Page last updated: 2024-10-29

ketoprofen and Ache

ketoprofen has been researched along with Ache in 168 studies

Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
"To compare the efficacy and safety of ketoprofen plasters and diclofenac plasters after 3 weeks of administration in patients with osteoarthritis-related knee pain."9.41Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial. ( Cha, JE; Ershova, O; Hyun, BJ; Kastanayan, A; Krechikova, D; Nikulenkova, N; Polyakova, S; Shvarts, Y; Vinogradova, I; Yakushin, S, 2021)
" The eligible population (n = 200) with confirmed pharyngitis diagnosis on the Tonsillo Pharyngitis Assessment and moderate to severe sore throat was randomly divided into two cohorts to be administered with 50 mg of dexketoprofen (n = 98) or 1000-mg paracetamol (n = 102)."9.41Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat. ( Cimen, U; Cimen, YK; Erdur, B; Oncel, G; Ozen, M; Seyit, M; Turkcuer, I; Yilmaz, A, 2021)
"To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department."9.27Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial ( Eken, C; Karcıoğlu, Ö; Serinken, M, 2018)
"A significant pain reduction was observed following the use of ketoprofen when tested against a control gel (placebo)."9.22The effect of benzocaine and ketoprofen gels on pain during fixed orthodontic appliance treatment: a randomised, double-blind, crossover trial. ( Borzabadi-Farahani, A; Eslamian, L; Gholami, H, 2016)
"Ketoprofen has high analgesic efficacy against inflammatory and nociceptive pain."9.20Intravenous dexketoprofen induces less injection pain than racemic ketoprofen. ( Halinen, L; Kokki, H; Kokki, M; Nokela, A; Sjövall, S; Turunen, M, 2015)
"The results of our study showed that lidocaine puffs provided the best pain relief than the other analgesics used."9.20Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial. ( Acmaz, G; Aksoy, H; Başer, M; Bayraktar, E; Müderris, İİ; Yilmaz, MO, 2015)
"A randomised controlled trial was conducted to investigate efficacy of paracetamol and dexketoprofen trometamol for perineal pain relief after perineal repair."9.19Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear. ( Akil, A; Api, O; Bektas, Y; Unal, O; Yalti, S; Yilmaz, AO, 2014)
") injection of ketoprofen and castration technique on physiological and behavioral indicators of pain in beef calves."9.19Effects of castration method and frequency of intramuscular injections of ketoprofen on behavioral and physiological indicators of pain in beef cattle. ( Caulkett, NA; Fireheller, E; González, LA; Janzen, E; Moya, D; Schwartzkopf-Genswein, KS, 2014)
"To assess the efficacy and safety of 12-week treatment with ketoprofen in ultradeformable phospholipid vesicles in patients with OA knee pain and to compare the efficacy with that of ketoprofen-free vehicle and celecoxib."9.17A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis. ( Bolten, W; Cevc, G; Conaghan, PG; Dickson, J; Rother, M, 2013)
"This randomized, double-blind, phase III study evaluated the efficacy and safety of ketoprofen in an ultradeformable vesicle gel compared with ketoprofen-free gel in osteoarthritis (OA) knee pain."9.17A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel. ( Conaghan, PG; Rother, M, 2013)
"5mg/ml oral suspension, compared to ketoprofen tablets in cats suffering from painful acute locomotor disorders."9.15Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders. ( Grant, D; Johnston, L; Letellier, IM; Morton, CM; Narbe, R, 2011)
"A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care."9.15A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011)
"This study assessed the efficacy and safety of ketoprofen patch compared with placebo in patients who had rheumatoid arthritis and persistent wrist pain."9.14Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study. ( Kawai, S; Kondo, M; Nagaya, I; Nawata, Y; Obata, J; Ohno, S; Oribe, M; Sugimoto, K; Uchida, E, 2010)
"Robenacoxib tablets administered once daily had noninferior efficacy and tolerability, and superior palatability, compared with the active control drug, ketoprofen, for the treatment of signs of acute pain and inflammation associated with musculoskeletal disorders in cats."9.14Evaluation of orally administered robenacoxib versus ketoprofen for treatment of acute pain and inflammation associated with musculoskeletal disorders in cats. ( Alexander, DG; Giraudel, JM; Gruet, P; King, JN; Seewald, W, 2010)
"To evaluate the efficacy and tolerability of ketoprofen patch in the treatment of tendinitis."9.11Topical ketoprofen patch in the treatment of tendinitis: a randomized, double blind, placebo controlled study. ( Guillon, Y; Mazières, B; Reiner, V; Rouanet, S; Scarsi, C, 2005)
"The efficacy and tolerability of aceclofenac, a new non-steroidal anti-inflammatory drug (NSAID) was compared to that of ketoprofen in a multicentre, double-blind, prospective, randomized study of 3-months duration in patients with rheumatoid arthritis."9.08Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis. ( Ansoleaga, JJ; Gijón-Baños, J; Martín-Mola, E, 1995)
"The effectiveness of a balanced analgesia with buprenorphine ketoprofen-propacetamol for pain control during extracorporeal shock wave lithotripsy (ESWL) was evaluated in order to reduce the requirements for general anaesthesia."9.08Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures. ( Bannwarth, B; Delort-Laval, S; Krol-Houdek, MC; Maurette, P; Tauzin-Fin, P, 1998)
"A double-blind, double-dummy, crossover study was carried out in 8 centres to compare the efficacy and tolerability of 'controlled-release' ketoprofen tablets (200 mg) with that of indomethacin suppositories (100 mg) in out-patients with definite or classical rheumatoid arthritis."9.07A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening. ( Leden, I; Rubin, B; Uddenfeldt, P, 1993)
"Fifty-nine patients with acute gouty arthritis entered into a 7-day multicenter, double blind trial of ketoprofen versus indomethacin."9.06Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study. ( Altman, RD; Honig, S; Levin, JM; Lightfoot, RW, 1988)
"Under double-blind, crossover conditions, 43 women with primary dysmenorrhea received ketoprofen, ibuprofen, and placebo during three consecutive menstrual cycles."9.06Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison. ( Mehlisch, DR, 1988)
"The analgesic effects of single oral doses of ketoprofen 100 and 300 mg, the combination of aspirin 650 mg plus codeine 60 mg, and placebo were compared under double-blind conditions in 160 hospitalized patients with cancer pain."9.06A double-blind parallel evaluation of the efficacy and safety of a single dose of ketoprofen in cancer pain. ( Drew, J; Stambaugh, J, 1988)
"Forty women with moderate to severe primary dysmenorrhea participated in a two-month, double-blind, crossover trial comparing ketoprofen with mefenamic acid."9.06Double-blind comparison of ketoprofen and mefenamic acid in the treatment of primary dysmenorrhea. ( Bourgouin, J; Hébert, JG; Le Morvan, P, 1986)
"Thirty-six patients suffering from severe pain due to bone involvement from cancer participated in an analgesic study that compared single doses of ketoprofen 100 or 400 mg iv or injectable acetylsalicylic acid 1 g."9.05Injectable ketoprofen vs. acetylsalicylic acid for the relief of severe cancer pain: a double-blind, crossover trial. ( Bruni, G; Camera, P; Martoni, A; Pannuti, F; Rossi, AP; Sacchetti, G, 1984)
"Fourteen patients with acute lumbar pain and cervico-brachial radicular pain were treated with a single oral dose of 100 mg ketoprofen."9.05Correlation between ketoprofen plasma levels and analgesic effect in acute lumbar pain and radicular pain. ( Köhler, G; Morand, J; Primbs, P; Rübelt, C, 1985)
"In a double-blind trial 40 patients with ostheoarthritis were treated for relief of pain with ketoprofen or with the N-methyl-d-glucamine salt of indomethacin, both drugs being administered i."9.04Parenteral administration of ketoprofen in osteoarthritis: a double-blind trial versus the N-methyl-d-glucamine salt of indomethacin. ( Franchi, R; Liverta, C; Pollini, C; Pontiroli, AE, 1979)
"In a double-blind study of ketoprofen versus placebo in the treatment of osteoarthritis of the hip, it was shown by a sequential technique, that ketoprofen was significantly better than placebo."9.04A double-blind trial of ketoprofen in the treatment of osteoarthritis of the hip. ( Colinet, E; Famaey, JP, 1976)
"Dexketoprofen, an NSAID used in the management of acute and chronic pains, is licensed in several countries but has not previously been the subjected of a systematic review."8.84Systematic review of dexketoprofen in acute and chronic pain. ( Barden, J; Moore, RA, 2008)
" Supplementation with Casperome® 250 mg/day showed beneficial effects in the reduction of signs and symptoms of ankle sprains evaluated at day 3 and day 7, and was shown to induce measurable plasma level of boswellic acids."7.85Effectiveness of a novel boswellic acids delivery form (Casperome®) in the management of grade II ankle sprains due to sport trauma - a registry study. ( Abdel-Tawab, M; Belcaro, G; Cacchio, M; Cesarone, MR; Dugall, M; Eggenhoffner, R; Feragalli, B; Giacomelli, L; Ippolito, E; Riva, A; Togni, S, 2017)
" By the fourth week, pain was well controlled (NRS 0 to 2) in 80% of patients receiving ketoprofen compared with 46% of patients without ketoprofen (P<0."7.76Long-term continuous subcutaneous infusion of ketoprofen combined with morphine: a safe and effective approach to cancer pain. ( Cruto, M; Debernardi, F; Massucco, P; Moselli, NM; Savojardo, M, 2010)
"Ketoprofen was recently approved for use as an analgesic for treatment of mild to moderate pain in total daily doses up to 300 mg; the recommended initial dose is 25 to 50 mg every 6 to 8 hours as necessary."7.76Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain. ( Olson, NZ; Sunshine, A, 1988)
" The safety profile of oral dexketoprofen trometamol for the treatment of acute mild to moderate pain of different causes in actual conditions of use in the primary care setting was assessed."7.75Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care. ( Carne, X; Rios, J; Torres, F, 2009)
"The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain)."7.74Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. ( Dursteler, C; Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2007)
"We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain."7.70Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998)
"Patients with renal lithiasis were included and were randomized to Group A (basal analgesia: midazolam (1 mg), fentanyl (0."7.11Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL). ( Alcoba-García, MP; Bueno-Serrano, G; González-Enguita, C; González-López, R; Llanos-Jiménez, L; Mahillo-Fernández, I; Tabares-Jiménez, J, 2022)
"To determine the efficacy and bioavailability of non-steroidal anti-inflammatory drugs (NSAIDs) when administered orally to sheep."6.80Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. ( Colditz, IG; Hinch, G; Lee, C; Marini, D; Petherick, JC; Pippia, J, 2015)
