Page last updated: 2024-10-29

ketorolac and Acute Pain

ketorolac has been researched along with Acute Pain in 28 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.

Research Excerpts

ExcerptRelevanceReference
"We conducted a randomized, double-blind trial to assess the analgesic efficacy of 3 doses of intravenous ketorolac (10, 15, and 30 mg) in patients aged 18 to 65 years and presenting to the ED with moderate to severe acute pain, defined by a numeric rating scale score greater than or equal to 5."9.24Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial. ( Cohen, V; Drapkin, J; Filk, N; Fromm, C; Homel, P; Hossain, R; Huang, F; Likourezos, A; Motov, S; Pushkar, I; Rockoff, B; Smith, A; Yasavolian, M, 2017)
"Determine the efficacy of intravenous lidocaine when compared to ketorolac for the treatment of acute radicular low back pain."9.19Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial. ( Danish, DC; Dos Santos, F; Makela, M; Riffenburgh, RH; Shimada, M; Tanen, DA, 2014)
"Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain."9.19Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014)
" A total of 28 adults with acute pain (numeric rating scale ≥ 4) received intranasal ketorolac."8.12Intranasal Ketorolac for Acute Pain in Adult Emergency Department Patients. ( Barbour, T; Gaul, E; Mace, SE; Nowacki, AS, 2022)
"Ketorolac administered in the first 24 hours after fracture repair for acute pain management does not seem to have a negative impact on time to healing or incidence of nonunion for femoral or tibial shaft fractures."7.83Ketorolac Administered in the Recovery Room for Acute Pain Management Does Not Affect Healing Rates of Femoral and Tibial Fractures. ( Donohue, D; Gaskins, R; Jordan, C; Sagi, HC; Sanders, D; Sanders, R; Serrano-Riera, R, 2016)
"Ketorolac was given at the end of surgery, and meloxicam was prescribed in the postoperative period to all patients in both groups."6.82Preventive Analgesic Efficacy of Nefopam in Acute and Chronic Pain After Breast Cancer Surgery: A Prospective, Double-Blind, and Randomized Trial. ( Han, JW; Koo, BW; Lim, DJ; Na, HS; Oh, AY; Ryu, JH, 2016)
"Postoperative pain is common and may be severe."6.72Single-dose intravenous ketorolac for acute postoperative pain in adults. ( Ferguson, MC; McNicol, ED; Schumann, R, 2021)
"Indomethacin is a nonsteroidal anti-inflammatory drug with potent antipyretic, analgesic, and anti-inflammatory activity that has been effectively used in the management of mild-to-moderate pain since the mid-1960s."6.50Role of indomethacin in acute pain and inflammation management: a review of the literature. ( Nalamachu, S; Wortmann, R, 2014)
"This study is to compare ibuprofen and ketorolac for children with trauma-related acute pain."5.69Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study. ( Amaddeo, A; Barbi, E; Barbieri, F; Cozzi, G; De Nardi, L; Ghirardo, S; Maestro, A; Ronfani, L; Trevisan, M; Zanon, D, 2023)
" The purpose of this study was to compare the efficacy of intranasal ketorolac (Sprix; Egalet US Inc, Wayne, PA) with a combination of ibuprofen/acetaminophen in an acute pain model of untreated endodontic patients experiencing moderate to severe pain and symptomatic apical periodontitis."5.30Ibuprofen and Acetaminophen Versus Intranasal Ketorolac (Sprix) in an Untreated Endodontic Pain Model: A Randomized, Double-blind Investigation. ( Balzer, S; Beck, M; Drum, M; Fowler, S; Nusstein, J; Reader, A; Watts, K, 2019)
"Ketorolac or weak opioids are equally effective on acute pain and on persistent postsurgical pain development after IHR, and drug choice should be based on their potential side effects and patient's comorbidities."5.20Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study. ( Allegri, M; Ambrosoli, AL; Braschi, A; Bugada, D; Fanelli, G; Klersy, C; Lavand'homme, P; Saccani Jotti, GM, 2015)
"Determine the efficacy of intravenous lidocaine when compared to ketorolac for the treatment of acute radicular low back pain."5.19Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial. ( Danish, DC; Dos Santos, F; Makela, M; Riffenburgh, RH; Shimada, M; Tanen, DA, 2014)
"Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain."5.19Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014)
" A total of 28 adults with acute pain (numeric rating scale ≥ 4) received intranasal ketorolac."4.12Intranasal Ketorolac for Acute Pain in Adult Emergency Department Patients. ( Barbour, T; Gaul, E; Mace, SE; Nowacki, AS, 2022)
"Clinical questionDoes the analgesic effect of intravenous ketorolac differ if given in doses of 10, 15, or 30 mg to patients presenting to the emergency department with acute pain?Article chosenMotov S, Yasavolian M, Likourezos A, et al."3.88Comparison of ketorolac dosing in an emergency department setting. ( Eke, O; Gottlieb, M; Shanechi, M, 2018)
"Ketorolac administered in the first 24 hours after fracture repair for acute pain management does not seem to have a negative impact on time to healing or incidence of nonunion for femoral or tibial shaft fractures."3.83Ketorolac Administered in the Recovery Room for Acute Pain Management Does Not Affect Healing Rates of Femoral and Tibial Fractures. ( Donohue, D; Gaskins, R; Jordan, C; Sagi, HC; Sanders, D; Sanders, R; Serrano-Riera, R, 2016)
"Ketorolac was given at the end of surgery, and meloxicam was prescribed in the postoperative period to all patients in both groups."2.82Preventive Analgesic Efficacy of Nefopam in Acute and Chronic Pain After Breast Cancer Surgery: A Prospective, Double-Blind, and Randomized Trial. ( Han, JW; Koo, BW; Lim, DJ; Na, HS; Oh, AY; Ryu, JH, 2016)
"Postoperative pain is common and may be severe."2.72Single-dose intravenous ketorolac for acute postoperative pain in adults. ( Ferguson, MC; McNicol, ED; Schumann, R, 2021)
"Indomethacin is a nonsteroidal anti-inflammatory drug with potent antipyretic, analgesic, and anti-inflammatory activity that has been effectively used in the management of mild-to-moderate pain since the mid-1960s."2.50Role of indomethacin in acute pain and inflammation management: a review of the literature. ( Nalamachu, S; Wortmann, R, 2014)
"The 17 patients treated for acute or chronic pain during the opioid-free shift were managed mainly with i."1.42Development of an opioid reduction protocol in an emergency department. ( Bosoy, D; Cohen, V; Fromm, C; Hossain, R; Jellinek-Cohen, SP; Likourezos, A; Marshall, J; Motov, S; Rockoff, B; Smith, A, 2015)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's18 (64.29)24.3611
2020's10 (35.71)2.80

