ketoconazole has been researched along with Pregnancy in 58 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the clinical efficacy of ketoconazole (KCZ) as an inhibitory enzyme on ovarian steroidogenesis, in prevention of ovarian hyper- stimulation syndrome (OHSS) during assisted reproductive technology (ART) in patients with polycystic ovarian syndrome (PCOS)." | 9.11 | The role of ketoconazole in the prevention of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during assisted reproductive technology cycles. ( Ahmadi, J; Amirchaghmaghi, E; Baghestani, AR; Owj, M; Tehrani-Nejad, ES, 2005) |
| "To evaluate the role of ketoconazole in prevention of ovarian hyperstimulation syndrome (OHSS) in women with the polycystic ovary syndrome (PCOS) undergoing ovarian stimulation with gonadotropins." | 9.10 | A double-blind, randomized, placebo-controlled study to assess the efficacy of ketoconazole for reducing the risk of ovarian hyperstimulation syndrome. ( Alborzi, S; Pakniat, M; Parsanezhad, ME; Schmidt, EH, 2003) |
| "We describe a case of a CD patient managed with Ketoconazole during the first and second trimester and other cares for her metabolic CS aspects during pregnancy." | 7.81 | A successful case of Cushing's disease pregnancy treated with ketoconazole. ( Costenaro, F; Czepielewski, MA; de Lima, PB; Rodrigues, TC; Rollin, G; Ruszczyk, J, 2015) |
| "Ketoconazole is the most widely used medical treatment for Cushing's syndrome, but, because of its potential to cause birth defects, it is not recommended during pregnancy." | 7.77 | Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation. ( Barber, M; Boronat, M; López-Plasencia, Y; Marrero, D; Nóvoa, FJ; Schamann, Y, 2011) |
| "A 25-year-old pregnant women with cryptococcal meningitis treated with itraconazole during the first few weeks and 12th-16th week of pregnancy is reported." | 7.68 | Itraconazole in cryptococcal meningitis in pregnancy: a case report. ( Chotmongkol, V; Sookprasert, A, 1992) |
| " We report a patient with Cushing's syndrome due to adrenocortical adenoma who became pregnant and was successfully treated with ketoconazole during the last period of pregnancy." | 7.68 | Successful treatment with ketoconazole of Cushing's syndrome in pregnancy. ( Alvarez, A; Amado, JA; Freijanes, J; Gonzalez, EM; Otero, M; Pesquera, C, 1990) |
| "The ketoconazole was shift to metyrapone but afterwards ketoconazole was added again." | 5.46 | A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone. ( Michalak, R; Zieleniewski, W, 2017) |
| "Ketoconazole (KCZ) is an imidazole antifungal agent that also affects P450 enzymes of the mammalian steroidogenic system." | 5.30 | Ketoconazole impairs early pregnancy and the decidual cell response via alterations in ovarian function. ( Cummings, AM; Hedge, JL; Laskey, J, 1997) |
