Page last updated: 2024-10-29

ketoconazole and Pituitary ACTH Hypersecretion

ketoconazole has been researched along with Pituitary ACTH Hypersecretion in 44 studies

1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.

Pituitary ACTH Hypersecretion: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.

Research Excerpts

ExcerptRelevanceReference
"We describe a case of a CD patient managed with Ketoconazole during the first and second trimester and other cares for her metabolic CS aspects during pregnancy."7.81A successful case of Cushing's disease pregnancy treated with ketoconazole. ( Costenaro, F; Czepielewski, MA; de Lima, PB; Rodrigues, TC; Rollin, G; Ruszczyk, J, 2015)
"Ketoconazole is the most widely used medical treatment for Cushing's syndrome, but, because of its potential to cause birth defects, it is not recommended during pregnancy."7.77Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation. ( Barber, M; Boronat, M; López-Plasencia, Y; Marrero, D; Nóvoa, FJ; Schamann, Y, 2011)
"Ketoconazole is a common and effective adjuvant therapy for hypercortisolism, but the major concern is liver enzyme dysfunction."5.37Pseudotumor cerebri during Cushing's disease treatment with ketoconazole. ( Boschi, V; Costa, TG; Costenaro, F; Czepielewski, MA; Ferreira, NP; Rodrigues, TC; Schuch, T, 2011)
"We describe a case of a CD patient managed with Ketoconazole during the first and second trimester and other cares for her metabolic CS aspects during pregnancy."3.81A successful case of Cushing's disease pregnancy treated with ketoconazole. ( Costenaro, F; Czepielewski, MA; de Lima, PB; Rodrigues, TC; Rollin, G; Ruszczyk, J, 2015)
"Ketoconazole is the most widely used medical treatment for Cushing's syndrome, but, because of its potential to cause birth defects, it is not recommended during pregnancy."3.77Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation. ( Barber, M; Boronat, M; López-Plasencia, Y; Marrero, D; Nóvoa, FJ; Schamann, Y, 2011)
"Ketoconazole has been used as a second-line drug despite limited data on its safety and efficacy for this purpose."3.01Ketoconazole as second-line treatment for Cushing's disease after transsphenoidal surgery: systematic review and meta-analysis. ( Czepielewski, MA; Garcia, SP; Hirakata, VN; Mattos, ACV; Rodrigues, TDC; Viecceli, C, 2023)
"The effect of clinical treatment of hypercortisolism with ketoconazole on ACTH secretion in CD is controversial."2.75Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6). ( Correa-Silva, SR; Lengyel, AM; Molica, P; Nascif, SO; Sá, LB; Vieira, JG, 2010)
"Osilodrostat has been shown to be highly effective at maintaining normal urinary free cortisol in patients with CD."2.72Updates in adrenal steroidogenesis inhibitors for Cushing's syndrome - A practical guide. ( Fleseriu, M; Han, AJ; Varlamov, EV, 2021)
"Cushing's disease is a syndromic pathological condition caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (ACTHomas) mediated by hypercortisolemia."2.72Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach. ( Fukuoka, H; Nakao, T; Ogawa, W; Yamamoto, M, 2021)
