ketoprofen has been researched along with Stomach Ulcer in 25 studies
Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The interaction between reserpine and nonsteroidal anti-inflammatory agents ( NSAIA ) in producing experimental gastric ulcers was studied in rats." | 7.67 | Interaction between reserpine and non-steroidal anti-inflammatory agents in producing gastric ulcers in rats. ( Radmanović, BZ; Sćepović, Z, 1984) |
| "The interaction between reserpine and nonsteroidal anti-inflammatory agents ( NSAIA ) in producing experimental gastric ulcers was studied in rats." | 3.67 | Interaction between reserpine and non-steroidal anti-inflammatory agents in producing gastric ulcers in rats. ( Radmanović, BZ; Sćepović, Z, 1984) |
| " In the carrageenan edema test, eight compounds exhibited higher antiinflammatory activities than did indomethacin." | 3.65 | 6,11-Dihydro-11-oxodibenz [b,e] oxepinacetic acids with potent antiinflammatory activity. ( Kubo, S; Tagawa, H; Tsukada, W; Ueno, K; Yoshioka, T, 1976) |
| "Ketoprofen (K) was synthesized in 1968." | 2.72 | Future prospects of ketoprofen in improving the safety of the gastric mucosa. ( Kuczyńska, J; Nieradko-Iwanicka, B, 2021) |
| "(R)- flurbiprofen was not statistically significant." | 2.69 | Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial. ( Caubet, JF; Handley, DA; Jerussi, TP; McCray, JE, 1998) |
| "Ketoprofen is a potent nonsteroidal antiinflammatory agent (NSAID) recently approved for OTC use as an analgesic/antipyretic at doses of 75 mg versus the usual dose of < or = 300 mg daily." | 2.69 | An endoscopic comparison of gastroduodenal injury with over-the-counter doses of ketoprofen and acetaminophen. ( Codispoti, JR; Lanza, FL; Nelson, EB, 1998) |
| " Each subject took, over four separate 10-day dosing periods, ibuprofen 400 mg t." | 2.69 | Dose-dependent effects of ketoprofen on the human gastric mucosa in comparison with ibuprofen. ( Courtauld, E; Donnelly, MT; Hawkey, CJ; Richardson, P; Stack, WA, 2000) |
| "Dexketoprofen trometamol is a water-soluble salt of the dextrorotatory enantiomer of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen." | 2.39 | Preclinical and clinical development of dexketoprofen. ( Artigas, R; Carganico, G; García, ML; Mauleón, D, 1996) |
| " Dose-response curves were carried out for dexketoprofen, tapentadol, and dexketoprofen-tapentadol combinations in the acetic acid-induced writhing test in mice." | 1.62 | Antinociception and less gastric injury with the dexketoprofen-tapentadol combination in mice. ( Alonso-Castro, ÁJ; Franco de la-Torre, L; Granados-Soto, V; Isiordia-Espinoza, MA; Partida-Castellanos, EM; Rivas-Carrillo, JD; Vidaurrazaga-Lugo, J; Zapata-Morales, JR, 2021) |
| " The experimental findings elicited higher AUC and plasma concentration at 1 and 2 h indicating improved oral bioavailability as compared to parent drug ketoprofen." | 1.43 | Preparation and Pharmacological Evaluation of Novel Orally Active Ester Prodrugs of Ketoprofen with Non-Ulcerogenic Property. ( Bandgar, BP; Bhale, PS; Chavan, HV; Dhakane, VD; Dongare, SB; Mule, YB; Thakare, VN, 2016) |
| "The previous study indicated the enhancement of the anti-inflammatory effect of ketoprofen by acute and sub chronic administration of zinc hydroaspartate." | 1.40 | Chronic treatment with zinc hydroaspartate induces anti-inflammatory and anti-ulcerogenic activity in rats. ( Gaweł, M; Golasik, M; Gomolka, E; Herman, M; Librowski, T; Lipkowska, A; Nowak, G; Opoka, W; Piekoszewski, W; Schlegel-Zawadzka, M, 2014) |
| "Ketoprofen (Ket) was intercalated into layered double hydroxides (ZnAlLDH and MgAlLDH) using the ionic exchange method." | 1.36 | In vitro and in vivo behavior of ketoprofen intercalated into layered double hydroxides. ( Hritcu, D; Ionescu, D; Jaba, IM; Mungiu, OC; Popa, IM; Silion, M; Tamba, B, 2010) |
| " These results suggest that the adverse effects seen after administration of ketoprofen were due to differences between barriers." | 1.35 | Adverse effects of incorporating ketoprofen into established rodent studies. ( Browder, EJ; Ihrig, M; Lamon, TK; Sohrabji, F, 2008) |
