ketorolac has been researched along with Acute Renal Colic in 16 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, use of ketorolac resulted in significantly fewer renal colic-related unplanned emergency department/clinic visits in the treatment group (2%) compared with the control group (13%, p=0." | 9.51 | Efficacy of Intramuscular Ketorolac for Preventing Renal Colic Post Stent Removal: Randomized Controlled Trial. ( Antonelli, J; Johnson, BA; Pearle, M; Sorokin, I, 2022) |
| " The purpose of this study was to evaluate the effects of adding dexamethasone to ketorolac on pain control in acute renal colic." | 9.51 | Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial. ( Farrokhi, E; Haghighi, R; Hosseini, SS; Lotfabadi, P; Rameshrad, M; Razi, A; Saadati, H, 2022) |
| "Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that is extensively used for the management of renal colic in the emergency department (ED)." | 9.41 | Comparison of intravenous ketorolac at three doses for treating renal colic in the emergency department: A noninferiority randomized controlled trial. ( Ahmadi, A; Bahreini, M; Eidinejad, L; Mirfazaelian, H; Thiruganasambandamoorthy, V; Yazdchi, M, 2021) |
| "Fentanyl is highly effective in controlling pain in patients with severe renal colic referring to the emergency department." | 9.34 | Atomized intranasal vs intravenous fentanyl in severe renal colic pain management: A randomized single-blinded clinical trial. ( Mirzaee, M; Nazemian, N; Torabi, M, 2020) |
| "To compare analgesic efficacy and safety of intravenous lidocaine and ketorolac combination to each analgesic alone for ED patients with suspected renal colic." | 9.34 | Comparison of intravenous lidocaine/ketorolac combination to either analgesic alone for suspected renal colic pain in the ED. ( Brady, J; Butt, M; Drapkin, J; Fassassi, C; Flom, P; Gulati, V; Hossain, R; Likourezos, A; Mann, SS; Marshall, J; Monfort, R; Motov, S; Rothberger, N, 2020) |
| "In this double-blind clinical trial study, the patients with renal colic pain were randomly divided into 2 groups; Group I received an intravenous infusion of 30 mg of Ketorolac and normal saline as placebo, Group II 50 mg/kg magnesium sulphate 50%/100 ml normal plus 30 mg of Ketorolac." | 9.30 | Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study. ( Aryan, A; Fahimi, MA; Maleki Verki, M; Motamed, H; Porozan, S, 2019) |
| " This trial aims to compare a single-dose of Spasmofen rectal suppository to a single intravenous (IV) ketorolac tromethamine 30 mg/2 mL dose in patients with acute renal colic." | 9.19 | Clinical efficacy of Spasmofen® suppository in the emergency treatment of renal colic: a randomized, double-blind, double-dummy comparative trial. ( Helmy, S; Salem, A; Yakoot, M; Yousef, S, 2014) |
| "To evaluate the effect of adding butylscopolammonium bromide (BB) to morphine and ketorolac in the treatment of acute renal colic in the ED." | 9.16 | Butylscopolammonium bromide does not provide additional analgesia when combined with morphine and ketorolac for acute renal colic. ( Kim, K; Lee, JH; Park, HM; Rhee, JE; Seo, GJ; Song, SW, 2012) |
| "The effect of ketorolac addition for the pain control of renal colic remains controversial." | 9.12 | The analgesic effect of ketorolac addition for renal colic pain: A meta-analysis of randomized controlled studies. ( De-Sheng, C; Hua, L; Yan-Jun, Y; Zhen, N, 2021) |
| "Intravenous ketorolac had better analgesic effects in renal colic patients compared with nebulized fentanyl." | 8.02 | Comparison of efficacy nebulized fentanyl with intravenous ketorolac for renal colic in patients over 12 years old. ( Astaraki, P; Kalantari, A; Rezaei, B; Salimi, R, 2021) |