Authors

AuthorsStudies
Chowdhury, SS1
Shaw, M1
Berezowski, I1
Abdelmonem, A1
Patel, J1
Atif, H1
McGhee, J1
Slawson, DC1
Ghirardo, S2
Trevisan, M2
Ronfani, L2
Zanon, D2
Maestro, A2
Barbieri, F2
De Nardi, L2
Amaddeo, A2
Barbi, E2
Cozzi, G2
Jaglal, R1
Nemec, EC1
da Silva, J1
Gingras, A1
McNicol, ED1
Ferguson, MC1
Schumann, R1
Irizarry, E1
Restivo, A1
Salama, M1
Davitt, M1
Feliciano, C1
Cortijo-Brown, A1
Friedman, BW1
Turner, NJ1
Long, DA1
Bongiorno, JR1
Katoski, TP1
Jin, LM1
Horsch, JP1
Ahern, BJ1
Gaul, E1
Barbour, T1
Nowacki, AS1
Mace, SE1
Carpenter, CR1
Shrikant Kulkarni, N1
Benhamou, D1
Shanechi, M1
Eke, O1
Gottlieb, M1
Watts, K1
Balzer, S1
Drum, M1
Nusstein, J1
Reader, A1
Fowler, S1
Beck, M1
Wang, L1
Bauer, M1
Curry, R1
Larsson, A1
Sessler, DI1
Eisenach, JC1
Yamamoto, T1
Tanen, DA1
Shimada, M1
Danish, DC1
Dos Santos, F1
Makela, M1
Riffenburgh, RH1
Nalamachu, S1
Wortmann, R1
Buccelletti, F1
Marsiliani, D1
Zuccalà, G1
Iacomini, P1
Proietti, L1
Pola, E1
Zirio, G1
Genitiempo, M1
Marrocco, R1
Conti, C1
Brunetti, C1
Rocchi, L1
Merendi, G1
D'Aurizio, G1
Gilardi, E1
Franceschi, F1
Bugada, D1
Lavand'homme, P1
Ambrosoli, AL1
Klersy, C1
Braschi, A1
Fanelli, G1
Saccani Jotti, GM1
Allegri, M1
Cohen, V2
Motov, S2
Rockoff, B2
Smith, A2
Fromm, C2
Bosoy, D1
Hossain, R2
Likourezos, A2
Jellinek-Cohen, SP1
Marshall, J1
Donohue, D1
Sanders, D1
Serrano-Riera, R1
Jordan, C1
Gaskins, R1
Sanders, R1
Sagi, HC1
Na, HS1
Oh, AY1
Koo, BW1
Lim, DJ1
Ryu, JH1
Han, JW1
Yasavolian, M1
Pushkar, I1
Drapkin, J1
Filk, N1
Huang, F1
Homel, P1
Baddam, S1
Aban, I1
Hilliard, L1
Howard, T1
Askenazi, D1
Lebensburger, JD1
Ortiz, MI1
Monroy-Maya, R1
Soto-Ríos, M1
Carrillo-Alarcón, LC1
Ponce-Monter, HA1
Rangel-Flores, E1
Loo-Estrada, JJ1
Izquierdo-Vega, JA1
Sánchez-Gutiérrez, M1
Gan, TJ1
Daniels, SE1
Singla, N1
Hamilton, DA1
Carr, DB1