"ketoconazole (n = 20) in dogs with Cushing's disease was assigned for a period of 180 d."2.72Retinoic acid as a novel medical therapy for Cushing's disease in dogs. ( Arzt, E; Castillo, V; Giacomini, D; Grossman, AB; Holsboer, F; Labeur, M; Páez-Pereda, M; Stalla, GK; Stalla, J; Theodoropoulou, M, 2006)
"Medical therapy to control hypercortisolism in adrenal Cushing's syndrome is currently not the first-line therapy."2.66What is the role of medical therapy in adrenal-dependent Cushing's syndrome? ( Braun, LT; Reincke, M, 2020)
"Medical therapy for Cushing disease is primarily used to control hypercortisolism in patients whose disease persists or with recurrent disease after pituitary surgery, including those awaiting the salutary effects of radiation therapy."2.61Medical Management of Cushing Disease. ( Biller, BMK; Tritos, NA, 2019)
"Pasireotide was the only treatment to be assessed in a randomized trial and was supported by a 'moderate' level of evidence."2.50Efficacy of medical treatment in Cushing's disease: a systematic review. ( Gadelha, MR; Vieira Neto, L, 2014)
"Hypercortisolism induced by Cushing disease causes high morbidity and mortality."2.48New prospects for drug treatment in Cushing disease. ( Barahona Constanzo, MJ; del Pozo Picó, C, 2012)
"The goals of ideal medical therapy for Cushing's disease should be to target the aetiology of the disorder, and thus surgery is the current 'gold standard' treatment."2.46Medical therapy of Cushing's disease: where are we now? ( Alexandraki, KI; Grossman, AB, 2010)
"Cushing disease is most frequently caused by pituitary adenomas that secrete adrenocorticotrophic hormone."2.44Management of recurrent and refractory Cushing disease. ( Aghi, MK, 2008)
"To our knowledge, histoplasmosis has not been previously reported in Cushing's disease, and has rarely been reported in patients with exogenous glucocorticoid use."2.44Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review. ( Jordan, RM; Kosseifi, SG; Nassour, DN; Peiris, AN; Sarubbi, FA; Shaikh, MA, 2007)
"Hypokalemia is a frequent metabolic effect not yet described in other series, which should be monitored during treatment."1.72Evaluation of ketoconazole as a treatment for Cushing's disease in a retrospective cohort. ( Costa, MCB; Czepielewski, MA; de Melo, RB; Mattos, ACV; Rodrigues, TDC; Viecceli, C, 2022)
"The evaluation of β-arrestin mRNA in corticotroph adenomas from CD patients with variable disease activity showed a significant positive correlation between β-arrestin 1 mRNA and urinary cortisol levels."1.56β-arrestin expression in corticotroph tumor cells is modulated by glucocorticoids. ( Arvigo, M; Bruzzone, E; Dogan, F; Feelders, RA; Ferone, D; Gatto, F; Hofland, L; Lamberts, S; van der Pas, R; van Koetsveld, P, 2020)
"BLA = bilateral adrenalectomy CD = Cushing disease CS = Cushing syndrome eCRF = electronic case report form MRI = magnetic resonance imaging PCOS = polycystic ovary syndrome."1.46BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY. ( Ayala, A; Biller, BMK; Bonert, V; Broder, MS; Carmichael, JD; Cherepanov, D; Eagan, M; Geer, EB; Gordon, MB; Hannoush, Z; Katznelson, L; Lalazar, Y; Lee, J; Manuylova, E; Neary, MP; Pulaski-Liebert, KJ; Said, Q; Shafiq, I; Surampudi, V; Swerdloff, RS, 2017)