| "The combination of ketoconazole and cindamycin was effective to prevent premature membrane rupture in patients with vulvovaginitis." | 5.13 | [Ketoconazole and clindamycin efficacy vs oral clindamycin in premature membranes rupture prevention]. ( Castillo Huerta, E; Garibay Valencia, M; Mirabent-González, F, 2008) |
| "To assess the clinical efficacy of ketoconazole (KCZ) as an inhibitory enzyme on ovarian steroidogenesis, in prevention of ovarian hyper- stimulation syndrome (OHSS) during assisted reproductive technology (ART) in patients with polycystic ovarian syndrome (PCOS)." | 5.11 | The role of ketoconazole in the prevention of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during assisted reproductive technology cycles. ( Ahmadi, J; Amirchaghmaghi, E; Baghestani, AR; Owj, M; Tehrani-Nejad, ES, 2005) |
| "To evaluate the role of ketoconazole in prevention of ovarian hyperstimulation syndrome (OHSS) in women with the polycystic ovary syndrome (PCOS) undergoing ovarian stimulation with gonadotropins." | 5.10 | A double-blind, randomized, placebo-controlled study to assess the efficacy of ketoconazole for reducing the risk of ovarian hyperstimulation syndrome. ( Alborzi, S; Pakniat, M; Parsanezhad, ME; Schmidt, EH, 2003) |
| "We describe a case of a CD patient managed with Ketoconazole during the first and second trimester and other cares for her metabolic CS aspects during pregnancy." | 3.81 | A successful case of Cushing's disease pregnancy treated with ketoconazole. ( Costenaro, F; Czepielewski, MA; de Lima, PB; Rodrigues, TC; Rollin, G; Ruszczyk, J, 2015) |
| "Ketoconazole is the most widely used medical treatment for Cushing's syndrome, but, because of its potential to cause birth defects, it is not recommended during pregnancy." | 3.77 | Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation. ( Barber, M; Boronat, M; López-Plasencia, Y; Marrero, D; Nóvoa, FJ; Schamann, Y, 2011) |
| "Active Ca transport in the duodenum and the circulating level of calcitriol are elevated during pregnancy and lactation in the rat." | 3.69 | Suppression of circulating calcitriol and duodenal active Ca transport by ketoconazole in pregnant rats. ( Boass, A; Toverud, SU, 1995) |
| "A 25-year-old pregnant women with cryptococcal meningitis treated with itraconazole during the first few weeks and 12th-16th week of pregnancy is reported." | 3.68 | Itraconazole in cryptococcal meningitis in pregnancy: a case report. ( Chotmongkol, V; Sookprasert, A, 1992) |
| " We report a patient with Cushing's syndrome due to adrenocortical adenoma who became pregnant and was successfully treated with ketoconazole during the last period of pregnancy." | 3.68 | Successful treatment with ketoconazole of Cushing's syndrome in pregnancy. ( Alvarez, A; Amado, JA; Freijanes, J; Gonzalez, EM; Otero, M; Pesquera, C, 1990) |
| "Pregnancy is a rare occurrence in women with Cushing's syndrome." | 2.38 | Cushing's syndrome and pregnancy. ( Aron, DC; Schnall, AM; Sheeler, LR, 1990) |