| " However, use of ketorolac resulted in significantly fewer renal colic-related unplanned emergency department/clinic visits in the treatment group (2%) compared with the control group (13%, p=0." | 5.51 | Efficacy of Intramuscular Ketorolac for Preventing Renal Colic Post Stent Removal: Randomized Controlled Trial. ( Antonelli, J; Johnson, BA; Pearle, M; Sorokin, I, 2022) |
| " The purpose of this study was to evaluate the effects of adding dexamethasone to ketorolac on pain control in acute renal colic." | 5.51 | Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial. ( Farrokhi, E; Haghighi, R; Hosseini, SS; Lotfabadi, P; Rameshrad, M; Razi, A; Saadati, H, 2022) |
| "Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that is extensively used for the management of renal colic in the emergency department (ED)." | 5.41 | Comparison of intravenous ketorolac at three doses for treating renal colic in the emergency department: A noninferiority randomized controlled trial. ( Ahmadi, A; Bahreini, M; Eidinejad, L; Mirfazaelian, H; Thiruganasambandamoorthy, V; Yazdchi, M, 2021) |
| "Fentanyl is highly effective in controlling pain in patients with severe renal colic referring to the emergency department." | 5.34 | Atomized intranasal vs intravenous fentanyl in severe renal colic pain management: A randomized single-blinded clinical trial. ( Mirzaee, M; Nazemian, N; Torabi, M, 2020) |
| "To compare analgesic efficacy and safety of intravenous lidocaine and ketorolac combination to each analgesic alone for ED patients with suspected renal colic." | 5.34 | Comparison of intravenous lidocaine/ketorolac combination to either analgesic alone for suspected renal colic pain in the ED. ( Brady, J; Butt, M; Drapkin, J; Fassassi, C; Flom, P; Gulati, V; Hossain, R; Likourezos, A; Mann, SS; Marshall, J; Monfort, R; Motov, S; Rothberger, N, 2020) |
| "In this double-blind clinical trial study, the patients with renal colic pain were randomly divided into 2 groups; Group I received an intravenous infusion of 30 mg of Ketorolac and normal saline as placebo, Group II 50 mg/kg magnesium sulphate 50%/100 ml normal plus 30 mg of Ketorolac." | 5.30 | Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study. ( Aryan, A; Fahimi, MA; Maleki Verki, M; Motamed, H; Porozan, S, 2019) |
| " This trial aims to compare a single-dose of Spasmofen rectal suppository to a single intravenous (IV) ketorolac tromethamine 30 mg/2 mL dose in patients with acute renal colic." | 5.19 | Clinical efficacy of Spasmofen® suppository in the emergency treatment of renal colic: a randomized, double-blind, double-dummy comparative trial. ( Helmy, S; Salem, A; Yakoot, M; Yousef, S, 2014) |
| "The effect of ketorolac addition for the pain control of renal colic remains controversial." | 5.12 | The analgesic effect of ketorolac addition for renal colic pain: A meta-analysis of randomized controlled studies. ( De-Sheng, C; Hua, L; Yan-Jun, Y; Zhen, N, 2021) |
| "Intravenous ketorolac had better analgesic effects in renal colic patients compared with nebulized fentanyl." | 4.02 | Comparison of efficacy nebulized fentanyl with intravenous ketorolac for renal colic in patients over 12 years old. ( Astaraki, P; Kalantari, A; Rezaei, B; Salimi, R, 2021) |
| "The introduction of CPOE is associated with an increase in ketorolac use for ED renal colic visits." | 3.80 | Computerized physician order entry and decision support improves ED analgesic ordering for renal colic. ( Lang, E; Lonergan, K; McRae, A; Netherton, SJ; Wang, D, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 11 (68.75) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, BA | 1 |
| Sorokin, I | 1 |
| Antonelli, J | 1 |
| Pearle, M | 1 |
| Razi, A | 2 |
| Farrokhi, E | 2 |
| Lotfabadi, P | 2 |
| Hosseini, SS | 2 |
| Saadati, H | 2 |
| Haghighi, R | 2 |
| Rameshrad, M | 2 |
| Togo, K | 1 |
