ketoconazole has been researched along with Weight Gain in 3 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Weight Gain: Increase in BODY WEIGHT over existing weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketoconazole (KT) is a broad-spectrum antifungal agent whose pharmacological activity is based on the capability to interfere with steroid biosynthesis through an interaction with fungal cytochrome P-450 enzymes and thereby avoiding the formation of fungal walls." | 1.35 | Prednisone reduces ketoconazole-induced skeletal defects in rat fetuses. ( Amaral, VC; Nunes, GP, 2009) |
| " In two similar experiments, weanling female rats were dosed for 20 days by gavage with vehicle (0." | 1.30 | Evaluation of the EDSTAC female pubertal assay in CD rats using 17beta-estradiol, steroid biosynthesis inhibitors, and a thyroid inhibitor. ( Carney, EW; Crissman, JW; Marty, MS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amaral, VC | 1 |
| Nunes, GP | 1 |
| Comby, F | 1 |
| Lagorce, JF | 1 |
| Buxeraud, J | 1 |
| Raby, C | 1 |
| Marty, MS | 1 |
| Crissman, JW | 1 |
| Carney, EW | 1 |
3 other studies available for ketoconazole and Weight Gain
| Article | Year |
|---|---|
Prednisone reduces ketoconazole-induced skeletal defects in rat fetuses.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Dose-Response Relationship, Drug; Drinking; Dr | 2009 |
Antithyroid action of ketoconazole: in-vitro studies and rat in-vivo studies.
Topics: Animals; Antithyroid Agents; In Vitro Techniques; Iodine; Ketoconazole; Lactoperoxidase; Male; Methi | 1994 |
Evaluation of the EDSTAC female pubertal assay in CD rats using 17beta-estradiol, steroid biosynthesis inhibitors, and a thyroid inhibitor.
Topics: 5-alpha Reductase Inhibitors; Animals; Antineoplastic Agents, Hormonal; Antithyroid Agents; Endocrin | 1999 |