ketoconazole has been researched along with Pachymeningitis in 37 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the efficacy of orally administered itraconazole in the treatment of coccidioidal meningitis." | 9.06 | Itraconazole therapy for chronic coccidioidal meningitis. ( Denning, DW; Dupont, B; Stevens, DA; Tucker, RM, 1990) |
| "Ketoconazole is the newest antifungal agent evaluated for efficacy in the treatment of coccidioidomycosis and the only one used by oral administration." | 8.76 | Ketoconazole in the treatment of coccidioidomycosis. ( Galgiani, JN, 1983) |
| "Experiments are described of the treatment of two patients with cryptococcal meningitis using antifungal drugs and amphotericin B." | 7.68 | Treatment of cryptococcal meningitis with five anti-fungal drugs: the role of amphotericin B. ( Shindo, K, 1990) |
| "A new antifungal triazole, itraconazole (R51211), was compared with ketoconazole in treatment of murine cryptococcosis." | 7.67 | R 51211 (itraconazole) therapy of murine cryptococcosis. ( Ahrens, J; Graybill, JR, 1984) |
| "We studied the efficacy of itraconazole, a new oral triazole, in 33 patients (32 were immunocompromised) with cryptococcosis." | 7.67 | Itraconazole therapy for cryptococcal meningitis and cryptococcosis. ( Denning, DW; Hamilton, JR; Hanson, LH; Stevens, DA; Tucker, RM, 1989) |
| " We compared fluconazole in murine cryptococcosis with ketoconazole and amphotericin B." | 7.67 | Treatment of cryptococcal meningitis in mice with fluconazole. ( Graybill, JR; Palou de Fernandez, E; Patino, MM; Tarbit, MH, 1986) |
| "Fifteen patients with coccidioidal meningitis were treated with high doses of ketoconazole for up to 4 years." | 7.67 | Ketoconazole treatment of coccidioidal meningitis. ( Cloud, G; Craven, PC; Dismukes, WE; Galgiani, JN; Graybill, JR; Gregg, C; Huppert, M; Stevens, DA; Sugar, AM, 1988) |
| "Sixty patients with coccidioidomycosis were treated with ketoconazole rather than with another antifungal agent, and their responses were evaluated in relation to the predominant site of involvement." | 7.66 | Ketoconazole treatment of nonprimary coccidioidomycosis. Evaluation of 60 patients during three years of study. ( Barbee, RA; Campbell, SC; DeFelice, R; Dodge, RR; Friedman, BA; Galgiani, JN; Lincoln, LJ; Palpant, SD; Tennican, PO; Weinberg, MG, 1982) |
| " Ketoconazole, a new oral imidazole, has therefore been evaluated in a murine model of cryptococcosis." | 7.66 | Ketoconazole therapy of murine cryptococcal meningitis. ( Craven, PC; Graybill, JR; Jorgensen, JH, 1982) |
| "Ketoconazole, amphotericin B, 5-fluorocytosine, and combinations of these drugs were compared as therapy for chronic cryptococcal meningitis in steroid-treated rabbits." | 7.66 | Treatment of experimental cryptococcal meningitis with amphotericin B, 5-fluorocytosine, and ketoconazole. ( Durack, DT; Perfect, JR, 1982) |
| "Ketoconazole has been shown to penetrate into brain tissue of mice and cerebrospinal fluid of humans and to improve the course of human coccidioidal meningitis." | 5.27 | Combination of oral flucytosine and ketoconazole as therapy for experimental cryptococcal meningitis. ( Craven, PC; Graybill, JR, 1984) |
