ketoprofen has been researched along with Aging in 11 studies
Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the influences of ketoprofen on the proteoglycan (PG) turnover of human articular cartilage explants in three groups: normal young with a high basal PG synthesis, normal adult and osteoarthritis cartilage, both with a low basal PG synthesis." | 7.68 | In vitro influence of ketoprofen on the proteoglycan metabolism of human normal and osteoarthritis cartilage. ( Huber, J; Huber-Bruning, O; Van der Veen, MJ; Van Roy, JL; Wilbrink, B, 1991) |
| "A total of 823 patients (620 women and 203 men) aged greater than or equal to 65 years (mean age: 72 years) with osteoarthritis (n = 642) or rheumatoid arthritis (n = 181) were enrolled in an international prospective study designed to assess the safety profile of ketoprofen, a propionic acid derivative, over a 12-month treatment period." | 5.07 | Long-term safety of ketoprofen in an elderly population of arthritic patients. ( Schattenkirchner, M, 1991) |
| "We investigated the influences of ketoprofen on the proteoglycan (PG) turnover of human articular cartilage explants in three groups: normal young with a high basal PG synthesis, normal adult and osteoarthritis cartilage, both with a low basal PG synthesis." | 3.68 | In vitro influence of ketoprofen on the proteoglycan metabolism of human normal and osteoarthritis cartilage. ( Huber, J; Huber-Bruning, O; Van der Veen, MJ; Van Roy, JL; Wilbrink, B, 1991) |
| " No significant differences in CL/F, area under the curve (AUC), half-life (t1/2), time to reach peak concentration (tmax), or maximum peak plasma concentration (Cmax) were found between groups or between doses, and values were similar to those previously reported in young adults." | 2.67 | Ketoprofen pharmacokinetics in the elderly: influence of rheumatic disease, renal function, and dose. ( Jamali, F; Russell, AS; Skeith, KJ, 1993) |
| " Blood samples were collected at standardized times after dosing and assayed for ketoprofen by high-performance reversed-phase liquid chromatography (HPLC)." | 1.31 | Chiral inversion of (R)-ketoprofen: influence of age and differing physiological status in dairy cattle. ( Auza, N; Igarza, L; Soraci, A; Zeballos, H, 2002) |
| "Ketoprofen was administered i." | 1.30 | Pharmacokinetics of ketoprofen in healthy foals less than twenty-four hours old. ( Crisman, MV; Sams, RA; Scarratt, WK; Wilcke, JR, 1998) |
| " Thus, changes in the pharmacokinetic parameters based on total drug concentrations were offset by the increase in the unbound fraction of ketoprofen." | 1.28 | Pharmacokinetics of ketoprofen in rats: effect of age and dose. ( Boudinot, FD; Satterwhite, JH, 1992) |
| " Following oral administration of a 150 mg dose of ketoprofen, no difference in tmax was observed between the two groups." | 1.27 | Pharmacokinetics of ketoprofen in the elderly. ( Advenier, C; Flouvat, B; Gobert, C; Massias, P; Roux, A; Varoquaux, O, 1983) |
| " There were no significant differences between pharmacokinetic indices calculated after single and multiple doses, or between the two groups." | 1.27 | Pharmacokinetics of ketoprofen enantiomers in young and elderly arthritic patients following single and multiple doses. ( Alballa, SR; Foster, RT; Jamali, F; Russell, AS, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Verbeeck, RK | 1 |
| Wallace, SM | 1 |
| Loewen, GR | 1 |
| Advenier, C | 1 |
| Roux, A | 1 |
| Gobert, C | 1 |
| Massias, P | 1 |
| Varoquaux, O | 1 |
| Flouvat, B | 1 |
| Skeith, KJ | 1 |
| Russell, AS | 2 |
| Jamali, F | 2 |
| Wilcke, JR | 1 |
| Crisman, MV | 1 |
| Scarratt, WK | 1 |
| Sams, RA | 1 |
| Ngawhirunpat, T | 1 |
| Yoshikawa, H | 1 |
| Hatanaka, T | 1 |
| Koizumi, T | 1 |
| Adachi, I | 1 |
| Igarza, L | 1 |
| Soraci, A | 1 |
| Auza, N | 1 |
| Zeballos, H | 1 |
| Satterwhite, JH | 1 |
| Boudinot, FD | 1 |
| Schattenkirchner, M | 1 |
| Weiss, Y | 1 |
| Chenard, A | 1 |
| De Kermadec, JM | 1 |
| Tertrain, F | 1 |
| Abiteboul, M | 1 |
| Wilbrink, B | 1 |
| Van der Veen, MJ | 1 |
| Huber, J | 1 |
| Van Roy, JL | 1 |
| Huber-Bruning, O | 1 |
| Foster, RT | 1 |
| Alballa, SR | 1 |
3 trials available for ketoprofen and Aging
| Article | Year |
|---|---|
Ketoprofen pharmacokinetics in the elderly: influence of rheumatic disease, renal function, and dose.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Arthritis, Rheumatoid; Female; Humans; Ketoprofen; Kidn | 1993 |
Long-term safety of ketoprofen in an elderly population of arthritic patients.
Topics: Age Factors; Aged; Aging; Arthritis; Blood Pressure; Delayed-Action Preparations; Female; Gastrointe | 1991 |
Maintenance of blood pressure control in elderly hypertensives on ketoprofen.
Topics: Acebutolol; Aged; Aged, 80 and over; Aging; Atenolol; Blood Pressure; Double-Blind Method; Drug Ther | 1991 |
8 other studies available for ketoprofen and Aging
| Article | Year |
|---|---|
Reduced elimination of ketoprofen in the elderly is not necessarily due to impaired glucuronidation.
Topics: Aged; Aging; Clofibric Acid; Diflunisal; Glucuronates; Humans; Ketoprofen; Phenylpropionates; Proben | 1984 |
Pharmacokinetics of ketoprofen in the elderly.
Topics: Adult; Aged; Aging; Female; Half-Life; Humans; Ketoprofen; Kinetics; Male; Phenylpropionates; Sex Fa | 1983 |
Pharmacokinetics of ketoprofen in healthy foals less than twenty-four hours old.
Topics: Aging; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Chromatograp | 1998 |
Age-related changes in skin permeability of hydrophilic and lipophilic compounds in rats.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry, Physical; De | 2001 |
Chiral inversion of (R)-ketoprofen: influence of age and differing physiological status in dairy cattle.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Dairying; Female; Ketoprofen; Pregn | 2002 |
Pharmacokinetics of ketoprofen in rats: effect of age and dose.
Topics: Aging; Animals; Blood Proteins; Dose-Response Relationship, Drug; Injections, Intravenous; Ketoprofe | 1992 |
In vitro influence of ketoprofen on the proteoglycan metabolism of human normal and osteoarthritis cartilage.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cartilage; Humans; Ketoprofen; Kinetics; Middle Aged; Osteoar | 1991 |
Pharmacokinetics of ketoprofen enantiomers in young and elderly arthritic patients following single and multiple doses.
Topics: Adult; Aged; Aging; Arthritis; Chromatography, High Pressure Liquid; Female; Humans; Ketoprofen; Mal | 1988 |