| "Since assessment of the acute gastrotoxicity of nonsteroidal antiinflammatory drugs (NSAIDs) in rats requires high doses of the drugs, we sought to establish an experimental model with which this adverse NSAID effect can be estimated at therapy-relevant doses." | 1.31 | Estimation of acute flurbiprofen and ketoprofen toxicity in rat gastric mucosa at therapy-relevant doses. ( Cabré, F; Holzer, P; Jocic, M; Mauléon, D, 2001) |
| "R(-)-ketoprofen was also less ulcerogenic, but when administered as the racemate exacerbated gastric ulceration caused by S(+)-ketoprofen." | 1.31 | Gastric toxicity of racemic ketoprofen and its enantiomers in rat: oxygen radical generation and COX-expression. ( Alarcón de la Lastra, C; Cabré, F; Herrerías, JM; Martín, MJ; Motilva, V; Nieto, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ueno, K | 1 |
| Kubo, S | 1 |
| Tagawa, H | 1 |
| Yoshioka, T | 1 |
| Tsukada, W | 1 |
| Navarro, L | 1 |
| Rosell, G | 1 |
| Sánchez, S | 1 |
| Boixareu, N | 1 |
| Pors, K | 1 |
| Pouplana, R | 1 |
| Campanera, JM | 1 |
| Pujol, MD | 1 |
| Franco de la-Torre, L | 1 |
| Alonso-Castro, ÁJ | 1 |
| Zapata-Morales, JR | 1 |
| Rivas-Carrillo, JD | 1 |
| Vidaurrazaga-Lugo, J | 1 |
| Partida-Castellanos, EM | 1 |
| Granados-Soto, V | 1 |
| Isiordia-Espinoza, MA | 1 |
| Kuczyńska, J | 1 |
| Nieradko-Iwanicka, B | 1 |
| Sehajpal, S | 1 |
| Prasad, DN | 1 |
| Singh, RK | 1 |
| Gaweł, M | 1 |
| Lipkowska, A | 1 |
| Herman, M | 1 |
| Golasik, M | 1 |
| Piekoszewski, W | 1 |
| Gomolka, E | 1 |
| Schlegel-Zawadzka, M | 1 |
| Opoka, W | 1 |
| Nowak, G | 1 |
| Librowski, T | 1 |
| Dhokchawle, BV | 1 |
| Tauro, SJ | 1 |
| Bhandari, AB | 1 |
| Dhakane, VD | 1 |
| Thakare, VN | 1 |
| Dongare, SB | 1 |
| Bhale, PS | 1 |
| Mule, YB | 1 |
| Bandgar, BP | 1 |
| Chavan, HV | 1 |
| Lamon, TK | 1 |
| Browder, EJ | 1 |
| Sohrabji, F | 1 |
| Ihrig, M | 1 |
| Silion, M | 1 |
| Hritcu, D | 1 |
| Jaba, IM | 1 |
| Tamba, B | 1 |
| Ionescu, D | 1 |
| Mungiu, OC | 1 |
| Popa, IM | 1 |
| Bonina, F | 1 |
| Puglia, C | 2 |
| Santagati, NA | 2 |
| Saija, A | 2 |
| Tomaino, A | 1 |
| Tita, B | 1 |
| Bonina, FP | 1 |
| Ventura, D | 1 |
| Trombetta, D | 1 |
| Solankar, AK | 1 |
| Jagtap, AG | 1 |
| Sćepović, Z | 1 |
| Radmanović, BZ | 1 |
| Humes, JL | 1 |
| Winter, CA | 1 |
| Sadowski, SJ | 1 |
| Kuehl, FA | 1 |
| Wallace, JL | 1 |
| Reuter, B | 1 |
| Cicala, C | 1 |
| McKnight, W | 1 |
| Grisham, MB | 1 |
| Cirino, G | 1 |
| Mauleón, D | 2 |
| Artigas, R | 1 |
| García, ML | 1 |
| Carganico, G | 1 |
| Kido, H | 1 |
| Murakami, N | 1 |
| Ito, A | 1 |
| Kimura, K | 1 |
| Kodera, N | 1 |
| Doi, T | 1 |
| Naruse, T | 1 |
| Jerussi, TP | 1 |
| Caubet, JF | 1 |
| McCray, JE | 1 |
| Handley, DA | 1 |
| Lanza, FL | 1 |
| Codispoti, JR | 1 |
| Nelson, EB | 1 |
| Forsyth, SF | 1 |
| Guilford, WG | 1 |
| Haslett, SJ | 1 |
| Godfrey, J | 1 |
| Donnelly, MT | 1 |
| Richardson, P | 1 |
| Hawkey, CJ | 1 |
| Courtauld, E | 1 |
| Stack, WA | 1 |
| Holzer, P | 1 |
| Jocic, M | 1 |
| Cabré, F | 2 |
| Alarcón de la Lastra, C | 1 |
| Nieto, A | 1 |
| Martín, MJ | 1 |
| Herrerías, JM | 1 |
| Motilva, V | 1 |
| O'Brien, JD | 1 |
| Burnham, WR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001] | Phase 4 | 60 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Does Acetaminophen Potentiate the Gastroduodenal Mucosal Injury of Aspirin? A Prospective, Randomized, Pilot Study.[NCT00594867] | Phase 4 | 94 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ketoprofen and Stomach Ulcer
| Article | Year |
|---|---|
Future prospects of ketoprofen in improving the safety of the gastric mucosa.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Humans; Ketoprofen; Stomach Ulcer | 2021 |
Preclinical and clinical development of dexketoprofen.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase Inhibitor | 1996 |
3 trials available for ketoprofen and Stomach Ulcer
| Article | Year |
|---|---|
Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Duodenal Dise | 1998 |