| "Amphotericin B was more efficacious than fluconazole." | 5.27 | Treatment of murine coccidioidal meningitis with fluconazole (UK 49,858). ( Ahrens, J; Graybill, JR; Sun, SH, 1986) |
| "To assess the efficacy of orally administered itraconazole in the treatment of coccidioidal meningitis." | 5.06 | Itraconazole therapy for chronic coccidioidal meningitis. ( Denning, DW; Dupont, B; Stevens, DA; Tucker, RM, 1990) |
| "Ketoconazole is the newest antifungal agent evaluated for efficacy in the treatment of coccidioidomycosis and the only one used by oral administration." | 4.76 | Ketoconazole in the treatment of coccidioidomycosis. ( Galgiani, JN, 1983) |
| "The triazole SCH39304 was compared with itraconazole and fluconazole for treatment of murine coccidioidal meningitis." | 3.68 | Treatment of murine coccidioidal meningitis with SCH39304. ( Defaveri, J; Graybill, JR; Sun, SH, 1990) |
| "The triazole Bay R 3783 was compared with fluconazole, itraconazole, ketoconazole, and amphotericin B in rodent models of superficial and systemic candidiasis, meningocerebral cryptococcosis, and pulmonary aspergillosis." | 3.68 | Evaluation of Bay R 3783 in rodent models of superficial and systemic candidiasis, meningeal cryptococcosis, and pulmonary aspergillosis. ( Hector, RF; Yee, E, 1990) |
| "Experiments are described of the treatment of two patients with cryptococcal meningitis using antifungal drugs and amphotericin B." | 3.68 | Treatment of cryptococcal meningitis with five anti-fungal drugs: the role of amphotericin B. ( Shindo, K, 1990) |
| "A new antifungal triazole, itraconazole (R51211), was compared with ketoconazole in treatment of murine cryptococcosis." | 3.67 | R 51211 (itraconazole) therapy of murine cryptococcosis. ( Ahrens, J; Graybill, JR, 1984) |
| "We studied the efficacy of itraconazole, a new oral triazole, in 33 patients (32 were immunocompromised) with cryptococcosis." | 3.67 | Itraconazole therapy for cryptococcal meningitis and cryptococcosis. ( Denning, DW; Hamilton, JR; Hanson, LH; Stevens, DA; Tucker, RM, 1989) |
| " We examined four issues: the efficacy of treatment with amphotericin plus flucytosine as compared with amphotericin alone, the efficacy of suppressive therapy, the prognostic clinical characteristics, and the course of nonmeningeal cryptococcosis." | 3.67 | Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome. ( Chuck, SL; Sande, MA, 1989) |
| " We compared fluconazole in murine cryptococcosis with ketoconazole and amphotericin B." | 3.67 | Treatment of cryptococcal meningitis in mice with fluconazole. ( Graybill, JR; Palou de Fernandez, E; Patino, MM; Tarbit, MH, 1986) |
| "Fifteen patients with coccidioidal meningitis were treated with high doses of ketoconazole for up to 4 years." | 3.67 | Ketoconazole treatment of coccidioidal meningitis. ( Cloud, G; Craven, PC; Dismukes, WE; Galgiani, JN; Graybill, JR; Gregg, C; Huppert, M; Stevens, DA; Sugar, AM, 1988) |
