ketoconazole has been researched along with Pituitary Neoplasms in 32 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An extremely ill patient with Cushing's syndrome caused by adrenocorticotropic hormone producing pituitary macro adenoma responded dramatically to ketoconazole and cabergoline treatment." | 7.78 | Disappearance of pituitary macro adenoma with combination of ketoconazole and cabergoline treatment: an unusual case of Cushing's syndrome with interesting findings. ( Ahmed, A; Furqan, S; Islam, N, 2012) |
| "The direct effects of ketoconazole on the secretion of ACTH by human pituitary adenoma cells from 2 patient with Nelson's syndrome were studied in vitro." | 7.67 | In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome. ( Astorga, R; Bernal, G; Garcia, J; Garcia-Luna, PP; Jimenez Reina, L; Leal-Cerro, A, 1989) |
| " An extremely ill patient with Cushing's syndrome caused by adrenocorticotropic hormone producing pituitary macro adenoma responded dramatically to ketoconazole and cabergoline treatment." | 3.78 | Disappearance of pituitary macro adenoma with combination of ketoconazole and cabergoline treatment: an unusual case of Cushing's syndrome with interesting findings. ( Ahmed, A; Furqan, S; Islam, N, 2012) |
| "The direct effects of ketoconazole on the secretion of ACTH by human pituitary adenoma cells from 2 patient with Nelson's syndrome were studied in vitro." | 3.67 | In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome. ( Astorga, R; Bernal, G; Garcia, J; Garcia-Luna, PP; Jimenez Reina, L; Leal-Cerro, A, 1989) |
| "Ketoconazole has been used as a palliative treatment of Cushing's syndrome, due to its ability to lower cortisol production." | 3.67 | ACTH response to corticotropin releasing hormone in Cushing's disease before and after ketoconazole: in vivo and in vitro studies. ( Boscaro, M; Mantero, F; Menegus, AM; Rampazzo, A; Sonino, N, 1987) |
| "The effect of clinical treatment of hypercortisolism with ketoconazole on ACTH secretion in CD is controversial." | 2.75 | Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6). ( Correa-Silva, SR; Lengyel, AM; Molica, P; Nascif, SO; Sá, LB; Vieira, JG, 2010) |
| "Cushing's disease is a syndromic pathological condition caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (ACTHomas) mediated by hypercortisolemia." | 2.72 | Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach. ( Fukuoka, H; Nakao, T; Ogawa, W; Yamamoto, M, 2021) |
| "ketoconazole (n = 20) in dogs with Cushing's disease was assigned for a period of 180 d." | 2.72 | Retinoic acid as a novel medical therapy for Cushing's disease in dogs. ( Arzt, E; Castillo, V; Giacomini, D; Grossman, AB; Holsboer, F; Labeur, M; Páez-Pereda, M; Stalla, GK; Stalla, J; Theodoropoulou, M, 2006) |
| "Hypercortisolism induced by Cushing disease causes high morbidity and mortality." | 2.48 | New prospects for drug treatment in Cushing disease. ( Barahona Constanzo, MJ; del Pozo Picó, C, 2012) |
| "Cushing's syndrome is a complex endocrine condition with potential serious complications if untreated or inadequately treated." | 2.45 | Drugs in the medical treatment of Cushing's syndrome. ( Schteingart, DE, 2009) |
| "Cushing disease is most frequently caused by pituitary adenomas that secrete adrenocorticotrophic hormone." | 2.44 | Management of recurrent and refractory Cushing disease. ( Aghi, MK, 2008) |
