ketoconazole has been researched along with Neuroblastoma in 3 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Excerpt | Relevance | Reference |
---|---|---|
" We have now determined the effects of concurrent ketoconazole on 4-HPR cytotoxic dose-response in four neuroblastoma (NB) cell lines in vitro and on 4-HPR activity against two cell line-derived, subcutaneous NB xenografts (CDX) and three patient-derived NB xenografts (PDX)." | 5.46 | P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models. ( Kang, MH; Lopez-Barcons, L; Maurer, BJ; Reynolds, CP, 2017) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (33.33) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (66.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Lopez-Barcons, L | 1 |
Maurer, BJ | 1 |
Kang, MH | 1 |
Reynolds, CP | 1 |
Wu, Z | 1 |
Li, L | 1 |
Zheng, LT | 1 |
Xu, Z | 1 |
Guo, L | 1 |
Zhen, X | 1 |
Berkowitz, RJ | 1 |
Hughes, C | 1 |
Rudnick, M | 1 |
Gordon, EM | 1 |
Strandjord, S | 1 |
Cheung, NK | 1 |
Warkentin, P | 1 |
Coccia, PF | 1 |
3 other studies available for ketoconazole and Neuroblastoma
Article | Year |
---|---|
P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cy | 2017 |
Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Allosteric Regulation; Animals; Anti-Inf | 2015 |
Oropharyngeal Candida prophylaxis in pediatric bone marrow transplant patients.
Topics: Adolescent; Anemia, Aplastic; Bone Marrow Transplantation; Burkitt Lymphoma; Candidiasis; Child; Chi | 1985 |