An endoscopic comparison of gastroduodenal injury with over-the-counter doses of ketoprofen and acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 1998 |
Dose-dependent effects of ketoprofen on the human gastric mucosa in comparison with ibuprofen.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Dose-Respo | 2000 |
20 other studies available for ketoprofen and Stomach Ulcer
| Article | Year |
|---|---|
6,11-Dihydro-11-oxodibenz [b,e] oxepinacetic acids with potent antiinflammatory activity.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dibenzoxepins; Edema; Female; Le | 1976 |
Synthesis and biological properties of aryl methyl sulfones.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimet | 2018 |
Antinociception and less gastric injury with the dexketoprofen-tapentadol combination in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Ketoprofen | 2021 |
Novel ketoprofen-antioxidants mutual codrugs as safer nonsteroidal anti-inflammatory drugs: Synthesis, kinetic and pharmacological evaluation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Biphe | 2019 |
Chronic treatment with zinc hydroaspartate induces anti-inflammatory and anti-ulcerogenic activity in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspartic Acid; Disease Models, Ani | 2014 |
Ester Prodrugs of Ketoprofen: Synthesis, Hydrolysis Kinetics and Pharmacological Evaluation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Stability; Female; Gastric Absorption; Hydrog | 2016 |
Preparation and Pharmacological Evaluation of Novel Orally Active Ester Prodrugs of Ketoprofen with Non-Ulcerogenic Property.
Topics: Administration, Oral; Animals; Drug Evaluation, Preclinical; Ketoprofen; Mice; Prodrugs; Rats; Sigmo | 2016 |
Adverse effects of incorporating ketoprofen into established rodent studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Gastric Mucosa; Gastroenteriti | 2008 |
In vitro and in vivo behavior of ketoprofen intercalated into layered double hydroxides.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Drug Carriers; Gastroin | 2010 |
Oligoethylene ester derivatives of ketoprofen, naproxen and diclofenac as oral prodrugs: a pharmacological evaluation.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Edema; Ester | 2002 |
1-ethyl and 1-propylazacycloalkan-2-one ester prodrugs of ketoprofen. Synthesis, chemical stability, enzymatic hydrolysis, anti-inflammatory activity, and gastrointestinal toxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Drug Stabili | 2002 |
Chronobiological and chronopharmacological studies of ketoprofen and its solid dispersion form using adjuvant arthritis model in rats.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Oral; Animals; Arthritis, Experimental; beta-Cycl | 2005 |
Interaction between reserpine and non-steroidal anti-inflammatory agents in producing gastric ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Synergism; Female; Indomet | 1984 |
Multiple sites on prostaglandin cyclooxygenase are determinants in the action of nonsteroidal antiinflammatory agents.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Diflunisal; Indomethaci | 1981 |
Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Flurbiprofen; Ketoprofen; Leukocyte | 1994 |
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1998 |
Endoscopy of the gastroduodenal mucosa after carprofen, meloxicam and ketoprofen administration in dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Dogs; Endoscopy, Gastrointestinal; Gas | 1998 |
Estimation of acute flurbiprofen and ketoprofen toxicity in rat gastric mucosa at therapy-relevant doses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2001 |
Gastric toxicity of racemic ketoprofen and its enantiomers in rat: oxygen radical generation and COX-expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; | 2002 |
Bleeding from peptic ulcers and use of non-steroidal anti-inflammatory drugs in the Romford area.
Topics: Aged; Anti-Inflammatory Agents; Drug Utilization; England; Humans; Ketoprofen; Peptic Ulcer Hemorrha | 1985 |