"The risk of oral NSAID including Cox-2 inhibitors to cause gastrointestinal, renal or cardiovascular adverse events related to systemic drug exposure could be reduced by local application."6.74A multiple-dose, open-label, safety, compliance, and usage evaluation study of epicutaneously applied Diractin (ketoprofen in Transfersome) in joint/musculoskeletal pain or soft tissue inflammation. ( Kneer, W; Rother, I; Rother, M; Seidel, E, 2009)
"ketorolac (10mg q."6.71Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003)
"Oral ketoprofen (50 mg) was less effective and reduced the pain intensity by 45% (P<0."6.70Analgesic profile of peroral and topical ketoprofen upon low pH-induced muscle pain. ( Meller, ST; Steen, KH; Wegner, H, 2001)
"A double-blind randomized parallel-group trial was undertaken to evaluate the influence of the dosing time of sustained-release ketoprofen (SRK) on its acceptability and efficacy."6.67Dosing time optimizes sustained-release ketoprofen treatment of osteoarthritis. ( Buchmuller, A; Decousus, H; Hocquart, J; Mismetti, P; Perpoint, B; Queneau, P; Rambaud, C; Simitsidis, S, 1994)
"Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity."6.40Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997)
" This results in an increase in the rate of absorption of the active compound and, consequently, in an earlier onset of analgesic action."6.38Piroxicam-beta-cyclodextrin in the treatment of acute pain of rheumatic disease. ( Franchimont, P; Reginster, JY, 1993)
"There is a strong correlation between treatment resistant depression and increase in inflammatory cytokines in plasma and cerebrospinal fluid."5.48Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain. ( Abagyan, R; Cohen, IV; Lee, KC; Makunts, T, 2018)
"Acute and chronic pain have an important socio-economical impact."5.46A "novel" association to treat pain: tramadol/dexketoprofen. The first drug of a "new pharmacological class". ( Allegri, M; Fanelli, G; Fornasari, D; Gerboni, S, 2017)
"To compare the efficacy and safety of ketoprofen plasters and diclofenac plasters after 3 weeks of administration in patients with osteoarthritis-related knee pain."5.41Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial. ( Cha, JE; Ershova, O; Hyun, BJ; Kastanayan, A; Krechikova, D; Nikulenkova, N; Polyakova, S; Shvarts, Y; Vinogradova, I; Yakushin, S, 2021)
" The eligible population (n = 200) with confirmed pharyngitis diagnosis on the Tonsillo Pharyngitis Assessment and moderate to severe sore throat was randomly divided into two cohorts to be administered with 50 mg of dexketoprofen (n = 98) or 1000-mg paracetamol (n = 102)."5.41Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat. ( Cimen, U; Cimen, YK; Erdur, B; Oncel, G; Ozen, M; Seyit, M; Turkcuer, I; Yilmaz, A, 2021)
" Dose-response curves for DEX and TRM, individually and combined in a 1 : 1 proportion based on their potency were obtained, and the doses that produced a 50% inhibition calculated."5.38Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice. ( Miranda, HF; Puig, MM; Romero, MA, 2012)
"Ankle sprains mainly caused by accidents or strenuous sport activities can often be quite painful and impair motility."5.35Management of uncomplicated ankle sprains with topical or oral ketoprofen treatment. A registry study. ( Belcaro, G; Cacchio, M; Cesarone, MR; Di Renzo, A; Dugall, M; Errichi, BM; Errichi, S; Fano, F; Gizzi, G; Grossi, MG; Ippolito, E; Ricci, A; Ruffini, I; Stuard, S; Vinciguerra, G, 2008)
"Analgesics are required to prevent and treat postpartum pain, but breast-feeding may be contraindicated, because data on milk transfer are very limited."5.34Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. ( Boissinot, C; Jacqz-Aigrain, E; Michel, J; Popon, M; Serreau, R; Sibony, O; Sobel, A, 2007)
" These data suggest that ketoprofen at the dosage rate of 1."5.29Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse. ( Kamerling, SG; Keowen, ML; Owens, JG; Stanton, SR, 1995)
"Ketoprofen was found to be significantly effective in all cases of non calcific rotator cuff tendinitis while no improvement was noted in calcific tendinitis."5.28[Ketoprofen efficacy and tolerance in simple painful shoulder]. ( Amanda Dal Pra, ML; Battisti, E; Cataldi, V; Cecconami, L; Franci, A; Gelli, R; Giordano, N; Marcolongo, R; Marcucci, P; Stuart, R, 1992)
"To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department."5.27Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial ( Eken, C; Karcıoğlu, Ö; Serinken, M, 2018)
"A significant pain reduction was observed following the use of ketoprofen when tested against a control gel (placebo)."5.22The effect of benzocaine and ketoprofen gels on pain during fixed orthodontic appliance treatment: a randomised, double-blind, crossover trial. ( Borzabadi-Farahani, A; Eslamian, L; Gholami, H, 2016)
"Ketoprofen has high analgesic efficacy against inflammatory and nociceptive pain."5.20Intravenous dexketoprofen induces less injection pain than racemic ketoprofen. ( Halinen, L; Kokki, H; Kokki, M; Nokela, A; Sjövall, S; Turunen, M, 2015)
"The results of our study showed that lidocaine puffs provided the best pain relief than the other analgesics used."5.20Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial. ( Acmaz, G; Aksoy, H; Başer, M; Bayraktar, E; Müderris, İİ; Yilmaz, MO, 2015)
"Rocuronium is a non-depolarizing neuromuscular blocking agent which is associated with injection pain and induces withdrawal movement of the injected hand or arm or generalized movements of the body after intravenous injection."5.19Comparison of randomized preemptive dexketoprofen trometamol or placebo tablets to prevent withdrawal movement caused by rocuronium injection. ( Aydın, GB; Caparlar, CO; Ergil, J; Polat, R; Sayın, M, 2014)
"A randomised controlled trial was conducted to investigate efficacy of paracetamol and dexketoprofen trometamol for perineal pain relief after perineal repair."5.19Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear. ( Akil, A; Api, O; Bektas, Y; Unal, O; Yalti, S; Yilmaz, AO, 2014)
") injection of ketoprofen and castration technique on physiological and behavioral indicators of pain in beef calves."5.19Effects of castration method and frequency of intramuscular injections of ketoprofen on behavioral and physiological indicators of pain in beef cattle. ( Caulkett, NA; Fireheller, E; González, LA; Janzen, E; Moya, D; Schwartzkopf-Genswein, KS, 2014)
"To assess the efficacy and safety of 12-week treatment with ketoprofen in ultradeformable phospholipid vesicles in patients with OA knee pain and to compare the efficacy with that of ketoprofen-free vehicle and celecoxib."5.17A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis. ( Bolten, W; Cevc, G; Conaghan, PG; Dickson, J; Rother, M, 2013)
"This randomized, double-blind, phase III study evaluated the efficacy and safety of ketoprofen in an ultradeformable vesicle gel compared with ketoprofen-free gel in osteoarthritis (OA) knee pain."5.17A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel. ( Conaghan, PG; Rother, M, 2013)
"5mg/ml oral suspension, compared to ketoprofen tablets in cats suffering from painful acute locomotor disorders."5.15Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders. ( Grant, D; Johnston, L; Letellier, IM; Morton, CM; Narbe, R, 2011)
"A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care."5.15A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011)
"This study assessed the efficacy and safety of ketoprofen patch compared with placebo in patients who had rheumatoid arthritis and persistent wrist pain."5.14Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study. ( Kawai, S; Kondo, M; Nagaya, I; Nawata, Y; Obata, J; Ohno, S; Oribe, M; Sugimoto, K; Uchida, E, 2010)
"The severity of SWL-related pain was significantly better tolerated with dexketoprofen trometamol."5.14Comparison of the analgesic effects of dexketoprofen and diclofenac during shockwave lithotripsy: a randomized, double-blind clinical trial. ( Akduman, B; Erol, B; Hanci, V; Mungan, A; Tokgoz, H; Turksoy, O; Yurtlu, S, 2010)
"No statistically significant difference was found among the mean pain scores of women during the procedure in the dexketoprofen and saline, placebo and lidocaine, and dexketoprofen and lidocaine groups."5.14Comparison of oral nonsteroidal analgesic and intrauterine local anesthetic for pain relief in uterine fractional curettage: a randomized, double-blind, placebo-controlled trial. ( Api, M; Api, O; Emeksiz, MB; Ergen, B; Ugurel, V; Unal, O, 2010)
"Robenacoxib tablets administered once daily had noninferior efficacy and tolerability, and superior palatability, compared with the active control drug, ketoprofen, for the treatment of signs of acute pain and inflammation associated with musculoskeletal disorders in cats."5.14Evaluation of orally administered robenacoxib versus ketoprofen for treatment of acute pain and inflammation associated with musculoskeletal disorders in cats. ( Alexander, DG; Giraudel, JM; Gruet, P; King, JN; Seewald, W, 2010)
"To compare the ketoprofen TDS patch with diclofenac gel in the treatment of traumatic acute pain in benign sport-related soft-tissue injuries."5.12Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries. ( Cobián, C; Esparza, F; García-Cota, JJ; Jiménez, JF; Maestro, A; Sánchez, C, 2007)
"The optimum doses of carprofen, flunixin, ketoprofen and sodium salicylate for the treatment of inflammatory pain were determined in domestic fowl using the microcrystalline sodium urate model of articular pain."5.11Effects of non-steroidal anti-inflammatory drugs on pain-related behaviour in a model of articular pain in the domestic fowl. ( Gentle, MJ; Hocking, PM; Robertson, GW, 2005)
"After 1 week of treatment, the decrease in spontaneous pain was -50+/-20 mm for ketoprofen and -38+/-24 mm for the placebo, showing a statistically significant intergroup difference (P=."5.11Topical ketoprofen patch (100 mg) for the treatment of ankle sprain: a randomized, double-blind, placebo-controlled study. ( Mazières, B; Reiner, V; Rouanet, S; Scarsi, C; Velicy, J, 2005)
"To evaluate the efficacy and tolerability of ketoprofen patch in the treatment of tendinitis."5.11Topical ketoprofen patch in the treatment of tendinitis: a randomized, double blind, placebo controlled study. ( Guillon, Y; Mazières, B; Reiner, V; Rouanet, S; Scarsi, C, 2005)
"Patients who fitted the study criteria were given either 25 mg oral dexketoprofen trometamol or 50 mg sodium diclofenac immediately after triage; baseline and 15 minute pain scores were then recorded for one hour."5.10Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury. ( Herington, J; Kapadia, Y; Leman, P, 2003)
"The efficacy and tolerability of aceclofenac, a new non-steroidal anti-inflammatory drug (NSAID) was compared to that of ketoprofen in a multicentre, double-blind, prospective, randomized study of 3-months duration in patients with rheumatoid arthritis."5.08Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis. ( Ansoleaga, JJ; Gijón-Baños, J; Martín-Mola, E, 1995)
