ketoprofen has been researched along with Periodontitis in 13 studies
Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Various preclinical/clinical studies support the effectiveness of ketoprofen in periodontitis; however, the literature reveals that novel delivery systems have been less explored for the drug in periodontitis." | 7.85 | Systematically Optimized Ketoprofen-Loaded Novel Proniosomal Formulation for Periodontitis: In Vitro Characterization and In Vivo Pharmacodynamic Evaluation. ( Katare, OP; Nanda, S; Sharma, G; Yadav, NK, 2017) |
| "The aim of the novel study was to check the efficacy of a locally applied 2%w/w nanoemulgel (NEG) of Ketoprofen (KP) in preventing the periodontitis, and was also checked NEG without KP to ensure the effect of eugenol in NEG as an oil phase." | 7.83 | Nanoemulgel (NEG) of Ketoprofen with eugenol as oil phase for the treatment of ligature-induced experimental periodontitis in Wistar rats. ( Kohli, K; Kumar, P; Neupane, YR; Srivastava, M, 2016) |
| " The relative systemic bioavailability of the gels compared with peroral administration ranged from 54% to 69%." | 6.69 | Pharmacokinetic and safety evaluations of ketoprofen gels in subjects with adult periodontitis. ( Annett, M; Binder, T; Friedman, M; Lawrence, HP; Mann, GL; Maynor, G; Offenbacher, S; Paquette, DW; Smith, PC; Troullos, E; Wilder, R, 1998) |
| " This randomized, partially double-blind, controlled trial was conducted to evaluate the pharmacodynamic effects of the NSAID, ketoprofen (KTP), on gingival crevicular fluid (GCF) prostanoids." | 6.69 | Pharmacodynamic effects of ketoprofen on crevicular fluid prostanoids in adult periodontitis. ( Annett, M; Binder, TA; Friedman, M; Lawrence, HP; McCombs, GB; Offenbacher, S; Paquette, DW; Smith, PC; Troullos, E; Wilder, R, 2000) |
| "Periodontitis was induced by a single intragingival injection of 1 μl LPS (10 μg/μl), Our results show that 14 h after intragingival injection of LPS, there was a high tissue damage associated with bone resorption, and in gingivomucosal tissues there was a significant expression of NF-kb p65 and pro-inflammatory cytokine as well as a higher expression of COX-2 and iNOS, activation of the apoptotic process, and also increased levels of NGF expression, often associated with a higher nociceptive perception." | 5.48 | Anti-inflammatory effect of ATB-352, a H2S -releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats. ( Cuzzocrea, S; D'Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Militi, A; Oteri, G; Wallace, JL, 2018) |
| "3% (S)-ketoprofen demonstrated a reduction and other groups demonstrated elevations over the 60-day dosing period." | 5.30 | Enantiospecific inhibition of ligature-induced periodontitis in beagles with topical (S)-ketoprofen. ( Fiorellini, JP; Howell, TH; Martuscelli, G; McCullough, JR; Oringer, RJ; Paquette, DW; Reasner, DS; Williams, RC, 1997) |
| "Various preclinical/clinical studies support the effectiveness of ketoprofen in periodontitis; however, the literature reveals that novel delivery systems have been less explored for the drug in periodontitis." | 3.85 | Systematically Optimized Ketoprofen-Loaded Novel Proniosomal Formulation for Periodontitis: In Vitro Characterization and In Vivo Pharmacodynamic Evaluation. ( Katare, OP; Nanda, S; Sharma, G; Yadav, NK, 2017) |
| "The aim of the novel study was to check the efficacy of a locally applied 2%w/w nanoemulgel (NEG) of Ketoprofen (KP) in preventing the periodontitis, and was also checked NEG without KP to ensure the effect of eugenol in NEG as an oil phase." | 3.83 | Nanoemulgel (NEG) of Ketoprofen with eugenol as oil phase for the treatment of ligature-induced experimental periodontitis in Wistar rats. ( Kohli, K; Kumar, P; Neupane, YR; Srivastava, M, 2016) |
| " The relative systemic bioavailability of the gels compared with peroral administration ranged from 54% to 69%." | 2.69 | Pharmacokinetic and safety evaluations of ketoprofen gels in subjects with adult periodontitis. ( Annett, M; Binder, T; Friedman, M; Lawrence, HP; Mann, GL; Maynor, G; Offenbacher, S; Paquette, DW; Smith, PC; Troullos, E; Wilder, R, 1998) |
| " This randomized, partially double-blind, controlled trial was conducted to evaluate the pharmacodynamic effects of the NSAID, ketoprofen (KTP), on gingival crevicular fluid (GCF) prostanoids." | 2.69 | Pharmacodynamic effects of ketoprofen on crevicular fluid prostanoids in adult periodontitis. ( Annett, M; Binder, TA; Friedman, M; Lawrence, HP; McCombs, GB; Offenbacher, S; Paquette, DW; Smith, PC; Troullos, E; Wilder, R, 2000) |
| "Periodontitis was induced by a single intragingival injection of 1 μl LPS (10 μg/μl), Our results show that 14 h after intragingival injection of LPS, there was a high tissue damage associated with bone resorption, and in gingivomucosal tissues there was a significant expression of NF-kb p65 and pro-inflammatory cytokine as well as a higher expression of COX-2 and iNOS, activation of the apoptotic process, and also increased levels of NGF expression, often associated with a higher nociceptive perception." | 1.48 | Anti-inflammatory effect of ATB-352, a H2S -releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats. ( Cuzzocrea, S; D'Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Militi, A; Oteri, G; Wallace, JL, 2018) |