| "To our knowledge, histoplasmosis has not been previously reported in Cushing's disease, and has rarely been reported in patients with exogenous glucocorticoid use." | 2.44 | Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review. ( Jordan, RM; Kosseifi, SG; Nassour, DN; Peiris, AN; Sarubbi, FA; Shaikh, MA, 2007) |
| "The evaluation of β-arrestin mRNA in corticotroph adenomas from CD patients with variable disease activity showed a significant positive correlation between β-arrestin 1 mRNA and urinary cortisol levels." | 1.56 | β-arrestin expression in corticotroph tumor cells is modulated by glucocorticoids. ( Arvigo, M; Bruzzone, E; Dogan, F; Feelders, RA; Ferone, D; Gatto, F; Hofland, L; Lamberts, S; van der Pas, R; van Koetsveld, P, 2020) |
| "The hypercortisolism is a rare endocrine disease characterized by an autonomous steroid secretion or excessive adrenal stimulation by ACTH." | 1.43 | [Indications and future perspectives in the pharmacological treatment of hypercortisolism]. ( Stigliano, A; Toscano, V, 2016) |
| "Ketoconazole, which was initially developed as an antifungal agent, is a potent inhibitor of adrenal steroidogenesis and has therefore been used in the management of Cushing's disease." | 1.42 | Ketoconazole Treatment Decreases the Viability of Immortalized Pituitary Cell Lines Associated with an Increased Expression of Apoptosis-Related Genes and Cell Cycle Inhibitors. ( Bronstein, MD; Carvalho, LR; Guzzo, MF, 2015) |
| "Treatment of Cushing's disease poses interesting dilemmas in clinical practice." | 1.42 | Assessment of the outcomes of the treatment of Cushing's disease in the hospitals of Castilla-La Mancha. ( Aguirre, M; Alramadan, M; Huguet, I; Lamas, C; Quiroga, I; Silva, J; Vicente, A, 2015) |
| "All patients with Cushing's disease treated with Gamma Knife surgery (GKS) were identified." | 1.39 | Results of gamma knife surgery for Cushing's disease. ( Salvetti, DJ; Schmitt, PJ; Sheehan, JP; Vance, ML; Xu, Z, 2013) |
| "Since Cushing's disease due to large pituitary tumors is rare, we evaluated biochemical characteristics at entry and the results of first surgical approach and of adjuvant therapeutic strategies during a long-term follow-up period." | 1.32 | Long-term results of treatment in patients with ACTH-secreting pituitary macroadenomas. ( Almoto, B; Ambrosi, B; Cannavò, S; Corsello, S; Dall'Asta, C; De Menis, E; Lovicu, RM; Trimarchi, F, 2003) |
| "Treatment with ketoconazole normalized urinary free cortisol (UFC) from 433." | 1.32 | Spontaneous remission of Cushing's disease after disappearance of a microadenoma attached to the pituitary stalk. ( Bruno, OD; Díaz, AG; Gómez, RM; Pignatta, AB, 2004) |
| "Ketoconazole, an imidazole is a powerful antimycotic that has recently been used in the treatment of endocrinological and lipid metabolism disorders as well as in anti-cancer chemotherapy." | 1.28 | [Long-term induced effects by only one treatment with ketoconazole on rat tumoral pituitary cells (GH3/B6 strains)]. ( Darret, D; Drouhault, R; Larrue, J; Vacher, AM; Vacher, P; Vilayleck, N, 1991) |
| " Twenty dogs with hyperadrenocorticism (11 with PDH, 9 with adrenocortical tumor) were treated with ketoconazole at a dosage of 15 mg/kg given every 12 hours for a half month to 12 months." | 1.28 | Plasma cortisol response to ketoconazole administration in dogs with hyperadrenocorticism. ( Bruyette, DS; Farver, TB; Feldman, EC; Nelson, RW, 1990) |
