ketorolac has been researched along with Acute Pain in 28 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a randomized, double-blind trial to assess the analgesic efficacy of 3 doses of intravenous ketorolac (10, 15, and 30 mg) in patients aged 18 to 65 years and presenting to the ED with moderate to severe acute pain, defined by a numeric rating scale score greater than or equal to 5." | 9.24 | Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial. ( Cohen, V; Drapkin, J; Filk, N; Fromm, C; Homel, P; Hossain, R; Huang, F; Likourezos, A; Motov, S; Pushkar, I; Rockoff, B; Smith, A; Yasavolian, M, 2017) |
| "Determine the efficacy of intravenous lidocaine when compared to ketorolac for the treatment of acute radicular low back pain." | 9.19 | Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial. ( Danish, DC; Dos Santos, F; Makela, M; Riffenburgh, RH; Shimada, M; Tanen, DA, 2014) |
| "Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain." | 9.19 | Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014) |
| " A total of 28 adults with acute pain (numeric rating scale ≥ 4) received intranasal ketorolac." | 8.12 | Intranasal Ketorolac for Acute Pain in Adult Emergency Department Patients. ( Barbour, T; Gaul, E; Mace, SE; Nowacki, AS, 2022) |
| "Ketorolac administered in the first 24 hours after fracture repair for acute pain management does not seem to have a negative impact on time to healing or incidence of nonunion for femoral or tibial shaft fractures." | 7.83 | Ketorolac Administered in the Recovery Room for Acute Pain Management Does Not Affect Healing Rates of Femoral and Tibial Fractures. ( Donohue, D; Gaskins, R; Jordan, C; Sagi, HC; Sanders, D; Sanders, R; Serrano-Riera, R, 2016) |
| "Ketorolac was given at the end of surgery, and meloxicam was prescribed in the postoperative period to all patients in both groups." | 6.82 | Preventive Analgesic Efficacy of Nefopam in Acute and Chronic Pain After Breast Cancer Surgery: A Prospective, Double-Blind, and Randomized Trial. ( Han, JW; Koo, BW; Lim, DJ; Na, HS; Oh, AY; Ryu, JH, 2016) |
| "Postoperative pain is common and may be severe." | 6.72 | Single-dose intravenous ketorolac for acute postoperative pain in adults. ( Ferguson, MC; McNicol, ED; Schumann, R, 2021) |
| "Indomethacin is a nonsteroidal anti-inflammatory drug with potent antipyretic, analgesic, and anti-inflammatory activity that has been effectively used in the management of mild-to-moderate pain since the mid-1960s." | 6.50 | Role of indomethacin in acute pain and inflammation management: a review of the literature. ( Nalamachu, S; Wortmann, R, 2014) |
| "This study is to compare ibuprofen and ketorolac for children with trauma-related acute pain." | 5.69 | Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study. ( Amaddeo, A; Barbi, E; Barbieri, F; Cozzi, G; De Nardi, L; Ghirardo, S; Maestro, A; Ronfani, L; Trevisan, M; Zanon, D, 2023) |
| " The purpose of this study was to compare the efficacy of intranasal ketorolac (Sprix; Egalet US Inc, Wayne, PA) with a combination of ibuprofen/acetaminophen in an acute pain model of untreated endodontic patients experiencing moderate to severe pain and symptomatic apical periodontitis." | 5.30 | Ibuprofen and Acetaminophen Versus Intranasal Ketorolac (Sprix) in an Untreated Endodontic Pain Model: A Randomized, Double-blind Investigation. ( Balzer, S; Beck, M; Drum, M; Fowler, S; Nusstein, J; Reader, A; Watts, K, 2019) |
| "Ketorolac or weak opioids are equally effective on acute pain and on persistent postsurgical pain development after IHR, and drug choice should be based on their potential side effects and patient's comorbidities." | 5.20 | Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study. ( Allegri, M; Ambrosoli, AL; Braschi, A; Bugada, D; Fanelli, G; Klersy, C; Lavand'homme, P; Saccani Jotti, GM, 2015) |
