Page last updated: 2024-10-29

ketoconazole and Osteomyelitis

ketoconazole has been researched along with Osteomyelitis in 22 studies

1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.

Osteomyelitis: INFLAMMATION of the bone as a result of infection. It may be caused by a variety of infectious agents, especially pyogenic (PUS - producing) BACTERIA.

Research Excerpts

ExcerptRelevanceReference
" We present a case of coccidioidal osteomyelitis of a tarsal bone successfully treated with local surgical debridement and oral ketoconazole and propose clinical guidelines for selecting the proper chemotherapeutic agent and for following the efficacy of the treatment regimen."7.67Coccidioidomycosis of the first cuneiform: successful treatment utilizing local debridement and long-term ketoconazole therapy. ( Buckley, SL; Burkus, JK, 1986)
"Blastomycotic osteomyelitis of the mandible in a 40-year-old man was treated with ketoconazole for 26 months."7.67Blastomycotic osteomyelitis of the mandible: successful treatment with ketoconazole. ( Head, MD; Varkey, B; Wagner, DK, 1985)
"Treatment with amphotericin B resulted in only moderate improvement of the lesions and was accompanied by considerable toxicity."5.28Treatment of invasive aspergillosis with itraconazole in a patient with chronic granulomatous disease. ( Raven, EJ; van 't Wout, JW; van der Meer, JW, 1990)
"Ketoconazole was prescribed because, unlike amphotericin B, the antibiotic usually used in such cases, it is not nephrotoxic, it can be taken orally and it has proved successful in other reported cases of osteomyelitis due to C."5.28Ketoconazole in the treatment of osteomyelitis due to Candida albicans. ( Bannatyne, RM; Clarke, HM, 1989)
" The dog was treated with ketoconazole and itraconazole perorally for 5 months; however, the osteomyelitis became aggravated, and an amputation from the scapula was performed."3.74Lecythophora hoffmannii isolated from a case of canine osteomyelitis in Japan. ( Hatai, K; Kamei, K; Murata, Y; Nishimura, K; Sakaeyama, S; Sano, A, 2007)
" The child underwent surgical drainage of a paravertebral abscess and administration of intravenous amphotericin B."3.70Chronic paronychia, osteomyelitis, and paravertebral abscess in a child with blastomycosis. ( Evans, T; Muñiz, AE, 2000)
"5 years developed an elevated serum concentration of digoxin in association with digoxin toxicity (characterized by nausea and vomiting) 9 days after the addition of itraconazole to his regimen for the treatment of sternal osteomyelitis."3.68Interaction of itraconazole and digoxin. ( Blanchard, LM; Green, PJ; Sachs, MK, 1993)
" We present a case of coccidioidal osteomyelitis of a tarsal bone successfully treated with local surgical debridement and oral ketoconazole and propose clinical guidelines for selecting the proper chemotherapeutic agent and for following the efficacy of the treatment regimen."3.67Coccidioidomycosis of the first cuneiform: successful treatment utilizing local debridement and long-term ketoconazole therapy. ( Buckley, SL; Burkus, JK, 1986)
"Blastomycotic osteomyelitis of the mandible in a 40-year-old man was treated with ketoconazole for 26 months."3.67Blastomycotic osteomyelitis of the mandible: successful treatment with ketoconazole. ( Head, MD; Varkey, B; Wagner, DK, 1985)
"A 35-year-old man with osteomyelitis of the calvarium, from which Acremonium kiliense was consistently isolated, was successfully treated with amphotericin-B and ketoconazole in addition to craniectomy."3.67Acremonium kiliense osteomyelitis of the calvarium. ( Barnes, WG; Brabender, W; Hodges, GR; Ketcherside, J; Rengachary, S, 1985)
"Treatment with amphotericin B resulted in only moderate improvement of the lesions and was accompanied by considerable toxicity."1.28Treatment of invasive aspergillosis with itraconazole in a patient with chronic granulomatous disease. ( Raven, EJ; van 't Wout, JW; van der Meer, JW, 1990)
"Treatment with amphotericin B and, more recently, with ketoconazole, in conjunction with operative treatment, was very effective."1.28Orthopaedic manifestations of blastomycosis. ( Black, GB; MacDonald, PB; MacKenzie, R, 1990)
"Ketoconazole was prescribed because, unlike amphotericin B, the antibiotic usually used in such cases, it is not nephrotoxic, it can be taken orally and it has proved successful in other reported cases of osteomyelitis due to C."1.28Ketoconazole in the treatment of osteomyelitis due to Candida albicans. ( Bannatyne, RM; Clarke, HM, 1989)
"The spondylitis was probably superinfected with Staphylococcus aureus."1.27Hematogenous Candida spondylitis. A case report. ( Pohjola-Sintonen, S; Ruutu, P; Tallroth, K, 1984)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199010 (45.45)18.7374
1990's9 (40.91)18.2507
2000's2 (9.09)29.6817
2010's1 (4.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Langlois, DK1
Sutton, DA1
Swenson, CL1
Bailey, CJ1
Wiederhold, NP1
Nelson, NC1
Thompson, EH1
Wickes, BL1
French, S1
Fu, J1
Vilar-Saavedra, P1
Peterson, SW1
Sakaeyama, S1
Sano, A1
Murata, Y1
Kamei, K1
Nishimura, K1
Hatai, K1
Galgiani, JN1
Stevens, DA1
Graybill, JR1
Stevens, DL2
Tillinghast, AJ1
Levine, HB1
Meier, J1
Claflin, K1
Milbauer, J1
Sullivan, B1
Pohjola-Sintonen, S1
Ruutu, P1
Tallroth, K1
Sachs, MK2
Blanchard, LM1
Green, PJ1
Hung, LH1
Norwood, LA1
Pitche, P1
Dossim, A1
Mijiyawa, M1
Napo-Koura, G1
Tchangaï-Walla, K1
Muñiz, AE1
Evans, T1
Farr, RC1
Gardner, G1
Acker, JD1
Brint, JM1
Haglund, LF1
Land, M1
Schweitzer, JB1
West, BC1
Paluzzi, RG1
Moore, JH1
Fraimow, HS1
Ost, D1
van 't Wout, JW1
Raven, EJ1
van der Meer, JW1
Piper, JP1
Golden, J1
Brown, D1
Broestler, J1
Malekzadeh, M1
Overturf, GD1
Auerbach, SB1
Wong, L1
Hirsch, M1
MacDonald, PB1
Black, GB1
MacKenzie, R1
Bannatyne, RM1
Clarke, HM1
Buckley, SL1
Burkus, JK1
Ansari, RA1
Hindson, DA1
Kloss, JG1
Wagner, DK1
Varkey, B1
Head, MD1
Thorpe, CD1
Spjut, HJ1
Brabender, W1
Ketcherside, J1
Hodges, GR1
Rengachary, S1
Barnes, WG1