" The aim of this study was to assess the QT interval in patients with Cushing's disease during long-term administration of ketoconazole."1.43No Untoward Effect of Long-Term Ketoconazole Administration on Electrocardiographic QT Interval in Patients with Cushing's Disease. ( Cavagnini, F; De Martin, M; Goulene, K; Pecori Giraldi, F; Radaelli, P; Stramba-Badiale, M; Toja, PM, 2016)
"They had been diagnosed with Cushing's disease between 2000 and 2012, and were monitored at Complejo Hospitalario Universitario-Albacete, Hospital Virgen de la Salud-Toledo Hospital General Universitario de Ciudad Real, Hospital Virgen de la Luz-Cuenca, Hospital Nuestra Señora del Prado-Talavera de la Reina, and Complejo Hospitalario la Mancha Centro-Alcázar de San Juan."1.42Assessment of the outcomes of the treatment of Cushing's disease in the hospitals of Castilla-La Mancha. ( Aguirre, M; Alramadan, M; Huguet, I; Lamas, C; Quiroga, I; Silva, J; Vicente, A, 2015)
"Ketoconazole is an effective drug with acceptable side effects."1.40Ketoconazole in Cushing's disease: is it worth a try? ( Baudry, C; Bertherat, J; Bihan, H; Brue, T; Caron, P; Castinetti, F; Chabre, O; Chanson, P; Christin-Maitre, S; Conte-Devolx, B; Delemer, B; Donadille, B; Drui, D; Giraud, P; Goichot, B; Guignat, L; Kamenicky, P; Le Bras, M; Luca, F; Martinie, M; Morange, I; Motte, E; Muller, M; Philippon, M; Quinquis, L; Raverot, G; Tabarin, A; Vantyghem, MC; Vezzosi, D; Young, J, 2014)
"All patients with Cushing's disease treated with Gamma Knife surgery (GKS) were identified."1.39Results of gamma knife surgery for Cushing's disease. ( Salvetti, DJ; Schmitt, PJ; Sheehan, JP; Vance, ML; Xu, Z, 2013)
"However, pregnancy is at risk even when ACTH and cortisol levels are normalized by treatment."1.38Course of pregnancies in women with Cushing's disease treated by gamma-knife. ( Cannavò, S; Cotta, OR; Ferraù, F; Losa, M; Ragonese, M; Torre, ML; Trimarchi, F, 2012)
"Without treatment, Cushing's disease has significant morbidity and mortality."1.37Effectiveness of chronic treatment with ketoconazole in a patient with diabetic Cushing's disease resistant to surgery. ( Kocabay, G; Mert, M, 2011)
"Ketoconazole is a common and effective adjuvant therapy for hypercortisolism, but the major concern is liver enzyme dysfunction."1.37Pseudotumor cerebri during Cushing's disease treatment with ketoconazole. ( Boschi, V; Costa, TG; Costenaro, F; Czepielewski, MA; Ferreira, NP; Rodrigues, TC; Schuch, T, 2011)
" The aim of this study was to evaluate the effectiveness of cabergoline (at doses of up 3 mg/week), alone or combined with relatively low doses of ketoconazole (up to 400 mg/day), in 12 patients with CD unsuccessfully treated by transsphenoidal surgery."1.36Effectiveness of cabergoline in monotherapy and combined with ketoconazole in the management of Cushing's disease. ( Agra, R; Albuquerque, JL; Arahata, CM; Arruda, MJ; Azevedo, MF; Canadas, V; Montenegro, L; Moura E Silva, L; Naves, LA; Pontes, L; Vilar, L, 2010)
"Ketoconazole was similarly efficacious as a primary or postoperative treatment."1.35Ketoconazole revisited: a preoperative or postoperative treatment in Cushing's disease. ( Brue, T; Castinetti, F; Conte-Devolx, B; Jaquet, P; Morange, I, 2008)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (20.45)29.6817
2010's26 (59.09)24.3611
2020's9 (20.45)2.80