| "Determine the efficacy of intravenous lidocaine when compared to ketorolac for the treatment of acute radicular low back pain." | 5.19 | Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial. ( Danish, DC; Dos Santos, F; Makela, M; Riffenburgh, RH; Shimada, M; Tanen, DA, 2014) |
| "Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain." | 5.19 | Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014) |
| " A total of 28 adults with acute pain (numeric rating scale ≥ 4) received intranasal ketorolac." | 4.12 | Intranasal Ketorolac for Acute Pain in Adult Emergency Department Patients. ( Barbour, T; Gaul, E; Mace, SE; Nowacki, AS, 2022) |
| "Clinical questionDoes the analgesic effect of intravenous ketorolac differ if given in doses of 10, 15, or 30 mg to patients presenting to the emergency department with acute pain?Article chosenMotov S, Yasavolian M, Likourezos A, et al." | 3.88 | Comparison of ketorolac dosing in an emergency department setting. ( Eke, O; Gottlieb, M; Shanechi, M, 2018) |
| "Ketorolac administered in the first 24 hours after fracture repair for acute pain management does not seem to have a negative impact on time to healing or incidence of nonunion for femoral or tibial shaft fractures." | 3.83 | Ketorolac Administered in the Recovery Room for Acute Pain Management Does Not Affect Healing Rates of Femoral and Tibial Fractures. ( Donohue, D; Gaskins, R; Jordan, C; Sagi, HC; Sanders, D; Sanders, R; Serrano-Riera, R, 2016) |
| "Ketorolac was given at the end of surgery, and meloxicam was prescribed in the postoperative period to all patients in both groups." | 2.82 | Preventive Analgesic Efficacy of Nefopam in Acute and Chronic Pain After Breast Cancer Surgery: A Prospective, Double-Blind, and Randomized Trial. ( Han, JW; Koo, BW; Lim, DJ; Na, HS; Oh, AY; Ryu, JH, 2016) |
| "Postoperative pain is common and may be severe." | 2.72 | Single-dose intravenous ketorolac for acute postoperative pain in adults. ( Ferguson, MC; McNicol, ED; Schumann, R, 2021) |
| "Indomethacin is a nonsteroidal anti-inflammatory drug with potent antipyretic, analgesic, and anti-inflammatory activity that has been effectively used in the management of mild-to-moderate pain since the mid-1960s." | 2.50 | Role of indomethacin in acute pain and inflammation management: a review of the literature. ( Nalamachu, S; Wortmann, R, 2014) |
| "The 17 patients treated for acute or chronic pain during the opioid-free shift were managed mainly with i." | 1.42 | Development of an opioid reduction protocol in an emergency department. ( Bosoy, D; Cohen, V; Fromm, C; Hossain, R; Jellinek-Cohen, SP; Likourezos, A; Marshall, J; Motov, S; Rockoff, B; Smith, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 18 (64.29) | 24.3611 |
| 2020's | 10 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Chowdhury, SS | 1 |
| Shaw, M | 1 |
| Berezowski, I | 1 |
| Abdelmonem, A | 1 |
| Patel, J | 1 |
| Atif, H | 1 |
| McGhee, J | 1 |
| Slawson, DC | 1 |
| Ghirardo, S | 2 |
| Trevisan, M | 2 |
| Ronfani, L | 2 |
| Zanon, D | 2 |
| Maestro, A | 2 |
| Barbieri, F | 2 |
| De Nardi, L | 2 |
| Amaddeo, A | 2 |
| Barbi, E | 2 |
| Cozzi, G | 2 |
| Jaglal, R | 1 |
| Nemec, EC | 1 |
| da Silva, J | 1 |
| Gingras, A | 1 |
| McNicol, ED | 1 |
| Ferguson, MC | 1 |
| Schumann, R | 1 |
| Irizarry, E | 1 |
| Restivo, A | 1 |
| Salama, M | 1 |
| Davitt, M | 1 |
| Feliciano, C | 1 |
| Cortijo-Brown, A | 1 |
| Friedman, BW | 1 |
| Turner, NJ | 1 |
| Long, DA | 1 |
| Bongiorno, JR | 1 |
| Katoski, TP | 1 |
| Jin, LM | 1 |
| Horsch, JP | 1 |
| Ahern, BJ | 1 |
| Gaul, E | 1 |
| Barbour, T | 1 |
| Nowacki, AS | 1 |
| Mace, SE | 1 |
| Carpenter, CR | 1 |
| Shrikant Kulkarni, N | 1 |
