ketoconazole has been researched along with Primary Myelofibrosis in 2 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Primary Myelofibrosis: A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fedratinib is an orally administered Janus kinase 2-selective inhibitor that is indicated for the treatment of adult patients with intermediate-2 or high-risk myelofibrosis in the United States." | 1.56 | Effects of repeated oral doses of ketoconazole on a sequential ascending single oral dose of fedratinib in healthy subjects. ( Kanamaluru, V; Krishna, G; Ogasawara, K; Palmisano, M; Xu, C, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ogasawara, K | 1 |
| Xu, C | 1 |
| Kanamaluru, V | 1 |
| Palmisano, M | 1 |
| Krishna, G | 2 |
| Wu, F | 1 |
| Surapaneni, S | 1 |
2 other studies available for ketoconazole and Primary Myelofibrosis
| Article | Year |
|---|---|
Effects of repeated oral doses of ketoconazole on a sequential ascending single oral dose of fedratinib in healthy subjects.
Topics: Adult; Area Under Curve; Cohort Studies; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Dose | 2020 |
Physiologically based pharmacokinetic modeling to assess metabolic drug-drug interaction risks and inform the drug label for fedratinib.
Topics: Area Under Curve; Computer Simulation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome | 2020 |