ketoconazole has been researched along with Pancreatic Neoplasms in 9 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results indicate that ketoconazole significantly reduced hepatic metastases from the human pancreatic carcinoma RWP-2 in the nude mouse model, and inhibited thromboxane B2 formation, potentiating a concomitant redirection of platelet endoperoxide metabolism into PGD2, PGE2, and 6-keto-F1a." | 3.71 | The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis. ( Krambovitis, E; Tsatsakis, AM; Tzanakakis, GN; Vezeridis, MP, 2002) |
| "Ketoconazole also induced increase in G0/G1 phase in both cell lines and arrest in phase G2/M of BON-1 cells." | 1.51 | Effects of Ketoconazole on ACTH-Producing and Non-ACTH-Producing Neuroendocrine Tumor Cells. ( Castaño, JP; de Herder, WW; Dogan, F; Feelders, RA; Gálvez Moreno, MÁ; Herrera-Martínez, AD; Hofland, LJ; van Dungen, R; van Koetsveld, P, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Karniadakis, I | 1 |
| Garoufalia, Z | 1 |
| Kouskos, E | 1 |
| Mantas, D | 1 |
| Simó-Servat, A | 1 |
| Peiró, I | 1 |
| Villabona, C | 1 |
| Herrera-Martínez, AD | 1 |
| Feelders, RA | 1 |
| de Herder, WW | 1 |
| Castaño, JP | 1 |
| Gálvez Moreno, MÁ | 1 |
| Dogan, F | 1 |
| van Dungen, R | 1 |
| van Koetsveld, P | 1 |
| Hofland, LJ | 1 |
| Davi', MV | 1 |
| Salgarello, M | 1 |
| Francia, G | 1 |
| La Rosa, S | 1 |
| Marando, A | 1 |
| Ghezzi, F | 1 |
| Colombo, P | 1 |
| Finzi, G | 1 |
| Capella, C | 1 |
| Matarazzo, P | 1 |
| Tuli, G | 1 |
| Tessaris, D | 1 |
| Verna, F | 1 |
| Rabbone, I | 1 |
| Lezo, A | 1 |
| Brunati, A | 1 |
| Salizzoni, M | 1 |
| Carbonaro, G | 1 |
| Terzolo, M | 1 |
| Reimondo, G | 1 |
| Papotti, M | 1 |
| Lala, R | 1 |
| Tzanakakis, GN | 3 |
| Krambovitis, E | 1 |
| Tsatsakis, AM | 1 |
| Vezeridis, MP | 3 |
| Agarwal, KC | 2 |
| Veronikis, DK | 1 |
9 other studies available for ketoconazole and Pancreatic Neoplasms
| Article | Year |
|---|---|
Pancreatic adenocarcinoma presenting with Cushing's syndrome.
Topics: 14-alpha Demethylase Inhibitors; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; Diagnosis, Dif | 2021 |
Pancreatic adenocarcinoma presenting with Cushing's syndrome.
Topics: 14-alpha Demethylase Inhibitors; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; Diagnosis, Dif | 2021 |
Pancreatic adenocarcinoma presenting with Cushing's syndrome.
Topics: 14-alpha Demethylase Inhibitors; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; Diagnosis, Dif | 2021 |
Pancreatic adenocarcinoma presenting with Cushing's syndrome.
Topics: 14-alpha Demethylase Inhibitors; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; Diagnosis, Dif | 2021 |
Corticotropin secreting pancreatic neuroendocrine tumour, a therapeutic management challenge. A presentation of 2 cases.
Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Chromogranins; Combined Modality Therapy; Embol | 2019 |
Effects of Ketoconazole on ACTH-Producing and Non-ACTH-Producing Neuroendocrine Tumor Cells.
Topics: 14-alpha Demethylase Inhibitors; Adrenocorticotropic Hormone; Apoptosis; Cell Cycle; Cell Line, Tumo | 2019 |
Positive (68)Ga-DOTATOC-PET/CT after cortisol level control during ketoconazole treatment in a patient with liver metastases from a pancreatic neuroendocrine tumor and ectopic Cushing syndrome.
Topics: Cushing Syndrome; Gallium Radioisotopes; Humans; Hydrocortisone; Ketoconazole; Liver Neoplasms; Male | 2015 |
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case.
Topics: ACTH Syndrome, Ectopic; Adult; Carcinoma, Neuroendocrine; Cushing Syndrome; Fatal Outcome; Female; H | 2011 |
Cushing syndrome due to ectopic adrenocorticotropic hormone secretion in a 3-year-old child.
Topics: Adrenocorticotropic Hormone; Carcinoma, Acinar Cell; Child, Preschool; Combined Modality Therapy; Cu | 2011 |
The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis.
Topics: 6-Ketoprostaglandin F1 alpha; Adenocarcinoma; Animals; Antineoplastic Agents; Dinoprostone; Humans; | 2002 |
Effects of antiplatelet agents alone or in combinations on platelet aggregation and on liver metastases from a human pancreatic adenocarcinoma in the nude mouse.
Topics: Adenocarcinoma; Animals; Colforsin; Drug Interactions; Humans; Indomethacin; Ketoconazole; Liver Neo | 1991 |
Inhibition of hepatic metastasis from a human pancreatic adenocarcinoma (RWP-2) in the nude mouse by prostacyclin, forskolin, and ketoconazole.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Colforsin; Epoprostenol; Hu | 1990 |