| Benhamou, D | 1 |
| Shanechi, M | 1 |
| Eke, O | 1 |
| Gottlieb, M | 1 |
| Watts, K | 1 |
| Balzer, S | 1 |
| Drum, M | 1 |
| Nusstein, J | 1 |
| Reader, A | 1 |
| Fowler, S | 1 |
| Beck, M | 1 |
| Wang, L | 1 |
| Bauer, M | 1 |
| Curry, R | 1 |
| Larsson, A | 1 |
| Sessler, DI | 1 |
| Eisenach, JC | 1 |
| Yamamoto, T | 1 |
| Tanen, DA | 1 |
| Shimada, M | 1 |
| Danish, DC | 1 |
| Dos Santos, F | 1 |
| Makela, M | 1 |
| Riffenburgh, RH | 1 |
| Nalamachu, S | 1 |
| Wortmann, R | 1 |
| Buccelletti, F | 1 |
| Marsiliani, D | 1 |
| Zuccalà, G | 1 |
| Iacomini, P | 1 |
| Proietti, L | 1 |
| Pola, E | 1 |
| Zirio, G | 1 |
| Genitiempo, M | 1 |
| Marrocco, R | 1 |
| Conti, C | 1 |
| Brunetti, C | 1 |
| Rocchi, L | 1 |
| Merendi, G | 1 |
| D'Aurizio, G | 1 |
| Gilardi, E | 1 |
| Franceschi, F | 1 |
| Bugada, D | 1 |
| Lavand'homme, P | 1 |
| Ambrosoli, AL | 1 |
| Klersy, C | 1 |
| Braschi, A | 1 |
| Fanelli, G | 1 |
| Saccani Jotti, GM | 1 |
| Allegri, M | 1 |
| Cohen, V | 2 |
| Motov, S | 2 |
| Rockoff, B | 2 |
| Smith, A | 2 |
| Fromm, C | 2 |
| Bosoy, D | 1 |
| Hossain, R | 2 |
| Likourezos, A | 2 |
| Jellinek-Cohen, SP | 1 |
| Marshall, J | 1 |
| Donohue, D | 1 |
| Sanders, D | 1 |
| Serrano-Riera, R | 1 |
| Jordan, C | 1 |
| Gaskins, R | 1 |
| Sanders, R | 1 |
| Sagi, HC | 1 |
| Na, HS | 1 |
| Oh, AY | 1 |
| Koo, BW | 1 |
| Lim, DJ | 1 |
| Ryu, JH | 1 |
| Han, JW | 1 |
| Yasavolian, M | 1 |
| Pushkar, I | 1 |
| Drapkin, J | 1 |
| Filk, N | 1 |
| Huang, F | 1 |
| Homel, P | 1 |
| Baddam, S | 1 |
| Aban, I | 1 |
| Hilliard, L | 1 |
| Howard, T | 1 |
| Askenazi, D | 1 |
| Lebensburger, JD | 1 |
| Ortiz, MI | 1 |
| Monroy-Maya, R | 1 |
| Soto-Ríos, M | 1 |
| Carrillo-Alarcón, LC | 1 |
| Ponce-Monter, HA | 1 |
| Rangel-Flores, E | 1 |
| Loo-Estrada, JJ | 1 |
| Izquierdo-Vega, JA | 1 |
| Sánchez-Gutiérrez, M | 1 |
| Gan, TJ | 1 |
| Daniels, SE | 1 |
| Singla, N | 1 |
| Hamilton, DA | 1 |
| Carr, DB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Intrathecal Ketorolac on Mechanical Hypersensitivity After Total Hip Arthroplasty[NCT00621530] | Phase 2 | 62 participants (Actual) | Interventional | 2008-03-31 | Terminated (stopped due to Terminated due to discontinuation of Acular PF (investigational medication)) | ||
| Randomized, Prospective Study of the Assessment, Prevention and Management of Acute Post-herniotomy Pain[NCT01345162] | Phase 4 | 200 participants (Actual) | Interventional | 2010-03-31 | Completed | ||
| Perioperative Pain Management With Multi-discipline Team(pMDT) in Thoracic Surgery: a Multi-center，Prospective, Observational Study--The Process Implementation Stage[NCT03761550] | 480 participants (Actual) | Observational | 2018-12-01 | Completed | |||
| Perioperative Pain Management With Multi-discipline Team(pMDT) in Thoracic Surgery: a Multi-center，Prospective, Observational Study--------For the Baseline Investigation and Technical Preparation Stage[NCT03759275] | 480 participants (Actual) | Observational | 2018-09-01 | Completed | |||
| Effect of Toradol on Post-operative Foot and Ankle Healing[NCT03727048] | Phase 4 | 128 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
| Evaluation of the Effects of Ketorolac 15mg IV Versus 30mg IV on Duration of Analgesia in Patients Who Present to the Emergency Department With Renal Colic[NCT05776953] | Phase 4 | 200 participants (Anticipated) | Interventional | 2023-12-21 | Recruiting | ||
| Oral v. Parenteral Medications for the Emergency Management of Acute Migraine: a Pilot Randomized Control Trial[NCT05983354] | 55 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | |||