Authors

AuthorsStudies
Pivonello, R1
Simeoli, C1
Di Paola, N1
Colao, A1
Viecceli, C2
Mattos, ACV2
Costa, MCB1
de Melo, RB1
Rodrigues, TDC2
Czepielewski, MA4
Hirakata, VN1
Garcia, SP1
Tritos, NA1
Biller, BMK2
Luque-Ramírez, M1
Ortiz-Flóres, AE1
Nattero-Chávez, L1
Escobar-Morreale, HF1
Gatto, F1
Feelders, RA4
van der Pas, R3
van Koetsveld, P1
Bruzzone, E1
Arvigo, M1
Dogan, F1
Lamberts, S1
Ferone, D1
Hofland, L1
Braun, LT1
Reincke, M1
Kudsieh, B1
Casado López de la Franca, E1
Díez Gómez, MA1
Ruiz Moreno, JM1
Varlamov, EV1
Han, AJ1
Fleseriu, M1
Yamamoto, M1
Nakao, T1
Ogawa, W1
Fukuoka, H1
Espinosa-de-Los-Monteros, AL1
Sosa-Eroza, E1
Espinosa, E1
Mendoza, V1
Arreola, R1
Mercado, M1
Geer, EB1
Shafiq, I1
Gordon, MB1
Bonert, V1
Ayala, A1
Swerdloff, RS1
Katznelson, L1
Lalazar, Y1
Manuylova, E1
Pulaski-Liebert, KJ1
Carmichael, JD1
Hannoush, Z1
Surampudi, V1
Broder, MS2
Cherepanov, D2
Eagan, M1
Lee, J1
Said, Q1
Neary, MP2
Seow, CJ1
Young, WF1
Barbot, M1
Albiger, N1
Ceccato, F1
Zilio, M1
Frigo, AC1
Denaro, L1
Mantero, F1
Scaroni, C1
van den Bosch, OF1
Stades, AM1
Zelissen, PM4
Sheehan, JP1
Xu, Z1
Salvetti, DJ1
Schmitt, PJ1
Vance, ML1
Gadelha, MR1
Vieira Neto, L1
Castinetti, F2
Guignat, L1
Giraud, P1
Muller, M1
Kamenicky, P1
Drui, D1
Caron, P1
Luca, F1
Donadille, B1
Vantyghem, MC1
Bihan, H1
Delemer, B1
Raverot, G1
Motte, E1
Philippon, M1
Morange, I2
Conte-Devolx, B2
Quinquis, L1
Martinie, M1
Vezzosi, D1
Le Bras, M1
Baudry, C1
Christin-Maitre, S1
Goichot, B1
Chanson, P1
Young, J1
Chabre, O1
Tabarin, A1
Bertherat, J1
Brue, T2
Newell-Price, J1
Hamrahian, AH1
Yuen, KC1
Hoffman, AR1
Chang, E1
Sun, GH1
Ludlam, WH1
Costenaro, F2
Rodrigues, TC2
de Lima, PB1
Ruszczyk, J1
Rollin, G1
Huguet, I1
Aguirre, M1
Vicente, A1
Alramadan, M1
Quiroga, I1
Silva, J1
Lamas, C1
De Martin, M1
Toja, PM1
Goulene, K1
Radaelli, P1
Cavagnini, F2
Stramba-Badiale, M1
Pecori Giraldi, F2
Aghi, MK1
Méndez Pérez, P1
Barrio Castellanos, R1
Núñez Estévez, M1
Pérez Rodríguez, C1
Hernández Doménech, R1
Correa-Silva, SR2
Nascif, SO2
Molica, P2
Sá, LB2
Vieira, JG2
Lengyel, AM2
Vilar, L1
Naves, LA1
Azevedo, MF1
Arruda, MJ1
Arahata, CM1
Moura E Silva, L1
Agra, R1
Pontes, L1
Montenegro, L1
Albuquerque, JL1
Canadas, V1
de Bruin, C3
Pereira, AM3
Romijn, JA3
Netea-Maier, RT3
Hermus, AR3
van Heerebeek, R1
de Jong, FH3
van der Lely, AJ3
de Herder, WW3
Hofland, LJ3
Lamberts, SW3
Alexandraki, KI1
Grossman, AB2
Boronat, M1
Marrero, D1
López-Plasencia, Y1
Barber, M1
Schamann, Y1
Nóvoa, FJ1
Mert, M1
Kocabay, G1
Ferreira, NP1
Costa, TG1
Schuch, T1
Boschi, V1
Leebeek, FW1
de Maat, MP1
Rijken, DC1
Ferraù, F1
Losa, M1
Cotta, OR1
Torre, ML1
Ragonese, M1
Trimarchi, F1
Cannavò, S1
Barahona Constanzo, MJ1
del Pozo Picó, C1
Webb, SM1
Polli, N1
Castillo, V1
Giacomini, D1
Páez-Pereda, M1
Stalla, J1
Labeur, M1
Theodoropoulou, M1
Holsboer, F1
Stalla, GK1
Arzt, E1
Castillo, VA1
Gómez, NV1
Lalia, JC1
Cabrera Blatter, MF1
García, JD1
Jaquet, P1
Kosseifi, SG1
Nassour, DN1
Shaikh, MA1
Sarubbi, FA1
Jordan, RM1
Peiris, AN1
Joubert, M1
Bravard, P1
Reznik, Y1

