ketoconazole has been researched along with Neuralgia in 2 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intrathecal administration of the P450c17 inhibitor, ketoconazole during the induction phase of neuropathic pain (day 0 to day 3 post-surgery) significantly reduced the development of mechanical allodynia and thermal hyperalgesia in the ipsilateral hind paw." | 3.91 | Spinal cytochrome P450c17 plays a key role in the development of neuropathic mechanical allodynia: Involvement of astrocyte sigma-1 receptors. ( Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Lee, JH; Roh, DH; Yoon, SY, 2019) |
| "The CCI-induced development of mechanical allodynia was attenuated by administration of either ketoconazole (10 nmol) or the p38 MAPK inhibitor, SB203580 (5 nmol)." | 1.51 | Inhibition of cytochrome P450c17 reduces spinal astrocyte activation in a mouse model of neuropathic pain via regulation of p38 MAPK phosphorylation. ( Beitz, AJ; Choi, SR; Lee, JH, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, SR | 2 |
| Roh, DH | 1 |
| Yoon, SY | 1 |
| Choi, HS | 1 |
| Kang, SY | 1 |
| Han, HJ | 1 |
| Beitz, AJ | 2 |
| Lee, JH | 2 |
2 other studies available for ketoconazole and Neuralgia
| Article | Year |
|---|---|
Spinal cytochrome P450c17 plays a key role in the development of neuropathic mechanical allodynia: Involvement of astrocyte sigma-1 receptors.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Astrocytes; Dihydrotestosterone; Disease Models, Animal; H | 2019 |
Inhibition of cytochrome P450c17 reduces spinal astrocyte activation in a mouse model of neuropathic pain via regulation of p38 MAPK phosphorylation.
Topics: Animals; Astrocytes; Constriction, Pathologic; Disease Models, Animal; Hyperalgesia; Imidazoles; Ket | 2019 |