Reviews

1 review available for ketoconazole and Osteomyelitis

ArticleYear
Osteomyelitis due to Pseudallescheria boydii.
    Southern medical journal, 1993, Volume: 86, Issue:2

    Topics: Administration, Oral; Adult; Amputation, Surgical; Arthritis, Infectious; Arthroscopy; Biopsy; Diagn

1993

Other Studies

21 other studies available for ketoconazole and Osteomyelitis

ArticleYear
Clinical, morphological, and molecular characterization of Penicillium canis sp. nov., isolated from a dog with osteomyelitis.
    Journal of clinical microbiology, 2014, Volume: 52, Issue:7

    Topics: Amphotericin B; Animals; Antifungal Agents; Cluster Analysis; DNA, Fungal; DNA, Ribosomal Spacer; Do

2014
Lecythophora hoffmannii isolated from a case of canine osteomyelitis in Japan.
    Medical mycology, 2007, Volume: 45, Issue:3

    Topics: Animals; Antifungal Agents; Ascomycota; Biopsy; DNA, Fungal; DNA, Ribosomal; Dog Diseases; Dogs; Dru

2007
Pseudallescheria boydii infections treated with ketoconazole. Clinical evaluations of seven patients and in vitro susceptibility results.
    Chest, 1984, Volume: 86, Issue:2

    Topics: Aged; Combined Modality Therapy; Female; Humans; Ketoconazole; Lung Diseases, Fungal; Male; Miconazo

1984
[Report on two cases of mandibular osteomyelitis caused by Candida albicans (author's transl)].
    Mykosen, 1982, Volume: 25, Issue:1

    Topics: Adult; Candidiasis, Oral; Child; Female; Humans; Imidazoles; Ketoconazole; Male; Mandibular Diseases

1982
Ketoconazole and blastomycotic osteomyelitis.
    Annals of internal medicine, 1983, Volume: 98, Issue:2

    Topics: Adolescent; Antifungal Agents; Blastomycosis; Humans; Imidazoles; Ketoconazole; Male; Osteomyelitis;

1983
Hematogenous Candida spondylitis. A case report.
    Acta medica Scandinavica, 1984, Volume: 215, Issue:1

    Topics: Amphotericin B; Candidiasis; Clindamycin; Drug Therapy, Combination; Female; Flucytosine; Humans; Ke