| "The mortality related to coccidioidal meningitis (CM) has been reduced since the introduction of amphotericin B therapy, but children with CM continue to suffer significant morbidity." | 3.67 | Imidazole therapy of coccidioidal meningitis in children. ( Britton, H; Dunn, JH; Shehab, ZM, 1988) |
| "Two patients with fungal infection of the central nervous system (coccidioidal meningitis and cerebral histoplasmomas) were treated with ketoconazole for 30 months." | 3.67 | Treatment of central nervous system fungal infection with ketoconazole. ( Barnett, AM; Goodpasture, HC; Hershberger, RE; Peterie, JD, 1985) |
| "Sixty patients with coccidioidomycosis were treated with ketoconazole rather than with another antifungal agent, and their responses were evaluated in relation to the predominant site of involvement." | 3.66 | Ketoconazole treatment of nonprimary coccidioidomycosis. Evaluation of 60 patients during three years of study. ( Barbee, RA; Campbell, SC; DeFelice, R; Dodge, RR; Friedman, BA; Galgiani, JN; Lincoln, LJ; Palpant, SD; Tennican, PO; Weinberg, MG, 1982) |
| " Ketoconazole, a new oral imidazole, has therefore been evaluated in a murine model of cryptococcosis." | 3.66 | Ketoconazole therapy of murine cryptococcal meningitis. ( Craven, PC; Graybill, JR; Jorgensen, JH, 1982) |
| "Ketoconazole, amphotericin B, 5-fluorocytosine, and combinations of these drugs were compared as therapy for chronic cryptococcal meningitis in steroid-treated rabbits." | 3.66 | Treatment of experimental cryptococcal meningitis with amphotericin B, 5-fluorocytosine, and ketoconazole. ( Durack, DT; Perfect, JR, 1982) |
| "The therapy of coccidioidomycosis has been an early target, both experimentally and clinically, for study of new members of the azole class of drugs, because of the recognition that coccidioidomycosis is one of the most difficult mycoses to treat, and because our research group and our collaborators have been eager to pioneer new therapies for this problem pathogen." | 2.44 | Azole therapy of clinical and experimental coccidioidomycosis. ( Clemons, KV; Stevens, DA, 2007) |
| "I have tried to use the AIDS commentaries to keep up with these advances." | 2.38 | Azoles and AIDS. ( Larsen, RA, 1990) |
| "Antifungal agents useful in the treatment of coccidioidomycosis are amphotericin B, which is administered intravenously and is relatively toxic, and ketoconazole, which is administered orally and whose toxicities are less serious and reversible." | 2.37 | Systemic fungal infections: diagnosis and treatment. I. Coccidioidomycosis. ( Galgiani, JN; Knoper, SR, 1988) |
| "Metastases to the meninges from prostatic cancer are rare, accounting for less than 0." | 1.29 | Hormonal ablation as effective therapy for carcinomatous meningitis from prostatic carcinoma. ( DeAngelis, LM; Mencel, PJ; Motzer, RJ, 1994) |
| "Amphotericin B was more efficacious than fluconazole." | 1.27 | Treatment of murine coccidioidal meningitis with fluconazole (UK 49,858). ( Ahrens, J; Graybill, JR; Sun, SH, 1986) |
| "Ketoconazole has been shown to penetrate into brain tissue of mice and cerebrospinal fluid of humans and to improve the course of human coccidioidal meningitis." | 1.27 | Combination of oral flucytosine and ketoconazole as therapy for experimental cryptococcal meningitis. ( Craven, PC; Graybill, JR, 1984) |
