Page last updated: 2024-10-29

ketoconazole and Neuroblastoma

ketoconazole has been researched along with Neuroblastoma in 3 studies

1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
" We have now determined the effects of concurrent ketoconazole on 4-HPR cytotoxic dose-response in four neuroblastoma (NB) cell lines in vitro and on 4-HPR activity against two cell line-derived, subcutaneous NB xenografts (CDX) and three patient-derived NB xenografts (PDX)."5.46P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models. ( Kang, MH; Lopez-Barcons, L; Maurer, BJ; Reynolds, CP, 2017)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lopez-Barcons, L1
Maurer, BJ1
Kang, MH1
Reynolds, CP1
Wu, Z1
Li, L1
Zheng, LT1
Xu, Z1
Guo, L1
Zhen, X1
Berkowitz, RJ1
Hughes, C1
Rudnick, M1
Gordon, EM1
Strandjord, S1
Cheung, NK1
Warkentin, P1
Coccia, PF1

Other Studies

3 other studies available for ketoconazole and Neuroblastoma

ArticleYear
P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models.
    International journal of cancer, 2017, 07-15, Volume: 141, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cy

2017
Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation.
    Journal of neurochemistry, 2015, Volume: 134, Issue:5

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Allosteric Regulation; Animals; Anti-Inf

2015
Oropharyngeal Candida prophylaxis in pediatric bone marrow transplant patients.
    The American journal of pediatric hematology/oncology, 1985,Spring, Volume: 7, Issue:1

    Topics: Adolescent; Anemia, Aplastic; Bone Marrow Transplantation; Burkitt Lymphoma; Candidiasis; Child; Chi

1985