Reviews

13 reviews available for ketoconazole and Pituitary ACTH Hypersecretion

ArticleYear
Cushing's disease: adrenal steroidogenesis inhibitors.
    Pituitary, 2022, Volume: 25, Issue:5

    Topics: Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Hypokalemia; Ketoconazole; Male; Mety

2022
Ketoconazole as second-line treatment for Cushing's disease after transsphenoidal surgery: systematic review and meta-analysis.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Cushing Syndrome; Humans; Hydrocortisone; Ketoconazole; Pituitary ACTH Hypersecretion; Prospective S

2023
Medical Management of Cushing Disease.
    Neurosurgery clinics of North America, 2019, Volume: 30, Issue:4

    Topics: Cabergoline; Etomidate; Humans; Ketoconazole; Metyrapone; Mitotane; Pituitary ACTH Hypersecretion; S

2019
What is the role of medical therapy in adrenal-dependent Cushing's syndrome?
    Best practice & research. Clinical endocrinology & metabolism, 2020, Volume: 34, Issue:3

    Topics: Adrenal Gland Diseases; Cushing Syndrome; Humans; Ketoconazole; Metyrapone; Mitotane; Pituitary ACTH

2020
Updates in adrenal steroidogenesis inhibitors for Cushing's syndrome - A practical guide.
    Best practice & research. Clinical endocrinology & metabolism, 2021, Volume: 35, Issue:1

    Topics: Cushing Syndrome; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Etomidate; Humans; Hydrocortisone; Im

2021
Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenocorticotropic Hormone; Carcinoma; Dopamine Agonists

2021
Efficacy of medical treatment in Cushing's disease: a systematic review.
    Clinical endocrinology, 2014, Volume: 80, Issue:1

    Topics: Cabergoline; Ergolines; Female; Humans; Ketoconazole; Male; Metyrapone; Mitotane; Pituitary ACTH Hyp

2014
AACE/ACE Disease State Clinical Review: Medical Management of Cushing Disease.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2014, Volume: 20, Issue:7

    Topics: Adrenocorticotropic Hormone; Cabergoline; Drug Therapy, Combination; Ergolines; Humans; Ketoconazole

2014
Management of recurrent and refractory Cushing disease.
    Nature clinical practice. Endocrinology & metabolism, 2008, Volume: 4, Issue:10

    Topics: ACTH-Secreting Pituitary Adenoma; Adrenalectomy; Humans; Hypophysectomy; Ketoconazole; Models, Biolo

2008
Medical therapy of Cushing's disease: where are we now?
    Frontiers of hormone research, 2010, Volume: 38

    Topics: Dopamine Agonists; Humans; Hydrocortisone; Ketoconazole; Metyrapone; Mifepristone; Mitotane; Pituita

2010
New prospects for drug treatment in Cushing disease.
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2012, Volume: 59, Issue:10

    Topics: Adenoma; Adrenocorticotropic Hormone; Animals; Cabergoline; Clinical Trials as Topic; Clinical Trial

2012
Cushing's disease and pregnancy.
    Pituitary, 2004, Volume: 7, Issue:4

    Topics: ACTH-Secreting Pituitary Adenoma; Adrenocorticotropic Hormone; Female; Humans; Hydrocortisone; Hypot

2004
Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review.
    Tennessee medicine : journal of the Tennessee Medical Association, 2007, Volume: 100, Issue:12

    Topics: Adenoma; Aminoglutethimide; Dexamethasone; Histoplasmosis; Humans; Itraconazole; Ketoconazole; Lung

2007

Trials

6 trials available for ketoconazole and Pituitary ACTH Hypersecretion

ArticleYear
Combination therapy for Cushing's disease: effectiveness of two schedules of treatment: should we start with cabergoline or ketoconazole?
    Pituitary, 2014, Volume: 17, Issue:2

    Topics: Adult; Aged; Biomarkers; Cabergoline; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Admin

2014
Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6).
    Clinical endocrinology, 2010, Volume: 72, Issue:1

    Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Ghrelin; Hormone Antagonists;

2010
Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease.
    The New England journal of medicine, 2010, May-13, Volume: 362, Issue:19

