ketoconazole has been researched along with Miosis in 2 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Miosis: Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alfentanil (ALF) is a validated probe for hepatic, first-pass, and intestinal cytochrome P450 (CYP) 3A activity, using plasma clearances, single-point concentrations, and noninvasive pupil diameter change (miosis)." | 5.15 | Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. ( Blood, J; Buck, N; Kharasch, ED; Kim, T; London, A; Mach, RH; Vangveravong, S, 2011) |
| "Pre-treatment with ketoconazole increased the AUC for oxycodone 2- to 3-fold compared with placebo or paroxetine." | 2.76 | Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. ( Drewe, J; Hammann, F; Krähenbühl, S; Kummer, O; Moser, C; Schaller, O, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kummer, O | 1 |
| Hammann, F | 1 |
| Moser, C | 1 |
| Schaller, O | 1 |
| Drewe, J | 1 |
| Krähenbühl, S | 1 |
| Kharasch, ED | 1 |
| Vangveravong, S | 1 |
| Buck, N | 1 |
| London, A | 1 |
| Kim, T | 1 |
| Blood, J | 1 |
| Mach, RH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation[NCT04310579] | Phase 1 | 55 participants (Actual) | Interventional | 2020-06-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for ketoconazole and Miosis
| Article | Year |
|---|---|
Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 | 2011 |
Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil.
Topics: Administration, Oral; Adult; Alfentanil; Anesthetics, Intravenous; Area Under Curve; Beverages; Citr | 2011 |