ketoconazole has been researched along with Sensitivity and Specificity in 34 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The data suggest that dosing diltiazem XR for 2 days predicts the change in midazolam AUC as reliably as 5 days of XR dosing and 2 days of CR dosing." | 2.76 | Effect of different durations and formulations of diltiazem on the single-dose pharmacokinetics of midazolam: how long do we go? ( Bergman, AJ; Chodakewitz, J; Fraser, IP; Friedman, EJ; Larson, PJ; Li, CC; Stoch, SA; Wagner, JA; Wang, YH, 2011) |
| "Pactimibe sulfate is a novel acyl coenzyme A:cholesterol acyltransferase inhibitor developed for the treatment of hypercholesterolemia and atherosclerotic diseases." | 2.73 | Effects of ketoconazole and quinidine on pharmacokinetics of pactimibe and its plasma metabolite, R-125528, in humans. ( Freudenthaler, S; Kotsuma, M; Nishimura, K; Tokui, T, 2008) |
| " The bioassay was applied for a dose-response study of mono(2-ethylhexyl)phthalate (MEHP), a chemical known to disrupt several steroidogenic enzymes." | 1.35 | Steroidogenesis-disrupting compounds can be effectively studied for major fertility-related endpoints using in vitro cultured mouse follicles. ( Lenie, S; Smitz, J, 2009) |
| "Invasive candidiasis is associated with high morbidity and mortality." | 1.35 | Direct antifungal susceptibility testing of positive Candida blood cultures by sensititre YeastOne. ( Avolio, M; Bruschetta, G; Camporese, A; De Rosa, R; Grosso, S, 2009) |
| " The method is applicable to the assay of the three drugs under investigation in different dosage forms and the results are in good agreement with those obtained by the official methods (USP and JP)." | 1.32 | Quantitative determination of some pharmaceutical piperazine derivatives through complexation with iron(III) chloride. ( Abdel-Gawad, FM; Abdel-Hamid, SM; Abou-Attia, FM; Issa, YM, 2003) |
| "Formaldehyde was measured at 345 nm after derivatisation with a 2,4-dinitrophenylhydrazine solution." | 1.31 | Simultaneous determination of ketoconazole and formaldehyde in a shampoo: liquid chromatography method development and validation. ( Detaevenier, MR; Massart, DL; Nguyet, AN; Plaizier-Vercammen, J; Vander Heyde, Y, 2002) |
| "Ketoconazole is a well established potent inhibitor of CYP 3A4 and P-glycoprotein." | 1.31 | Simple high-performance liquid chromatography method for the simultaneous determination of ketoconazole and piperine in rat plasma and hepatocyte culture. ( Bajad, S; Bedi, KL; Johri, RK; Singh, J; Singh, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (23.53) | 18.2507 |
| 2000's | 22 (64.71) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sortino, M | 1 |
| Delgado, P | 1 |
| Juárez, S | 1 |
| Quiroga, J | 1 |
| Abonía, R | 1 |
| Insuasty, B | 1 |
| Nogueras, M | 1 |
| Rodero, L | 1 |
| Garibotto, FM | 1 |
| Enriz, RD | 1 |
| Zacchino, SA | 1 |
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Wang, K | 1 |
