ketorolac has been researched along with Abnormality, Heart in 4 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketorolac can be used to treat pain after congenital heart surgery without an increased risk of bleeding complications." | 5.11 | Prospective randomized trial of ketorolac after congenital heart surgery. ( Daggett, C; Drant, S; Gupta, A; Lewis, A; Rivero, N, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uber, AM | 1 |
| Montez-Rath, ME | 1 |
| Kwiatkowski, DM | 1 |
| Krawczeski, CD | 1 |
| Sutherland, SM | 1 |
| Kim, JS | 1 |
| Kaufman, J | 1 |
| Patel, SS | 1 |
| Manco-Johnson, M | 1 |
| Di Paola, J | 1 |
| da Cruz, EM | 1 |
| Gupta, A | 2 |
| Daggett, C | 2 |
| Drant, S | 1 |
| Rivero, N | 1 |
| Lewis, A | 2 |
| Ludwick, J | 1 |
| Wells, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Randomized, Allocation-Concealed, Blinded Study Designed to Compare Ketorolac Sublingual and Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children[NCT02653742] | Phase 4 | 150 participants (Anticipated) | Interventional | 2015-05-31 | Recruiting | ||
| A Randomized, Double-blinded, Placebo-controlled Study of Ketorolac Use in Pediatric Patients Undergoing Tonsillectomy[NCT03453541] | Phase 4 | 600 participants (Anticipated) | Interventional | 2017-11-21 | Recruiting | ||
| Continuous Infusion Versus Intermittent Ketorolac for Postoperative Pain Control in Pediatric Cardiac Surgery Patients[NCT04040452] | Phase 4 | 166 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for ketorolac and Abnormality, Heart
| Article | Year |
|---|---|
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
3 other studies available for ketorolac and Abnormality, Heart
| Article | Year |
|---|---|
Nephrotoxin exposure and acute kidney injury in critically ill children undergoing congenital cardiac surgery.
Topics: Acute Kidney Injury; Adolescent; Aspirin; Cardiac Surgical Procedures; Child; Child, Preschool; Crit | 2018 |
Antiplatelet Effect of Ketorolac in Children After Congenital Cardiac Surgery.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Child; Child, Pres | 2018 |
Ketorolac after congenital heart surgery: does it increase the risk of significant bleeding complications?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Child; Heart Defects, Congenit | 2005 |
Ketorolac after congenital heart surgery: does it increase the risk of significant bleeding complications?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Child; Heart Defects, Congenit | 2005 |
Ketorolac after congenital heart surgery: does it increase the risk of significant bleeding complications?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Child; Heart Defects, Congenit | 2005 |
Ketorolac after congenital heart surgery: does it increase the risk of significant bleeding complications?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Child; Heart Defects, Congenit | 2005 |