverses hypersensitivity following acute fentanyl exposure.
Topics: Anesthetics, Intravenous; Animals; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Fentanyl; Hyper | 2002 |
Report of an anaphylactoid and an anaphylactic reaction to ketorolac in two pediatric surgical patients.
Topics: Analgesics; Anaphylaxis; Child; Child, Preschool; Drug Hypersensitivity; Female; Humans; Ketorolac; | 2006 |
Ketorolac-precipitated asthma.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Drug Hypersensitivity; Emergencies; Female; | 1994 |
Acute angioedema after ketorolac ingestion: report of case.
Topics: Acute Disease; Administration, Oral; Aged; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Drug | 1994 |
Ketorolac.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Apnea; Aspirin; Asthma; Drug Hypersensitivity; | 1993 |
Problems and pitfalls in providing acute and short-term pain relief with nonsteroidal anti-inflammatory agents.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Drug Int | 1996 |
Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system.
Topics: Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Prescho | 1996 |
Cross sensitivities. Medication errors waiting to happen.
Topics: Analgesics, Non-Narcotic; Aspirin; Asthma; Cross Reactions; Drug Hypersensitivity; Drug Interactions | 1999 |