| Wu, Y | 1 |
| Chi, Z | 1 |
| Shu, C | 1 |
| Li, L | 1 |
| Wei, J | 1 |
| Tao, L | 1 |
| Ma, P | 1 |
| Ding, L | 1 |
| Sadeghi, G | 1 |
| Khaksar, AA | 1 |
| Bassiri Jahromi, S | 1 |
| Amirkhani, A | 1 |
| Eslamifar, A | 1 |
| Ajdary, S | 1 |
| Katiraee, F | 1 |
| Taeb, J | 1 |
| Paskiabi, FA | 1 |
| Sayyah, M | 1 |
| Lenie, S | 1 |
| Smitz, J | 1 |
| Avolio, M | 1 |
| Grosso, S | 1 |
| Bruschetta, G | 1 |
| De Rosa, R | 1 |
| Camporese, A | 1 |
| Huang, Q | 1 |
| Yu, Y | 1 |
| Tang, C | 1 |
| Peng, X | 1 |
| Friedman, EJ | 1 |
| Fraser, IP | 1 |
| Wang, YH | 1 |
| Bergman, AJ | 1 |
| Li, CC | 1 |
| Larson, PJ | 1 |
| Chodakewitz, J | 1 |
| Wagner, JA | 1 |
| Stoch, SA | 1 |
| Venishetty, VK | 1 |
| Parikh, N | 1 |
| Sistla, R | 1 |
| Ahmed, FJ | 1 |
| Diwan, PV | 1 |
| Vander Heyde, Y | 1 |
| Nguyet, AN | 1 |
| Detaevenier, MR | 1 |
| Massart, DL | 2 |
| Plaizier-Vercammen, J | 2 |
| Bhoopathy, S | 1 |
| Sarkar, MA | 1 |
| Karnes, HT | 1 |
| Bernal, JL | 1 |
| Toribio, L | 1 |
| del Nozal, MJ | 1 |
| Nieto, EM | 1 |
| Montequi, MI | 1 |
| Nguyen, MN | 1 |
| Tallieu, L | 1 |
| Vander Heyden, Y | 1 |
| Abou-Attia, FM | 1 |
| Issa, YM | 1 |
| Abdel-Gawad, FM | 1 |
| Abdel-Hamid, SM | 1 |
| Moody, DE | 1 |
| Walsh, SL | 1 |
| Rollins, DE | 1 |
| Neff, JA | 1 |
| Huang, W | 1 |
| Li, M | 1 |
| Alnouti, Y | 1 |
| Leverence, R | 1 |
| Bi, H | 1 |
| Gusev, AI | 1 |
| Kotsuma, M | 1 |
| Tokui, T | 1 |
| Freudenthaler, S | 1 |
| Nishimura, K | 1 |
| Colombo, AL | 1 |
| Barchiesi, F | 1 |
| McGough, DA | 1 |
| Rinaldi, MG | 1 |
| Chandra, J | 1 |
| Patwari, AK | 1 |
| Aoki, Y | 1 |
| Yoshihara, F | 1 |
| Kondoh, M | 1 |
| Nakamura, Y | 1 |
| Nakayama, N | 1 |
| Arisawa, M | 1 |
| Ghahramani, P | 1 |
| Lennard, MS | 1 |
| Woolf, E | 1 |
| Haddix, HM | 1 |
| Matuszewski, B | 1 |
| Paine, MF | 1 |
| Schmiedlin-Ren, P | 1 |
| Watkins, PB | 1 |
| Low, AS | 1 |
| Wangboonskul, J | 1 |
| Veldhuis, JD | 1 |
| Zwart, A | 1 |
| Mulligan, T | 1 |
| Iranmanesh, A | 1 |
| de Bruijn, P | 1 |
| Kehrer, DF | 1 |
| Verweij, J | 1 |
| Sparreboom, A | 1 |
| Crego, AL | 1 |
| Gómez, J | 1 |
| Marina, ML | 1 |
| Lavandera, JL | 1 |
| Peng, TZ | 1 |
| Cheng, Q | 1 |
| Yang, CF | 1 |
| Fernández-Torres, B | 2 |
| Pereiro, M | 1 |
| Guarro, J | 2 |
| Bajad, S | 1 |
| Johri, RK | 1 |
| Singh, K | 1 |
| Singh, J | 1 |
| Bedi, KL | 1 |
| Chen, YL | 1 |
| Felder, L | 1 |
| Jiang, X | 1 |
| Naidong, W | 1 |
| Crawford, F | 1 |
| Young, P | 1 |
| Godfrey, C | 1 |
| Bell-Syer, SE | 1 |
| Hart, R | 1 |
| Brunt, E | 1 |
| Russell, I | 1 |
| Pujol, I | 1 |
| Capilla, J | 1 |
| Ortoneda, M | 1 |
| Badcock, NR | 1 |
| Davies, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone in Human Subjects[NCT00504413] | Phase 1 | 20 participants (Anticipated) | Interventional | 2007-07-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ketoconazole and Sensitivity and Specificity
| Article | Year |
|---|---|
Diagnosis and treatment of kala-azar.
