ketoconazole has been researched along with Uremia in 4 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketoconazole is an antifungal agent widely used in the management of patients with fungal infection, especially in patients with acute acquired immuno-deficiency syndrome (AIDS)." | 1.30 | Valproic acid-ketoconazole interaction in normal, hypoalbuminemic, and uremic sera: lack of interaction in uremic serum caused by the presence of inhibitor. ( Dasgupta, A; Luke, M, 1997) |
| " This study could not demonstrate any significant effect of renal dysfunction and hemodialysis or continuous ambulatory peritoneal dialysis treatment upon the pharmacokinetics of itraconazole, and firm conclusions concerning dosing in such patients should await confirmation of our data in a larger patient population." | 1.27 | Itraconazole pharmacokinetics in patients with renal dysfunction. ( Boelaert, J; Daneels, R; De Beule, K; Heykants, J; Matthys, E; Schurgers, M; van Peer, A; Woestenborghs, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Robitaille, P | 1 |
| Mérouani, A | 1 |
| Clermónt, MJ | 1 |
| Hébert, E | 1 |
| Dasgupta, A | 1 |
| Luke, M | 1 |
| Dusso, AS | 1 |
| Finch, J | 1 |
| Brown, A | 1 |
| Ritter, C | 1 |
| Delmez, J | 1 |
| Schreiner, G | 1 |
| Slatopolsky, E | 1 |
| Boelaert, J | 1 |
| Schurgers, M | 1 |
| Matthys, E | 1 |
| Daneels, R | 1 |
| van Peer, A | 1 |
| De Beule, K | 1 |
| Woestenborghs, R | 1 |
| Heykants, J | 1 |
4 other studies available for ketoconazole and Uremia
| Article | Year |
|---|---|
Successful antifungal prophylaxis in chronic peritoneal dialysis: a pediatric experience.
Topics: Anti-Bacterial Agents; Bacterial Infections; Candidiasis; Child; Gastrostomy; Humans; Jejunostomy; K | 1995 |
Valproic acid-ketoconazole interaction in normal, hypoalbuminemic, and uremic sera: lack of interaction in uremic serum caused by the presence of inhibitor.
Topics: Anticonvulsants; Antifungal Agents; Drug Interactions; Humans; Ketoconazole; Uremia; Valproic Acid | 1997 |
Extrarenal production of calcitriol in normal and uremic humans.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Calcitriol; Cytochrome P-450 Enzyme Inhibitors; Humans; Ke | 1991 |
Itraconazole pharmacokinetics in patients with renal dysfunction.
Topics: Administration, Oral; Aged; Antifungal Agents; Female; Humans; Itraconazole; Ketoconazole; Male; Mid | 1988 |