| "A patient with invasive basophilic pituitary adenoma is described, in whom the hypercortisolaemia and clinical features persisted despite two attempts to reduce the tumour mass by transfrontal pituitary surgery and external beam radiotherapy." | 1.28 | Persistent Cushing's disease in a patient with invasive pituitary adenoma. ( Dash, RJ; Kak, VK; Khandekar, S, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.38) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 8 (25.00) | 29.6817 |
| 2010's | 11 (34.38) | 24.3611 |
| 2020's | 4 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Pivonello, R | 1 |
| Simeoli, C | 1 |
| Di Paola, N | 1 |
| Colao, A | 1 |
| Gatto, F | 1 |
| Feelders, RA | 1 |
| van der Pas, R | 1 |
| van Koetsveld, P | 1 |
| Bruzzone, E | 1 |
| Arvigo, M | 1 |
| Dogan, F | 1 |
| Lamberts, S | 1 |
| Ferone, D | 1 |
| Hofland, L | 1 |
| Kudsieh, B | 1 |
| Casado López de la Franca, E | 1 |
| Díez Gómez, MA | 1 |
| Ruiz Moreno, JM | 1 |
| Yamamoto, M | 1 |
| Nakao, T | 1 |
| Ogawa, W | 1 |
| Fukuoka, H | 1 |
| Seow, CJ | 1 |
| Young, WF | 1 |
| Sheehan, JP | 1 |
| Xu, Z | 1 |
| Salvetti, DJ | 1 |
| Schmitt, PJ | 1 |
| Vance, ML | 1 |
| Guzzo, MF | 1 |
| Carvalho, LR | 1 |
| Bronstein, MD | 2 |
| Huguet, I | 1 |
| Aguirre, M | 1 |
| Vicente, A | 1 |
| Alramadan, M | 1 |
| Quiroga, I | 1 |
| Silva, J | 1 |
| Lamas, C | 1 |
| Stigliano, A | 1 |
| Toscano, V | 1 |
| Aghi, MK | 1 |
| Correa-Silva, SR | 1 |
| Nascif, SO | 1 |
| Molica, P | 1 |
| Sá, LB | 1 |
| Vieira, JG | 1 |
| Lengyel, AM | 1 |
| Schteingart, DE | 1 |
| Paraiba, DB | 1 |
| Jallad, RS | 1 |
| Shimon, I | 1 |
| Manisterski, Y | 1 |
| Kanner, AA | 1 |
| Ahmed, A | 1 |
| Furqan, S | 1 |
| Islam, N | 1 |
| Barna, M | 1 |
| Wilson, K | 1 |
| Chiaruttini, R | 1 |
| Muchowski, K | 1 |
| Barahona Constanzo, MJ | 1 |
| del Pozo Picó, C | 1 |
| Cannavò, S | 1 |
| Almoto, B | 1 |
| Dall'Asta, C | 1 |
| Corsello, S | 1 |
| Lovicu, RM | 1 |
| De Menis, E | 1 |
| Trimarchi, F | 1 |
| Ambrosi, B | 1 |
| Pignatta, AB | 1 |
| Díaz, AG | 1 |
| Gómez, RM | 1 |
| Bruno, OD | 1 |
| Polli, N | 1 |
| Pecori Giraldi, F | 1 |
| Cavagnini, F | 1 |
| Castillo, V | 1 |
| Giacomini, D | 1 |
| Páez-Pereda, M | 1 |
| Stalla, J | 1 |
| Labeur, M | 1 |
| Theodoropoulou, M | 1 |
| Holsboer, F | 1 |
| Grossman, AB | 1 |
| Stalla, GK | 1 |
| Arzt, E | 1 |
| Kosseifi, SG | 1 |
| Nassour, DN | 1 |
| Shaikh, MA | 1 |
| Sarubbi, FA | 1 |
| Jordan, RM | 1 |
| Peiris, AN | 1 |
| Wolff, DJ | 1 |
| Datto, GA | 1 |
| Samatovicz, RA | 1 |
| Nichols, R | 1 |
| Behrend, EN | 1 |
| Kemppainen, RJ | 1 |
| Clark, TP | 1 |
| Salman, MD | 1 |
| Peterson, ME | 1 |
| Luisetto, G | 1 |
| Zangari, M | 1 |
| Camozzi, V | 1 |
| Boscaro, M | 2 |
| Sonino, N | 2 |
| Fallo, F | 1 |
| Drouhault, R | 2 |
| Vacher, P | 2 |
| Darret, D | 1 |
| Larrue, J | 1 |
| Vacher, AM | 1 |
| Vilayleck, N | 2 |
| Feldman, EC | 1 |
| Bruyette, DS | 1 |
| Nelson, RW | 1 |
| Farver, TB | 1 |
| Dash, RJ | 1 |
| Khandekar, S | 1 |
| Kak, VK | 1 |
| David, JP | 1 |
| Courtes, AM | 1 |
| Dufy, B | 1 |
| Jimenez Reina, L | 1 |
| Leal-Cerro, A | 1 |
| Garcia, J | 1 |
| Garcia-Luna, PP | 1 |
| Astorga, R | 1 |
| Bernal, G | 1 |
| Rampazzo, A | 1 |
| Menegus, AM | 1 |
| Mantero, F | 1 |
9 reviews available for ketoconazole and Pituitary Neoplasms
| Article | Year |
|---|---|
Cushing's disease: adrenal steroidogenesis inhibitors.
