ketoprofen has been researched along with Intestinal Diseases in 5 studies
Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
Intestinal Diseases: Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dexketoprofen trometamol is a water-soluble salt of the dextrorotatory enantiomer of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen." | 2.39 | Preclinical and clinical development of dexketoprofen. ( Artigas, R; Carganico, G; García, ML; Mauleón, D, 1996) |
| "When indomethacin (3 mg/kg) was administered after a morning meal (fed condition) for 7 days, it produced many lesions in the small intestine." | 1.43 | Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs. ( Idaka, S; Ishigami, K; Kondo, R; Satoh, H; Shinoda, T; Shiotani, S, 2016) |
| " Pharmacokinetic analysis of Inh-1 revealed an absolute bioavailability (F) of 21% and a short t1/2 of <1 h." | 1.40 | Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. ( Boelsterli, UA; Fujimoto, K; Lee, KK; Redinbo, MR; Saitta, KS; Zhang, C, 2014) |
| "Ketoprofen is a NSAID that exists as a pair of R(-) and S (+) enantiomers; like other 2-arylpropionic acids, its anti-inflammatory effects resides almost exclusively in the S (+) isomer." | 1.31 | Intestinal toxicity of ketoprofen-trometamol vs its enantiomers in rat. Role of oxidative stress. ( Cabré, F; de la Lastra, CA; Herrerías, JM; Martín, MJ; Mauleón, D; Motilva, V; Nieto, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saitta, KS | 1 |
| Zhang, C | 1 |
| Lee, KK | 1 |
| Fujimoto, K | 1 |
| Redinbo, MR | 1 |
| Boelsterli, UA | 1 |
| Satoh, H | 1 |
| Kondo, R | 1 |
| Shinoda, T | 1 |
| Idaka, S | 1 |
| Ishigami, K | 1 |
| Shiotani, S | 1 |
| Mauleón, D | 3 |
| Artigas, R | 1 |
| García, ML | 2 |
| Carganico, G | 1 |
| Cabré, F | 2 |
| Fernández, F | 1 |
| Zapatero, MI | 1 |
| Araño, A | 1 |
| de la Lastra, CA | 1 |
| Nieto, A | 1 |
| Motilva, V | 1 |
| Martín, MJ | 1 |
| Herrerías, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001] | Phase 4 | 60 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketoprofen and Intestinal Diseases
| Article | Year |
|---|---|
Preclinical and clinical development of dexketoprofen.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase Inhibitor | 1996 |
4 other studies available for ketoprofen and Intestinal Diseases
| Article | Year |
|---|---|
Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Diclofenac; Enzyme Inhibit | 2014 |
Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Dietary Fiber; Dietary Supplements; Dog | 2016 |
Intestinal ulcerogenic effect of S(+)-ketoprofen in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Intestinal Diseases; Ketoprofen; Male; Rats; Rats, | 1998 |
Intestinal toxicity of ketoprofen-trometamol vs its enantiomers in rat. Role of oxidative stress.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Intestinal Diseases; Intesti | 2000 |