ketoprofen has been researched along with Osteoarthritis, Knee in 10 studies
Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy and safety of ketoprofen plasters and diclofenac plasters after 3 weeks of administration in patients with osteoarthritis-related knee pain." | 9.41 | Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial. ( Cha, JE; Ershova, O; Hyun, BJ; Kastanayan, A; Krechikova, D; Nikulenkova, N; Polyakova, S; Shvarts, Y; Vinogradova, I; Yakushin, S, 2021) |
| "To assess the efficacy and safety of 12-week treatment with ketoprofen in ultradeformable phospholipid vesicles in patients with OA knee pain and to compare the efficacy with that of ketoprofen-free vehicle and celecoxib." | 9.17 | A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis. ( Bolten, W; Cevc, G; Conaghan, PG; Dickson, J; Rother, M, 2013) |
| "This randomized, double-blind, phase III study evaluated the efficacy and safety of ketoprofen in an ultradeformable vesicle gel compared with ketoprofen-free gel in osteoarthritis (OA) knee pain." | 9.17 | A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel. ( Conaghan, PG; Rother, M, 2013) |
| "To compare the efficacy and safety of ketoprofen plasters and diclofenac plasters after 3 weeks of administration in patients with osteoarthritis-related knee pain." | 5.41 | Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial. ( Cha, JE; Ershova, O; Hyun, BJ; Kastanayan, A; Krechikova, D; Nikulenkova, N; Polyakova, S; Shvarts, Y; Vinogradova, I; Yakushin, S, 2021) |
| "To assess the efficacy and safety of 12-week treatment with ketoprofen in ultradeformable phospholipid vesicles in patients with OA knee pain and to compare the efficacy with that of ketoprofen-free vehicle and celecoxib." | 5.17 | A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis. ( Bolten, W; Cevc, G; Conaghan, PG; Dickson, J; Rother, M, 2013) |
| "This randomized, double-blind, phase III study evaluated the efficacy and safety of ketoprofen in an ultradeformable vesicle gel compared with ketoprofen-free gel in osteoarthritis (OA) knee pain." | 5.17 | A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel. ( Conaghan, PG; Rother, M, 2013) |
| " In patients with neuropathic pain, topical forms of both capsaicin and lidocaine have been shown to be useful in the treatment of postherpetic neuralgia and diabetic peripheral neuropathic pain." | 4.89 | Topical therapies in the management of chronic pain. ( Galluzzi, KE; Stanos, SP, 2013) |
| " Gastrointestinal adverse events for IDEA-033 were similar to placebo." | 2.73 | Efficacy and safety of epicutaneous ketoprofen in Transfersome (IDEA-033) versus oral celecoxib and placebo in osteoarthritis of the knee: multicentre randomised controlled trial. ( Kneer, W; Lavins, BJ; Lehnhardt, K; Mazgareanu, S; Rother, M; Seidel, EJ, 2007) |
| " Topical NSAIDs are known to have a lower side-effect profile when compared with systemic administration." | 2.55 | Safety and efficacy of topical ketoprofen in transfersome gel in knee osteoarthritis: A systematic review. ( Burzynski, J; Sardana, V; Zalzal, P, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yakushin, S | 1 |
| Polyakova, S | 1 |
| Shvarts, Y | 1 |
| Kastanayan, A | 1 |
| Krechikova, D | 1 |
| Ershova, O | 1 |
| Nikulenkova, N | 1 |
| Vinogradova, I | 1 |
| Hyun, BJ | 1 |
| Cha, JE | 1 |
| Conaghan, PG | 2 |
| Dickson, J | 1 |
| Bolten, W | 1 |
| Cevc, G | 1 |
| Rother, M | 3 |
| Boyaci, A | 1 |
| Tutoglu, A | 1 |
| Boyaci, N | 1 |
| Aridici, R | 1 |
| Koca, I | 1 |
| Stanos, SP | 1 |
| Galluzzi, KE | 1 |
| Sardana, V | 1 |
| Burzynski, J | 1 |
| Zalzal, P | 1 |
| Shinkai, N | 1 |
| Korenaga, K | 1 |
| Mizu, H | 1 |
| Yamauchi, H | 1 |
| Lavins, BJ | 1 |
| Kneer, W | 1 |
| Lehnhardt, K | 1 |
| Seidel, EJ | 1 |
| Mazgareanu, S | 1 |
| Beltrán, J | 1 |
| Martín-Mola, E | 1 |
| Figueroa, M | 1 |
| Granados, J | 1 |
| Sanmartí, R | 1 |
| Artigas, R | 1 |
| Torres, F | 1 |
| Forns, M | 1 |
| Mauleón, D | 1 |
| Jokhio, IA | 1 |
| Siddiqui, KA | 1 |
| Waraich, T | 1 |
| Abbas, M | 1 |
| Ali, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Double-blind, Placebo Controlled Study of Topical FLEXISEQ® for the Treatment of Osteoarthritis of the Knee in Patients Contraindicated for or With Clinical Intolerance to NSAIDs[NCT02594176] | 600 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | |||
| Multicenter, Randomized, Double-blind, Placebo- and Active-controlled Study of Safety and Efficacy of Two Dosages of Epicutaneously Applied Diractin® (Ketoprofen in Transfersome® Gel) for the Treatment of Osteoarthritis of the Knee[NCT00716547] | Phase 3 | 1,399 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| Multicentre, Randomized, Double-blind, Placebo-controlled Study of Safety and Efficacy of Epicutaneously Applied Diractin® (Ketoprofen in Transfersome® Gel) for the Treatment of Osteoarthritis of the Knee[NCT00722852] | Phase 3 | 555 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)[NCT03199417] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2017-05-01 | Terminated (stopped due to Terminated prematurely due to feasibility issues with rate of recruitment) | ||
| A Double-Blind, Placebo-Controlled Evaluation of Safety and Efficacy of Epicutaneously Applied IDEA-033 (Ketoprofen in Transfersome) in Comparison to Oral Celecoxib for the Treatment of Pain Associated With Osteoarthritis of the Knee[NCT00317733] | Phase 2 | 360 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ketoprofen and Osteoarthritis, Knee
| Article | Year |
|---|---|
Topical therapies in the management of chronic pain.
Topics: Administration, Cutaneous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; C | 2013 |
Safety and efficacy of topical ketoprofen in transfersome gel in knee osteoarthritis: A systematic review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Gels; Humans; Ketoprofen; Osteoarthritis, Knee; Treatment O | 2017 |
6 trials available for ketoprofen and Osteoarthritis, Knee
2 other studies available for ketoprofen and Osteoarthritis, Knee
| Article | Year |
|---|---|
Intra-articular penetration of ketoprofen and analgesic effects after topical patch application in rats.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; A | 2008 |
Study of efficacy and tolerance of ketoprofen and diclofenac sodium in the treatment of acute rheumatic and traumatic conditions.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Diclofenac; Female; Humans; Ketoprofen; Male; Middle | 1998 |