ketoconazole has been researched along with Ovarian Hyperstimulation Syndrome in 3 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Ovarian Hyperstimulation Syndrome: A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the clinical efficacy of ketoconazole (KCZ) as an inhibitory enzyme on ovarian steroidogenesis, in prevention of ovarian hyper- stimulation syndrome (OHSS) during assisted reproductive technology (ART) in patients with polycystic ovarian syndrome (PCOS)." | 9.11 | The role of ketoconazole in the prevention of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during assisted reproductive technology cycles. ( Ahmadi, J; Amirchaghmaghi, E; Baghestani, AR; Owj, M; Tehrani-Nejad, ES, 2005) |
| "To evaluate the role of ketoconazole in prevention of ovarian hyperstimulation syndrome (OHSS) in women with the polycystic ovary syndrome (PCOS) undergoing ovarian stimulation with gonadotropins." | 9.10 | A double-blind, randomized, placebo-controlled study to assess the efficacy of ketoconazole for reducing the risk of ovarian hyperstimulation syndrome. ( Alborzi, S; Pakniat, M; Parsanezhad, ME; Schmidt, EH, 2003) |
| "To investigate the clinical efficacy of mild inhibition of ovarian steroidogenesis by very low-dose ketoconazole during induction of ovulation in patients with polycystic ovary syndrome (PCOS)." | 9.09 | Attenuation of ovarian response by low-dose ketoconazole during superovulation in patients with polycystic ovary syndrome. ( Barr, I; Diamant, YZ; Eldar-Geva, T; Gal, M; Margalioth, EJ; Orly, J, 1999) |
| "To assess the clinical efficacy of ketoconazole (KCZ) as an inhibitory enzyme on ovarian steroidogenesis, in prevention of ovarian hyper- stimulation syndrome (OHSS) during assisted reproductive technology (ART) in patients with polycystic ovarian syndrome (PCOS)." | 5.11 | The role of ketoconazole in the prevention of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during assisted reproductive technology cycles. ( Ahmadi, J; Amirchaghmaghi, E; Baghestani, AR; Owj, M; Tehrani-Nejad, ES, 2005) |
| "To evaluate the role of ketoconazole in prevention of ovarian hyperstimulation syndrome (OHSS) in women with the polycystic ovary syndrome (PCOS) undergoing ovarian stimulation with gonadotropins." | 5.10 | A double-blind, randomized, placebo-controlled study to assess the efficacy of ketoconazole for reducing the risk of ovarian hyperstimulation syndrome. ( Alborzi, S; Pakniat, M; Parsanezhad, ME; Schmidt, EH, 2003) |
| "To investigate the clinical efficacy of mild inhibition of ovarian steroidogenesis by very low-dose ketoconazole during induction of ovulation in patients with polycystic ovary syndrome (PCOS)." | 5.09 | Attenuation of ovarian response by low-dose ketoconazole during superovulation in patients with polycystic ovary syndrome. ( Barr, I; Diamant, YZ; Eldar-Geva, T; Gal, M; Margalioth, EJ; Orly, J, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parsanezhad, ME | 1 |
| Alborzi, S | 1 |
| Pakniat, M | 1 |
| Schmidt, EH | 1 |
| Owj, M | 1 |
| Tehrani-Nejad, ES | 1 |
| Amirchaghmaghi, E | 1 |
| Baghestani, AR | 1 |
| Ahmadi, J | 1 |
| Gal, M | 1 |
| Eldar-Geva, T | 1 |
| Margalioth, EJ | 1 |
| Barr, I | 1 |
| Orly, J | 1 |
| Diamant, YZ | 1 |
3 trials available for ketoconazole and Ovarian Hyperstimulation Syndrome
| Article | Year |
|---|---|
A double-blind, randomized, placebo-controlled study to assess the efficacy of ketoconazole for reducing the risk of ovarian hyperstimulation syndrome.
Topics: Adult; Androgen Antagonists; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combin | 2003 |
The role of ketoconazole in the prevention of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during assisted reproductive technology cycles.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fertilization in Vitr | 2005 |
Attenuation of ovarian response by low-dose ketoconazole during superovulation in patients with polycystic ovary syndrome.
Topics: Adolescent; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Estradiol; Female; Humans; | 1999 |