"The clinical efficacy of the two topical analgesics, ketoprofen hydroalcoholic gel (Fastum gel) and diclofenac emulgel, for osteoarthritis of the knee was studied."5.08Topical analgesics for knee arthrosis: a parallel study of ketoprofen gel and diclofenac emulgel. ( Boonsanong, W; Penkitti, P; Soparat, K; Waikakul, S, 1997)
"The effectiveness of a balanced analgesia with buprenorphine ketoprofen-propacetamol for pain control during extracorporeal shock wave lithotripsy (ESWL) was evaluated in order to reduce the requirements for general anaesthesia."5.08Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures. ( Bannwarth, B; Delort-Laval, S; Krol-Houdek, MC; Maurette, P; Tauzin-Fin, P, 1998)
"A double-blind, double-dummy, crossover study was carried out in 8 centres to compare the efficacy and tolerability of 'controlled-release' ketoprofen tablets (200 mg) with that of indomethacin suppositories (100 mg) in out-patients with definite or classical rheumatoid arthritis."5.07A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening. ( Leden, I; Rubin, B; Uddenfeldt, P, 1993)
"Three groups of 20 patients, who suffered of acute pain (dental or low back or menorrhalgia) have been randomized and treated, obtained their informed consent, with meclofenamic acid 100 mg or ketoprofene 50 mg by oral route."5.07[Analgesic effect of sodium meclofenamate on several painful symptoms]. ( Castellari, A, 1993)
"Fifty-nine patients with acute gouty arthritis entered into a 7-day multicenter, double blind trial of ketoprofen versus indomethacin."5.06Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study. ( Altman, RD; Honig, S; Levin, JM; Lightfoot, RW, 1988)
"Under double-blind, crossover conditions, 43 women with primary dysmenorrhea received ketoprofen, ibuprofen, and placebo during three consecutive menstrual cycles."5.06Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison. ( Mehlisch, DR, 1988)
"The analgesic effects of single oral doses of ketoprofen 100 and 300 mg, the combination of aspirin 650 mg plus codeine 60 mg, and placebo were compared under double-blind conditions in 160 hospitalized patients with cancer pain."5.06A double-blind parallel evaluation of the efficacy and safety of a single dose of ketoprofen in cancer pain. ( Drew, J; Stambaugh, J, 1988)
"Forty women with moderate to severe primary dysmenorrhea participated in a two-month, double-blind, crossover trial comparing ketoprofen with mefenamic acid."5.06Double-blind comparison of ketoprofen and mefenamic acid in the treatment of primary dysmenorrhea. ( Bourgouin, J; Hébert, JG; Le Morvan, P, 1986)
" Effectiveness of the two forms of ketoprofen on morning stiffness and pain scale was found to be comparable."5.05[Double-blind comparative study of Bi-Profenid tablets and Profenid capsules in inflammatory rheumatism]. ( Ayrolles, C; Camus, JP; Fournie, A; Koeger, AC; Prier, A, 1983)
"Thirty-six patients suffering from severe pain due to bone involvement from cancer participated in an analgesic study that compared single doses of ketoprofen 100 or 400 mg iv or injectable acetylsalicylic acid 1 g."5.05Injectable ketoprofen vs. acetylsalicylic acid for the relief of severe cancer pain: a double-blind, crossover trial. ( Bruni, G; Camera, P; Martoni, A; Pannuti, F; Rossi, AP; Sacchetti, G, 1984)
"Fourteen patients with acute lumbar pain and cervico-brachial radicular pain were treated with a single oral dose of 100 mg ketoprofen."5.05Correlation between ketoprofen plasma levels and analgesic effect in acute lumbar pain and radicular pain. ( Köhler, G; Morand, J; Primbs, P; Rübelt, C, 1985)
"In a double-blind trial 40 patients with ostheoarthritis were treated for relief of pain with ketoprofen or with the N-methyl-d-glucamine salt of indomethacin, both drugs being administered i."5.04Parenteral administration of ketoprofen in osteoarthritis: a double-blind trial versus the N-methyl-d-glucamine salt of indomethacin. ( Franchi, R; Liverta, C; Pollini, C; Pontiroli, AE, 1979)
"Ninety patients with rheumatoid arthritis completed a double-blind crossover trial comparing fenoprofen, ibuprofen, ketoprofen, and naproxen."5.04Four new anti-inflammatory drugs: responses and variations. ( Balme, HW; Franklin, S; Huskisson, EC; Scott, J; Woolf, DL, 1976)
"In a double-blind study of ketoprofen versus placebo in the treatment of osteoarthritis of the hip, it was shown by a sequential technique, that ketoprofen was significantly better than placebo."5.04A double-blind trial of ketoprofen in the treatment of osteoarthritis of the hip. ( Colinet, E; Famaey, JP, 1976)
" Data from randomized, phase III studies in OA knee pain in which TDT 064 was used as the drug-free vehicle control for IDEA-033 (ketoprofen in ultra-deformable phospholipid vesicles) demonstrate a marked and consistent response to TDT 064 in terms of pain, stiffness, and function."4.90Drug-free gel containing ultra-deformable phospholipid vesicles (TDT 064) as topical therapy for the treatment of pain associated with osteoarthritis: a review of clinical efficacy and safety. ( Bijlsma, JW; Conaghan, PG; Kneer, W; Kvien, TK; Rother, M; Wise, E, 2014)
"Dexketoprofen, an NSAID used in the management of acute and chronic pains, is licensed in several countries but has not previously been the subjected of a systematic review."4.84Systematic review of dexketoprofen in acute and chronic pain. ( Barden, J; Moore, RA, 2008)
" Supplementation with Casperome® 250 mg/day showed beneficial effects in the reduction of signs and symptoms of ankle sprains evaluated at day 3 and day 7, and was shown to induce measurable plasma level of boswellic acids."3.85Effectiveness of a novel boswellic acids delivery form (Casperome®) in the management of grade II ankle sprains due to sport trauma - a registry study. ( Abdel-Tawab, M; Belcaro, G; Cacchio, M; Cesarone, MR; Dugall, M; Eggenhoffner, R; Feragalli, B; Giacomelli, L; Ippolito, E; Riva, A; Togni, S, 2017)
"The combination of pomegranate seed oil and ketoprofen in nanoemulsions aiming to improve the antinociceptive effect was evaluated according to the writhing test and Complete Freud's Adjuvant induced paw inflammation in mice."3.83Pomegranate seed oil nanoemulsions improve the photostability and in vivo antinociceptive effect of a non-steroidal anti-inflammatory drug. ( Barbieri, AV; Beck, RCR; Cervi, VF; Cruz, L; Ferreira, LM; Gehrcke, M; Nogueira, CW; Sari, MHM; Zborowski, VA, 2016)
"The median pain reduction in ketoprofen and placebo groups at 15 minutes was 27 (19."3.83Topical Ketoprofen Versus Placebo in Treatment of Acute Ankle Sprain in the Emergency Department. ( Eken, C; Elicabuk, H; Serinken, M, 2016)
" The present study used assays of pain-related stimulation and depression of behavior in rats to compare effects of 1) two peripherally restricted κ agonists [the tetrapeptide D-Phe-D-Phe-D-Ile-D-Arg-NH(2) (ffir) and the nonpeptidic compound ((R,S)-N-[2-(N-methyl-3,4-dichlorophenylacetamido)-2-(3-carboxyphenyl)-ethyl]pyrrolidine hydrochloride (ICI204448)], 2) a centrally penetrating κ agonist (salvinorin A), and 3) several reference drugs, including a nonsteroidal anti-inflammatory drug (NSAID; ketoprofen)."3.78Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats. ( Cheng, K; Morrissey, E; Negus, SS; O'Connell, R; Rice, KC, 2012)
"Topical ketoprofen patches are widely used in the treatment of musculoskeletal pain, but the pharmacokinetics of ketoprofen following topical application remain unclear."3.76Ketoprofen absorption by muscle and tendon after topical or oral administration in patients undergoing anterior cruciate ligament reconstruction. ( Hara, K; Ju, YJ; Mochizuki, T; Morito, T; Muneta, T; Sekiya, I; Tsuji, K; Yagishita, K; Yamazaki, J, 2010)
" By the fourth week, pain was well controlled (NRS 0 to 2) in 80% of patients receiving ketoprofen compared with 46% of patients without ketoprofen (P<0."3.76Long-term continuous subcutaneous infusion of ketoprofen combined with morphine: a safe and effective approach to cancer pain. ( Cruto, M; Debernardi, F; Massucco, P; Moselli, NM; Savojardo, M, 2010)
" The animal was administered multiple nonsteroidal anti-inflammatory drugs (NSAIDs), including meloxicam, flunixin meglumine, and ketoprofen for pain management."3.76Nonsteroidal anti-inflammatory drug-associated renal papillary necrosis in a white-tailed deer (Odocoileus virginianus). ( Genova, SG; Hall, B; Ketz-Riley, CJ; Ritchey, JW; Stern, AW, 2010)
"Ketoprofen is a potent non-steroidal anti-inflammatory drug has been used in the treatment of various kinds of pains, inflammation and arthritis."3.76Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion. ( Azmin, MN; Elrashid, SM; Munavvar, AS; Sakeena, MH; Yam, MF, 2010)
"Ketoprofen was recently approved for use as an analgesic for treatment of mild to moderate pain in total daily doses up to 300 mg; the recommended initial dose is 25 to 50 mg every 6 to 8 hours as necessary."3.76Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain. ( Olson, NZ; Sunshine, A, 1988)
"The antinociceptive activity of dexketoprofen was studied in mice using the formalin assay for orofacial pain."3.75The effect of opioid antagonists on synergism between dexketoprofen and tramadol. ( Gonzalez, C; Miranda, HF; Pinardi, G; Zegpi, C, 2009)
" The safety profile of oral dexketoprofen trometamol for the treatment of acute mild to moderate pain of different causes in actual conditions of use in the primary care setting was assessed."3.75Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care. ( Carne, X; Rios, J; Torres, F, 2009)
" The size of the udder, the signs of pain and the concentrations of thromboxane B2, especially in plasma, were also reduced, and the appearance of their milk was almost normal."3.74Efficacy of oral and parenteral ketoprofen in lactating cows with endotoxin-induced acute mastitis. ( Banting, A; Banting, S; Heinonen, K; Mustonen, K, 2008)
"The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain)."3.74Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. ( Dursteler, C; Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2007)
"Pain threshold increased after treatment, and was significantly increased in the loxoprofen-Na group compared with the control group (p < 0."3.74Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model. ( Kikuchi, S; Konno, S; Sekiguchi, M; Shirasaka, M, 2008)
"The aim of this study was to validate a model of postfracture pain in mice, which was evaluated in the presence and the absence of morphine and ketoprofen."3.74Mouse model of fracture pain. ( Fourcade, O; Girolami, JP; Laffosse, JM; Minville, V; Tack, I, 2008)
" Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously)."3.74Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008)
" Physical therapy intervention consisted of 6 visits over a 3-week period with traditional interventions (including rest, discontinuation of activities that aggravate the condition, hot and cold packs, heel lifts, calf stretching, and strengthening) and the addition of ketoprofen gel to reduce local inflammation and relieve pain."3.73Ketoprofen gel as an adjunct to physical therapist management of a child with Sever disease. ( White, RL, 2006)