| " Our knowledge about how chemicals can cause adverse health outcomes in females is, however, poorer than our knowledge in males." | 1.62 | Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole. ( Boberg, J; Christiansen, S; Draskau, MK; Johansson, HKL; Svingen, T, 2021) |
| "The ketoconazole was shift to metyrapone but afterwards ketoconazole was added again." | 1.46 | A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone. ( Michalak, R; Zieleniewski, W, 2017) |
| "However, pregnancy is at risk even when ACTH and cortisol levels are normalized by treatment." | 1.38 | Course of pregnancies in women with Cushing's disease treated by gamma-knife. ( Cannavò, S; Cotta, OR; Ferraù, F; Losa, M; Ragonese, M; Torre, ML; Trimarchi, F, 2012) |
| "Fenticonazole was assessed by European Committee on Antimicrobial Susceptibility Testing and CLSI microdilution methods for the first time, and the results showed excellent agreement (97%) and significant interclass correlation coefficient (P < 0." | 1.35 | Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes. ( Alexopoulos, EC; Antonopoulou, S; Aoun, M; Baka, S; Grigoriou, O; Kalambokas, T; Kouskouni, E; Logothetis, E; Papadias, K; Velegraki, A; Zannos, A, 2009) |
| "Ketoconazole was administered orally at 0 and 25 mg/kg/day during gestation days (GDs) 12 to 14, and the placentas were sampled on GDs 15, 17 and 21." | 1.35 | Histopathological effect of ketoconazole on rat placenta. ( Abe, M; Furukawa, S; Hayashi, S; Ogawa, I; Usuda, K, 2008) |
| "Ketoconazole (KT) is a broad-spectrum antifungal agent whose pharmacological activity is based on the capability to interfere with steroid biosynthesis through an interaction with fungal cytochrome P-450 enzymes and thereby avoiding the formation of fungal walls." | 1.35 | Prednisone reduces ketoconazole-induced skeletal defects in rat fetuses. ( Amaral, VC; Nunes, GP, 2009) |
| "Ketoconazole has been given a teratogenic classification of C by the US Food and Drug Administration, but human controlled epidemiological studies of the treatment's effects have not been reported." | 1.33 | Population-based case-control study of oral ketoconazole treatment for birth outcomes. ( Czeizel, AE; Kazy, Z; Puhó, E, 2005) |
| "Spinal cord compressions are mainly due to Pott disease." | 1.30 | [Dorsal cord compression by aspergilloma. Apropos of a case]. ( Ba, MC; Badiane, M; Badiane, SB; Gueye, EM; Gueye, M; Ndao, AK; Sakho, Y, 1997) |
| "Perilla ketone (PK) is a potent lung toxin that causes increased microvascular permeability pulmonary edema in grazing animals." | 1.29 | Perilla ketone increases endothelial cell monolayer permeability in vitro. ( Alexander, JS; Harris, TR; Haselton, FR; Waters, CM, 1993) |
| "Bacterial vaginosis was more common in non-pregnant women (33% vs 23%) whereas C." | 1.29 | Aetiology of vaginal infections in pregnant and non-pregnant women in Barbados. ( Levett, PN, 1995) |