Clinical Trials (11)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Intrathecal Ketorolac on Mechanical Hypersensitivity After Total Hip Arthroplasty[NCT00621530]Phase 262 participants (Actual)Interventional2008-03-31Terminated (stopped due to Terminated due to discontinuation of Acular PF (investigational medication))
Randomized, Prospective Study of the Assessment, Prevention and Management of Acute Post-herniotomy Pain[NCT01345162]Phase 4200 participants (Actual)Interventional2010-03-31Completed
Perioperative Pain Management With Multi-discipline Team(pMDT) in Thoracic Surgery: a Multi-center,Prospective, Observational Study--The Process Implementation Stage[NCT03761550]480 participants (Actual)Observational2018-12-01Completed
Perioperative Pain Management With Multi-discipline Team(pMDT) in Thoracic Surgery: a Multi-center,Prospective, Observational Study--------For the Baseline Investigation and Technical Preparation Stage[NCT03759275]480 participants (Actual)Observational2018-09-01Completed
Effect of Toradol on Post-operative Foot and Ankle Healing[NCT03727048]Phase 4128 participants (Actual)Interventional2016-08-31Completed
Evaluation of the Effects of Ketorolac 15mg IV Versus 30mg IV on Duration of Analgesia in Patients Who Present to the Emergency Department With Renal Colic[NCT05776953]Phase 4200 participants (Anticipated)Interventional2023-12-21Recruiting
Oral v. Parenteral Medications for the Emergency Management of Acute Migraine: a Pilot Randomized Control Trial[NCT05983354]55 participants (Anticipated)Interventional2024-01-01Not yet recruiting
Chronobiology and Chronopharmacology to Prevent Sickle Cell Kidney Disease[NCT02373241]Phase 21 participants (Actual)Interventional2015-04-30Terminated (stopped due to Estimated GFR was determined not to be a reliable endpoint for this study. We identified significant variabilty in annual eGFR that it became inappropriate to randomize to a medication but use EGFR as the primary endpoint.)
Acute Kidney Injury in Patients With Sickle Cell Disease[NCT03105271]60 participants (Actual)Observational2017-01-01Completed
Randomized, Double-Blind, Active- and Placebo-Controlled Study of the Efficacy and Safety of Repeated Dosing of DIC075V Relative To Parenteral Ketorolac and Placebo in Patients With Acute Post-Op Pain After Abdominal or Pelvic Surgery[NCT00448110]Phase 3331 participants (Actual)Interventional2006-05-31Completed
A Randomized Double-blinded Trial Comparing the Clinical Efficacy and Pharmacokinetic Parameters of Oral Diclofenac and Intramuscular Diclofenac in Patients With Acute Limb Injuries[NCT03472339]Phase 4300 participants (Anticipated)Interventional2018-01-15Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Area of Hypersensitivity to Mechanical Stimuli Surrounding the Wound 48 Hours After Surgery