Topics: Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Hypokalemia; Ketoconazole; Male; Mety | 2022 |
Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenocorticotropic Hormone; Carcinoma; Dopamine Agonists | 2021 |
Management of recurrent and refractory Cushing disease.
Topics: ACTH-Secreting Pituitary Adenoma; Adrenalectomy; Humans; Hypophysectomy; Ketoconazole; Models, Biolo | 2008 |
Drugs in the medical treatment of Cushing's syndrome.
Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Antiparkinson Agents; Cabergoline; Cushing Sy | 2009 |
Management of pituitary tumors in pregnancy.
Topics: Dopamine Agonists; Female; Humans; Ketoconazole; Metyrapone; Pituitary Neoplasms; Pregnancy; Pregnan | 2011 |
New prospects for drug treatment in Cushing disease.
Topics: Adenoma; Adrenocorticotropic Hormone; Animals; Cabergoline; Clinical Trials as Topic; Clinical Trial | 2012 |
Cushing's disease and pregnancy.
Topics: ACTH-Secreting Pituitary Adenoma; Adrenocorticotropic Hormone; Female; Humans; Hydrocortisone; Hypot | 2004 |
Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review.
Topics: Adenoma; Aminoglutethimide; Dexamethasone; Histoplasmosis; Humans; Itraconazole; Ketoconazole; Lung | 2007 |
Concurrent illness and complications associated with canine hyperadrenocorticism.
Topics: Acute Disease; Animals; Cushing Syndrome; Diabetes Complications; Diabetes Mellitus; Dog Diseases; D | 1994 |
2 trials available for ketoconazole and Pituitary Neoplasms
| Article | Year |
|---|---|
Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6).
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Ghrelin; Hormone Antagonists; | 2010 |
Retinoic acid as a novel medical therapy for Cushing's disease in dogs.
Topics: Adenoma; Adrenocorticotropic Hormone; alpha-MSH; Animals; Body Weight; Creatinine; Dog Diseases; Dog | 2006 |
21 other studies available for ketoconazole and Pituitary Neoplasms
| Article | Year |
|---|---|
β-arrestin expression in corticotroph tumor cells is modulated by glucocorticoids.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adult; Aged; Animals; Anti-Inflammatory Agents; beta-Arre | 2020 |
Open angle glaucoma secondary to endogenous cortisone due to pituitary microadenoma in a young patient, a case report.
Topics: ACTH-Secreting Pituitary Adenoma; Adult; Combined Modality Therapy; Cortisone; Diagnostic Techniques | 2020 |
An Overlooked Cause of Hypokalemia.
Topics: 14-alpha Demethylase Inhibitors; Adenoma; Cabergoline; Cushing Syndrome; Dopamine Agonists; Ergoline | 2017 |
Results of gamma knife surgery for Cushing's disease.