"Despite ketoprofen infusion and free access to a patient-controlled pump with fentanyl citrate for rescue analgesia, inadequate pain relief was common both after uvulopalatoplasty (35%) and after tonsillectomy (28%) during the first 24 hours after surgery."3.72Pain intensity after laseruvulopalatoplasty and tonsillectomy. ( Aho, M; Kokki, H; Nikanne, E; Virtaniemi, J, 2003)
"We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain."3.70Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998)
" Both etodolac and bromelain inhibited the inflammatory pain in concanavalin A-treated paws of rats in a dose-dependent manner, but indomethacin did not."3.69Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation. ( Dainaka, J; Hashii, H; Inoue, K; Kimura, K; Motonaga, A; Nishimura, T; Ueda, F; Yamate, K, 1994)
"Evidence for the effectiveness of ketoprofen in animal models of inflammation and its antipyretic effect is reviewed."3.65Some pharmacological and toxicological studies on ketoprofen. ( Ducrot, R; Guyonnet, JC; Julou, L; Pasquet, J, 1976)
"Patients with renal lithiasis were included and were randomized to Group A (basal analgesia: midazolam (1 mg), fentanyl (0."3.11Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL). ( Alcoba-García, MP; Bueno-Serrano, G; González-Enguita, C; González-López, R; Llanos-Jiménez, L; Mahillo-Fernández, I; Tabares-Jiménez, J, 2022)
"Pain has a negative impact on life satisfaction (LS)."2.87Life satisfaction and pain interference in spine surgery patients before and after surgery: comparison between on-opioid and opioid-naïve patients. ( Kokki, H; Kokki, M; Kuronen, M; Nyyssönen, T; Savolainen, S, 2018)
" Adverse drug reactions may be renal, gastrointestinal, hematological, or immunologic."2.82Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years. ( Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC, 2022)
"Pain was assessed by a visual analogue scale (VAS) during and after the HSG procedure."2.80Factors influencing the severity of pain during hysterosalpingography. ( Grzechocińska, B; Kaczyński, B; Marianowski, P; Szymusik, I; Wielgoś, M, 2015)
"To determine the efficacy and bioavailability of non-steroidal anti-inflammatory drugs (NSAIDs) when administered orally to sheep."2.80Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. ( Colditz, IG; Hinch, G; Lee, C; Marini, D; Petherick, JC; Pippia, J, 2015)
"Oral ketoprofen was well tolerated and no adverse events were observed."2.76Oral ketoprofen is effective in the treatment of non-infectious lameness in sows. ( Ala-Kurikka, E; Heinonen, M; Mustonen, K; Orro, T; Peltoniemi, O; Raekallio, M; Vainio, O, 2011)
"The risk of oral NSAID including Cox-2 inhibitors to cause gastrointestinal, renal or cardiovascular adverse events related to systemic drug exposure could be reduced by local application."2.74A multiple-dose, open-label, safety, compliance, and usage evaluation study of epicutaneously applied Diractin (ketoprofen in Transfersome) in joint/musculoskeletal pain or soft tissue inflammation. ( Kneer, W; Rother, I; Rother, M; Seidel, E, 2009)
"ketoprofen was prevented by i."2.72Involvement of opioidergic and alpha2-adrenergic mechanisms in the central analgesic effects of non-steroidal anti-inflammatory drugs in sheep. ( Chambers, JP; Lizarraga, I, 2006)
"ketorolac (10mg q."2.71Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003)
"Ketoprofen treatment after muscle damaging exercise reduces muscle soreness and improves force recovery."2.70Effect of ketoprofen on muscle function and sEMG activity after eccentric exercise. ( Clarkson, PM; Kamen, G; Knight, CA; Sayers, SP; Van Wegen, EH, 2001)
"Oral ketoprofen (50 mg) was less effective and reduced the pain intensity by 45% (P<0."2.70Analgesic profile of peroral and topical ketoprofen upon low pH-induced muscle pain. ( Meller, ST; Steen, KH; Wegner, H, 2001)
"A double-blind randomized parallel-group trial was undertaken to evaluate the influence of the dosing time of sustained-release ketoprofen (SRK) on its acceptability and efficacy."2.67Dosing time optimizes sustained-release ketoprofen treatment of osteoarthritis. ( Buchmuller, A; Decousus, H; Hocquart, J; Mismetti, P; Perpoint, B; Queneau, P; Rambaud, C; Simitsidis, S, 1994)
"Diclofenac was preferred to naproxen, aspirin and indomethacin, while piroxicam and placebo were preferred only to aspirin."2.66Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment. ( Bassi, GP; Borghi, C; Camarri, E; Cocco, F; Francucci, BM; Giannini, R; Giordano, N; Marcolongo, R; Mordini, M; Neri, D, 1985)
"Osteoarthritis is a good indication for these medications whose effectiveness is well documented."2.65[Comparative double-blind study of ketoprofen slow-release tablets and indomethacin in coxarthrosis and gonarthrosis]. ( Gougeon, J, 1983)
" Pharmacokinetic data indicate that although plasma levels of ketoprofen are higher when the drug is administered as a patch versus a gel, the total systemic bioavailability of ketoprofen 100 mg administered via a patch is no more than 10% of that reported for ketoprofen 100 mg administered orally."2.43Topical ketoprofen patch. ( Mazières, B, 2005)
"Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity."2.40Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997)
"Dexketoprofen trometamol is a water-soluble salt of the dextrorotatory enantiomer of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen."2.39Preclinical and clinical development of dexketoprofen. ( Artigas, R; Carganico, G; García, ML; Mauleón, D, 1996)
" This results in an increase in the rate of absorption of the active compound and, consequently, in an earlier onset of analgesic action."2.38Piroxicam-beta-cyclodextrin in the treatment of acute pain of rheumatic disease. ( Franchimont, P; Reginster, JY, 1993)
"Ketoprofen is clinically used to treat osteoporotic pain, while long-term oral administration of ketoprofen can cause some side effects."1.62An Mg-MOFs based multifunctional medicine for the treatment of osteoporotic pain. ( Ge, Y; Li, H; Lin, Y; Lin, Z; Tang, B; Tian, Y; Wang, K; Wang, Y; Wu, Y; Zhang, J, 2021)
"Mechanical allodynia, heat hyperalgesia, biased weight-bearing, and hindpaw thickness were assessed 0."1.62Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats. ( Britch, SC; Craft, RM; Hewitt, KA, 2021)
"Pain is a significant public health problem, and assessment of pain-related impairment of behavior is a key clinical indicator and treatment target."1.51Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice. ( Alexander, KS; Miller, LL; Patton, TB; Rodriguez, TR; Sarfo, AN, 2019)
"There is a strong correlation between treatment resistant depression and increase in inflammatory cytokines in plasma and cerebrospinal fluid."1.48Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain. ( Abagyan, R; Cohen, IV; Lee, KC; Makunts, T, 2018)
"Acute and chronic pain have an important socio-economical impact."1.46A "novel" association to treat pain: tramadol/dexketoprofen. The first drug of a "new pharmacological class". ( Allegri, M; Fanelli, G; Fornasari, D; Gerboni, S, 2017)
"With a suspected diagnosis of dystonia, biperiden lactate 5 mg/ml was administered via the intramuscular route and the contractions abated within 30 seconds of the injection."1.42Acute dystonic reaction due to dexketoprofen trometamol. ( Giray, TA; Kavalci, C; Kayipmaz, AE; Kocalar, UG; Tasci, SS, 2015)
"Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treatment."1.40Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids. ( Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC, 2014)
" Dose-response curves for DEX and TRM, individually and combined in a 1 : 1 proportion based on their potency were obtained, and the doses that produced a 50% inhibition calculated."1.38Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice. ( Miranda, HF; Puig, MM; Romero, MA, 2012)
"We evaluated the modulatory role of the groundwater contaminant arsenic on the pharmacodynamic responses of the nonsteroidal analgesic-antipyretic drug ketoprofen and the major pro-inflammatory mediators linked to the mechanism of ketoprofen's therapeutic effects."1.38Subacute arsenic exposure through drinking water reduces the pharmacodynamic effects of ketoprofen in male rats. ( Ahmad, W; Chanderashekara, HH; Prawez, S; Sankar, P; Sarkar, SN; Tandan, SK, 2012)
"Ketoprofen treatment significantly reduced the rectal temperature and total clinical scores, and lowered blood thromboxane B(2) concentrations when compared with the control group."1.38Dose-response investigation of oral ketoprofen in pigs challenged with Escherichia coli endotoxin. ( Banting, A; Heinonen, M; Mustonen, K; Peltoniemi, OA; Raekallio, M; Vainio, O, 2012)
"Ankle sprains mainly caused by accidents or strenuous sport activities can often be quite painful and impair motility."1.35Management of uncomplicated ankle sprains with topical or oral ketoprofen treatment. A registry study. ( Belcaro, G; Cacchio, M; Cesarone, MR; Di Renzo, A; Dugall, M; Errichi, BM; Errichi, S; Fano, F; Gizzi, G; Grossi, MG; Ippolito, E; Ricci, A; Ruffini, I; Stuard, S; Vinciguerra, G, 2008)
"Analgesics are required to prevent and treat postpartum pain, but breast-feeding may be contraindicated, because data on milk transfer are very limited."1.34Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. ( Boissinot, C; Jacqz-Aigrain, E; Michel, J; Popon, M; Serreau, R; Sibony, O; Sobel, A, 2007)
"Muscle hyperalgesia (post-operative decrease in threshold with respect to pre-stone implantation) was significantly reduced in extent and duration in ketoprofen with respect to saline-injected animals but no difference was found between the pre- and post-operative treatment."1.31Pre-emptive analgesia in rats with artificial ureteric calculosis. Effects on visceral pain behavior in the post-operative period. ( Affaitati, G; Giamberardino, MA; Lerza, R; Vecchiet, L, 2000)
" These data suggest that ketoprofen at the dosage rate of 1."1.29Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse. ( Kamerling, SG; Keowen, ML; Owens, JG; Stanton, SR, 1995)
"Ketoprofen was found to be significantly effective in all cases of non calcific rotator cuff tendinitis while no improvement was noted in calcific tendinitis."1.28[Ketoprofen efficacy and tolerance in simple painful shoulder]. ( Amanda Dal Pra, ML; Battisti, E; Cataldi, V; Cecconami, L; Franci, A; Gelli, R; Giordano, N; Marcolongo, R; Marcucci, P; Stuart, R, 1992)
" In 6 patients the "therapeutic follow-up test" allowed to decrease dosage to one tablet a day."1.27[Long-term study of 150 mg. Bi-Profenid in patients followed at the Department of Rheumatology of Cochin Hospital]. ( Amor, B; Dougados, M; Harrewyn, JM, 1983)
" The mean (+/- SD) values of clinical parameters were as follows: distribution half-life = 0."1.27Clinical pharmacokinetics of ketoprofen after single intravenous administration as a bolus or infusion. ( Albessard, F; Debruyne, D; Hurault de Ligny, B; Moulin, M; Ryckelynck, JP, 1987)