Hyperalgesia (using a von Frey filament) and allodynia (using a cotton swab) were evaluated around the surgical site 48 hours after surgery. (NCT00621530)
Timeframe: 48 hours

Interventionarea in centimeters squared (Median)
Ketorolac0
Placebo0

McGill Affective Pain

Pain was assessed 2 days, and 2 and 6 months after surgery using a validated questionnaire wherein subjects rate the degree to which adjectives describe the emotional component of their pain experience. This is termed the McGill Pain Affective Score and is scored from 0 to 12 with 12 being the highest pain emotional impact. (NCT00621530)
Timeframe: 6 months

,
Interventionunits on a scale (Mean)
Postoperative: 2 daysPostoperative: 2 monthsPostoperative: 6 months
Ketorolac2.30.40.1
Placebo2.30.50.4

McGill Pain Intensity

Pain was assessed 2 days and 2 and 6 months after surgery using a validated questionnaire wherein subjects rate the degree to which adjectives describe the intensity of their pain experience. This is termed the McGill Pain Intensity Score and is scored from 0 to 33 with 33 being the highest pain intensity. (NCT00621530)
Timeframe: 6 months

,
Interventionunits on a scale (Mean)
Postoperative: 2 daysPostoperative: 2 monthsPostoperative: 6 months
Ketorolac112.31.4
Placebo103.11.2

Neuropathic Pain Symptom Inventory

Pain was assessed 2 days, and 2 and 6 months after surgery using a validated questionnaire to assess the degree of neuropathic characteristics of pain. This is termed the Neuropathic Pain Symptom Inventory which is scored 0-100 with 100 being the worst possible pain. (NCT00621530)
Timeframe: 6 months

,
Interventionunits on a scale (Mean)
Postoperative: 2 daysPostoperative: 2 monthsPostoperative: 6 months
Ketorolac132.92.4
Placebo214.51.4

Present Pain Intensity

Pain was assessed preoperatively, 2 days, and 2 and 6 months after surgery using a 0-10 (10 being worse) verbal Present Pain Intensity (PPI) scale (NCT00621530)
Timeframe: 6 months

,
Interventionunits on a scale (Mean)
PreoperativePostoperative: 2 daysPostoperative: 2 monthsPostoperative: 6 months
Ketorolac1.72.10.60.4
Placebo1.62.50.20.1

Analgesic Efficacy

"percentage of patients with NRS≥4. (NRS=numeric rating scale; o quantify pain from0=no pain to 10=worst pain possible).~NRS≥4 is cosidered as suboptimal pain control worth to be treated with adjunctive analgesics. We therefore condidered the difference in percentage of patients experiencing not optimal pain control in the two groups to understand, if any, the difference in analgesic efficacy between the two drugs." (NCT01345162)
Timeframe: 4 days postherniotomy

Interventionpercentage of patients with NRS≥4 (Number)
Ketorolac26.5
Acetaminophene + Tramadol32.3

Feasibility as Measured by the Number of Patients That Accept Enrollment, Remain Adherent to Losartan, and Remain Adherent to Study Procedures.

"Outcome 1a. Document the rate of acceptance (quantitative) and reasons for acceptance/rejection (qualitative) in a randomized trial of trial of losartan for SCD patients with abnormal nocturnal blood pressures.~Outcome 1b. Identify the adherence rate to losartan during a randomized three year trial of losartan for SCD patients (n=40) with abnormal nocturnal blood pressure.~Outcome 1c. Determine the adherence rate to study procedures among participants enrolled in a three year trial of losartan for SCD patients (n=40) with abnormal nocturnal blood pressure." (NCT02373241)
Timeframe: 5 yrs

InterventionParticipants (Count of Participants)
Standard Blood Pressure Management0
Experimental Blood Pressure Management1

Feasibility as Measured by the Number of Patients With Improvement in Nocturnal Blood Pressure While Receiving Losartan.