Topics: Allopurinol; Amphotericin B; Antimony Sodium Gluconate; Child; Combined Modality Therapy; Humans; Ke | 1994 |
Oral treatments for toenail onychomycosis: a systematic review.
Topics: Administration, Oral; Antifungal Agents; Dose-Response Relationship, Drug; Drug Administration Sched | 2002 |
4 trials available for ketoconazole and Sensitivity and Specificity
| Article | Year |
|---|---|
A highly sensitive LC-MS/MS method for determination of ketoconazole in human plasma: Application to a clinical study of the exposure to ketoconazole in patients after topical administration.
Topics: Administration, Topical; Adult; Chromatography, High Pressure Liquid; Dermatitis, Seborrheic; Drug S | 2016 |
Effect of different durations and formulations of diltiazem on the single-dose pharmacokinetics of midazolam: how long do we go?
Topics: Adult; Area Under Curve; Chemistry, Pharmaceutical; Cross-Over Studies; Cytochrome P-450 CYP3A; Cyto | 2011 |
Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individuals.
Topics: Administration, Oral; Analysis of Variance; Area Under Curve; Biological Availability; Cross-Over St | 2004 |
Effects of ketoconazole and quinidine on pharmacokinetics of pactimibe and its plasma metabolite, R-125528, in humans.
Topics: Adult; Alkanes; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind | 2008 |
28 other studies available for ketoconazole and Sensitivity and Specificity
| Article | Year |
|---|---|
Synthesis and antifungal activity of (Z)-5-arylidenerhodanines.
Topics: Antifungal Agents; Computer Simulation; Drug Design; Microbial Sensitivity Tests; Microwaves; Mitosp | 2007 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Fungistatic effects of optical brightener 220 against Trichophyton tonsurans, Aspergillus fumigatus and Candida albicans.
Topics: Antifungal Agents; Aspergillus fumigatus; Candida albicans; Cells, Cultured; Culture Media; Fibrobla | 2009 |
Steroidogenesis-disrupting compounds can be effectively studied for major fertility-related endpoints using in vitro cultured mouse follicles.
Topics: Aminoglutethimide; Animals; Animals, Newborn; Diethylhexyl Phthalate; Dose-Response Relationship, Dr | 2009 |
Direct antifungal susceptibility testing of positive Candida blood cultures by sensititre YeastOne.
Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Flucy | 2009 |
Determination of commonly used azole antifungals in various waters and sewage sludge using ultra-high performance liquid chromatography-tandem mass spectrometry.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Imidazoles; Ketoconazole; Linear Models; Re | 2010 |
Application of validated RP-HPLC method for simultaneous determination of docetaxel and ketoconazole in solid lipid nanoparticles.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Docetaxel; Drug Delivery System | 2011 |
Simultaneous determination of ketoconazole and formaldehyde in a shampoo: liquid chromatography method development and validation.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Excipients; Formaldehyde; Hair Preparations | 2002 |
Characterization of quinidine 3-hydroxylation as a probe for the CYP 3A enzyme using a novel capillary electrophoresis technique.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP3A; Electrophoresis, Capilla | 2002 |
Separation of antifungal chiral drugs by SFC and HPLC: a comparative study.
Topics: Amylose; Antifungal Agents; Benzoates; Carbamates; Cellulose; Chromatography, High Pressure Liquid; | 2002 |
Validation of an HPLC method on short columns to assay ketoconazole and formaldehyde in shampoo.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Excipients; Formaldehyde; Hair Preparations | 2003 |
Quantitative determination of some pharmaceutical piperazine derivatives through complexation with iron(III) chloride.
