Page last updated: 2024-10-29

ketoprofen and Ulcer

ketoprofen has been researched along with Ulcer in 7 studies

Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.

Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.

Research Excerpts

ExcerptRelevanceReference
"Dexketoprofen trometamol is a water-soluble salt of the dextrorotatory enantiomer of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen."2.39Preclinical and clinical development of dexketoprofen. ( Artigas, R; Carganico, G; García, ML; Mauleón, D, 1996)
"When indomethacin (3 mg/kg) was administered after a morning meal (fed condition) for 7 days, it produced many lesions in the small intestine."1.43Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs. ( Idaka, S; Ishigami, K; Kondo, R; Satoh, H; Shinoda, T; Shiotani, S, 2016)
"Ketoprofen is a NSAID that exists as a pair of R(-) and S (+) enantiomers; like other 2-arylpropionic acids, its anti-inflammatory effects resides almost exclusively in the S (+) isomer."1.31Intestinal toxicity of ketoprofen-trometamol vs its enantiomers in rat. Role of oxidative stress. ( Cabré, F; de la Lastra, CA; Herrerías, JM; Martín, MJ; Mauleón, D; Motilva, V; Nieto, A, 2000)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's2 (28.57)18.2507
2000's1 (14.29)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hirose, S1
Matsuura, K1
Kato-Hayashi, H1
Suzuki, A1
Ohata, K1
Kobayashi, R1
Ibuka, T1
Araki, H1
Shimizu, M1
Itoh, Y1
Koessler, T1
Servois, V1
Mariani, P1
Aubert, E1
Cacheux, W1
Satoh, H1
Kondo, R1
Shinoda, T1
Idaka, S1
Ishigami, K1
Shiotani, S1
Mauleón, D3
Artigas, R1
García, ML2
Carganico, G1
Cabré, F2
Fernández, F1
Zapatero, MI1
Araño, A1
de la Lastra, CA1
Nieto, A1
Motilva, V1
Martín, MJ1
Herrerías, JM1
Niemegeers, CJ1
Lenaerts, FM1
Awouters, F1
Janssen, PA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001]Phase 460 participants (Actual)Interventional2015-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for ketoprofen and Ulcer

ArticleYear
Preclinical and clinical development of dexketoprofen.
    Drugs, 1996, Volume: 52 Suppl 5

    Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase Inhibitor

1996

Other Studies

6 other studies available for ketoprofen and Ulcer

ArticleYear
Gastrointestinal bleeding associated with chronic excessive use overdosing with topical ketoprofen patch in elderly patient.
    Scandinavian journal of gastroenterology, 2018, Volume: 53, Issue:1

    Topics: Administration, Topical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Endoscopy, Ga

2018
Rectal ulcer: Due to ketoprofen, argon plasma coagulation and prostatic brachytherapy.
    World journal of gastroenterology, 2014, Dec-07, Volume: 20, Issue:45

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Argon Plasma Coagulation; Brachytherapy; Hemorrhage;

2014
Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2016, Volume: 67, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Dietary Fiber; Dietary Supplements; Dog

2016
Intestinal ulcerogenic effect of S(+)-ketoprofen in the rat.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:S1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Intestinal Diseases; Ketoprofen; Male; Rats; Rats,

1998
Intestinal toxicity of ketoprofen-trometamol vs its enantiomers in rat. Role of oxidative stress.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2000, Volume: 49, Issue:11

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Intestinal Diseases; Intesti

2000
Gastrointestinal effects and acute toxicity of suprofen.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:10

    Topics: Animals; Antidiarrheals; Aspirin; Digestive System; Dogs; Dose-Response Relationship, Drug; Drug Eva

1975