ketorolac has been researched along with Abdominal Cramps in 22 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The parameters considered as prognostic factors were pain relief with ketorolac (K) or ketorolac plus opiate treatment (KO), and stone size (>or= or <6 mm)." | 3.71 | Comparison of stone size and response to analgesic treatment in predicting outcome of patients with renal colic. ( Prina, LD; Rancatore, E; Secic, M; Weber, RE, 2002) |
| "In the patients with renal colic the average resistive index (RI) was significantly greater on the side of the colic after administration of either indomethacin or ketorolac (p<0." | 2.71 | Resistive index in patients with renal colic: differences after medical treatment with indomethacin and ketorolac. ( Bertolotto, M; Calderan, L; Gasparini, C; Pozzi Mucelli, R; Quaia, E, 2003) |
| "Ketorolac tromethamine is a well-tolerated, effective medication in the treatment of acute biliary colic." | 2.70 | Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic. ( Henderson, SO; Newton, E; Swadron, S, 2002) |
| "Ketorolac is a nonsteroidal anti-inflammatory medication that is used widely for pain management." | 2.70 | A prospective study comparing i.m. ketorolac with i.m. meperidine in the treatment of acute biliary colic. ( Anderson, R; Dula, DJ; Wood, GC, 2001) |
| "Ketorolac was significantly (P < ." | 2.69 | Efficacy of ketorolac tromethamine versus meperidine in the ED treatment of acute renal colic. ( Blair, GA; D'Amico, F; Larkin, GL; Peacock, WF; Pearl, SM, 1999) |
| " The time to first administration of rescue analgesic, up to 24 h following dosing with the study medication, was recorded." | 2.67 | A comparison of intramuscular ketorolac and pethidine in the alleviation of renal colic. ( Arkell, DG; Fletcher, MS; Iacovou, JW; Kaisary, AV; Philip, NH; Sandhu, DP, 1994) |
| "Twenty-five patients with renal colic were participants." | 1.29 | The use of intravenous ketorolac for the treatment of renal colic in the emergency department. ( Allegra, JR; Larsen, LS; Miller, A, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (54.55) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Togo, K | 1 |
| Ono, S | 1 |
| Matsui, R | 1 |
| Watanabe, J | 1 |
| Razi, A | 1 |
| Farrokhi, E | 1 |
| Lotfabadi, P | 1 |
| Hosseini, SS | 1 |
| Saadati, H | 1 |
| Haghighi, R | 1 |
| Rameshrad, M | 1 |
| Barry, HC | 1 |
| Olsen, JC | 1 |
| McGrath, NA | 1 |
| Schwarz, DG | 1 |
| Cutcliffe, BJ | 1 |
| Stern, JL | 1 |
| Prina, LD | 1 |
| Rancatore, E | 1 |
| Secic, M | 1 |
| Weber, RE | 1 |
| Henderson, SO | 1 |
| Swadron, S | 1 |
| Newton, E | 1 |
| Bertolotto, M | 1 |
| Quaia, E | 1 |
| Gasparini, C | 1 |
| Calderan, L | 1 |
| Pozzi Mucelli, R | 1 |
| Meyers, D | 1 |
| Feldstein, DA | 1 |
| Safdar, B | 1 |
| Degutis, LC | 1 |
| Landry, K | 1 |
| Vedere, SR | 1 |
| Moscovitz, HC | 1 |
| D'Onofrio, G | 1 |
| Sandhu, DP | 1 |
| Iacovou, JW | 1 |
| Fletcher, MS | 1 |
| Kaisary, AV | 1 |
| Philip, NH | 1 |
| Arkell, DG | 1 |
| Larsen, LS | 1 |
| Miller, A | 1 |
| Allegra, JR | 1 |
| Cordell, WH | 1 |
| Wright, SW | 1 |
| Wolfson, AB | 1 |
| Timerding, BL | 1 |
| Maneatis, TJ | 1 |
| Lewis, RH | 1 |
| Bynum, L | 1 |
| Nelson, DR | 1 |
| Stein, A | 1 |
| Ben Dov, D | 1 |
| Finkel, B | 1 |
| Mecz, Y | 1 |
| Kitzes, R | 1 |
| Lurie, A | 1 |
| Bergus, GR | 1 |
| Smally, AJ | 1 |
| Mofenson, HC | 1 |
| Caraccio, TR | 1 |
| Benson, DM | 1 |
| Cohen, E | 1 |
| Hafner, R | 1 |
| Rotenberg, Z | 1 |
| Fadilla, M | 1 |
| Garty, M | 1 |
| Larkin, GL | 1 |
| Peacock, WF | 1 |
| Pearl, SM | 1 |
| Blair, GA | 1 |
| D'Amico, F | 1 |
| Nicolás Torralba, JA | 1 |
| Rigabert Montiel, M | 1 |
| Bañón Pérez, V | 1 |
| Valdelvira Nadal, P | 1 |
| Pérez Albacete, M | 1 |
| Di Trolio, RN | 1 |
| Sing, RF | 1 |
| Bates, GM | 1 |
| Dula, DJ | 1 |
| Anderson, R | 1 |
| Wood, GC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of the Analgesic Efficacy of Intravenous Ibuprofen in Biliary Colic[NCT02268955] | 22 participants (Actual) | Interventional | 2014-09-09 | Completed | |||
| A Randomized Trial Comparing the Combination of Intravenous Lidocaine and Ketorolac to Either Analgesics Alone for ED Patients With Acute Renal Colic[NCT02902770] | Phase 4 | 150 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Pain is measured on a visual analog scale 0=no pain and 10=worst pain imaginable. (NCT02268955)
Timeframe: 120 minutes post medication administration
| Intervention | score on a scale (Median) |
|---|---|