Topics: Chlorides; Drug Stability; Ferric Compounds; Hydrogen-Ion Concentration; Ketoconazole; Ointments; Pi | 2003 |
Increase of the LC-MS/MS sensitivity and detection limits using on-line sample preparation with large volume plasma injection.
Topics: Animals; Calibration; Chromatography, Liquid; Ketoconazole; Propranolol; Rats; Reproducibility of Re | 2005 |
Comparison of Etest and National Committee for Clinical Laboratory Standards broth macrodilution method for azole antifungal susceptibility testing.
Topics: Antifungal Agents; Candida; Cryptococcus neoformans; Double-Blind Method; Fluconazole; Itraconazole; | 1995 |
Ro 09-1470 is a selective inhibitor of P-450 lanosterol C-14 demethylase of fungi.
Topics: Animals; Antifungal Agents; Carbon Monoxide; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; Cytoch | 1993 |
Quantitative analysis of amitriptyline and nortriptyline in human plasma and liver microsomal preparations by high-performance liquid chromatography.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chromatography, High | 1996 |
Determination of an in vivo metabolite of a human immunodeficiency virus protease-inhibitor in human plasma by high-performance liquid chromatography with tandem mass spectrometry.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Circadian Rhythm; HIV Protease Inhibitors; | 1997 |
Cytochrome P-450 1A1 expression in human small bowel: interindividual variation and inhibition by ketoconazole.
Topics: Blotting, Western; Caco-2 Cells; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP3A; Cytochrome P-450 E | 1999 |
An HPLC assay for the determination of ketoconazole in common pharmaceutical preparations.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Hair Preparations; Ketoconazole; Ointments; | 1999 |
Muting of androgen negative feedback unveils impoverished gonadotropin-releasing hormone/luteinizing hormone secretory reactivity in healthy older men.
Topics: Adolescent; Adult; Aged; Aging; Androgens; Androstenedione; Dehydroepiandrosterone; Feedback; Follic | 2001 |
Liquid chromatographic determination of ketoconazole, a potent inhibitor of CYP3A4-mediated metabolism.
Topics: Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 | 2001 |
Application of capillary zone electrophoresis with off-line solid-phase extraction to in vitro metabolism studies of antifungals.
Topics: Acetic Acid; Acetonitriles; Antifungal Agents; Clotrimazole; Drug Stability; Electrophoresis, Capill | 2001 |
Adsorptive behavior and electrochemical determination of the anti-fungal agent ketoconazole.
Topics: Adsorption; Antifungal Agents; Calibration; Electrochemistry; Ketoconazole; Reproducibility of Resul | 2001 |
Comparison of two methods for antifungal susceptibility testing of Trichophyton rubrum.
Topics: Antifungal Agents; Clotrimazole; Culture Media; Humans; Itraconazole; Ketoconazole; Microbial Sensit | 2002 |
Simple high-performance liquid chromatography method for the simultaneous determination of ketoconazole and piperine in rat plasma and hepatocyte culture.
Topics: Alkaloids; Animals; Benzodioxoles; Biological Availability; Chromatography, High Pressure Liquid; He | 2002 |
Determination of ketoconazole in human plasma by high-performance liquid chromatography-tandem mass spectrometry.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Humans; Ketoconazole; Mass Spectrometry; Re | 2002 |
Use of the sensititre colorimetric microdilution panel for antifungal susceptibility testing of dermatophytes.
Topics: Amphotericin B; Antifungal Agents; Arthrodermataceae; Colorimetry; Coloring Agents; Dermatomycoses; | 2002 |
Assay of itraconazole in nail clippings by reversed phase, high performance liquid chromatography.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Drug Stability; Humans; Itraconazole; Ketoc | 1990 |