| Chronobiology and Chronopharmacology to Prevent Sickle Cell Kidney Disease[NCT02373241] | Phase 2 | 1 participants (Actual) | Interventional | 2015-04-30 | Terminated (stopped due to Estimated GFR was determined not to be a reliable endpoint for this study. We identified significant variabilty in annual eGFR that it became inappropriate to randomize to a medication but use EGFR as the primary endpoint.) | ||
| Acute Kidney Injury in Patients With Sickle Cell Disease[NCT03105271] | 60 participants (Actual) | Observational | 2017-01-01 | Completed | |||
| Randomized, Double-Blind, Active- and Placebo-Controlled Study of the Efficacy and Safety of Repeated Dosing of DIC075V Relative To Parenteral Ketorolac and Placebo in Patients With Acute Post-Op Pain After Abdominal or Pelvic Surgery[NCT00448110] | Phase 3 | 331 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| A Randomized Double-blinded Trial Comparing the Clinical Efficacy and Pharmacokinetic Parameters of Oral Diclofenac and Intramuscular Diclofenac in Patients With Acute Limb Injuries[NCT03472339] | Phase 4 | 300 participants (Anticipated) | Interventional | 2018-01-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Hyperalgesia (using a von Frey filament) and allodynia (using a cotton swab) were evaluated around the surgical site 48 hours after surgery. (NCT00621530)
Timeframe: 48 hours
| Intervention | area in centimeters squared (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0 |
Pain was assessed 2 days, and 2 and 6 months after surgery using a validated questionnaire wherein subjects rate the degree to which adjectives describe the emotional component of their pain experience. This is termed the McGill Pain Affective Score and is scored from 0 to 12 with 12 being the highest pain emotional impact. (NCT00621530)
Timeframe: 6 months
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Postoperative: 2 days | Postoperative: 2 months | Postoperative: 6 months | |
| Ketorolac | 2.3 | 0.4 | 0.1 |
| Placebo | 2.3 | 0.5 | 0.4 |
Pain was assessed 2 days and 2 and 6 months after surgery using a validated questionnaire wherein subjects rate the degree to which adjectives describe the intensity of their pain experience. This is termed the McGill Pain Intensity Score and is scored from 0 to 33 with 33 being the highest pain intensity. (NCT00621530)
Timeframe: 6 months
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Postoperative: 2 days | Postoperative: 2 months | Postoperative: 6 months | |
| Ketorolac | 11 | 2.3 | 1.4 |
| Placebo | 10 | 3.1 | 1.2 |
Pain was assessed 2 days, and 2 and 6 months after surgery using a validated questionnaire to assess the degree of neuropathic characteristics of pain. This is termed the Neuropathic Pain Symptom Inventory which is scored 0-100 with 100 being the worst possible pain. (NCT00621530)
Timeframe: 6 months
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Postoperative: 2 days | Postoperative: 2 months | Postoperative: 6 months | |
| Ketorolac | 13 | 2.9 | 2.4 |
| Placebo | 21 | 4.5 | 1.4 |
Pain was assessed preoperatively, 2 days, and 2 and 6 months after surgery using a 0-10 (10 being worse) verbal Present Pain Intensity (PPI) scale (NCT00621530)
Timeframe: 6 months
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| Preoperative | Postoperative: 2 days | Postoperative: 2 months | Postoperative: 6 months | |
| Ketorolac | 1.7 | 2.1 | 0.6 | 0.4 |
| Placebo | 1.6 | 2.5 | 0.2 | 0.1 |
"percentage of patients with NRS≥4. (NRS=numeric rating scale; o quantify pain from0=no pain to 10=worst pain possible).~NRS≥4 is cosidered as suboptimal pain control worth to be treated with adjunctive analgesics. We therefore condidered the difference in percentage of patients experiencing not optimal pain control in the two groups to understand, if any, the difference in analgesic efficacy between the two drugs." (NCT01345162)
Timeframe: 4 days postherniotomy
| Intervention | percentage of patients with NRS≥4 (Number) |