| Control Group: Adults Age 18-55 Years | 3.0 |
| IV Ibuprofen: Adults Age 18-55 Years | 0.3 |
The trial will compare the patient's pain score on a 11 point Likert scale, ranging from 0 to 10 with 0 being no pain, 5 moderate pain and 10 very severe pain, at 30 minutes (NCT02902770)
Timeframe: 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Lidocaine and Normal Saline Push | 5.52 |
| Ketorolac and Normal Saline Drip | 3.88 |
| Lidocaine and Ketorolac | 3.14 |
13 trials available for ketorolac and Abdominal Cramps
| Article | Year |
|---|---|
Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colic; Dexamethasone; Double-Blind Method; Humans; Ketorola | 2022 |
A double-blind randomized clinical trial evaluating the analgesic efficacy of ketorolac versus butorphanol for patients with suspected biliary colic in the emergency department.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract Diseases; Butorpha | 2008 |
Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract Diseases; Colic; D | 2002 |
Resistive index in patients with renal colic: differences after medical treatment with indomethacin and ketorolac.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Colic; Humans; Indomethacin; Ketorolac; Kidn | 2003 |
Intravenous morphine plus ketorolac is superior to either drug alone for treatment of acute renal colic.
Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Colic; Double-Blind | 2006 |
A comparison of intramuscular ketorolac and pethidine in the alleviation of renal colic.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Colic; Double-B | 1994 |
Comparison of intravenous ketorolac, meperidine, and both (balanced analgesia) for renal colic.
Topics: Adult; Aged; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Colic; Double-Blind Method; Dr | 1996 |
Single-dose intramuscular ketorolac versus diclofenac for pain management in renal colic.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Colic; Diclofenac; Double-Blind Method; Female | 1996 |
Pain relief for renal colic.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Colic; Double-Blind Method; Drug | 1996 |
Comparison of ketorolac and diclofenac in the treatment of renal colic.
Topics: Adult; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Coli | 1998 |
Efficacy of ketorolac tromethamine versus meperidine in the ED treatment of acute renal colic.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Colic; | 1999 |
[Intramuscular ketorolac compared to subcutaneous tramadol in the initial emergency treatment of renal colic].
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Colic; Emergencies; Humans; Injections, Intramuscular; | 1999 |
A prospective study comparing i.m. ketorolac with i.m. meperidine in the treatment of acute biliary colic.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract | 2001 |
9 other studies available for ketorolac and Abdominal Cramps
| Article | Year |
|---|---|
Dexamethasone and ketorolac vs ketorolac in acute renal colic: The authors reply.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colic; Dexamethasone; Humans; Ketorolac; Renal Colic | 2022 |
Ketorolac Plus Dexamethasone Is More Effective for Pain Relief Than Ketorolac Alone in Adults With Renal Colic.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colic; Dexamethasone; Double-Blind Method; Humans; K | 2023 |
Comparison of stone size and response to analgesic treatment in predicting outcome of patients with renal colic.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Colic; Emergency Service, Hospital; Fem | 2002 |
Initial treatment of biliary colic: are NSAIDs better than opiates?
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract Diseases; Cholecystitis; | 2005 |
The use of intravenous ketorolac for the treatment of renal colic in the emergency department.
Topics: Adult; Analgesics; Colic; Emergencies; Humans; Injections, Intravenous; Ketorolac; Kidney Diseases; | 1993 |
Analgesia in renal colic.
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Colic; Humans; Ketorolac; Kidney Calculi; | 1997 |
Analgesia in renal colic.
Topics: Acute Kidney Injury; Analgesics, Non-Narcotic; Colic; Humans; Ketorolac; Kidney Calculi; Tolmetin | 1997 |
Analgesia in renal colic.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Colic; Drug Therapy, Combination; Humans; Ketorolac; K | 1997 |
Use of ketorolac in renal colic.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colic; Humans; Ketorolac; Kidney Diseases; Male; Middle Age | 1999 |