| "3% (S)-ketoprofen demonstrated a reduction and other groups demonstrated elevations over the 60-day dosing period." | 1.30 | Enantiospecific inhibition of ligature-induced periodontitis in beagles with topical (S)-ketoprofen. ( Fiorellini, JP; Howell, TH; Martuscelli, G; McCullough, JR; Oringer, RJ; Paquette, DW; Reasner, DS; Williams, RC, 1997) |
| "Ketoprofen creams were evaluated for the treatment of periodontal disease in a placebo-controlled, double-blind study in the rhesus monkeys, Macaca mulatta." | 1.29 | The effect of ketoprofen creams on periodontal disease in rhesus monkeys. ( Alfano, MC; Collins, JG; Jeffcoat, MK; Li, KL; Offenbacher, S; Smith, MA; Vogel, R, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gugliandolo, E | 1 |
| Fusco, R | 1 |
| D'Amico, R | 1 |
| Militi, A | 1 |
| Oteri, G | 1 |
| Wallace, JL | 1 |
| Di Paola, R | 1 |
| Cuzzocrea, S | 1 |
| Sundararaj, SC | 1 |
| Thomas, MV | 1 |
| Peyyala, R | 1 |
| Dziubla, TD | 1 |
| Puleo, DA | 1 |
| Zbidi, ND | 1 |
| Mbarek, R | 1 |
| Zokkar, N | 1 |
| Feki, H | 1 |
| Koubar, S | 1 |
| Srivastava, M | 2 |
| Kohli, K | 2 |
| Ali, M | 1 |
| Neupane, YR | 1 |
| Kumar, P | 1 |
| Yadav, NK | 1 |
| Nanda, S | 1 |
| Sharma, G | 1 |
| Katare, OP | 1 |
| Funosas, E | 1 |
| Feser, G | 1 |
| Escovich, L | 1 |
| Maestri, L | 1 |
| Li, KL | 1 |
| Vogel, R | 1 |
| Jeffcoat, MK | 1 |
| Alfano, MC | 1 |
| Smith, MA | 2 |
| Collins, JG | 1 |
| Offenbacher, S | 4 |
| Paquette, DW | 3 |
| Fiorellini, JP | 1 |
| Martuscelli, G | 1 |
| Oringer, RJ | 1 |
| Howell, TH | 1 |
| McCullough, JR | 1 |
| Reasner, DS | 1 |
| Williams, RC | 1 |
| Lawrence, HP | 2 |
| Smith, PC | 2 |
| Maynor, G | 1 |
| Wilder, R | 2 |
| Mann, GL | 1 |
| Binder, T | 1 |
| Troullos, E | 2 |
| Annett, M | 2 |
| Friedman, M | 2 |
| McCombs, GB | 1 |
| Binder, TA | 1 |
| Santoro, F | 1 |
| Maiorana, C | 1 |
| Odle, BM | 1 |
| Green, MD | 1 |
| Mayambala, CS | 1 |
| Fritz, ME | 1 |
| van Dyke, TE | 1 |
| Yeh, KC | 1 |
| Sena, FJ | 1 |
4 trials available for ketoprofen and Periodontitis
| Article | Year |
|---|---|
Alteration of hemostasis in patients treated with subgingival NSAIDs during periodontal therapy.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; G | 2012 |
Pharmacokinetic and safety evaluations of ketoprofen gels in subjects with adult periodontitis.
Topics: Administration, Oral; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biolo | 1998 |
Pharmacodynamic effects of ketoprofen on crevicular fluid prostanoids in adult periodontitis.
Topics: Administration, Topical; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Area | 2000 |
[Proglumetacin in acute periodontitis. Effectiveness and tolerance].
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Facial Pain; Female; Humans; In | 1991 |
9 other studies available for ketoprofen and Periodontitis
| Article | Year |
|---|---|
Anti-inflammatory effect of ATB-352, a H2S -releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bone Resorption; Cyclooxygenase 2; Hydrogen Sulfide; Interleukin- | 2018 |
Design of a multiple drug delivery system directed at periodontitis.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Cellulose; Delayed-Action Preparations; Doxycycline | 2013 |
[Efficiency of mesotherapy in dental medecine. 16 Clinical cases].
Topics: Analgesics; Humans; Ketoprofen; Mesotherapy; Periodontitis; Postoperative Care; Tooth, Impacted; Too | 2013 |
Formulation development of novel in situ nanoemulgel (NEG) of ketoprofen for the treatment of periodontitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Drug Delivery Systems; | 2016 |
Nanoemulgel (NEG) of Ketoprofen with eugenol as oil phase for the treatment of ligature-induced experimental periodontitis in Wistar rats.
Topics: Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Dental Cementum; Emuls | 2016 |
Systematically Optimized Ketoprofen-Loaded Novel Proniosomal Formulation for Periodontitis: In Vitro Characterization and In Vivo Pharmacodynamic Evaluation.
Topics: Administration, Cutaneous; Animals; Chickens; Drug Compounding; Drug Delivery Systems; Drug Evaluati | 2017 |
The effect of ketoprofen creams on periodontal disease in rhesus monkeys.
Topics: Administration, Topical; Alveolar Bone Loss; Animals; Anti-Inflammatory Agents, Non-Steroidal; Denta | 1996 |
Enantiospecific inhibition of ligature-induced periodontitis in beagles with topical (S)-ketoprofen.
Topics: Alveolar Bone Loss; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsules | 1997 |
Inhibition of human periodontal prostaglandin E2 synthesis with selected agents.
Topics: Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors | 1990 |