| Ono, S | 1 |
| Matsui, R | 1 |
| Watanabe, J | 1 |
| Barry, HC | 1 |
| Nazemian, N | 1 |
| Torabi, M | 1 |
| Mirzaee, M | 1 |
| Minhaj, FS | 1 |
| Hoang-Nguyen, M | 1 |
| Tenney, A | 1 |
| Bragg, A | 1 |
| Zhang, W | 1 |
| Foster, J | 1 |
| Rotoli, J | 1 |
| Acquisto, NM | 1 |
| Rezaei, B | 1 |
| Salimi, R | 1 |
| Kalantari, A | 1 |
| Astaraki, P | 1 |
| Eidinejad, L | 1 |
| Bahreini, M | 1 |
| Ahmadi, A | 1 |
| Yazdchi, M | 1 |
| Thiruganasambandamoorthy, V | 1 |
| Mirfazaelian, H | 1 |
| Zhen, N | 1 |
| De-Sheng, C | 1 |
| Yan-Jun, Y | 1 |
| Hua, L | 1 |
| Maleki Verki, M | 1 |
| Porozan, S | 1 |
| Motamed, H | 1 |
| Fahimi, MA | 1 |
| Aryan, A | 1 |
| Motov, S | 1 |
| Fassassi, C | 1 |
| Drapkin, J | 1 |
| Butt, M | 1 |
| Hossain, R | 1 |
| Likourezos, A | 1 |
| Monfort, R | 1 |
| Brady, J | 1 |
| Rothberger, N | 1 |
| Mann, SS | 1 |
| Flom, P | 1 |
| Gulati, V | 1 |
| Marshall, J | 1 |
| Yakoot, M | 1 |
| Salem, A | 1 |
| Yousef, S | 1 |
| Helmy, S | 1 |
| Netherton, SJ | 1 |
| Lonergan, K | 1 |
| Wang, D | 1 |
| McRae, A | 1 |
| Lang, E | 1 |
| Montiel-Jarquín, ÁJ | 1 |
| Rocha-Rocha, VM | 1 |
| Solís-Mendoza, HA | 1 |
| Romero-Figueroa, MS | 1 |
| Etchegaray-Morales, I | 1 |
| Alvarado-Ortega, I | 1 |
| Song, SW | 1 |
| Kim, K | 1 |
| Rhee, JE | 1 |
| Lee, JH | 1 |
| Seo, GJ | 1 |
| Park, HM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intra-nasal Ketorolac Versus Oral Diclofenac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease[NCT06158620] | Phase 1/Phase 2 | 80 participants (Anticipated) | Interventional | 2024-02-01 | Not yet recruiting | ||
| Evaluation of the Effects of Ketorolac 15mg IV Versus 30mg IV on Duration of Analgesia in Patients Who Present to the Emergency Department With Renal Colic[NCT05776953] | Phase 4 | 200 participants (Anticipated) | Interventional | 2023-12-21 | Recruiting | ||
| Comparison of Intravenous Ketorolac 10, 20, and 30mg for Treating Renal Colic Pain in the Emergency Department: A Randomized Controlled Trial[NCT03665753] | Early Phase 1 | 165 participants (Actual) | Interventional | 2018-11-05 | Completed | ||
| Randomized Trial Evaluating Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisis - RELIEF-SCC[NCT04614610] | Phase 2 | 100 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| A Randomized Trial Comparing the Combination of Intravenous Lidocaine and Ketorolac to Either Analgesics Alone for ED Patients With Acute Renal Colic[NCT02902770] | Phase 4 | 150 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The trial will compare the patient's pain score on a 11 point Likert scale, ranging from 0 to 10 with 0 being no pain, 5 moderate pain and 10 very severe pain, at 30 minutes (NCT02902770)
Timeframe: 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Lidocaine and Normal Saline Push | 5.52 |
| Ketorolac and Normal Saline Drip | 3.88 |
| Lidocaine and Ketorolac | 3.14 |
1 review available for ketorolac and Acute Renal Colic
| Article | Year |
|---|---|
The analgesic effect of ketorolac addition for renal colic pain: A meta-analysis of randomized controlled studies.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Female; Humans; Ketorolac | 2021 |
10 trials available for ketorolac and Acute Renal Colic
| Article | Year |
|---|---|
Efficacy of Intramuscular Ketorolac for Preventing Renal Colic Post Stent Removal: Randomized Controlled Trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ketorolac; Pain, Postoperative | 2022 |
Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Dexamethasone; Double-Blin | 2022 |
Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colic; Dexamethasone; Double-Blind Method; Humans; Ketorola | 2022 |
Atomized intranasal vs intravenous fentanyl in severe renal colic pain management: A randomized single-blinded clinical trial.
