ketoconazole has been researched along with Nelson Syndrome in 3 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Nelson Syndrome: A syndrome characterized by HYPERPIGMENTATION, enlarging pituitary mass, visual defects secondary to compression of the OPTIC CHIASM, and elevated serum ACTH. It is caused by the expansion of an underlying ACTH-SECRETING PITUITARY ADENOMA that grows in the absence of feedback inhibition by adrenal CORTICOSTEROIDS, usually after ADRENALECTOMY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The direct effects of ketoconazole on the secretion of ACTH by human pituitary adenoma cells from 2 patient with Nelson's syndrome were studied in vitro." | 7.67 | In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome. ( Astorga, R; Bernal, G; Garcia, J; Garcia-Luna, PP; Jimenez Reina, L; Leal-Cerro, A, 1989) |
| "The direct effects of ketoconazole on the secretion of ACTH by human pituitary adenoma cells from 2 patient with Nelson's syndrome were studied in vitro." | 3.67 | In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome. ( Astorga, R; Bernal, G; Garcia, J; Garcia-Luna, PP; Jimenez Reina, L; Leal-Cerro, A, 1989) |
| "Cushing's disease is a syndromic pathological condition caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (ACTHomas) mediated by hypercortisolemia." | 2.72 | Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach. ( Fukuoka, H; Nakao, T; Ogawa, W; Yamamoto, M, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Yamamoto, M | 1 |
| Nakao, T | 1 |
| Ogawa, W | 1 |
| Fukuoka, H | 1 |
| Espinosa-de-Los-Monteros, AL | 1 |
| Sosa-Eroza, E | 1 |
| Espinosa, E | 1 |
| Mendoza, V | 1 |
| Arreola, R | 1 |
| Mercado, M | 1 |
| Jimenez Reina, L | 1 |
| Leal-Cerro, A | 1 |
| Garcia, J | 1 |
| Garcia-Luna, PP | 1 |
| Astorga, R | 1 |
| Bernal, G | 1 |
1 review available for ketoconazole and Nelson Syndrome
| Article | Year |
|---|---|
Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenocorticotropic Hormone; Carcinoma; Dopamine Agonists | 2021 |
2 other studies available for ketoconazole and Nelson Syndrome
| Article | Year |
|---|---|
LONG-TERM OUTCOME OF THE DIFFERENT TREATMENT ALTERNATIVES FOR RECURRENT AND PERSISTENT CUSHING DISEASE.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectomy; Adult; Antifungal Agents; Coho | 2017 |
In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome.
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Cells, Cultured; Female; Humans; Immunohistochemistry; | 1989 |