|---|---|
| Ketorolac | 26.5 |
| Acetaminophene + Tramadol | 32.3 |
"Outcome 1a. Document the rate of acceptance (quantitative) and reasons for acceptance/rejection (qualitative) in a randomized trial of trial of losartan for SCD patients with abnormal nocturnal blood pressures.~Outcome 1b. Identify the adherence rate to losartan during a randomized three year trial of losartan for SCD patients (n=40) with abnormal nocturnal blood pressure.~Outcome 1c. Determine the adherence rate to study procedures among participants enrolled in a three year trial of losartan for SCD patients (n=40) with abnormal nocturnal blood pressure." (NCT02373241)
Timeframe: 5 yrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Standard Blood Pressure Management | 0 |
| Experimental Blood Pressure Management | 1 |
As a feasibility trial, the effect of losartan on lowering nocturnal hypertension will be monitored to identify the difference in nocturnal BP improvement between the two treatment arms, and within group standard deviation of BP (NCT02373241)
Timeframe: 5 years
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental Blood Pressure Management | 1 |
We will prospectively evaluate the incidence of hypertension (Clinic BP in pts >5yrs and ABPM in pts >10 yrs) and role of blood and urine biomarkers (pts >5ys) among participants with HbSS or SB0 thalassemia (expected cohort n=200) over 5 yrs. We identified 20 participants (34%) with incident hypertension but randomized one to the study. The study was terminated as the eGFR was determined not to be a reliable endpoint in pediatric sickle cell. (NCT02373241)
Timeframe: 5 yrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Standard Blood Pressure Management | 0 |
| Experimental Blood Pressure Management | 1 |
2 reviews available for ketorolac and Acute Pain
| Article | Year |
|---|---|
Single-dose intravenous ketorolac for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bias; Diclofenac; Hu | 2021 |
Role of indomethacin in acute pain and inflammation management: a review of the literature.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Inflammation; Ketorolac; | 2014 |
14 trials available for ketorolac and Acute Pain
| Article | Year |
|---|---|
IV metoclopramide Vs IV ketorolac in the treatment of acute primary headaches: A randomized clinical trial.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Headache; Humans; Ketorola | 2022 |
Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study.
Topics: Acute Pain; Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Double | 2023 |
Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study.
Topics: Acute Pain; Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Double | 2023 |
Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study.
Topics: Acute Pain; Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Double | 2023 |
Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study.
Topics: Acute Pain; Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Double | 2023 |
A randomized controlled trial of ibuprofen versus ketorolac versus diclofenac for acute, nonradicular low back pain.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Ibupro | 2021 |
Comparing two doses of intramuscular ketorolac for treatment of acute musculoskeletal pain in a military emergency department.
Topics: Acute Pain; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Emergency Service, Hospital; | 2021 |
No Added Benefit with Higher Doses of Ketorolac for Treatment of Acute Pain in the Emergency Department.
Topics: Acute Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double | 2017 |
Ibuprofen and Acetaminophen Versus Intranasal Ketorolac (Sprix) in an Untreated Endodontic Pain Model: A Randomized, Double-blind Investigation.
