ketorolac has been researched along with Adenocarcinoma in 5 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain." | 7.68 | Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993) |
| " We present the first patient, to our knowledge, who reacted to the use of the analgesic ketorolac with progressive reduction in biliary output, in the setting of malignant biliary obstruction from duodenal adenocarcinoma." | 4.31 | A possible role for ketorolac in the management of increased biliary drain output. ( Cohen, NA; Golas, BJ; Gross, A; Khajoueinejad, N; Yu, AT, 2023) |
| "To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain." | 3.68 | Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993) |
| "Ketorolac was administered to 686 patients (67%); use was observed to increase over the study period from 49% in 2006 to 92% in 2016." | 1.62 | Ketorolac use and anastomotic leak in patients with esophageal cancer. ( Corsini, EM; Hofstetter, WL, 2021) |
| "The intraoperative use of NSAIDs in breast cancer patients (Centre 1) is associated with a reduced recurrence rate (HR = 0." | 1.39 | Neutrophil:lymphocyte ratio and intraoperative use of ketorolac or diclofenac are prognostic factors in different cohorts of patients undergoing breast, lung, and kidney cancer surgery. ( Berliere, M; Canon, JL; Coulie, PG; De Kock, M; Forget, P; Kremer, Y; Legrand, C; Machiels, JP; Poncelet, AJ; Stainier, A; Tombal, B, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, AT | 1 |
| Khajoueinejad, N | 1 |
| Gross, A | 1 |
| Golas, BJ | 1 |
| Cohen, NA | 1 |
| Corsini, EM | 1 |
| Hofstetter, WL | 1 |
| Forget, P | 1 |
| Machiels, JP | 1 |
| Coulie, PG | 1 |
| Berliere, M | 1 |
| Poncelet, AJ | 1 |
| Tombal, B | 1 |
| Stainier, A | 1 |
| Legrand, C | 1 |
| Canon, JL | 1 |
| Kremer, Y | 1 |
| De Kock, M | 1 |
| Colacchio, TA | 1 |
| Yeager, MP | 1 |
| Hildebrandt, LW | 1 |
| Miller, LJ | 1 |
| Kramer, MA | 1 |
5 other studies available for ketorolac and Adenocarcinoma
| Article | Year |
|---|---|
A possible role for ketorolac in the management of increased biliary drain output.
Topics: Adenocarcinoma; Cholestasis; Drainage; Humans; Jaundice; Ketorolac; Treatment Outcome | 2023 |
Ketorolac use and anastomotic leak in patients with esophageal cancer.
Topics: Adenocarcinoma; Aged; Anastomosis, Surgical; Anti-Inflammatory Agents, Non-Steroidal; Endoleak; Enha | 2021 |
Neutrophil:lymphocyte ratio and intraoperative use of ketorolac or diclofenac are prognostic factors in different cohorts of patients undergoing breast, lung, and kidney cancer surgery.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Carcinoma, Non-Small-Cell | 2013 |
Perioperative immunomodulation in cancer surgery.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Cytotoxicity, I | 1994 |
Pain management with intravenous ketorolac.
Topics: Adenocarcinoma; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bile Duct Neoplasms; Chr | 1993 |