Topics: 14-alpha Demethylase Inhibitors; Female; Follow-Up Studies; Humans; Hypopituitarism; Ketoconazole; M | 2013 |
Ketoconazole Treatment Decreases the Viability of Immortalized Pituitary Cell Lines Associated with an Increased Expression of Apoptosis-Related Genes and Cell Cycle Inhibitors.
Topics: 14-alpha Demethylase Inhibitors; Adrenocorticotropic Hormone; Apoptosis; Cell Cycle; Cell Line, Tumo | 2015 |
Assessment of the outcomes of the treatment of Cushing's disease in the hospitals of Castilla-La Mancha.
Topics: ACTH-Secreting Pituitary Adenoma; Adult; Combined Modality Therapy; Comorbidity; Craniotomy; Diabete | 2015 |
[Indications and future perspectives in the pharmacological treatment of hypercortisolism].
Topics: Adenoma; Cushing Syndrome; Humans; Hydrocortisone; Italy; Ketoconazole; Metyrapone; Pituitary Neopla | 2016 |
Acute cortisol release during stereotactic fractionated radiotherapy to an ACTH-secreting pituitary macroadenoma.
Topics: Adrenocorticotropic Hormone; Adult; Humans; Hydrocortisone; Ketoconazole; Male; Pituitary Neoplasms | 2012 |
Disappearance of pituitary macro adenoma with combination of ketoconazole and cabergoline treatment: an unusual case of Cushing's syndrome with interesting findings.
Topics: 14-alpha Demethylase Inhibitors; Adenoma; Adult; Antineoplastic Agents; Cabergoline; Cushing Syndrom | 2012 |
Diagnostic puzzler: hypertension in teen.
Topics: Adenoma; Adolescent; Adrenal Glands; Antifungal Agents; Cushing Syndrome; Diagnosis, Differential; D | 2012 |
Long-term results of treatment in patients with ACTH-secreting pituitary macroadenomas.
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Aged; Cushing Syndrome; Dexamethasone; Female; Glucocor | 2003 |
Spontaneous remission of Cushing's disease after disappearance of a microadenoma attached to the pituitary stalk.
Topics: Adenoma; Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Pituitary Neoplasms; | 2004 |
The dual mode of inhibition of calmodulin-dependent nitric-oxide synthase by antifungal imidazole agents.
Topics: Amino Acid Oxidoreductases; Animals; Antifungal Agents; Biopterins; Brain; Calmodulin; Cattle; Citru | 1993 |
Treatment of hyperadrenocorticism in dogs: a survey of internists and dermatologists.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; | 1999 |
Recovery of bone mineral density after surgical cure, but not by ketoconazole treatment, in Cushing's syndrome.
Topics: Absorptiometry, Photon; Adenoma; Adrenal Gland Neoplasms; Adult; Bone Density; Cushing Syndrome; Dex | 2001 |
[Long-term induced effects by only one treatment with ketoconazole on rat tumoral pituitary cells (GH3/B6 strains)].
Topics: Animals; Arachidonic Acids; Electrophysiology; Growth Hormone-Releasing Hormone; Ketoconazole; Pitui | 1991 |
Plasma cortisol response to ketoconazole administration in dogs with hyperadrenocorticism.
Topics: Adenoma; Administration, Oral; Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Animals; Carc | 1990 |
Persistent Cushing's disease in a patient with invasive pituitary adenoma.
Topics: Adenocarcinoma; Adult; Combined Modality Therapy; Cushing Syndrome; Female; Humans; Hydrocortisone; | 1990 |
Differential effects of ketoconazole on prolactin and growth hormone release by normal and tumoral rat anterior pituitary cells in vitro.
Topics: Animals; Electrophysiology; Female; Growth Hormone; In Vitro Techniques; Ketoconazole; Membrane Pote | 1989 |
In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome.
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Cells, Cultured; Female; Humans; Immunohistochemistry; | 1989 |
ACTH response to corticotropin releasing hormone in Cushing's disease before and after ketoconazole: in vivo and in vitro studies.
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Animals; Corticotropin-Releasing Hormone; Cushing Syndr | 1987 |