| "Ketoconazole was without effect on the 3 beta-HSD-I and 17 beta-HSD activities when using [3H] pregnenolone and [3H] oestradiol, respectively, as substrates." | 1.27 | Effect of ketoconazole on placental aromatase, 3 beta-hydroxysteroid dehydrogenase-isomerase and 17 beta-hydroxysteroid dehydrogenase. ( Ayub, M; Stitch, SR, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (18.97) | 18.7374 |
| 1990's | 15 (25.86) | 18.2507 |
| 2000's | 11 (18.97) | 29.6817 |
| 2010's | 14 (24.14) | 24.3611 |
| 2020's | 7 (12.07) | 2.80 |
| Authors | Studies |
|---|---|
| Rotstein, DM | 1 |
| Kertesz, DJ | 1 |
| Walker, KA | 1 |
| Swinney, DC | 1 |
| Antonopoulou, S | 1 |
| Aoun, M | 1 |
| Alexopoulos, EC | 1 |
| Baka, S | 1 |
| Logothetis, E | 1 |
| Kalambokas, T | 1 |
| Zannos, A | 1 |
| Papadias, K | 1 |
| Grigoriou, O | 1 |
| Kouskouni, E | 1 |
| Velegraki, A | 1 |
| Gobbi, S | 1 |
| Zimmer, C | 2 |
| Belluti, F | 1 |
| Rampa, A | 1 |
| Hartmann, RW | 3 |
| Recanatini, M | 1 |
| Bisi, A | 1 |
| Marchais-Oberwinkler, S | 1 |
| Wetzel, M | 1 |
| Ziegler, E | 1 |
| Kruchten, P | 1 |
| Werth, R | 1 |
| Henn, C | 1 |
| Frotscher, M | 1 |
| Stefanachi, A | 1 |
| Favia, AD | 1 |
| Nicolotti, O | 1 |
| Leonetti, F | 1 |
| Pisani, L | 1 |
| Catto, M | 1 |
| Carotti, A | 1 |
| Johnson, KJ | 1 |
| Costa, E | 1 |
| Marshall, V | 1 |
| Sriram, S | 1 |
| Venkatraman, A | 1 |
| Stebbins, K | 1 |
| LaRocca, J | 1 |
| Tang, L | 1 |
| Shi, L | 1 |
| Tang, Y | 1 |
| Ying, Y | 1 |
| Dong, Y | 1 |
| Li, H | 1 |
| Ge, RS | 1 |
| Li, T | 1 |
| Vazakidou, P | 1 |
| Leonards, PEG | 1 |
| Damdimopoulos, A | 1 |
| Panagiotou, EM | 1 |
| Arnelo, C | 1 |
| Jansson, K | 1 |
| Pettersson, K | 1 |
| Papaikonomou, K | 1 |
| van Duursen, M | 1 |
| Damdimopoulou, P | 1 |
| Kugathas, I | 1 |
| Johansson, HKL | 3 |
| Chan Sock Peng, E | 1 |
| Toupin, M | 1 |
| Evrard, B | 1 |
| Darde, TA | 1 |
| Boberg, J | 3 |
| Draskau, MK | 2 |
| Rolland, AD | 1 |
| Mazaud-Guittot, S | 1 |
| Chalmel, F | 1 |
| Svingen, T | 3 |
| Franssen, D | 1 |
| Lopez-Rodriguez, D | 1 |
| Lavergne, A | 1 |
| Terwagne, Q | 1 |
| Christiansen, S | 2 |
| Parent, AS | 1 |
| Melau, C | 1 |
| Nielsen, JE | 1 |
| Perlman, S | 1 |
| Lundvall, L | 1 |
| Langhoff Thuesen, L | 1 |
| Juul Hare, K | 1 |
| Schou Hammerum, M | 1 |
| Frederiksen, H | 1 |
| Mitchell, RT | 1 |
| Juul, A | 1 |
| Jørgensen, A | 1 |
| Slominski, AT | 1 |
| Kim, TK | 1 |
| Shehabi, HZ | 1 |
| Tang, EK | 1 |
| Benson, HA | 1 |
| Semak, I | 1 |
| Lin, Z | 1 |
| Yates, CR | 1 |
| Wang, J | 1 |
| Li, W | 1 |
| Tuckey, RC | 1 |
| Costenaro, F | 1 |
| Rodrigues, TC | 1 |
| de Lima, PB | 1 |
| Ruszczyk, J | 1 |
| Rollin, G | 1 |
| Czepielewski, MA | 1 |
| Ichikawa, A | 1 |
| Tamada, H | 1 |
| Zieleniewski, W | 1 |
| Michalak, R | 1 |
| Castillo Huerta, E | 1 |
| Garibay Valencia, M | 1 |
| Mirabent-González, F | 1 |
| Furukawa, S | 1 |
| Hayashi, S | 1 |
| Usuda, K | 1 |
| Abe, M | 1 |
| Ogawa, I | 1 |
| Amaral, VC | 1 |
| Nunes, GP | 1 |
| Dodo, T | 1 |