As a feasibility trial, the effect of losartan on lowering nocturnal hypertension will be monitored to identify the difference in nocturnal BP improvement between the two treatment arms, and within group standard deviation of BP (NCT02373241)
Timeframe: 5 years

InterventionParticipants (Count of Participants)
Experimental Blood Pressure Management1

Number of Patients With Incident Hypertension

We will prospectively evaluate the incidence of hypertension (Clinic BP in pts >5yrs and ABPM in pts >10 yrs) and role of blood and urine biomarkers (pts >5ys) among participants with HbSS or SB0 thalassemia (expected cohort n=200) over 5 yrs. We identified 20 participants (34%) with incident hypertension but randomized one to the study. The study was terminated as the eGFR was determined not to be a reliable endpoint in pediatric sickle cell. (NCT02373241)
Timeframe: 5 yrs

InterventionParticipants (Count of Participants)
Standard Blood Pressure Management0
Experimental Blood Pressure Management1

Reviews

2 reviews available for ketorolac and Acute Pain

ArticleYear
Single-dose intravenous ketorolac for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2021, 05-17, Volume: 5

    Topics: Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bias; Diclofenac; Hu

2021
Role of indomethacin in acute pain and inflammation management: a review of the literature.
    Postgraduate medicine, 2014, Volume: 126, Issue:4

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Inflammation; Ketorolac;

2014

Trials

14 trials available for ketorolac and Acute Pain

ArticleYear
IV metoclopramide Vs IV ketorolac in the treatment of acute primary headaches: A randomized clinical trial.
    The American journal of emergency medicine, 2022, Volume: 56

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Headache; Humans; Ketorola

2022
Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study.
    European journal of pediatrics, 2023, Volume: 182, Issue:2

    Topics: Acute Pain; Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Double

2023
Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study.
    European journal of pediatrics, 2023, Volume: 182, Issue:2

    Topics: Acute Pain; Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Double

2023
Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study.
    European journal of pediatrics, 2023, Volume: 182, Issue:2

    Topics: Acute Pain; Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Double

2023
Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study.
    European journal of pediatrics, 2023, Volume: 182, Issue:2

    Topics: Acute Pain; Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Double

2023
A randomized controlled trial of ibuprofen versus ketorolac versus diclofenac for acute, nonradicular low back pain.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2021, Volume: 28, Issue:11

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Ibupro

2021
Comparing two doses of intramuscular ketorolac for treatment of acute musculoskeletal pain in a military emergency department.
    The American journal of emergency medicine, 2021, Volume: 50

    Topics: Acute Pain; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Emergency Service, Hospital;

2021
No Added Benefit with Higher Doses of Ketorolac for Treatment of Acute Pain in the Emergency Department.
    American family physician, 2017, Aug-15, Volume: 96, Issue:4

    Topics: Acute Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double

2017
Ibuprofen and Acetaminophen Versus Intranasal Ketorolac (Sprix) in an Untreated Endodontic Pain Model: A Randomized, Double-blind Investigation.
    Journal of endodontics, 2019, Volume: 45, Issue:2

    Topics: Acetaminophen; Acute Pain; Administration, Intranasal; Administration, Oral; Adult; Dental Pulp Necr

2019
Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial.
    Journal of anesthesia, 2014, Volume: 28, Issue:5

    Topics: Acute Pain; Anesthesia, Spinal; Arthroplasty, Replacement, Hip; Bupivacaine; Chronic Pain; Double-Bl

2014
Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial.
    The Journal of emergency medicine, 2014, Volume: 47, Issue:1

    Topics: Acute Pain; Administration, Intravenous; Adult; Anesthetics, Local; Cyclooxygenase Inhibitors; Doubl

2014
Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:20

    Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster

2014
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Preventive Analgesic Efficacy of Nefopam in Acute and Chronic Pain After Breast Cancer Surgery: A Prospective, Double-Blind, and Randomized Trial.
    Medicine, 2016, Volume: 95, Issue:20

    Topics: Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Axilla; Breast Neoplasms; Chemoradiotherapy, Adju

2016
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.
    Annals of emergency medicine, 2017, Volume: 70, Issue:2

    Topics: Acute Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double

2017
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.
    Annals of emergency medicine, 2017, Volume: 70, Issue:2

    Topics: Acute Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double

2017
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.
    Annals of emergency medicine, 2017, Volume: 70, Issue:2

    Topics: Acute Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double

2017
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.
    Annals of emergency medicine, 2017, Volume: 70, Issue:2