    Topics: Adult; Cabergoline; Dopamine Agonists; Drug Therapy, Combination; Ergolines; Female; Humans; Hydroco

2010
The hypercoagulable state in Cushing's disease is associated with increased levels of procoagulant factors and impaired fibrinolysis, but is not reversible after short-term biochemical remission induced by medical therapy.
    The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:4

    Topics: Adult; Aged; Blood Coagulation; Blood Coagulation Factors; Cabergoline; Dopamine Agonists; Drug Moni

2012
Retinoic acid as a novel medical therapy for Cushing's disease in dogs.
    Endocrinology, 2006, Volume: 147, Issue:9

    Topics: Adenoma; Adrenocorticotropic Hormone; alpha-MSH; Animals; Body Weight; Creatinine; Dog Diseases; Dog

2006
Cushing's disease in dogs: cabergoline treatment.
    Research in veterinary science, 2008, Volume: 85, Issue:1

    Topics: Adrenocorticotropic Hormone; alpha-MSH; Animals; Cabergoline; Dog Diseases; Dogs; Dopamine Agonists;

2008

Other Studies

25 other studies available for ketoconazole and Pituitary ACTH Hypersecretion

ArticleYear
Evaluation of ketoconazole as a treatment for Cushing's disease in a retrospective cohort.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Cabergoline; Cushing Syndrome; Humans; Hydrocortisone; Hypokalemia; Ketoconazole; Pituitary ACTH Hyp

2022
Apparent mineralocorticoid excess as a side effect of ketoconazole therapy in a patient with Cushing's disease.
    Clinical endocrinology, 2020, Volume: 92, Issue:1

    Topics: 14-alpha Demethylase Inhibitors; Female; Humans; Ketoconazole; Middle Aged; Mineralocorticoid Excess

2020
β-arrestin expression in corticotroph tumor cells is modulated by glucocorticoids.
    The Journal of endocrinology, 2020, Volume: 245, Issue:1

    Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adult; Aged; Animals; Anti-Inflammatory Agents; beta-Arre

2020
Open angle glaucoma secondary to endogenous cortisone due to pituitary microadenoma in a young patient, a case report.
    Archivos de la Sociedad Espanola de Oftalmologia, 2020, Volume: 95, Issue:7

    Topics: ACTH-Secreting Pituitary Adenoma; Adult; Combined Modality Therapy; Cortisone; Diagnostic Techniques

2020
LONG-TERM OUTCOME OF THE DIFFERENT TREATMENT ALTERNATIVES FOR RECURRENT AND PERSISTENT CUSHING DISEASE.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017, Volume: 23, Issue:7

    Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectomy; Adult; Antifungal Agents; Coho

2017
BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017, Volume: 23, Issue:8

    Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectom

2017
An Overlooked Cause of Hypokalemia.
    The American journal of medicine, 2017, Volume: 130, Issue:10

    Topics: 14-alpha Demethylase Inhibitors; Adenoma; Cabergoline; Cushing Syndrome; Dopamine Agonists; Ergoline

2017
Increased long-term remission after adequate medical cortisol suppression therapy as presurgical treatment in Cushing's disease.
    Clinical endocrinology, 2014, Volume: 80, Issue:2

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Enzyme Inhibitors; Female; Humans; Hydrocortis

2014
Results of gamma knife surgery for Cushing's disease.
    Journal of neurosurgery, 2013, Volume: 119, Issue:6

    Topics: 14-alpha Demethylase Inhibitors; Female; Follow-Up Studies; Humans; Hypopituitarism; Ketoconazole; M

2013
Ketoconazole in Cushing's disease: is it worth a try?
    The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:5

    Topics: 14-alpha Demethylase Inhibitors; Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Humans;

2014
Ketoconazole as an adrenal steroidogenesis inhibitor: effectiveness and risks in the treatment of Cushing's disease.
    The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:5

    Topics: 14-alpha Demethylase Inhibitors; Female; Humans; Ketoconazole; Male; Pituitary ACTH Hypersecretion