| Uchida, K | 2 |
| Hirose, T | 1 |
| Fukuta, T | 2 |
| Kojima, C | 1 |
| Shiraishi, I | 1 |
| Kato, E | 2 |
| Horiba, T | 1 |
| Mineshima, H | 2 |
| Okuda, Y | 1 |
| Maeda, M | 1 |
| Katsutani, N | 1 |
| Hirano, K | 1 |
| Aoki, T | 2 |
| Boronat, M | 1 |
| Marrero, D | 1 |
| López-Plasencia, Y | 1 |
| Barber, M | 1 |
| Schamann, Y | 1 |
| Nóvoa, FJ | 1 |
| Matsuno, Y | 1 |
| Mori, C | 1 |
| Bronstein, MD | 1 |
| Paraiba, DB | 1 |
| Jallad, RS | 1 |
| Ma, J | 1 |
| Esplin, MS | 1 |
| Adair, CD | 1 |
| Mason, LA | 1 |
| Graves, SW | 1 |
| Ferraù, F | 1 |
| Losa, M | 1 |
| Cotta, OR | 1 |
| Torre, ML | 1 |
| Ragonese, M | 1 |
| Trimarchi, F | 1 |
| Cannavò, S | 1 |
| Lim, WH | 1 |
| Torpy, DJ | 1 |
| Jeffries, WS | 1 |
| Trainer, PJ | 1 |
| Parsanezhad, ME | 1 |
| Alborzi, S | 1 |
| Pakniat, M | 1 |
| Schmidt, EH | 1 |
| Kazy, Z | 1 |
| Puhó, E | 1 |
| Czeizel, AE | 1 |
| Polli, N | 1 |
| Pecori Giraldi, F | 1 |
| Cavagnini, F | 1 |
| Owj, M | 1 |
| Tehrani-Nejad, ES | 1 |
| Amirchaghmaghi, E | 1 |
| Baghestani, AR | 1 |
| Ahmadi, J | 1 |
| McGregor, JA | 1 |
| Pont, A | 1 |
| Duquesnoy, B | 1 |
| Fournier, E | 1 |
| Berniere, L | 1 |
| Delcambre, B | 1 |
| Boass, A | 1 |
| Toverud, SU | 1 |
| Waters, CM | 1 |
| Alexander, JS | 1 |
| Harris, TR | 1 |
| Haselton, FR | 1 |
| Kukner, S | 1 |
| Kuscu, E | 1 |
| Ergin, T | 1 |
| Gokmen, O | 1 |
| Mazor, M | 1 |
| Chaim, W | 1 |
| Shinwell, ES | 1 |
| Glezerman, M | 1 |
| Levett, PN | 1 |
| Cummings, AM | 1 |
| Hedge, JL | 1 |
| Laskey, J | 1 |
| Ba, MC | 1 |
| Badiane, M | 1 |
| Ndao, AK | 1 |
| Badiane, SB | 1 |
| Sakho, Y | 1 |
| Gueye, EM | 1 |
| Gueye, M | 1 |
| Berwaerts, J | 1 |
| Verhelst, J | 1 |
| Mahler, C | 1 |
| Abs, R | 1 |
| Busowski, JD | 1 |
| Safdar, A | 1 |
| Ali Hassan, H | 1 |
| El-Gezeiry, D | 1 |
| Nafaa, TM | 1 |
| Baghdady, I | 1 |
| Laufer, B | 1 |
| Bender, HG | 1 |
| Chotmongkol, V | 1 |
| Sookprasert, A | 1 |
| Barzilai, A | 1 |
| Sperling, RS | 1 |
| Hyatt, AC | 1 |
| Wedgwood, JF | 1 |
| Reidenberg, BE | 1 |
| Hodes, DS | 1 |
| Amado, JA | 1 |
| Pesquera, C | 1 |
| Gonzalez, EM | 1 |
| Otero, M | 1 |
| Freijanes, J | 1 |
| Alvarez, A | 1 |
| Divers, MJ | 1 |
| Aron, DC | 1 |
| Schnall, AM | 1 |
| Sheeler, LR | 1 |
| Hobbs, ER | 1 |
| Santana, JL | 1 |
| Ramírez-Ronda, CH | 1 |
| Ayub, M | 1 |
| Stitch, SR | 1 |
| Robertson, WH | 1 |
| Lüscher, KP | 1 |
| Schneitter, J | 1 |
| Vogt, HP | 1 |
| Tuthill, SW | 2 |
| Anderson, ML | 1 |
| Odds, FC | 1 |
| Moriello, KA | 1 |
8 reviews available for ketoconazole and Pregnancy
| Article | Year |
|---|---|
Management of pituitary tumors in pregnancy.
Topics: Dopamine Agonists; Female; Humans; Ketoconazole; Metyrapone; Pituitary Neoplasms; Pregnancy; Pregnan | 2011 |
The medical management of Cushing's syndrome during pregnancy.
Topics: Adrenalectomy; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Metyrapone; Pre-Eclam | 2013 |
Corticosteroids and pregnancy.