1984
Interaction of itraconazole and digoxin.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1993, Volume: 16, Issue:3

    Topics: Aged; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Digoxin; Drug Interactions; Half-Life

1993
[Multiple bone lesions of a type of disseminated African histoplasmosis in a Togolese immunocompetent child].
    Revue de chirurgie orthopedique et reparatrice de l'appareil moteur, 1995, Volume: 81, Issue:8

    Topics: Acromion; Amphotericin B; Antifungal Agents; Child; Clavicle; Histoplasmosis; Humans; Immunocompeten

1995
Chronic paronychia, osteomyelitis, and paravertebral abscess in a child with blastomycosis.
    The Journal of emergency medicine, 2000, Volume: 19, Issue:3

    Topics: Abscess; Amphotericin B; Antifungal Agents; Blastomycosis; Child; Chronic Disease; Humans; Ketoconaz

2000
Blastomycotic cranial osteomyelitis.
    The American journal of otology, 1992, Volume: 13, Issue:6

    Topics: Adult; Amphotericin B; Blastomyces; Blastomycosis; Central Nervous System; Ear, Middle; Female; Gran

1992
Amphotericin-resistant aspergillus osteomyelitis controlled by itraconazole.
    Lancet (London, England), 1990, Jun-16, Volume: 335, Issue:8703

    Topics: Aged; Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Drug Resistance, Micr

1990
Treatment of invasive aspergillosis with itraconazole in a patient with chronic granulomatous disease.
    The Journal of infection, 1990, Volume: 20, Issue:2

    Topics: Adolescent; Amphotericin B; Aspergillosis; Aspergillus fumigatus; Chromatography, High Pressure Liqu

1990
Successful treatment of Scedosporium apiospermum suppurative arthritis with itraconazole.
    The Pediatric infectious disease journal, 1990, Volume: 9, Issue:9

    Topics: Administration, Oral; Antifungal Agents; Arthritis, Infectious; Child; Humans; Itraconazole; Ketocon

1990
Chronic, recurrent osteomyelitis caused by Scedosporium inflatum.
    The Pediatric infectious disease journal, 1990, Volume: 9, Issue:5

    Topics: Child; Chronic Disease; Debridement; Drainage; Foot Diseases; Humans; Ketoconazole; Male; Mitosporic

1990
Orthopaedic manifestations of blastomycosis.
    The Journal of bone and joint surgery. American volume, 1990, Volume: 72, Issue:6

    Topics: Amphotericin B; Arthritis, Infectious; Blastomycosis; Child; Female; Humans; Ketoconazole; Male; Mid

1990
Ketoconazole in the treatment of osteomyelitis due to Candida albicans.
    Canadian journal of surgery. Journal canadien de chirurgie, 1989, Volume: 32, Issue:3

    Topics: Candidiasis; Child, Preschool; Finger Injuries; Humans; Ketoconazole; Male; Osteomyelitis; Radiograp

1989
Coccidioidomycosis of the first cuneiform: successful treatment utilizing local debridement and long-term ketoconazole therapy.
    Foot & ankle, 1986, Volume: 6, Issue:6

    Topics: Coccidioidomycosis; Debridement; Foot Diseases; Humans; Ketoconazole; Male; Middle Aged; Osteomyelit

1986
Pseudallescheria boydii arthritis and osteomyelitis in a patient with Cushing's disease.
    Southern medical journal, 1987, Volume: 80, Issue:1

    Topics: Adrenalectomy; Arthritis, Infectious; Combined Modality Therapy; Cushing Syndrome; Humans; Ketoconaz

1987
Blastomycotic osteomyelitis of the mandible: successful treatment with ketoconazole.
    Oral surgery, oral medicine, and oral pathology, 1985, Volume: 60, Issue:4

    Topics: Adult; Blastomycosis; Humans; Ketoconazole; Male; Mandibular Diseases; Osteomyelitis

1985
Coccidioidal osteomyelitis in a child's finger. A case report.
    The Journal of bone and joint surgery. American volume, 1985, Volume: 67, Issue:2

    Topics: Child, Preschool; Coccidioides; Coccidioidomycosis; Female; Fingers; Humans; Ketoconazole; Osteomyel

1985
Acremonium kiliense osteomyelitis of the calvarium.
    Neurosurgery, 1985, Volume: 16, Issue:4

    Topics: Adult; Amphotericin B; Clindamycin; Humans; Ketoconazole; Male; Mitosporic Fungi; Mycoses; Osteomyel

1985