2014
Treatment patterns in Cushing's disease patients in two large United States nationwide databases: application of a novel, graphical methodology.
    Pituitary, 2015, Volume: 18, Issue:4

    Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenalectomy; Adult; Antineoplastic Agents, Hormonal; Co

2015
A successful case of Cushing's disease pregnancy treated with ketoconazole.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2015, Volume: 31, Issue:3

    Topics: Adult; Female; Humans; Ketoconazole; Pituitary ACTH Hypersecretion; Pregnancy; Pregnancy Complicatio

2015
Assessment of the outcomes of the treatment of Cushing's disease in the hospitals of Castilla-La Mancha.
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2015, Volume: 62, Issue:5

    Topics: ACTH-Secreting Pituitary Adenoma; Adult; Combined Modality Therapy; Comorbidity; Craniotomy; Diabete

2015
No Untoward Effect of Long-Term Ketoconazole Administration on Electrocardiographic QT Interval in Patients with Cushing's Disease.
    Basic & clinical pharmacology & toxicology, 2016, Volume: 118, Issue:4

    Topics: Adrenocorticotropic Hormone; Adult; Dose-Response Relationship, Drug; Electrocardiography; Female; H

2016
[Treatment of Cushing's disease with ketoconazole].
    Anales de pediatria (Barcelona, Spain : 2003), 2009, Volume: 70, Issue:4

    Topics: Adolescent; Female; Humans; Ketoconazole; Pituitary ACTH Hypersecretion

2009
Partial restoration of GH responsiveness to ghrelin in Cushing's disease after 6 months of ketoconazole treatment: comparison with GHRP-6 and GHRH.
    European journal of endocrinology, 2009, Volume: 161, Issue:5

    Topics: Adult; Area Under Curve; Female; Ghrelin; Growth Hormone-Releasing Hormone; Human Growth Hormone; Hu

2009
Effectiveness of cabergoline in monotherapy and combined with ketoconazole in the management of Cushing's disease.
    Pituitary, 2010, Volume: 13, Issue:2

    Topics: Adult; Cabergoline; Drug Therapy, Combination; Ergolines; Female; Humans; Hydrocortisone; Ketoconazo

2010
Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:9

    Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adult; Cushing Syndrome; Female;

2011
Effectiveness of chronic treatment with ketoconazole in a patient with diabetic Cushing's disease resistant to surgery.
    Endokrynologia Polska, 2011, Volume: 62, Issue:3

    Topics: 14-alpha Demethylase Inhibitors; Aged; Diabetes Mellitus, Type 2; Female; Humans; Ketoconazole; Pitu

2011
Pseudotumor cerebri during Cushing's disease treatment with ketoconazole.
    Arquivos brasileiros de endocrinologia e metabologia, 2011, Volume: 55, Issue:4

    Topics: Adrenal Insufficiency; Child; Diagnosis, Differential; Female; Humans; Ketoconazole; Pituitary ACTH

2011
Course of pregnancies in women with Cushing's disease treated by gamma-knife.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2012, Volume: 28, Issue:10

    Topics: 14-alpha Demethylase Inhibitors; Abortion, Spontaneous; Abruptio Placentae; Adult; Female; Humans; H

2012
Cortisol diurnal rhythm and quality of life after successful medical treatment of Cushing's disease.
    Pituitary, 2013, Volume: 16, Issue:4

    Topics: Adult; Aged; Cabergoline; Circadian Rhythm; Dopamine Agonists; Ergolines; Female; Humans; Hydrocorti

2013
Ketoconazole revisited: a preoperative or postoperative treatment in Cushing's disease.
    European journal of endocrinology, 2008, Volume: 158, Issue:1

    Topics: Adolescent; Adult; Aged; Drug Administration Schedule; Female; Follow-Up Studies; France; Humans; Hy

2008
'Anti-cortisolic' treatment of warts.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2008, Volume: 22, Issue:4

    Topics: Adult; Hand Dermatoses; Humans; Hydrocortisone; Ketoconazole; Male; Pituitary ACTH Hypersecretion; W

2008