    Topics: Acute Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double

2017
Effectiveness of diclofenac, ketorolac and etoricoxib in the treatment of acute pain from ankle fracture.
    Proceedings of the Western Pharmacology Society, 2010, Volume: 53

    Topics: Acute Pain; Adult; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind

2010
A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain after abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:5

    Topics: Abdomen; Acute Pain; Adult; Chemistry, Pharmaceutical; Diclofenac; Dose-Response Relationship, Drug;

2012
A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain after abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:5

    Topics: Abdomen; Acute Pain; Adult; Chemistry, Pharmaceutical; Diclofenac; Dose-Response Relationship, Drug;

2012
A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain after abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:5

    Topics: Abdomen; Acute Pain; Adult; Chemistry, Pharmaceutical; Diclofenac; Dose-Response Relationship, Drug;

2012
A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain after abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:5

    Topics: Abdomen; Acute Pain; Adult; Chemistry, Pharmaceutical; Diclofenac; Dose-Response Relationship, Drug;

2012

Other Studies

12 other studies available for ketorolac and Acute Pain

ArticleYear
Randomized IV metoclopramide vs IV ketorolac in treatment of acute primary headache.
    The American journal of emergency medicine, 2022, Volume: 57

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Headache; Humans; Ketorola

2022
Ibuprofen, Ketorolac, and Diclofenac Are Equivalent for the Treatment of Acute, Nonradicular Low Back Pain.
    American family physician, 2022, 05-01, Volume: 105, Issue:5

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Ibupro

2022
What is the analgesic ceiling dose of ketorolac for treating acute pain in the ED?
    JAAPA : official journal of the American Academy of Physician Assistants, 2023, May-01, Volume: 36, Issue:5

    Topics: Acute Pain; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ketoro

2023
Usage analysis of ketorolac in the emergency department.
    The American journal of emergency medicine, 2021, Volume: 45

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Emergency Service, Hospital; Huma

2021
Intranasal Ketorolac for Acute Pain in Adult Emergency Department Patients.
    Western journal of nursing research, 2022, Volume: 44, Issue:11

    Topics: Acute Pain; Adult; Double-Blind Method; Emergency Service, Hospital; Humans; Ketorolac; Needlestick

2022
In patients in the emergency department with acute pain, 10, 15, and 30 mg of ketorolac did not differ for pain relief.
    Annals of internal medicine, 2017, 04-18, Volume: 166, Issue:8

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Emergency Service, Hospita

2017
Ketorolac dose-response for acute pain is well known and the safety rules for adequate prescribing are clear.
    Journal of clinical anesthesia, 2018, Volume: 44

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ketorolac; Pain, P

2018
Comparison of ketorolac dosing in an emergency department setting.
    CJEM, 2018, Volume: 20, Issue:S2

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Clinical Protocols; Emergency Service, Hospital

2018
When will we get a new class of analgesic agent based on animal study data?
    Journal of anesthesia, 2014, Volume: 28, Issue:3

    Topics: Acute Pain; Bupivacaine; Chronic Pain; Humans; Ketorolac

2014
Development of an opioid reduction protocol in an emergency department.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2015, Dec-01, Volume: 72, Issue:23

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Chronic Pain; Emergency Service, Hospital; Humans

2015
Ketorolac Administered in the Recovery Room for Acute Pain Management Does Not Affect Healing Rates of Femoral and Tibial Fractures.
    Journal of orthopaedic trauma, 2016, Volume: 30, Issue:9

    Topics: Acute Pain; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cau

2016
Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis.
    Pediatric nephrology (Berlin, Germany), 2017, Volume: 32, Issue:8

    Topics: Acute Kidney Injury; Acute Pain; Adolescent; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Ster

2017
Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis.
    Pediatric nephrology (Berlin, Germany), 2017, Volume: 32, Issue:8

    Topics: Acute Kidney Injury; Acute Pain; Adolescent; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Ster

2017
Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis.
    Pediatric nephrology (Berlin, Germany), 2017, Volume: 32, Issue:8

    Topics: Acute Kidney Injury; Acute Pain; Adolescent; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Ster

2017
Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis.
    Pediatric nephrology (Berlin, Germany), 2017, Volume: 32, Issue:8

    Topics: Acute Kidney Injury; Acute Pain; Adolescent; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Ster

2017