ketoconazole has been researched along with Torsade de Pointes in 14 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Recent clinical evidence shows that some of the early prototypes in this class, namely terfenadine and astemizole, have the potential for producing torsade de pointes, a rare form of ventricular arrhythmia that is life-threatening." | 7.69 | Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes. ( del Prado, M; Egan, RW; Hey, JA; Kreutner, W, 1996) |
| "Prolongation of the QT interval and torsade de pointes has been reported in patients with an overdose of astemizole." | 5.30 | Combined use of astemizole and ketoconazole resulting in torsade de pointes. ( Chen, JH; Tsai, LM; Tsai, WC, 1997) |
| "It has been difficult to experimentally reproduce synergistic effects of ketoconazole on terfenadine-induced torsade de pointes." | 3.96 | Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes. ( Chiba, K; Goto, A; Hagiwara-Nagasawa, M; Izumi-Nakaseko, H; Kambayashi, R; Matsumoto, A; Nunoi, Y; Sakamoto, K; Sugiyama, A, 2020) |
| " Recent clinical evidence shows that some of the early prototypes in this class, namely terfenadine and astemizole, have the potential for producing torsade de pointes, a rare form of ventricular arrhythmia that is life-threatening." | 3.69 | Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes. ( del Prado, M; Egan, RW; Hey, JA; Kreutner, W, 1996) |
| "Torsades de pointes is a form of polymorphic ventricular tachycardia that is associated with prolongation of the QT interval." | 1.28 | Torsades de pointes occurring in association with terfenadine use. ( Cantilena, LR; Ferguson, CL; Killeavy, ES; Lloyd, BK; Monahan, BP; Troy, J, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (78.57) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Goto, A | 1 |
| Sakamoto, K | 1 |
| Hagiwara-Nagasawa, M | 1 |
| Kambayashi, R | 1 |
| Chiba, K | 1 |
| Nunoi, Y | 1 |
| Izumi-Nakaseko, H | 1 |
| Matsumoto, A | 1 |
| Sugiyama, A | 1 |
| Mok, NS | 1 |
| Lo, YK | 1 |
| Tsui, PT | 1 |
| Lam, CW | 1 |
| Ciummo, PE | 1 |
| Katz, NL | 1 |
| Pohjola-Sintonen, S | 2 |
| Viitasalo, M | 1 |
| Toivonene, L | 1 |
| Neuvonen, P | 1 |
| Hey, JA | 2 |
| del Prado, M | 2 |
| Kreutner, W | 2 |
| Egan, RW | 2 |
| Ishizaki, T | 1 |
| Tsai, WC | 1 |
| Tsai, LM | 1 |
| Chen, JH | 1 |
| Roberts, DJ | 1 |
| Llenas, J | 1 |
| Sherwood, J | 1 |
| Zimmermann, M | 1 |
| Duruz, H | 1 |
| Guinand, O | 1 |
| Broccard, O | 1 |
| Levy, P | 1 |
| Lacatis, D | 1 |
| Bloch, A | 1 |
| Mathews, DR | 1 |
| McNutt, B | 1 |
| Okerholm, R | 1 |
| Flicker, M | 1 |
| McBride, G | 1 |
| Monahan, BP | 1 |
| Ferguson, CL | 1 |
| Killeavy, ES | 1 |
| Lloyd, BK | 1 |
| Troy, J | 1 |
| Cantilena, LR | 1 |
2 reviews available for ketoconazole and Torsade de Pointes
| Article | Year |
|---|---|
[Treatment with terfenadine and ketoconazole or itraconazole can cause torsades de pointes ventricular tachycardia].
Topics: Drug Interactions; Humans; Itraconazole; Ketoconazole; Terfenadine; Torsades de Pointes | 1993 |
Strategic proposals to avoid drug interactions during drug development: a lesson from a terfenadine-related drug interaction.
Topics: Drug Design; Drug Interactions; Humans; Ketoconazole; Risk Assessment; Terfenadine; Torsades de Poin | 1996 |
12 other studies available for ketoconazole and Torsade de Pointes
| Article | Year |
|---|---|
Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes.
Topics: Animals; Atrioventricular Block; Chronic Disease; Disease Models, Animal; Drug Synergism; Ketoconazo | 2020 |
Ketoconazole induced torsades de pointes without concomitant use of QT interval-prolonging drug.
Topics: Antifungal Agents; Coronary Artery Disease; Female; Humans; Ketoconazole; Long QT Syndrome; Middle A | 2005 |
Interactions and drug-metabolizing enzymes.
Topics: Adolescent; Adult; Anti-Allergic Agents; Antidepressive Agents, Second-Generation; Antifungal Agents | 1995 |
Torsades de pointes after terfenadine-itraconazole interaction.
Topics: Adult; Drug Interactions; Female; Humans; Itraconazole; Ketoconazole; Terfenadine; Torsades de Point | 1993 |
Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes.
Topics: Animals; Butyrophenones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; | 1996 |
Combined use of astemizole and ketoconazole resulting in torsade de pointes.
Topics: Antifungal Agents; Astemizole; Drug Interactions; Electrocardiography; Female; Histamine H1 Antagoni | 1997 |
Some observations on the cardiotoxic and drug interaction profiles of second generation antihistamines as measured in the guinea pig.
Topics: Animals; Antifungal Agents; Butyrophenones; Disease Models, Animal; Drug Interactions; Electrocardio | 1996 |
The guinea pig model for assessing cardiotoxic proclivities of second generation antihistamines.
Topics: Animals; Antifungal Agents; Butyrophenones; Cats; Disease Models, Animal; Drug Interactions; Guinea | 1996 |
Dofetilide for atrial fibrillation.
Topics: Anti-Arrhythmia Agents; Anti-Infective Agents; Anti-Infective Agents, Urinary; Anti-Ulcer Agents; An | 2000 |
Torsades de Pointes after treatment with terfenadine and ketoconazole.
Topics: Adult; Cardiac Pacing, Artificial; Dermatomycoses; Drug Therapy, Combination; Electrocardiography, A | 1992 |
Torsades de pointes occurring in association with terfenadine use.
Topics: Drug Interactions; Electrocardiography; Humans; Ketoconazole; Terfenadine; Torsades de Pointes | 1991 |
Torsades de pointes occurring in association with terfenadine use.
Topics: Adult; Benzhydryl Compounds; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Ketoconazo | 1990 |