Research

Studies (168)

TimeframeStudies, this research(%)All Research%
pre-199035 (20.83)18.7374
1990's25 (14.88)18.2507
2000's41 (24.40)29.6817
2010's54 (32.14)24.3611
2020's13 (7.74)2.80

Authors

AuthorsStudies
Bonacorso, HG1
Rosa, WC1
Oliveira, SM1
Brusco, I1
Brum, ES1
Rodrigues, MB1
Frizzo, CP1
Zanatta, N1
Chłoń-Rzepa, G1
Ślusarczyk, M1
Jankowska, A1
Gawalska, A1
Bucki, A1
Kołaczkowski, M1
Świerczek, A1
Pociecha, K1
Wyska, E1
Zygmunt, M1
Kazek, G1
Sałat, K1
Pawłowski, M1
Bua, S1
Lucarini, L1
Micheli, L1
Menicatti, M1
Bartolucci, G1
Selleri, S1
Di Cesare Mannelli, L1
Ghelardini, C1
Masini, E1
Carta, F1
Gratteri, P1
Nocentini, A1
Supuran, CT1
Yakushin, S1
Polyakova, S1
Shvarts, Y1
Kastanayan, A1
Krechikova, D1
Ershova, O1
Nikulenkova, N1
Vinogradova, I1
Hyun, BJ1
Cha, JE1
Ge, Y1
Wang, K1
Li, H1
Tian, Y1
Wu, Y1
Lin, Z1
Lin, Y1
Wang, Y1
Zhang, J1
Tang, B1
Nixon, E2
Carlson, AR1
Routh, PA1
Hernandez, L1
Almond, GW1
Baynes, RE2
Messenger, KM2
Meunier, V1
Mares, O1
Gricourt, Y1
Simon, N1
Kouyoumdjian, P1
Cuvillon, P1
Chittenden, JT1
Ziesenitz, VC1
Welzel, T1
van Dyk, M1
Saur, P1
Gorenflo, M1
van den Anker, JN1
Bueno-Serrano, G1
Alcoba-García, MP1
Tabares-Jiménez, J1
González-López, R1
Llanos-Jiménez, L1
Mahillo-Fernández, I1
González-Enguita, C1
Lobo, S1
Yan, G1
Miranda, HF7
Noriega, V1
Sierralta, F2
Poblete, P1
Aranda, N1
Prieto, JC4
Araujo, MAR1
Gromova, OA1
Torshin, IY1
Putilina, MV1
Stakhovskaia, LV1
Rudakov, KV1
Craft, RM1
Hewitt, KA1
Britch, SC1
Diester, CM1
Santos, EJ1
Moerke, MJ1
Negus, SS5
Cimen, U1
Yilmaz, A1
Cimen, YK1
Seyit, M1
Ozen, M1
Erdur, B1
Turkcuer, I1
Oncel, G1
Fornasari, D1
Allegri, M1
Gerboni, S1
Fanelli, G1
Feragalli, B1
Ippolito, E2
Dugall, M2
Cacchio, M2
Belcaro, G2
Cesarone, MR2
Abdel-Tawab, M1
Riva, A1
Togni, S1
Eggenhoffner, R1
Giacomelli, L1
Serinken, M2
Eken, C2
Karcıoğlu, Ö1
Makunts, T1
Cohen, IV1
Lee, KC1
Abagyan, R1
Kuronen, M1
Kokki, H3
Nyyssönen, T1
Savolainen, S1
Kokki, M2
Alexander, KS1
Rodriguez, TR1
Sarfo, AN1
Patton, TB1
Miller, LL2
Alsaaod, M1
Fadul, M1
Deiss, R1
Bucher, E1
Rehage, J1
Guccione, J1
Steiner, A1
Daly, KM1
Chaker, K1
Rhouma, SB1
Chehida, MAB1
Ouanes, Y1
Sellami, A1
Nouira, Y1
Sehajpal, S1
Prasad, DN1
Singh, RK1
Conaghan, PG3
Dickson, J1
Bolten, W1
Cevc, G1
Rother, M4
Leitl, MD2
Onvani, S1
Bowers, MS1
Cheng, K2
Rice, KC2
Carlezon, WA1
Banks, ML1
Bijlsma, JW1
Kneer, W2
Wise, E1
Kvien, TK1
Aydın, GB1
Polat, R1
Ergil, J1
Sayın, M1
Caparlar, CO1
Inal, S1
Kabay, S1
Cayci, MK1
Kuru, HI1
Altikat, S1
Akkas, G1
Deger, A1
Akil, A1
Api, O2
Bektas, Y1
Yilmaz, AO1
Yalti, S1
Unal, O2
Hacivelioglu, S1
Gencer, M1
Cakir Gungor, A1
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Sarkar, SN1
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Melnig, V1
Kwilasz, AJ1
Riou, B1
Plaisance, P1
Lecomte, F1
Soulat, L1
Orcel, P1
Mazoit, JX2
Fulga, I1
Lupescu, O1
Spircu, T1
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Raffa, RB1
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Kapadia, Y1
Herington, J1
Mason, L1
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Derry, S1
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Hocking, PM1
Robertson, GW1
Gentle, MJ1
Mazières, B4
Rouanet, S2
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Scarsi, C2
Reiner, V2
Marret, E1
Bazelly, B1
Taylor, G1
Lembert, N1
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Bonnet, FJ1
Guillon, Y1
White, RL1
Dursteler, C1
Esparza, F1
Cobián, C1
Jiménez, JF1
García-Cota, JJ1
Sánchez, C1
Maestro, A1
Jacqz-Aigrain, E1
Serreau, R1
Boissinot, C1
Popon, M1
Sobel, A1
Michel, J1
Sibony, O1
Sekiguchi, M1
Shirasaka, M1
Konno, S1
Kikuchi, S1
Minville, V1
Laffosse, JM1
Fourcade, O1
Girolami, JP1
Tack, I1
Girard, P1
Verniers, D1
Coppé, MC1
Pansart, Y1
Gillardin, JM1
Camus, JP1
Fournie, A1
Ayrolles, C1
Koeger, AC1
Prier, A1
Acqaviva, B1
Cayla, J1
Delcambre, B1
Le Goff, P1
Loyau, G1
Serratrice, G1
Ziegler, G1
Harrewyn, JM4
Arlet, J1
Gougeon, J1
Commandré, FA1
Fornaris, E1
Fourré, JM1
Raybaud, A1
Colonna, P1
Pirdas, C1
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Rossi, AP1
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Bruni, G2
Pannuti, F1
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Rinaldo, JF1
Pétriat, B1
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Vitali, G1
Facchini, R1
Selva, G1
Peretti, G1
Inoue, K1
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Dainaka, J1
Nishimura, T1
Hashii, H1
Yamate, K1
Ueda, F1
Kimura, K1
Reginster, JY1
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Mismetti, P1
Simitsidis, S1
Hocquart, J1
Rambaud, C1
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Venãlãinen, J1
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Kamerling, SG1
Stanton, SR1
Keowen, ML1
Martín-Mola, E1
Gijón-Baños, J1
Ansoleaga, JJ1
Hummel, T1
Huber, H1
Menzel, S1
Kobal, G1
Mauleón, D2
Artigas, R1
García, ML1
Carganico, G1
Burton, EA1
Jamieson, DG1
Fox, SM1
Johnston, SA1
Waikakul, S1
Penkitti, P1
Soparat, K1
Boonsanong, W1
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Tauzin-Fin, P1
Delort-Laval, S1
Krol-Houdek, MC1
Maurette, P1
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Mazario, J1
Roza, C1
Herrero, JF1
López-Muñoz, FJ1
Ventura, R1
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Tost, D1
Cabré, F1
McArdle, BF1
Giamberardino, MA1
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Vecchiet, L1
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Knight, CA1
Clarkson, PM1
Van Wegen, EH1
Kamen, G1
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Meller, ST1
Lascelles, BD1
Henderson, AJ1
Hackett, IJ1
Machin, KL1
Livingston, A1
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Miller, J1
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Buchanan, WW1
Franchi, R1
Liverta, C2
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Balme, HW1
Scott, J1
Franklin, S1
Famaey, JP2
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Bullier, R1
Ginsberg, F1
Julou, L1
Guyonnet, JC1
Ducrot, R1
Pasquet, J1
Brune, K1
Geisslinger, G1
Menzel-Soglowek, S1
Giordano, N2
Cecconami, L1
Gelli, R1
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Amanda Dal Pra, ML1
Marcolongo, R2
Roveda, S1
Colombo, P1
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Germogli, R1
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Lattuada, V1
Medway, DC1
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de Beaurepaire, R1
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Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery[NCT02573922]Phase 4180 participants (Actual)Interventional2012-05-31Completed
A Randomised, Double-blind, Placebo Controlled Study of Topical FLEXISEQ® for the Treatment of Osteoarthritis of the Knee in Patients Contraindicated for or With Clinical Intolerance to NSAIDs[NCT02594176]600 participants (Anticipated)Interventional2015-10-31Recruiting
Multicenter, Randomized, Double-blind, Placebo- and Active-controlled Study of Safety and Efficacy of Two Dosages of Epicutaneously Applied Diractin® (Ketoprofen in Transfersome® Gel) for the Treatment of Osteoarthritis of the Knee[NCT00716547]Phase 31,399 participants (Actual)Interventional2008-05-31Completed
Multicentre, Randomized, Double-blind, Placebo-controlled Study of Safety and Efficacy of Epicutaneously Applied Diractin® (Ketoprofen in Transfersome® Gel) for the Treatment of Osteoarthritis of the Knee[NCT00722852]Phase 3555 participants (Actual)Interventional2008-06-30Completed
The Effect of Intracervical Lidocaine Versus Intramuscular Diclofenac for Pain Relief During Hysterosalpingography Among Infertile Women In A Tertiary Hospital In Kano: A Randomized Controlled Trial[NCT02918812]Phase 4140 participants (Anticipated)Interventional2016-09-30Recruiting
[NCT01947205]111 participants (Actual)Interventional2012-11-30Completed
Safety and Efficacy of Sonohysterosalpingography for the Evaluation of Infertility[NCT03234569]27 participants (Actual)Interventional2018-01-31Completed
[NCT01993589]144 participants (Actual)Interventional2012-11-30Completed
Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001]Phase 460 participants (Actual)Interventional2015-01-31Completed
Double-blind Randomized Clinical Study on Topical Diclofenac Efficacy in Symptomatic Relief of Temporomandibular Degenerative Joint Disease in Women.[NCT00471393]28 participants (Actual)Interventional2006-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

11 reviews available for ketoprofen and Ache

ArticleYear
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
    Paediatric drugs, 2022, Volume: 24, Issue:6

    Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; C

2022
Drug-free gel containing ultra-deformable phospholipid vesicles (TDT 064) as topical therapy for the treatment of pain associated with osteoarthritis: a review of clinical efficacy and safety.
    Current medical research and opinion, 2014, Volume: 30, Issue:4

    Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Gels; Humans; Ketoprofen; Lipid Bi

2014
Systematic review of dexketoprofen in acute and chronic pain.
    BMC clinical pharmacology, 2008, Oct-31, Volume: 8

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dose-Response Relationship,

2008
Dexketoprofen trometamol: clinical evidence supporting its role as a painkiller.
    Expert review of neurotherapeutics, 2008, Volume: 8, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Humans; Ketoprofen; Pain

2008
Topical NSAIDs for acute pain: a meta-analysis.
    BMC family practice, 2004, May-17, Volume: 5

    Topics: Acute Disease; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind

2004
The welfare significance of the castration of cattle: a review.
    New Zealand veterinary journal, 2005, Volume: 53, Issue:5

    Topics: Anesthetics, Local; Animal Welfare; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Hydroc

2005
Topical ketoprofen patch.
    Drugs in R&D, 2005, Volume: 6, Issue:6

    Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketoprofen; Pain

2005
Piroxicam-beta-cyclodextrin in the treatment of acute pain of rheumatic disease.
    European journal of rheumatology and inflammation, 1993, Volume: 12, Issue:4

    Topics: Acute Disease; Adult; beta-Cyclodextrins; Controlled Clinical Trials as Topic; Cyclodextrins; Diclof

1993
Preclinical and clinical development of dexketoprofen.
    Drugs, 1996, Volume: 52 Suppl 5

    Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase Inhibitor

1996
Use of carprofen for the treatment of pain and inflammation in dogs.
    Journal of the American Veterinary Medical Association, 1997, May-15, Volume: 210, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

1997
Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain.
    Journal of clinical pharmacology, 1988, Volume: 28, Issue:s1

    Topics: Female; Humans; Ketoprofen; Neoplasms; Pain; Pain, Postoperative; Phenylpropionates; Postpartum Peri

1988

Trials

76 trials available for ketoprofen and Ache

ArticleYear
Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial.
    Clinical therapeutics, 2021, Volume: 43, Issue:10

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Ketoprofen;