Topics: Addison Disease; Adrenal Cortex Hormones; Animals; Cushing Syndrome; Female; Hydrocortisone; Hypotha | 2002 |
Cushing's disease and pregnancy.
Topics: ACTH-Secreting Pituitary Adenoma; Adrenocorticotropic Hormone; Female; Humans; Hydrocortisone; Hypot | 2004 |
Cushing's syndrome in pregnancy treated by ketoconazole: case report and review of the literature.
Topics: Adult; Cabergoline; Cushing Syndrome; Dopamine Agonists; Ergolines; Female; Humans; Ketoconazole; Pr | 1999 |
[Current developments in antimycotic therapy in gynecology and obstetrics].
Topics: Animals; Antifungal Agents; Candidiasis, Vulvovaginal; Dose-Response Relationship, Drug; Female; Flu | 1992 |
Cushing's syndrome and pregnancy.
Topics: Adrenalectomy; Carbohydrate Metabolism; Cushing Syndrome; Female; Fetal Diseases; Humans; Hydrocorti | 1990 |
Coccidioidomycosis.
Topics: Adult; Age Factors; Amphotericin B; Arizona; Biopsy; Child; Child, Preschool; Coccidioidomycosis; De | 1989 |
5 trials available for ketoconazole and Pregnancy
| Article | Year |
|---|---|
[Ketoconazole and clindamycin efficacy vs oral clindamycin in premature membranes rupture prevention].
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Clindamycin; Double-Blind Method; Dr | 2008 |
A double-blind, randomized, placebo-controlled study to assess the efficacy of ketoconazole for reducing the risk of ovarian hyperstimulation syndrome.
Topics: Adult; Androgen Antagonists; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combin | 2003 |
The role of ketoconazole in the prevention of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during assisted reproductive technology cycles.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fertilization in Vitr | 2005 |
Vaginal thrush and its management in pregnancy.
Topics: Candidiasis, Vulvovaginal; Female; Humans; Ketoconazole; Microscopy, Phase-Contrast; Pakistan; Pregn | 1995 |
Improved responsiveness of PCOS patients to clomiphene after CYP17a inhibitor.
Topics: Clomiphene; Estrogen Antagonists; Female; Humans; Insulin; Ketoconazole; Polycystic Ovary Syndrome; | 2001 |
45 other studies available for ketoconazole and Pregnancy
| Article | Year |
|---|---|
Stereoisomers of ketoconazole: preparation and biological activity.
Topics: Adrenal Glands; Animals; Cytochrome P-450 Enzyme Inhibitors; Female; Humans; Ketoconazole; Male; Mic | 1992 |
Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes.
Topics: Adult; Antifungal Agents; Candida albicans; Candida glabrata; Candidiasis, Vulvovaginal; Cluster Ana | 2009 |
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.
Topics: Aromatase Inhibitors; Female; Humans; Imidazoles; In Vitro Techniques; Microsomes; Molecular Conform | 2010 |
New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.
Topics: 17-Hydroxysteroid Dehydrogenases; Administration, Oral; Animals; Biological Availability; Cell Line, | 2011 |
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase.
Topics: Aromatase Inhibitors; Cell Line; Coumarins; Drug Design; Escherichia coli; Female; Humans; Imidazole | 2011 |
A microRNA or messenger RNA point of departure estimates an apical endpoint point of departure in a rat developmental toxicity model.
Topics: Animals; Female; Fetal Resorption; Humans; Ketoconazole; MicroRNAs; Pregnancy; Rats; Rats, Sprague-D | 2022 |
Chemicals of environmental concern as inhibitors of human placental 3β-hydroxysteroid dehydrogenase 1 and aromatase: Screening and docking analysis.
Topics: Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Diethylstilbestrol; Environmental Pollutants; Est | 2022 |
Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models.
Topics: Cesarean Section; Endocrine Disruptors; Female; Humans; Ketoconazole; Ovarian Follicle; Ovary; Pregn | 2023 |
Transcriptional profiling of the developing rat ovary following intrauterine exposure to the endocrine disruptors diethylstilbestrol and ketoconazole.
