ketoconazole has been researched along with Schizophrenia in 6 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Antiglucocorticoids, such as ketoconazole, have been investigated as antidepressant agents in major depression and other conditions." | 5.10 | Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot study. ( Lichtmacher, J; Marco, EJ; Poole, JH; Reus, VI; Vinogradov, S; Wolkowitz, OM, 2002) |
| " As ciproxifan and thioperamide are inhibitors of cytochrome P450 enzymes, responsible for metabolizing risperidone and haloperidol, the possibility that the augmentation of antipsychotics by imidazoles resulted from drug-drug interactions was tested." | 1.33 | Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug-drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs. ( Ballard, ME; Cowart, M; Decker, MW; Esbenshade, TA; Faghih, R; Fox, GB; Hancock, AA; Pan, L; Roberts, S; Rueter, LE; Zhang, M, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chetty, M | 1 |
| d'Esposito, F | 1 |
| Zhang, WV | 1 |
| Glen, J | 1 |
| Dore, G | 1 |
| Stankovic, Z | 1 |
| Edwards, RJ | 1 |
| Ramzan, I | 1 |
| Murray, M | 1 |
| Reist, C | 1 |
| Wu, JC | 1 |
| Lilja, Y | 1 |
| Mukherjee, J | 1 |
| Gripeos, D | 1 |
| Constantinescu, C | 1 |
| Raggi, MA | 1 |
| Mercolini, L | 1 |
| Ozdemir, V | 1 |
| Marco, EJ | 1 |
| Wolkowitz, OM | 1 |
| Vinogradov, S | 1 |
| Poole, JH | 1 |
| Lichtmacher, J | 1 |
| Reus, VI | 1 |
| Fogl, T | 1 |
| Margolese, HC | 1 |
| Zhang, M | 1 |
| Ballard, ME | 1 |
| Pan, L | 1 |
| Roberts, S | 1 |
| Faghih, R | 1 |
| Cowart, M | 1 |
| Esbenshade, TA | 1 |
| Fox, GB | 1 |
| Decker, MW | 1 |
| Hancock, AA | 1 |
| Rueter, LE | 1 |
| Lane, HY | 1 |
| Chiu, CC | 1 |
| Kazmi, Y | 1 |
| Desai, H | 1 |
| Lam, YW | 1 |
| Jann, MW | 1 |
| Chang, WH | 1 |
1 trial available for ketoconazole and Schizophrenia
| Article | Year |
|---|---|
Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot study.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Depression; Double-Blind Method; Female; Glucoco | 2002 |
5 other studies available for ketoconazole and Schizophrenia
| Article | Year |
|---|---|
In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation.
Topics: Adult; Antipsychotic Agents; Biotransformation; Chromatography, High Pressure Liquid; Clozapine; Cyt | 2009 |
Ketoconazole-associated preferential increase in dopamine D2 receptor occupancy in striatum compared to pituitary in vivo: role for drug transporters?
Topics: Administration, Oral; Adult; Anti-Allergic Agents; Antipsychotic Agents; ATP Binding Cassette Transp | 2012 |
Fungal dermatitis with olanzapine in schizophrenia.
Topics: Adult; Antifungal Agents; Antipsychotic Agents; Benzodiazepines; Drug Eruptions; Humans; Ketoconazol | 2003 |
Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug-drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Benzofurans; Brain Chemistry; Cataplexy; Cytochrome P-450 Enzyme Syst | 2005 |
Lack of CYP3A4 inhibition by grapefruit juice and ketoconazole upon clozapine administration in vivo.
Topics: Adult; Antifungal Agents; Antipsychotic Agents; Beverages; Citrus; Clozapine; Cross-Over Studies; Cy | 2001 |