2021
Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL).
    Archivos espanoles de urologia, 2022, Volume: 75, Issue:7

    Topics: Analgesics; Fentanyl; Humans; Ketoprofen; Lithiasis; Lithotripsy; Midazolam; Music; Nitrous Oxide; P

2022
Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat.
    International journal of clinical practice, 2021, Volume: 75, Issue:10

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ketoprofen; Pai

2021
Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial
    Balkan medical journal, 2018, 07-24, Volume: 35, Issue:4

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dysmenorrhea; Female; H

2018
Life satisfaction and pain interference in spine surgery patients before and after surgery: comparison between on-opioid and opioid-naïve patients.
    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2018, Volume: 27, Issue:11

    Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Drug Combinations; Elective Surgical Procedures; Fem

2018
[Evaluation of protocols on the use of analgesics for pain management in patients with extracorporeal shock wave lithotripsy (ESWL)].
    The Pan African medical journal, 2019, Volume: 32

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroi

2019
A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis.
    Rheumatology (Oxford, England), 2013, Volume: 52, Issue:7

    Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Age

2013
A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis.
    Rheumatology (Oxford, England), 2013, Volume: 52, Issue:7

    Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Age

2013
A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis.
    Rheumatology (Oxford, England), 2013, Volume: 52, Issue:7

    Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Age

2013
A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis.
    Rheumatology (Oxford, England), 2013, Volume: 52, Issue:7

    Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Age

2013
A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel.
    The Journal of rheumatology, 2013, Volume: 40, Issue:10

    Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal

2013
A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel.
    The Journal of rheumatology, 2013, Volume: 40, Issue:10

    Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal

2013
A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel.
    The Journal of rheumatology, 2013, Volume: 40, Issue:10

    Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal

2013
A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel.
    The Journal of rheumatology, 2013, Volume: 40, Issue:10

    Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal

2013
Comparison of randomized preemptive dexketoprofen trometamol or placebo tablets to prevent withdrawal movement caused by rocuronium injection.
    Journal of anesthesia, 2014, Volume: 28, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Androstanols; Anti-Inflammatory Agents, Non-Steroidal; Elective Surg

2014
Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2014, Volume: 34, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blin

2014
Can the addition of a paracervical block to systemic or local analgesics improve the pain perceived by the patient during hysterosalpingography?
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2014, Volume: 34, Issue:1

    Topics: Adolescent; Adult; Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Double-Blind Meth

2014
Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, and paracervical block application for pain relief during suction termination of first-trimester pregnancy.
    BioMed research international, 2013, Volume: 2013

    Topics: Abortion, Induced; Acetaminophen; Administration, Intravenous; Administration, Oral; Adult; Anesthes

2013
Effects of castration method and frequency of intramuscular injections of ketoprofen on behavioral and physiological indicators of pain in beef cattle.
    Journal of animal science, 2014, Volume: 92, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cattle; Cattle Diseases; Drug Ad

2014
Factors influencing the severity of pain during hysterosalpingography.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2015, Volume: 129, Issue:2

    Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Fallopian Tubes; Female; Human

2015
Intravenous dexketoprofen induces less injection pain than racemic ketoprofen.
    Journal of clinical pharmacy and therapeutics, 2015, Volume: 40, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Double-

2015
Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep.
    Australian veterinary journal, 2015, Volume: 93, Issue:8

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Car

2015
Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial.
    The Indian journal of medical research, 2015, Volume: 142, Issue:4

    Topics: Acetaminophen; Adult; Aged; Analgesia; Curettage; Diclofenac; Female; Gynecologic Surgical Procedure

2015
The effect of benzocaine and ketoprofen gels on pain during fixed orthodontic appliance treatment: a randomised, double-blind, crossover trial.
    Australian orthodontic journal, 2016, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Benzocaine; Cross-Ov

2016
A multiple-dose, open-label, safety, compliance, and usage evaluation study of epicutaneously applied Diractin (ketoprofen in Transfersome) in joint/musculoskeletal pain or soft tissue inflammation.
    Current drug safety, 2009, Volume: 4, Issue:1

    Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Drug Carriers;

2009
A randomized, controlled clinical trial of ketoprofen for sickle-cell disease vaso-occlusive crises in adults.
    Blood, 2009, Oct-29, Volume: 114, Issue:18

    Topics: Analgesics, Opioid; Anemia, Sickle Cell; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Hos

2009
Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study.
    Journal of clinical pharmacology, 2010, Volume: 50, Issue:10

    Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Bl

2010
Comparison of the analgesic effects of dexketoprofen and diclofenac during shockwave lithotripsy: a randomized, double-blind clinical trial.
    Journal of endourology, 2010, Volume: 24, Issue:6

    Topics: Adult; Aged; Analgesics; Diclofenac; Double-Blind Method; Humans; Ketoprofen; Lithotripsy; Male; Mid

2010
Comparison of oral nonsteroidal analgesic and intrauterine local anesthetic for pain relief in uterine fractional curettage: a randomized, double-blind, placebo-controlled trial.
    American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:1

    Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthesia, Local; Anesthesia, Obstetrica

2010
Evaluation of orally administered robenacoxib versus ketoprofen for treatment of acute pain and inflammation associated with musculoskeletal disorders in cats.
    American journal of veterinary research, 2010, Volume: 71, Issue:7

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Appetite; Aspartate Aminotransferases; Behavior

2010
Ketoprofen in piglets: enantioselective pharmacokinetics, pharmacodynamics and PK/PD modelling.
    Journal of veterinary pharmacology and therapeutics, 2011, Volume: 34, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Female; Fever; Inflammation; Kao

2011
Oral ketoprofen is effective in the treatment of non-infectious lameness in sows.
    Veterinary journal (London, England : 1997), 2011, Volume: 190, Issue:1

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female;

2011
Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders.
    Journal of feline medicine and surgery, 2011, Volume: 13, Issue:4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cat Diseases; Cats; Female;

2011
A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians.
    Italian journal of pediatrics, 2011, Sep-29, Volume: 37

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Ambulatory Care; Analgesics, Non-Narcotic; Anti-

2011
Comparison of two doses of ketoprofen to treat pain: a double-blind, randomized, noninferiority trial.
    Fundamental & clinical pharmacology, 2014, Volume: 28, Issue:1

    Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Ket

2014
Effects of local anaesthesia or local anaesthesia plus a non-steroidal anti-inflammatory drug on the acute cortisol response of calves to five different methods of castration.
    Research in veterinary science, 2002, Volume: 73, Issue:1

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cattle; Hydrocort

2002
Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain.
    Pain, 2003, Volume: 104, Issue:1-2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Ster

2003
Efficacy of transdermal ketoprofen for delayed onset muscle soreness.
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, 2003, Volume: 13, Issue:4

    Topics: Administration, Cutaneous; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind

2003
Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury.
    Emergency medicine journal : EMJ, 2003, Volume: 20, Issue:6

    Topics: Acute Disease; Administration, Oral; Adult; Analgesics; Diclofenac; Double-Blind Method; Female; Hum

2003
Effects of non-steroidal anti-inflammatory drugs on pain-related behaviour in a model of articular pain in the domestic fowl.
    Research in veterinary science, 2005, Volume: 78, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Chickens; Clonixin; Dose-Response Rela

2005
Topical ketoprofen patch (100 mg) for the treatment of ankle sprain: a randomized, double-blind, placebo-controlled study.
    The American journal of sports medicine, 2005, Volume: 33, Issue:4

    Topics: Administration, Topical; Adolescent; Adult; Aged; Ankle Injuries; Anti-Inflammatory Agents, Non-Ster

2005
Paravertebral block with ropivacaine 0.5% versus systemic analgesia for pain relief after thoracotomy.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:6

    Topics: Acetaminophen; Adult; Aged; Amides; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics,

2005
Topical ketoprofen patch in the treatment of tendinitis: a randomized, double blind, placebo controlled study.
    The Journal of rheumatology, 2005, Volume: 32, Issue:8

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketoprofen;

2005
Involvement of opioidergic and alpha2-adrenergic mechanisms in the central analgesic effects of non-steroidal anti-inflammatory drugs in sheep.
    Research in veterinary science, 2006, Volume: 80, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relati

2006
Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries.
    British journal of sports medicine, 2007, Volume: 41, Issue:3

    Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuri

2007
[Double-blind comparative study of Bi-Profenid tablets and Profenid capsules in inflammatory rheumatism].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Dec-12, Volume: 59, Issue:46

    Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Capsules; Child; Clinical Trials as Topic; Delayed-A

1983
[Bi-Profenid in rheumatologic practice].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Dec-12, Volume: 59, Issue:46

    Topics: Adult; Aged; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Ketoprofen; Male

1983
[Comparative double-blind study of ketoprofen slow-release tablets and indomethacin in coxarthrosis and gonarthrosis].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Dec-12, Volume: 59, Issue:46

    Topics: Aged; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Hip Joint;

1983
[Comparative double-blind study of Bi-Profenid and oxyphenbutazone in sports pathology].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Dec-12, Volume: 59, Issue:46

    Topics: Adolescent; Adult; Ankle Injuries; Athletic Injuries; Clinical Trials as Topic; Double-Blind Method;

1983
Injectable ketoprofen vs. acetylsalicylic acid for the relief of severe cancer pain: a double-blind, crossover trial.
    Drug intelligence & clinical pharmacy, 1984, Volume: 18, Issue:5

    Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Injections, Int

1984
[Controlled clinical experiment with the topical use of 2-(3-benzoyl-phenyl) propionic acid at 3 different concentrations].
    La Clinica terapeutica, 1980, Aug-15, Volume: 94, Issue:3

    Topics: Administration, Topical; Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Dose-Response Rel

1980
Tolerability of nimesulide and ketoprofen in paediatric patients with traumatic or surgical fractures.
    Drugs, 1993, Volume: 46 Suppl 1

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Female; Fractures, Bone; Humans; Ketopro

1993
Dosing time optimizes sustained-release ketoprofen treatment of osteoarthritis.
    Chronobiology international, 1994, Volume: 11, Issue:2

    Topics: Adult; Chronobiology Phenomena; Delayed-Action Preparations; Double-Blind Method; Drug Administratio

1994
A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening.
    Current medical research and opinion, 1993, Volume: 13, Issue:3

    Topics: Administration, Rectal; Adult; Aged; Ambulatory Care; Arthritis, Rheumatoid; Central Nervous System

1993
[Analgesic effect of sodium meclofenamate on several painful symptoms].
    Minerva anestesiologica, 1993, Volume: 59, Issue:9

    Topics: Analgesia; Double-Blind Method; Humans; Ketoprofen; Meclofenamic Acid; Pain; Pain Measurement; Time

1993
Ketoprofen 2.5% gel versus placebo gel in the treatment of acute soft tissue injuries.
    International journal of clinical pharmacology, therapy, and toxicology, 1993, Volume: 31, Issue:11

    Topics: Administration, Topical; Double-Blind Method; Female; Gels; Humans; Ketoprofen; Male; Pain; Pain Thr

1993
Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis.
    Rheumatology international, 1995, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac;

1995
Tonic versus phasic pain: dose-related effects of ketoprofen.
    European journal of clinical pharmacology, 1995, Volume: 49, Issue:1-2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Carbon Dioxide; Cross-Over Studies; Dose-Response Re

1995
Topical analgesics for knee arthrosis: a parallel study of ketoprofen gel and diclofenac emulgel.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1997, Volume: 80, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Chi-Square Distribution; Diclofenac; Female; Gel