| "Cryptococcosis is a systemic fungal disease and meningitis is the most serious complication." | 1.27 | Cryptococcal meningitis. ( Tan, CB; Tjia, TL; Yeow, YK, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (67.57) | 18.7374 |
| 1990's | 9 (24.32) | 18.2507 |
| 2000's | 3 (8.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stevens, DA | 4 |
| Clemons, KV | 1 |
| Graybill, JR | 7 |
| Ahrens, J | 2 |
| Fibbe, WE | 1 |
| Van Der Meer, JW | 1 |
| Thompson, J | 1 |
| Mouton, RP | 1 |
| DeFelice, R | 1 |
| Galgiani, JN | 5 |
| Campbell, SC | 1 |
| Palpant, SD | 1 |
| Friedman, BA | 1 |
| Dodge, RR | 1 |
| Weinberg, MG | 1 |
| Lincoln, LJ | 1 |
| Tennican, PO | 1 |
| Barbee, RA | 1 |
| Perfect, JR | 4 |
| Durack, DT | 3 |
| Hamilton, JD | 1 |
| Gallis, HA | 1 |
| Craven, PC | 3 |
| Jorgensen, JH | 1 |
| Spors, S | 1 |
| Möller, A | 1 |
| Schiess, RJ | 1 |
| Coscia, MF | 1 |
| McClellan, GA | 1 |
| Mencel, PJ | 1 |
| DeAngelis, LM | 1 |
| Motzer, RJ | 1 |
| Krupova, Y | 1 |
| Sejnova, D | 1 |
| Dzatkova, J | 1 |
| Kaiserova, E | 1 |
| Kiskova, M | 1 |
| Babela, R | 1 |
| Mateicka, F | 1 |
| Sabo, A | 1 |
| Pichnova, E | 1 |
| Jurga, L | 1 |
| Sulcova, M | 1 |
| Krcmery, V | 1 |
| Singhal, T | 1 |
| Bajpai, A | 1 |
| Kalra, V | 1 |
| Kabra, SK | 1 |
| Samantaray, JC | 1 |
| Satpathy, G | 1 |
| Gupta, AK | 1 |
| Yee, RW | 1 |
| Tio, FO | 1 |
| Martinez, JA | 1 |
| Held, KS | 1 |
| Shadduck, JA | 1 |
| Didier, ES | 1 |
| Shindo, K | 1 |
| Fish, DG | 1 |
| Ampel, NM | 1 |
| Dols, CL | 1 |
| Kelly, PC | 1 |
| Johnson, CH | 1 |
| Pappagianis, D | 1 |
| Edwards, JE | 1 |
| Wasserman, RB | 1 |
| Clark, RJ | 1 |
| Tucker, RM | 2 |
| Denning, DW | 2 |
| Dupont, B | 1 |
| Hector, RF | 1 |
| Yee, E | 1 |
| Defaveri, J | 1 |
| Sun, SH | 2 |
| Larsen, RA | 1 |
| Wright, KA | 1 |
| Ritter, W | 1 |
| Hanson, LH | 1 |
| Hamilton, JR | 1 |
| Giménez-Esparza, JA | 1 |
| Gómez Trujillo, FM | 1 |
| Cárdenas Martínez, A | 1 |
| Juárez Fernández, C | 1 |
| Chuck, SL | 1 |
| Sande, MA | 1 |
| de Gans, J | 1 |
| Eeftinck Schattenkerk, JK | 1 |
| van Ketel, RJ | 1 |
| Savani, DV | 1 |
| Palou de Fernandez, E | 1 |
| Patino, MM | 1 |
| Tarbit, MH | 1 |
| Knoper, SR | 1 |
| Iida, Y | 1 |
| Maehara, K | 1 |
| Okamoto, Y | 1 |
| Mase, K | 1 |
| Uwamori, H | 1 |
| Yonezu, S | 1 |
| Takeuchi, J | 1 |
| Simojo, M | 1 |
| Yasunaga, K | 1 |
| Sugar, AM | 1 |
| Gregg, C | 1 |
| Huppert, M | 1 |
| Cloud, G | 1 |
| Dismukes, WE | 1 |
| Shehab, ZM | 1 |
| Britton, H | 1 |
| Dunn, JH | 1 |
| Karaffa, CA | 1 |
| Rehm, SJ | 1 |
| Keys, TF | 1 |
| Ogushi, F | 1 |
| Tamura, M | 1 |
| Ozaki, T | 1 |
| Kamei, T | 1 |
| Nakanishi, M | 1 |
| Shimada, H | 1 |
| Kawano, T | 1 |
| Yasuoka, S | 1 |
| Tsubura, E | 1 |
| Goodpasture, HC | 1 |
| Hershberger, RE | 1 |
| Barnett, AM | 1 |
| Peterie, JD | 1 |
| Tjia, TL | 1 |
| Yeow, YK | 1 |
| Tan, CB | 1 |
4 reviews available for ketoconazole and Pachymeningitis
| Article | Year |
|---|---|
Azole therapy of clinical and experimental coccidioidomycosis.
