ketorolac and Aging
ketorolac has been researched along with Aging in 2 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research
Studies (2)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Schrage, WG | 1 |
| Eisenach, JH | 1 |
| Joyner, MJ | 1 |
| Fowler, CJ | 1 |
| Janson, U | 1 |
| Johnson, RM | 1 |
| Wahlström, G | 1 |
| Stenström, A | 1 |
| Norström, K | 1 |
| Tiger, G | 1 |
Trials
1 trial available for ketorolac and Aging
| Article | Year |
|---|---|
Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans.
Topics: Aged; Aged, 80 and over; Aging; Blood Pressure; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female | 2007 |
Other Studies
1 other study available for ketorolac and Aging
| Article | Year |
|---|---|
Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.
Topics: Aging; Animals; Arachidonic Acids; Brain; Cell Extracts; Cell Survival; Dose-Response Relationship, | 1999 |