ketoprofen has been researched along with Osteoarthritis of Knee in 10 studies
Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy and safety of ketoprofen plasters and diclofenac plasters after 3 weeks of administration in patients with osteoarthritis-related knee pain." | 9.41 | Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial. ( Cha, JE; Ershova, O; Hyun, BJ; Kastanayan, A; Krechikova, D; Nikulenkova, N; Polyakova, S; Shvarts, Y; Vinogradova, I; Yakushin, S, 2021) |
| "To assess the efficacy and safety of 12-week treatment with ketoprofen in ultradeformable phospholipid vesicles in patients with OA knee pain and to compare the efficacy with that of ketoprofen-free vehicle and celecoxib." | 9.17 | A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis. ( Bolten, W; Cevc, G; Conaghan, PG; Dickson, J; Rother, M, 2013) |
| "This randomized, double-blind, phase III study evaluated the efficacy and safety of ketoprofen in an ultradeformable vesicle gel compared with ketoprofen-free gel in osteoarthritis (OA) knee pain." | 9.17 | A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel. ( Conaghan, PG; Rother, M, 2013) |
| "To compare the efficacy and safety of ketoprofen plasters and diclofenac plasters after 3 weeks of administration in patients with osteoarthritis-related knee pain." | 5.41 | Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial. ( Cha, JE; Ershova, O; Hyun, BJ; Kastanayan, A; Krechikova, D; Nikulenkova, N; Polyakova, S; Shvarts, Y; Vinogradova, I; Yakushin, S, 2021) |
| "To assess the efficacy and safety of 12-week treatment with ketoprofen in ultradeformable phospholipid vesicles in patients with OA knee pain and to compare the efficacy with that of ketoprofen-free vehicle and celecoxib." | 5.17 | A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis. ( Bolten, W; Cevc, G; Conaghan, PG; Dickson, J; Rother, M, 2013) |
| "This randomized, double-blind, phase III study evaluated the efficacy and safety of ketoprofen in an ultradeformable vesicle gel compared with ketoprofen-free gel in osteoarthritis (OA) knee pain." | 5.17 | A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel. ( Conaghan, PG; Rother, M, 2013) |
| " In patients with neuropathic pain, topical forms of both capsaicin and lidocaine have been shown to be useful in the treatment of postherpetic neuralgia and diabetic peripheral neuropathic pain." | 4.89 | Topical therapies in the management of chronic pain. ( Galluzzi, KE; Stanos, SP, 2013) |
| " Gastrointestinal adverse events for IDEA-033 were similar to placebo." | 2.73 | Efficacy and safety of epicutaneous ketoprofen in Transfersome (IDEA-033) versus oral celecoxib and placebo in osteoarthritis of the knee: multicentre randomised controlled trial. ( Kneer, W; Lavins, BJ; Lehnhardt, K; Mazgareanu, S; Rother, M; Seidel, EJ, 2007) |
| " Topical NSAIDs are known to have a lower side-effect profile when compared with systemic administration." | 2.55 | Safety and efficacy of topical ketoprofen in transfersome gel in knee osteoarthritis: A systematic review. ( Burzynski, J; Sardana, V; Zalzal, P, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yakushin, S | 1 |
| Polyakova, S | 1 |
| Shvarts, Y | 1 |
| Kastanayan, A | 1 |
| Krechikova, D | 1 |
| Ershova, O | 1 |
| Nikulenkova, N | 1 |
| Vinogradova, I | 1 |
| Hyun, BJ | 1 |
| Cha, JE | 1 |
| Conaghan, PG | 2 |
| Dickson, J | 1 |
| Bolten, W | 1 |
| Cevc, G | 1 |
| Rother, M | 3 |
| Boyaci, A | 1 |
| Tutoglu, A | 1 |
| Boyaci, N | 1 |
| Aridici, R | 1 |
| Koca, I | 1 |
| Stanos, SP | 1 |
| Galluzzi, KE | 1 |
| Sardana, V | 1 |
| Burzynski, J | 1 |
| Zalzal, P | 1 |
| Shinkai, N | 1 |
| Korenaga, K | 1 |
| Mizu, H | 1 |
| Yamauchi, H | 1 |
| Lavins, BJ | 1 |
| Kneer, W | 1 |
| Lehnhardt, K | 1 |
| Seidel, EJ | 1 |
| Mazgareanu, S | 1 |
| Beltrán, J | 1 |
| Martín-Mola, E | 1 |
| Figueroa, M | 1 |
| Granados, J | 1 |
| Sanmartí, R | 1 |
| Artigas, R | 1 |
| Torres, F | 1 |
| Forns, M | 1 |
| Mauleón, D | 1 |
| Jokhio, IA | 1 |
| Siddiqui, KA | 1 |
| Waraich, T | 1 |
| Abbas, M | 1 |
| Ali, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Double-blind, Placebo Controlled Study of Topical FLEXISEQ® for the Treatment of Osteoarthritis of the Knee in Patients Contraindicated for or With Clinical Intolerance to NSAIDs[NCT02594176] | 600 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | |||
| Multicenter, Randomized, Double-blind, Placebo- and Active-controlled Study of Safety and Efficacy of Two Dosages of Epicutaneously Applied Diractin® (Ketoprofen in Transfersome® Gel) for the Treatment of Osteoarthritis of the Knee[NCT00716547] | Phase 3 | 1,399 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| Multicentre, Randomized, Double-blind, Placebo-controlled Study of Safety and Efficacy of Epicutaneously Applied Diractin® (Ketoprofen in Transfersome® Gel) for the Treatment of Osteoarthritis of the Knee[NCT00722852] | Phase 3 | 555 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)[NCT03199417] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2017-05-01 | Terminated (stopped due to Terminated prematurely due to feasibility issues with rate of recruitment) | ||
| A Double-Blind, Placebo-Controlled Evaluation of Safety and Efficacy of Epicutaneously Applied IDEA-033 (Ketoprofen in Transfersome) in Comparison to Oral Celecoxib for the Treatment of Pain Associated With Osteoarthritis of the Knee[NCT00317733] | Phase 2 | 360 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ketoprofen and Osteoarthritis of Knee
| Article | Year |
|---|---|
Topical therapies in the management of chronic pain.
Topics: Administration, Cutaneous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; C | 2013 |
Safety and efficacy of topical ketoprofen in transfersome gel in knee osteoarthritis: A systematic review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Gels; Humans; Ketoprofen; Osteoarthritis, Knee; Treatment O | 2017 |
6 trials available for ketoprofen and Osteoarthritis of Knee
2 other studies available for ketoprofen and Osteoarthritis of Knee
| Article | Year |
|---|---|
Intra-articular penetration of ketoprofen and analgesic effects after topical patch application in rats.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; A | 2008 |
Study of efficacy and tolerance of ketoprofen and diclofenac sodium in the treatment of acute rheumatic and traumatic conditions.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Diclofenac; Female; Humans; Ketoprofen; Male; Middle | 1998 |