Topics: Acetaminophen; Acute Pain; Administration, Intranasal; Administration, Oral; Adult; Dental Pulp Necr | 2019 |
Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial.
Topics: Acute Pain; Anesthesia, Spinal; Arthroplasty, Replacement, Hip; Bupivacaine; Chronic Pain; Double-Bl | 2014 |
Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial.
Topics: Acute Pain; Administration, Intravenous; Adult; Anesthetics, Local; Cyclooxygenase Inhibitors; Doubl | 2014 |
Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2014 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Preventive Analgesic Efficacy of Nefopam in Acute and Chronic Pain After Breast Cancer Surgery: A Prospective, Double-Blind, and Randomized Trial.
Topics: Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Axilla; Breast Neoplasms; Chemoradiotherapy, Adju | 2016 |
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.
Topics: Acute Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double | 2017 |
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.
Topics: Acute Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double | 2017 |
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.
Topics: Acute Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double | 2017 |
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.
Topics: Acute Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double | 2017 |
Effectiveness of diclofenac, ketorolac and etoricoxib in the treatment of acute pain from ankle fracture.
Topics: Acute Pain; Adult; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind | 2010 |
A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain after abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study.
Topics: Abdomen; Acute Pain; Adult; Chemistry, Pharmaceutical; Diclofenac; Dose-Response Relationship, Drug; | 2012 |
A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain after abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study.
Topics: Abdomen; Acute Pain; Adult; Chemistry, Pharmaceutical; Diclofenac; Dose-Response Relationship, Drug; | 2012 |
A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain after abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study.
Topics: Abdomen; Acute Pain; Adult; Chemistry, Pharmaceutical; Diclofenac; Dose-Response Relationship, Drug; | 2012 |
A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain after abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study.
Topics: Abdomen; Acute Pain; Adult; Chemistry, Pharmaceutical; Diclofenac; Dose-Response Relationship, Drug; | 2012 |
12 other studies available for ketorolac and Acute Pain
| Article | Year |
|---|---|
Randomized IV metoclopramide vs IV ketorolac in treatment of acute primary headache.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Headache; Humans; Ketorola | 2022 |
Ibuprofen, Ketorolac, and Diclofenac Are Equivalent for the Treatment of Acute, Nonradicular Low Back Pain.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Ibupro | 2022 |
What is the analgesic ceiling dose of ketorolac for treating acute pain in the ED?
Topics: Acute Pain; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ketoro | 2023 |
Usage analysis of ketorolac in the emergency department.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Emergency Service, Hospital; Huma | 2021 |
Intranasal Ketorolac for Acute Pain in Adult Emergency Department Patients.
Topics: Acute Pain; Adult; Double-Blind Method; Emergency Service, Hospital; Humans; Ketorolac; Needlestick | 2022 |
In patients in the emergency department with acute pain, 10, 15, and 30 mg of ketorolac did not differ for pain relief.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Emergency Service, Hospita | 2017 |
Ketorolac dose-response for acute pain is well known and the safety rules for adequate prescribing are clear.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ketorolac; Pain, P | 2018 |
Comparison of ketorolac dosing in an emergency department setting.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Clinical Protocols; Emergency Service, Hospital | 2018 |
When will we get a new class of analgesic agent based on animal study data?
Topics: Acute Pain; Bupivacaine; Chronic Pain; Humans; Ketorolac | 2014 |
Development of an opioid reduction protocol in an emergency department.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Chronic Pain; Emergency Service, Hospital; Humans | 2015 |
Ketorolac Administered in the Recovery Room for Acute Pain Management Does Not Affect Healing Rates of Femoral and Tibial Fractures.
Topics: Acute Pain; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cau | 2016 |
Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis.
Topics: Acute Kidney Injury; Acute Pain; Adolescent; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Ster | 2017 |
Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis.
Topics: Acute Kidney Injury; Acute Pain; Adolescent; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Ster | 2017 |
Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis.
Topics: Acute Kidney Injury; Acute Pain; Adolescent; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Ster | 2017 |
Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis.
Topics: Acute Kidney Injury; Acute Pain; Adolescent; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Ster | 2017 |