Topics: Administration, Oral; Animals; Antifungal Agents; Azoles; Coccidioidomycosis; Disease Models, Animal | 2007 |
Ketoconazole in the treatment of coccidioidomycosis.
Topics: Administration, Oral; Adult; Aged; Coccidioidomycosis; Dose-Response Relationship, Drug; Female; Hum | 1983 |
Azoles and AIDS.
Topics: Acquired Immunodeficiency Syndrome; Antifungal Agents; Azoles; Fluconazole; Humans; Itraconazole; Ke | 1990 |
Systemic fungal infections: diagnosis and treatment. I. Coccidioidomycosis.
Topics: Amphotericin B; Coccidioidomycosis; Humans; Ketoconazole; Lung Diseases, Fungal; Meningitis | 1988 |
1 trial available for ketoconazole and Pachymeningitis
| Article | Year |
|---|---|
Itraconazole therapy for chronic coccidioidal meningitis.
Topics: Adolescent; Adult; Aged; Antibodies, Fungal; Antifungal Agents; Chronic Disease; Coccidioidomycosis; | 1990 |
32 other studies available for ketoconazole and Pachymeningitis
| Article | Year |
|---|---|
R 51211 (itraconazole) therapy of murine cryptococcosis.
Topics: Administration, Oral; Animals; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Drug Resi | 1984 |
CSF concentrations of ketoconazole.
Topics: Candidiasis; Humans; Imidazoles; Ketoconazole; Male; Meningitis; Middle Aged; Piperazines | 1980 |
Ketoconazole treatment of nonprimary coccidioidomycosis. Evaluation of 60 patients during three years of study.
Topics: Bone Diseases; Coccidioidomycosis; Dermatomycoses; Humans; Imidazoles; Ketoconazole; Lung Diseases, | 1982 |
Failure of ketoconazole in cryptococcal meningitis.
Topics: Antigens, Fungal; Cerebrospinal Fluid; Cryptococcosis; Cryptococcus neoformans; Drug Resistance, Mic | 1982 |
Ketoconazole therapy of murine cryptococcal meningitis.
Topics: Animals; Antifungal Agents; Brain; Cryptococcosis; Cryptococcus neoformans; Female; Imidazoles; Keto | 1982 |
Treatment of experimental cryptococcal meningitis with amphotericin B, 5-fluorocytosine, and ketoconazole.
Topics: Amphotericin B; Animals; Cryptococcosis; Cryptococcus neoformans; Cytosine; Drug Synergism; Drug The | 1982 |
[Malignant hemangiopericytoma. Candida meningitis under ketoconazole therapy].
Topics: Adult; Candidiasis; Female; Hemangiopericytoma; Humans; Ketoconazole; Leukopenia; Meningitis; Neopla | 1983 |
Petriellidium boydii pachymeningitis treated with miconazole and ketoconazole.
Topics: Drug Therapy, Combination; Dura Mater; Female; Humans; Ketoconazole; Meningitis; Miconazole; Middle | 1984 |
Combination of oral flucytosine and ketoconazole as therapy for experimental cryptococcal meningitis.
Topics: Amphotericin B; Animals; Cryptococcosis; Cryptococcus neoformans; Cytosine; Drug Synergism; Drug The | 1984 |
Hormonal ablation as effective therapy for carcinomatous meningitis from prostatic carcinoma.
Topics: Adenocarcinoma; Aged; Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Dexameth | 1994 |
Prospective study on fungemia in children with cancer: analysis of 35 cases and comparison with 130 fungemias in adults.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Antifungal Agents; Candida albicans; Candidiasis; Child; | 2000 |
Successful treatment of Acanthamoeba meningitis with combination oral antimicrobials.
Topics: Acanthamoeba; Administration, Oral; Amebiasis; Animals; Anti-Infective Agents; Antifungal Agents; Ch | 2001 |
Resolution of microsporidial epithelial keratopathy in a patient with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Antifungal Agents; Corneal Diseases; Cryptococco | 1991 |
Treatment of cryptococcal meningitis with five anti-fungal drugs: the role of amphotericin B.
