ketoconazole has been researched along with Parkinson Disease in 3 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Parkinson's disease is a growing threat to an ever-ageing population." | 1.46 | Validating the Predicted Effect of Astemizole and Ketoconazole Using a Drosophila Model of Parkinson's Disease. ( Styczyńska-Soczka, K; Zechini, L; Zografos, L, 2017) |
| "Parkinson's disease is a neurodegenerative process characterized by progressive degeneration of the substantia nigra and concurrent loss of neuromelanin in these structures." | 1.35 | Activation of the proopiomelanocortin gene with ketoconazole as a treatment for Parkinson's disease: a new hypothesis. ( Halabe Bucay, A, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Styczyńska-Soczka, K | 1 |
| Zechini, L | 1 |
| Zografos, L | 1 |
| Halabe Bucay, A | 1 |
| Silva, V | 1 |
| Zepeda, G | 1 |
| Alvareda, D | 1 |
3 other studies available for ketoconazole and Parkinson Disease
| Article | Year |
|---|---|
Validating the Predicted Effect of Astemizole and Ketoconazole Using a Drosophila Model of Parkinson's Disease.
Topics: Animals; Astemizole; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila; Drug Repo | 2017 |
Activation of the proopiomelanocortin gene with ketoconazole as a treatment for Parkinson's disease: a new hypothesis.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Humans; Ketoconazole; Melanins; Melanocyte-Sti | 2008 |
[Nosocomial urinary infection due to Trichosporon asahii. First two cases in Chile].
Topics: Amphotericin B; Antifungal Agents; Chile; Communicable Diseases, Emerging; Cross Infection; Drug Res | 2003 |