Topics: Animals; Diethylstilbestrol; Endocrine Disruptors; Female; Humans; Ketoconazole; Mice; Ovary; Potass | 2023 |
Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats.
Topics: Animals; Female; Fungicides, Industrial; Gonadotropin-Releasing Hormone; Hypothalamus; Ketoconazole; | 2023 |
Establishment of a Novel Human Fetal Adrenal Culture Model that Supports de Novo and Manipulated Steroidogenesis.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Androgens; Cell Surviv | 2021 |
Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole.
Topics: Anal Canal; Animals; Diethylstilbestrol; Endocrine Disruptors; Female; Genitalia; Humans; Ketoconazo | 2021 |
In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Adrenal Glands; Animals; Caco-2 Cells; Cholesterol Side-Ch | 2014 |
A successful case of Cushing's disease pregnancy treated with ketoconazole.
Topics: Adult; Female; Humans; Ketoconazole; Pituitary ACTH Hypersecretion; Pregnancy; Pregnancy Complicatio | 2015 |
Ketoconazole-induced estrogen deficiency causes transient decrease in placental blood flow associated with hypoxia and later placental weight gain in rats.
Topics: Animals; Antifungal Agents; Estradiol; Estrogens; Female; Hypoxia; Ketoconazole; Organ Size; Placent | 2016 |
A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone.
Topics: Adult; Cushing Syndrome; Drug Therapy, Combination; Female; Humans; Ketoconazole; Metyrapone; Pregna | 2017 |
Histopathological effect of ketoconazole on rat placenta.
Topics: Animals; Apoptosis; Decidua; Female; Fetal Death; Ketoconazole; Mitosis; Organ Size; Placenta; Pregn | 2008 |
Prednisone reduces ketoconazole-induced skeletal defects in rat fetuses.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Dose-Response Relationship, Drug; Drinking; Dr | 2009 |
Increases in discontinuous rib cartilage and fused carpal bone in rat fetuses exposed to the teratogens, busulfan, acetazolamide, vitamin A, and ketoconazole.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Busulfan; Carpal Bones; Cartilage; Diterpenes; | 2010 |
Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation.
Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adult; Cushing Syndrome; Female; | 2011 |
Malformation spectrum induced by ketoconazole after single administration to pregnant rats during the critical period - comparison with vitamin A-induced malformation spectrum.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetal Diseases; Fetu | 2012 |
Increasing evidence for and regulation of a human placental endogenous digitalis-like factor.
Topics: 17-alpha-Hydroxyprogesterone; Cardenolides; Female; Humans; Immunoglobulin Fab Fragments; In Vitro T | 2012 |
Course of pregnancies in women with Cushing's disease treated by gamma-knife.
Topics: 14-alpha Demethylase Inhibitors; Abortion, Spontaneous; Abruptio Placentae; Adult; Female; Humans; H | 2012 |
Population-based case-control study of oral ketoconazole treatment for birth outcomes.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Adult; Antifungal Agents; Birth Weight; Case-Cont | 2005 |
Contraindication of ketoconazole in pregnancy.
Topics: Female; Humans; Ketoconazole; Mycoses; Pregnancy; Pregnancy Complications, Infectious | 1984 |
Ketoconazole for treatment of Candida arthritis.
Topics: Abscess; Adult; Arthritis, Infectious; Candidiasis; Female; Humans; Ketoconazole; Pregnancy; Puerper | 1984 |
Suppression of circulating calcitriol and duodenal active Ca transport by ketoconazole in pregnant rats.
Topics: Animals; Biological Transport, Active; Calcitriol; Calcium; Dose-Response Relationship, Drug; Duoden | 1995 |
Perilla ketone increases endothelial cell monolayer permeability in vitro.