1997
Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures.
    European journal of anaesthesiology, 1998, Volume: 15, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opi

1998
Effect of ketoprofen on muscle function and sEMG activity after eccentric exercise.
    Medicine and science in sports and exercise, 2001, Volume: 33, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Electromyography; Exercise; Female; Humans; Ketoprof

2001
Analgesic profile of peroral and topical ketoprofen upon low pH-induced muscle pain.
    Pain, 2001, Volume: 93, Issue:1

    Topics: Administration, Oral; Administration, Topical; Adult; Analgesics; Buffers; Double-Blind Method; Fema

2001
Evaluation of the clinical efficacy of meloxicam in cats with painful locomotor disorders.
    The Journal of small animal practice, 2001, Volume: 42, Issue:12

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cat Diseases; Cats; Female;

2001
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
    The Journal of rheumatology, 1976, Volume: 3, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Tri

1976
Parenteral administration of ketoprofen in osteoarthritis: a double-blind trial versus the N-methyl-d-glucamine salt of indomethacin.
    Scandinavian journal of rheumatology. Supplement, 1979, Issue:26

    Topics: Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Gait; Humans; Indomethacin;

1979
Four new anti-inflammatory drugs: responses and variations.
    British medical journal, 1976, May-01, Volume: 1, Issue:6017

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Fenoprofen; Gastrointesti

1976
A double-blind trial of ketoprofen in the treatment of osteoarthritis of the hip.
    Scandinavian journal of rheumatology. Supplement, 1976, Volume: 1976, Issue:0

    Topics: Analgesics; Benzophenones; Clinical Trials as Topic; Digestive System; Drug Evaluation; Female; Hip

1976
Results of the rectal administration of ketoprofen in fifty-two patients.
    Rheumatology and rehabilitation, 1976, Volume: Suppl

    Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Benzophenones; Clinical Tri

1976
[A double blind clinical trial of ketoprofen in rectal presentation in the treatment of painful shoulder (author's transl)].
    Journal belge de rhumatologie et de medecine physique = Belgisch tijdschrift voor reumatologie en fysische geneeskunde, 1976, Volume: 31 Suppl

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ketoprofen; Male; Middle

1976
[Clinical evaluation of pain. Value of a 2-dimensional index of pain].
    Revue du rhumatisme et des maladies osteo-articulaires, 1989, Volume: 56, Issue:1

    Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Ketoprofen; Pain; Phenylpropionates

1989
Central analgesic effect of ketoprofen in humans: electrophysiological evidence for a supraspinal mechanism in a double-blind and cross-over study.
    Pain, 1989, Volume: 38, Issue:1

    Topics: Adult; Analgesics; Brain; Double-Blind Method; Female; Humans; Ketoprofen; Male; Pain; Paraplegia; P

1989
Ketoprofen vs etofenamate in a controlled double-blind study: evidence of topical effectiveness in soft tissue rheumatic pain.
    International journal of clinical pharmacology research, 1988, Volume: 8, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; D

1988
Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study.
    The Journal of rheumatology, 1988, Volume: 15, Issue:9

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arthritis, Gouty; Clinical Trials as Topic; Do

1988
Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison.
    Journal of clinical pharmacology, 1988, Volume: 28, Issue:s1

    Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Ketop

1988
A double-blind parallel evaluation of the efficacy and safety of a single dose of ketoprofen in cancer pain.
    Journal of clinical pharmacology, 1988, Volume: 28, Issue:s1

    Topics: Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ketop

1988
Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain.
    Journal of clinical pharmacology, 1988, Volume: 28, Issue:s1

    Topics: Female; Humans; Ketoprofen; Neoplasms; Pain; Pain, Postoperative; Phenylpropionates; Postpartum Peri

1988
Double-blind comparison of ketoprofen and mefenamic acid in the treatment of primary dysmenorrhea.
    Clinical therapeutics, 1986, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Keto

1986
Double-blind comparison of ketoprofen and placebo in the treatment of sprains and strains.
    Clinical therapeutics, 1986, Volume: 8, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Cryotherapy; Double-Blind Method; Female; Humans; Immobilization;

1986
Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment.
    Clinical rheumatology, 1985, Volume: 4, Issue:3

    Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Administration

1985
Correlation between ketoprofen plasma levels and analgesic effect in acute lumbar pain and radicular pain.
    Clinical rheumatology, 1985, Volume: 4, Issue:4

    Topics: Acute Disease; Analgesia; Brachial Plexus Neuritis; Clinical Trials as Topic; Female; Humans; Ketopr

1985
Successful treatment of biliary colic with intravenous ketoprofen or lysine acetylsalicylate.
    Current medical research and opinion, 1985, Volume: 9, Issue:7

    Topics: Adult; Aged; Analgesics; Aspirin; Biliary Tract Diseases; Clinical Trials as Topic; Colic; Double-Bl

1985
Administration of ketoprofen suppositories for out-patient post-operative analgesia.
    Current medical research and opinion, 1985, Volume: 9, Issue:7

    Topics: Adenofibroma; Adolescent; Adult; Ambulatory Care; Breast Neoplasms; Double-Blind Method; Female; Hum

1985

Other Studies

82 other studies available for ketoprofen and Ache

ArticleYear
Synthesis of novel trifluoromethyl-substituted spiro-[chromeno[4,3-d]pyrimidine-5,1'-cycloalkanes], and evaluation of their analgesic effects in a mouse pain model.
    Bioorganic & medicinal chemistry letters, 2017, 04-01, Volume: 27, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzopyrans; Capsaicin; Heterocyclic Co

2017
Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain.
    European journal of medicinal chemistry, 2018, Oct-05, Volume: 158

    Topics: Amides; Analgesics; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phospho

2018
Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis.
    Journal of medicinal chemistry, 2020, 03-12, Volume: 63, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbonic Anhydrase Inhibito

2020
An Mg-MOFs based multifunctional medicine for the treatment of osteoporotic pain.
    Materials science & engineering. C, Materials for biological applications, 2021, Volume: 129

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Liberation; Humans; Ketoprofen; Pain; Pharmaceutical P

2021
Comparative effects of nonsteroidal anti-inflammatory drugs at castration and tail-docking in neonatal piglets.
    PloS one, 2021, Volume: 16, Issue:11

    Topics: Animal Husbandry; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Castration; Cl

2021
Patient satisfaction after distal upper limb surgery under WALANT versus axillary block: A propensity-matched comparative cohort study.
    Hand surgery & rehabilitation, 2022, Volume: 41, Issue:5

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Cohort Studies; Humans; Ketoprofen; Pain; Patient Sat

2022
Pharmacokinetic/pharmacodynamic modeling of ketoprofen and flunixin at piglet castration and tail-docking.
    Journal of veterinary pharmacology and therapeutics, 2022, Volume: 45, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Dinoprostone; Hydrocortisone; Ketoprofen

2022
Evaluation iontophoretic delivery of a cationic ketoprofen prodrug for treating nociceptive symptoms in monosodium iodoacetate induced osteoarthritic rat model.
    International journal of pharmaceutics, 2019, Oct-05, Volume: 569

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Female; Iodoacetates; Iont

2019
Nitric Oxide and Opioids Involvement in Isobolographic Nsaids Antinociception.
    Drug research, 2019, Volume: 69, Issue:12

    Topics: Acetaminophen; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase

2019
Ketoprofen hypersensibility and idiosyncratic response - a case report.
    Immunopharmacology and immunotoxicology, 2020, Volume: 42, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Humans; Hypersensitivity, Imm

2020
[The chemoreactomic analysis of the central mechanisms of action of non-steroidal anti-inflammatory drugs].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2020, Volume: 120, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Ketoprofen; Opiate Alkaloids; Pain; Pir

2020
Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats.
    Behavioural pharmacology, 2021, 04-01, Volume: 32, Issue:2&3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Disease Models, Animal; Dos

2021
Behavioral Battery for Testing Candidate Analgesics in Mice. I. Validation with Positive and Negative Controls.
    The Journal of pharmacology and experimental therapeutics, 2021, Volume: 377, Issue:2

    Topics: Amphetamine; Analgesics; Animals; Behavior, Animal; Diazepam; Drug Evaluation, Preclinical; False Ne

2021
A "novel" association to treat pain: tramadol/dexketoprofen. The first drug of a "new pharmacological class".
    Acta bio-medica : Atenei Parmensis, 2017, 04-28, Volume: 88, Issue:1

    Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Humans; Ketoprofen;

2017
Effectiveness of a novel boswellic acids delivery form (Casperome®) in the management of grade II ankle sprains due to sport trauma - a registry study.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:20

    Topics: Adult; Ankle Injuries; Drug Carriers; Female; Hematoma; Humans; Ketoprofen; Male; Pain; Pilot Projec

2017
Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain.
    PloS one, 2018, Volume: 13, Issue:4

    Topics: Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Anxiety; Cohort

2018
What place is there for tramadol/dexketoprofen?
    Drug and therapeutics bulletin, 2018, Volume: 56, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Humans;

2018
Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice.
    Behavioural pharmacology, 2019, Volume: 30, Issue:6

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bupropion; Citalopram; Conditioning, Operant; Dopamin

2019
Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies.
    PloS one, 2019, Volume: 14, Issue:6

    Topics: Analysis of Variance; Animals; Cattle; Cattle Diseases; Disease Management; Extremities; Gait; Ketop

2019
Novel ketoprofen-antioxidants mutual codrugs as safer nonsteroidal anti-inflammatory drugs: Synthesis, kinetic and pharmacological evaluation.
    Archiv der Pharmazie, 2019, Volume: 352, Issue:7

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Biphe

2019
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:3

    Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Depression; Disease Models, Animal; Dopamine; Gene E

2014
Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: an experimental rat model.
    Injury, 2014, Volume: 45, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Diclofenac; Fibula; Fract

2014
Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice.
    Pain, 2015, Volume: 156, Issue:6

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenea

2015
Acute dystonic reaction due to dexketoprofen trometamol.
    JPMA. The Journal of the Pakistan Medical Association, 2015, Volume: 65, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Dystonia; Humans; Ketoprofen; Male; Pain; Tromethamine; You

2015
Pomegranate seed oil nanoemulsions improve the photostability and in vivo antinociceptive effect of a non-steroidal anti-inflammatory drug.
    Colloids and surfaces. B, Biointerfaces, 2016, Aug-01, Volume: 144

    Topics: Abdomen; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Constriction, Pa

2016
Topical Ketoprofen Versus Placebo in Treatment of Acute Ankle Sprain in the Emergency Department.
    Foot & ankle international, 2016, Volume: 37, Issue:9

    Topics: Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Emergency Service, Hos

2016
Pain alleviation during castration of piglets: a comparative study of different farm options.
    Journal of animal science, 2016, Volume: 94, Issue:12

    Topics: Anesthesia, Local; Animal Husbandry; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Ani

2016
Efficacy of oral and parenteral ketoprofen in lactating cows with endotoxin-induced acute mastitis.
    The Veterinary record, 2008, Oct-25, Volume: 163, Issue:17

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cattle; En

2008
Prevention of N-methyl-D-aspartate-induced mechanical nociception by intrathecal administration of ketoprofen and ketamine in sheep.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Injections, Spinal; Ketamine; Ketoprofen;

