ketoconazole has been researched along with Seizures in 7 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three consecutive cases of severe aplastic anemia undergoing immunosuppressive therapy with cyclosporin A (CyA) and high-dose methylprednisolone (HDMP) developed grand mal seizures after receiving ketoconazole treatment." | 7.68 | Ketoconazole and high-dose methylprednisolone predisposing to cyclosporine-induced seizures: report of 3 cases. ( Chia, LG; Gau, JP; Hwang, WL; Young, JH, 1992) |
| "Three consecutive cases of severe aplastic anemia undergoing immunosuppressive therapy with cyclosporin A (CyA) and high-dose methylprednisolone (HDMP) developed grand mal seizures after receiving ketoconazole treatment." | 3.68 | Ketoconazole and high-dose methylprednisolone predisposing to cyclosporine-induced seizures: report of 3 cases. ( Chia, LG; Gau, JP; Hwang, WL; Young, JH, 1992) |
| "Pretreatment with ketoconazole significantly increased the percentage of animals with induced seizures in oestrus but not in dioestrus as compared to controls, probably through reduced progesterone levels." | 1.31 | Effects of ketoconazole on oestrus cycle and convulsant action of pentylenetetrazol in mice. ( Acevedo, X; Bustamante, D; Miranda, HF; Pesce, ME; Pinardi, G, 2001) |
| "The rhabdomyolysis was preceded by a grand mal seizure probably caused by a combination of cyclosporin A and corticosteroids given for the prevention and treatment of acute graft-versus-host disease." | 1.28 | Fatal rhabdomyolysis as a complication of bone marrow transplantation. ( Järventie, G; Ruutu, T; Volin, L, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kamiński, K | 2 |
| Rapacz, A | 2 |
| Łuszczki, JJ | 2 |
| Latacz, G | 3 |
| Obniska, J | 1 |
| Kieć-Kononowicz, K | 3 |
| Filipek, B | 1 |
| Zagaja, M | 1 |
| Andres-Mach, M | 1 |
| Kuder, K | 1 |
| Łażewska, D | 1 |
| Schwed, JS | 1 |
| Karcz, T | 1 |
| Stark, H | 1 |
| Karolak-Wojciechowska, J | 1 |
| Eghwrudjakpor, PO | 1 |
| Allison, AB | 1 |
| Pesce, ME | 1 |
| Acevedo, X | 1 |
| Bustamante, D | 1 |
| Miranda, HF | 1 |
| Pinardi, G | 1 |
| Hwang, WL | 1 |
| Gau, JP | 1 |
| Young, JH | 1 |
| Chia, LG | 1 |
| Volin, L | 1 |
| Järventie, G | 1 |
| Ruutu, T | 1 |
7 other studies available for ketoconazole and Seizures
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives.
Topics: Amides; Animals; Anticonvulsants; Benzylamines; Convulsants; Disease Models, Animal; Dose-Response R | 2015 |
Design, synthesis, and anticonvulsant activity of new hybrid compounds derived from 2-(2,5-dioxopyrrolidin-1-yl)propanamides and 2-(2,5-dioxopyrrolidin-1-yl)butanamides.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Ele | 2015 |
Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Humans; Ligands; Male; Mic | 2016 |
Neurocryptococcosis in a 10-year-old immunocompetent girl.
Topics: Antifungal Agents; Biopsy, Fine-Needle; Brain; Brain Abscess; Child; Consciousness Disorders; Cranio | 2009 |
Effects of ketoconazole on oestrus cycle and convulsant action of pentylenetetrazol in mice.
Topics: Animals; Antifungal Agents; Convulsants; Estrous Cycle; Female; Injections, Subcutaneous; Ketoconazo | 2001 |
Ketoconazole and high-dose methylprednisolone predisposing to cyclosporine-induced seizures: report of 3 cases.
Topics: Adolescent; Adult; Anemia, Aplastic; Cyclosporine; Drug Therapy, Combination; Female; Humans; Immuno | 1992 |
Fatal rhabdomyolysis as a complication of bone marrow transplantation.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Bone Marrow Transplantation; Cyclosporins; Graft vs H | 1990 |