Topics: Administration, Intranasal; Administration, Intravenous; Adult; Aerosols; Aged; Anesthetics, Intrave | 2020 |
Comparison of intravenous ketorolac at three doses for treating renal colic in the emergency department: A noninferiority randomized controlled trial.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Emergency Service, Hospit | 2021 |
Comparison of intravenous ketorolac at three doses for treating renal colic in the emergency department: A noninferiority randomized controlled trial.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Emergency Service, Hospit | 2021 |
Comparison of intravenous ketorolac at three doses for treating renal colic in the emergency department: A noninferiority randomized controlled trial.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Emergency Service, Hospit | 2021 |
Comparison of intravenous ketorolac at three doses for treating renal colic in the emergency department: A noninferiority randomized controlled trial.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Emergency Service, Hospit | 2021 |
Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study.
Topics: Adult; Analgesics; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Metho | 2019 |
Comparison of intravenous lidocaine/ketorolac combination to either analgesic alone for suspected renal colic pain in the ED.
Topics: Administration, Intravenous; Adult; Analgesics; Double-Blind Method; Drug Combinations; Emergency Se | 2020 |
Comparison of intravenous lidocaine/ketorolac combination to either analgesic alone for suspected renal colic pain in the ED.
Topics: Administration, Intravenous; Adult; Analgesics; Double-Blind Method; Drug Combinations; Emergency Se | 2020 |
Comparison of intravenous lidocaine/ketorolac combination to either analgesic alone for suspected renal colic pain in the ED.
Topics: Administration, Intravenous; Adult; Analgesics; Double-Blind Method; Drug Combinations; Emergency Se | 2020 |
Comparison of intravenous lidocaine/ketorolac combination to either analgesic alone for suspected renal colic pain in the ED.
Topics: Administration, Intravenous; Adult; Analgesics; Double-Blind Method; Drug Combinations; Emergency Se | 2020 |
Clinical efficacy of Spasmofen® suppository in the emergency treatment of renal colic: a randomized, double-blind, double-dummy comparative trial.
Topics: Administration, Rectal; Adult; Codeine; Double-Blind Method; Drug Combinations; Emergency Treatment; | 2014 |
[Management of ureteric colic with ketorolac and nifedipin vs. ketorolac and tamsulosin in the emergency room].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Emergency Service, | 2017 |
Butylscopolammonium bromide does not provide additional analgesia when combined with morphine and ketorolac for acute renal colic.
Topics: Adult; Analgesia; Butylscopolammonium Bromide; Double-Blind Method; Drug Administration Schedule; Dr | 2012 |
5 other studies available for ketorolac and Acute Renal Colic
| Article | Year |
|---|---|
Dexamethasone and ketorolac vs ketorolac in acute renal colic: The authors reply.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colic; Dexamethasone; Humans; Ketorolac; Renal Colic | 2022 |
Ketorolac Plus Dexamethasone Is More Effective for Pain Relief Than Ketorolac Alone in Adults With Renal Colic.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colic; Dexamethasone; Double-Blind Method; Humans; K | 2023 |
Evaluation of opioid requirements in the management of renal colic after guideline implementation in the emergency department.
Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adult; Analgesics, Non-Narcotic; A | 2020 |
Comparison of efficacy nebulized fentanyl with intravenous ketorolac for renal colic in patients over 12 years old.
Topics: Acute Disease; Administration, Inhalation; Administration, Intravenous; Adolescent; Adult; Aged; Ana | 2021 |
Computerized physician order entry and decision support improves ED analgesic ordering for renal colic.
Topics: Adult; Analgesics; Decision Support Systems, Clinical; Emergency Service, Hospital; Female; Fentanyl | 2014 |