Topics: Amphotericin B; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Drug Therapy, Combinatio | 1990 |
Coccidioidomycosis during human immunodeficiency virus infection. A review of 77 patients.
Topics: Adult; Amphotericin B; Arizona; California; Coccidioidomycosis; Dermatomycoses; Female; Follow-Up St | 1990 |
Evaluation of Bay R 3783 in rodent models of superficial and systemic candidiasis, meningeal cryptococcosis, and pulmonary aspergillosis.
Topics: Administration, Oral; Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Candidiasis; Crypto | 1990 |
Treatment of murine coccidioidal meningitis with SCH39304.
Topics: Animals; Antifungal Agents; Coccidioidomycosis; Dose-Response Relationship, Drug; Drug Evaluation, P | 1990 |
The pharmacokinetics of BAY R3783 and its efficacy in the treatment of experimental cryptococcal meningitis.
Topics: Animals; Cryptococcosis; Cryptococcus neoformans; Fluconazole; Itraconazole; Ketoconazole; Meningiti | 1990 |
Itraconazole therapy for cryptococcal meningitis and cryptococcosis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antifungal Agents; Antigens, Fungal; Cryptococcosis; Cryp | 1989 |
[Candida meningitis in a human immunodeficiency virus seropositive woman].
Topics: Adult; Amphotericin B; Candidiasis; Female; HIV Seropositivity; Humans; Ketoconazole; Meningitis | 1989 |
Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Amphotericin B; Cryptococcosis; Cryptococcus neofor | 1989 |
Itraconazole as maintenance treatment for cryptococcal meningitis in the acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Antifungal Agents; Cryptococcosis; Humans; Itraconazole; Ketocon | 1988 |
Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.
Topics: Animals; Candidiasis; Cortisone; Cryptococcosis; Dose-Response Relationship, Drug; Fluconazole; Immu | 1986 |
Treatment of murine coccidioidal meningitis with fluconazole (UK 49,858).
Topics: Amphotericin B; Animals; Antifungal Agents; Coccidioides; Coccidioidomycosis; Fluconazole; Ketoconaz | 1986 |
Treatment of cryptococcal meningitis in mice with fluconazole.
Topics: Amphotericin B; Animals; Antifungal Agents; Cryptococcosis; Fluconazole; Ketoconazole; Kinetics; Men | 1986 |
[A case of cryptococcal meningitis successfully treated by ketoconazole and amphotericin B combination therapy].
Topics: Adult; Amphotericin B; Cryptococcosis; Cryptococcus neoformans; Drug Therapy, Combination; Humans; K | 1986 |
Ketoconazole treatment of coccidioidal meningitis.
Topics: Amphotericin B; Coccidioidomycosis; Drug Therapy, Combination; Humans; Ketoconazole; Leukocyte Count | 1988 |
Imidazole therapy of coccidioidal meningitis in children.
Topics: Administration, Oral; Amphotericin B; Cerebrospinal Fluid Shunts; Child; Child, Preschool; Coccidioi | 1988 |
The acquired immunodeficiency syndrome and cryptococcosis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Cryptococcosis; Humans; Ketoconazole; Male; Meningitis | 1986 |
[A case of cryptococcal meningitis improved in the treatment of high dose ketoconazole].
Topics: Anemia, Hemolytic, Autoimmune; Cryptococcosis; Female; Humans; Ketoconazole; Lupus Erythematosus, Sy | 1985 |
Treatment of central nervous system fungal infection with ketoconazole.
Topics: Aged; Coccidioidomycosis; Drug Administration Schedule; Encephalitis; Female; Histoplasmosis; Humans | 1985 |
Cryptococcal meningitis.
Topics: Adolescent; Adult; Aged; Amphotericin B; Child; Cryptococcosis; Flucytosine; Follow-Up Studies; Garl | 1985 |