2008
Effects of tramadol and dexketoprofen on analgesia and gastrointestinal transit in mice.
    Fundamental & clinical pharmacology, 2009, Volume: 23, Issue:1

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Charcoal; Disease Models, Anim

2009
The effect of opioid antagonists on synergism between dexketoprofen and tramadol.
    Pharmacological research, 2009, Volume: 60, Issue:4

    Topics: Analgesics; Animals; Drug Synergism; Ketoprofen; Male; Mice; Narcotic Antagonists; Pain; Tramadol

2009
Management of uncomplicated ankle sprains with topical or oral ketoprofen treatment. A registry study.
    Minerva cardioangiologica, 2008, Volume: 56, Issue:5 Suppl

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Ankle Injuries; Anti-Inflammatory Agents, No

2008
Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care.
    Methods and findings in experimental and clinical pharmacology, 2009, Volume: 31, Issue:8

    Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Female; Humans; Ketop

2009
Ketoprofen absorption by muscle and tendon after topical or oral administration in patients undergoing anterior cruciate ligament reconstruction.
    AAPS PharmSciTech, 2010, Volume: 11, Issue:1

    Topics: Absorption; Administration, Cutaneous; Administration, Oral; Administration, Topical; Adolescent; Ad

2010
Long-term continuous subcutaneous infusion of ketoprofen combined with morphine: a safe and effective approach to cancer pain.
    The Clinical journal of pain, 2010, Volume: 26, Issue:4

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug Therapy, Combi

2010
Nonsteroidal anti-inflammatory drug-associated renal papillary necrosis in a white-tailed deer (Odocoileus virginianus).
    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2010, Volume: 22, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Connective Tissue; Deer; Fatal Outcome; Female; Ho

2010
Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion.
    Journal of oleo science, 2010, Volume: 59, Issue:12

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Emulsions; Esters;

2010
Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:3

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug C

2012
Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:3

    Topics: Animals; Behavior, Animal; Cocaine; Diterpenes, Clerodane; Flupenthixol; Ketoprofen; Male; Oligopept

2012
Subacute arsenic exposure through drinking water reduces the pharmacodynamic effects of ketoprofen in male rats.
    Environmental toxicology and pharmacology, 2012, Volume: 33, Issue:2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arsenites; Carrageenan; Cycl

2012
Dose-response investigation of oral ketoprofen in pigs challenged with Escherichia coli endotoxin.
    The Veterinary record, 2012, Jul-21, Volume: 171, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship,

2012
Ketoprofen-liposomes formulation for clinical therapy.
    Journal of materials science. Materials in medicine, 2012, Volume: 23, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ketoprofen; Liposomes; Mice; Pain

2012
Dissociable effects of the cannabinoid receptor agonists Δ9-tetrahydrocannabinol and CP55940 on pain-stimulated versus pain-depressed behavior in rats.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 343, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Brain; Cannabinoid R

2012
Local tolerability and effectiveness of Ketospray® 10% cutaneous spray solution.
    Panminerva medica, 2012, Volume: 54, Issue:1 Suppl 4

    Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-S

2012
Pain intensity after laseruvulopalatoplasty and tonsillectomy.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2003, Volume: 128, Issue:2

    Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; Fentanyl; Follow-Up Stud

2003
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:2

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No

2003
Analgesic effects of intra-nasal enkephalins.
    The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:9

    Topics: Acetic Acid; Administration, Intranasal; Analgesics; Animals; Dicarboxylic Acids; Drug Synergism; Ed

2003
Ketoprofen gel as an adjunct to physical therapist management of a child with Sever disease.
    Physical therapy, 2006, Volume: 86, Issue:3

    Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Calcaneus; Child; Combined Modalit

2006
Depression of NMDA-receptor-mediated segmental transmission by ketamine and ketoprofen, but not L-NAME, on the in vitro neonatal rat spinal cord preparation.
    Brain research, 2006, Jun-13, Volume: 1094, Issue:1

    Topics: Afferent Pathways; Animals; Animals, Newborn; Cyclooxygenase Inhibitors; Dose-Response Relationship,

2006
Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Acetaminophen; Acute Disease; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, N

2007
Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 88, Issue:4

    Topics: Acetaminophen; Acute Disease; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; An

2008
Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:6

    Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketoprofen; Milk

2007
Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.
    BMC musculoskeletal disorders, 2008, Jan-31, Volume: 9

    Topics: Acute Disease; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Contusions

2008
Mouse model of fracture pain.
    Anesthesiology, 2008, Volume: 108, Issue:3

    Topics: Animals; Disease Models, Animal; Fractures, Bone; Hot Temperature; Ketoprofen; Male; Mice; Mice, Inb

2008
Nefopam and ketoprofen synergy in rodent models of antinociception.
    European journal of pharmacology, 2008, Apr-28, Volume: 584, Issue:2-3

    Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, A

2008
[Clinical study of Bi-Profenid in rheumatologic practice].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Dec-12, Volume: 59, Issue:46

    Topics: Adult; Aged; Arthritis, Rheumatoid; Delayed-Action Preparations; Female; Humans; Ketoprofen; Male; M

1983
[Long-term study of 150 mg. Bi-Profenid in patients followed at the Department of Rheumatology of Cochin Hospital].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Dec-12, Volume: 59, Issue:46

    Topics: Adult; Aged; Delayed-Action Preparations; Female; Humans; Ketoprofen; Male; Middle Aged; Pain; Pheny

1983
[Ketoprofen in cervicofacial oncology].
    Journal francais d'oto-rhino-laryngologie; audiophonologie, chirurgie maxillo-faciale, 1980, Volume: 29, Issue:5

    Topics: Head and Neck Neoplasms; Humans; Injections, Intramuscular; Ketoprofen; Pain; Phenylpropionates; Sup

1980
[Controlled study of the analgesic action of Profenid in severe pain].
    Revue de laryngologie - otologie - rhinologie, 1983, Volume: 104, Issue:2

    Topics: Adult; Aged; Analgesics; Double-Blind Method; Drug Evaluation; Female; Humans; Ketoprofen; Male; Mid

1983
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
    Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 51, Issue:6

    Topics: Animals; Aspirin; Bradykinin; Bromelains; Cartilage, Articular; Cell Line; Concanavalin A; Depressio

1994
Ketoprofen in Pain. Proceedings of Actron International Experts Meeting. Interlaken, Switzerland, 20-23 March 1994.
    Fortschritte der Medizin. Monographie, 1994, Volume: 74

    Topics: Humans; Ketoprofen; Pain

1994
Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse.
    Equine veterinary journal, 1995, Volume: 27, Issue:4

    Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Female; Foot Diseases;

1995
Ketoprofen and carotico-cavernous fistula.
    Cephalalgia : an international journal of headache, 1997, Volume: 17, Issue:1

    Topics: Adult; Arteriovenous Fistula; Carotid Artery Injuries; Cavernous Sinus; Cyclooxygenase Inhibitors; H

1997
Assessing pain in animals.
    Journal of the American Veterinary Medical Association, 1997, Oct-15, Volume: 211, Issue:8

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Dog Diseases; Dog

1997
The NSAID dexketoprofen trometamol is as potent as mu-opioids in the depression of wind-up and spinal cord nociceptive reflexes in normal rats.
    Brain research, 1999, Jan-23, Volume: 816, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Depression, Chemical; Electri

1999
Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:S1

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Biotransformation; Dise

1998
Limiting sensitivity after quadrant scaling and root planing.
    Journal of the American Dental Association (1939), 2000, Volume: 131, Issue:2

    Topics: Anesthesia, Dental; Anti-Inflammatory Agents, Non-Steroidal; Dental Scaling; Fluorides, Topical; Hum

2000
Pre-emptive analgesia in rats with artificial ureteric calculosis. Effects on visceral pain behavior in the post-operative period.
    Brain research, 2000, Sep-29, Volume: 878, Issue:1-2

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Electric Stimulation; Female;

2000
Neostigmine interactions with non steroidal anti-inflammatory drugs.
    British journal of pharmacology, 2002, Volume: 135, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Diclofenac; Disease Mod

2002
Assessment of the analgesic effects of ketoprofen in ducks anesthetized with isoflurane.
    American journal of veterinary research, 2002, Volume: 63, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Ducks

2002
Some pharmacological and toxicological studies on ketoprofen.
    Rheumatology and rehabilitation, 1976, Volume: Suppl

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzophenones; Fever; Guinea Pigs; Indometha

1976
Pure enantiomers of 2-arylpropionic acids: tools in pain research and improved drugs in rheumatology.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:10

    Topics: Animals; Humans; Ibuprofen; Ketoprofen; Pain; Propionates; Research; Rheumatic Diseases; Stereoisome

1992
[Ketoprofen efficacy and tolerance in simple painful shoulder].
    La Clinica terapeutica, 1992, Volume: 141, Issue:7

    Topics: Adult; Aged; Drug Evaluation; Drug Tolerance; Female; Humans; Ketoprofen; Male; Middle Aged; Pain; P

1992
[Evaluation of the analgesic activity of a new ketoprofen-sucralfate combination].
    Bollettino chimico farmaceutico, 1991, Volume: 130, Issue:11

    Topics: Adolescent; Adult; Aged; Analgesics; Drug Combinations; Female; Humans; Ketoprofen; Male; Middle Age

1991
Ketoprofen in the treatment of scleritis.
    American journal of ophthalmology, 1991, Feb-15, Volume: 111, Issue:2

    Topics: Female; Humans; Ketoprofen; Male; Middle Aged; Pain; Scleritis

1991
Ketoprofen: i.c.v. injection and electrophysiological aspects of antinociceptive effect.
    European journal of pharmacology, 1990, Aug-10, Volume: 184, Issue:2-3

    Topics: Animals; Arthritis, Experimental; Brain; Electrodes; Evoked Potentials; Injections, Intraventricular

1990
Anatomical mapping of brain sites involved in the antinociceptive effects of ketoprofen.
    Brain research, 1990, Dec-17, Volume: 536, Issue:1-2

    Topics: Animals; Brain Mapping; Ketoprofen; Male; Motor Activity; Pain; Rats; Rats, Inbred Strains; Reaction

1990
[Ketoprofen lysine treatment of painful manifestations of spinal osteoarthrosis].
    La Clinica terapeutica, 1988, Jul-31, Volume: 126, Issue:2

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation; Female; Humans; Ketoprofen; L

1988
Ketoprofen: a new nonsteroidal anti-inflammatory analgesic.
    Journal of clinical pharmacology, 1988, Volume: 28, Issue:s1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketoprofen; Pain; Phenylpropionates; United States;

1988
Ketoprofen (Orudis): U.S. and European experience in arthritis and pain.
    Journal of clinical pharmacology, 1988, Volume: 28, Issue:s1

    Topics: Arthritis; Humans; Ketoprofen; Pain; Phenylpropionates

1988
Clinical pharmacokinetics of ketoprofen after single intravenous administration as a bolus or infusion.
    Clinical pharmacokinetics, 1987, Volume: 12, Issue:3

    Topics: Adult; Colic; Female; Humans; Infusions, Intravenous; Injections, Intravenous; Ketoprofen; Kidney Di

1987
Diclofenac in the treatment of painful joints and traumatic tendinitis (including strains and sprains): a brief review.
    Seminars in arthritis and rheumatism, 1985, Volume: 15, Issue:2 Suppl 1

    Topics: Diclofenac; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Joint Diseases; Ketoprofen; Naproxen;

1985