Topics: Actins; Animals; Aorta, Thoracic; Blotting, Western; Cattle; Cell Membrane Permeability; Cytochrome | 1993 |
Asymptomatic amniotic fluid invasion with Candida albicans in preterm premature rupture of membranes. Implications for obstetric and neonatal management.
Topics: Adult; Amniotic Fluid; Amphotericin B; Candida albicans; Candidiasis; Chorioamnionitis; Female; Feta | 1993 |
Aetiology of vaginal infections in pregnant and non-pregnant women in Barbados.
Topics: Adolescent; Adult; Animals; Antifungal Agents; Antitrichomonal Agents; Barbados; Candida albicans; F | 1995 |
Ketoconazole impairs early pregnancy and the decidual cell response via alterations in ovarian function.
Topics: Administration, Oral; Animals; Antifungal Agents; Dose-Response Relationship, Drug; Embryo Implantat | 1997 |
[Dorsal cord compression by aspergilloma. Apropos of a case].
Topics: Abscess; Adult; Antifungal Agents; Aspergillosis; Diagnosis, Differential; Discitis; Epidural Space; | 1997 |
Treatment for coccidioidomycosis in pregnancy?
Topics: Amphotericin B; Antifungal Agents; Coccidioidomycosis; Erythema Nodosum; Female; Fluconazole; Humans | 2001 |
Itraconazole in cryptococcal meningitis in pregnancy: a case report.
Topics: Adult; Amphotericin B; Antifungal Agents; Female; Flucytosine; Humans; Infant, Newborn; Itraconazole | 1992 |
Mother to child transmission of human immunodeficiency virus 1 infection despite zidovudine therapy from 18 weeks of gestation.
Topics: Acyclovir; Adult; Diseases in Twins; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Human | 1990 |
Successful treatment with ketoconazole of Cushing's syndrome in pregnancy.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Cushing Syndrome; Female; Humans; Ketoconazole; Pregnancy; | 1990 |
Ketoconazole treatment of Cushing's syndrome in pregnancy.
Topics: Adenoma; Adrenal Gland Neoplasms; Cushing Syndrome; Female; Humans; Ketoconazole; Pregnancy; Pregnan | 1990 |
[The pregnant woman infected with the human immunodeficiency virus: recommendations for her management].
Topics: Acquired Immunodeficiency Syndrome; Candidiasis; Cytomegalovirus Infections; Female; Humans; Ketocon | 1988 |
Effect of ketoconazole on placental aromatase, 3 beta-hydroxysteroid dehydrogenase-isomerase and 17 beta-hydroxysteroid dehydrogenase.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Aromatase Inhibitors; Estradiol; | 1986 |
Mycology of vulvovaginitis.
Topics: Adrenal Cortex Hormones; Antifungal Agents; Candida; Candida albicans; Candidiasis, Vulvovaginal; Co | 1988 |
[Incidence of Candida infections during pregnancy and their treatment with ketoconazole-ovula].
Topics: Administration, Intravaginal; Candidiasis, Vulvovaginal; Female; Humans; Ketoconazole; Pregnancy; Pr | 1987 |
Disseminated blastomycosis treated with ketoconazole.
Topics: Blastomycosis; Dermatomycoses; Female; Humans; Infant, Newborn; Ketoconazole; Lung Diseases, Fungal; | 1986 |
Adherence of Candida albicans to vaginal epithelia: significance of morphological form and effect of ketoconazole.
Topics: Candida albicans; Female; Humans; In Vitro Techniques; Ketoconazole; Microscopy, Electron; Mucous Me | 1985 |
Ketoconazole: clinical pharmacology and therapeutic recommendations.
Topics: Amphotericin B; Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Drug Interactions; Female; Humans; | 1986 |
Disseminated blastomycosis with intrauterine transmission.
Topics: Adult; Blastomycosis; Female; Humans; Infant, Newborn; Ketoconazole; Pregnancy; Pregnancy Complicati | 1985 |