ketoconazole has been researched along with Milk-Alkali Syndrome in 15 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate whether tuberculosis-associated hypercalcemia is related to abnormal synthesis of 1,25-dihydroxyvitamin D (1,25[OH]2D) and whether ketoconazole administration may be useful in treating tuberculosis-associated hypercalcemia." | 8.78 | Ketoconazole decreases the serum ionized calcium and 1,25-dihydroxyvitamin D levels in tuberculosis-associated hypercalcemia. ( Baroncelli, GI; Bertelloni, S; Di Nero, G; Saggese, G, 1993) |
| "In a syndrome characterized by intermittent hypercalcemia, hypercalciuria, elevated 1,25-dihydroxyvitamin D, undetectable 24,25-dihydroxyvitamin D concentrations, splice junction mutations of the CYP24A1 gene, and autosomal dominant transmission of the trait, treatment with ketoconazole is useful in reducing urinary calcium." | 7.78 | Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: effects of ketoconazole therapy. ( Chelminski, PR; Foreman, JW; Harris, PC; Horst, RL; Kumar, R; Milliner, DS; Singh, RJ; Tebben, PJ; Wu, Y, 2012) |
| "To analyze vitamin D metabolism and response to ketoconazole, an imidazole derivative that inhibits the vitamin D-1-hydroxylase, in infants with idiopathic hypercalcemia, and hypercalciuria." | 7.76 | Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment. ( Boutignon, H; Garabedian, M; Guillozo, H; Jehan, F; Linglart, A; Mallet, E; Nguyen, M, 2010) |
| " These data suggest that long-term use of ketoconazole may be a safe and effective alternative to corticosteroid treatment for sarcoid-associated hypercalcemia." | 5.28 | Treatment of sarcoidosis-associated hypercalcemia with ketoconazole. ( Bia, MJ; Insogna, K, 1991) |
| "Ketoconazole is an antifungal agent capable of inhibiting human steroid hormone synthesis, including renal 1,25-dihydroxyvitamin D [1,25-(OH)2D] synthesis." | 5.28 | Ketoconazole decreases the serum 1,25-dihydroxyvitamin D and calcium concentration in sarcoidosis-associated hypercalcemia. ( Adams, JS; Diz, MM; Endres, DB; Sharma, OP, 1990) |
| "To evaluate whether tuberculosis-associated hypercalcemia is related to abnormal synthesis of 1,25-dihydroxyvitamin D (1,25[OH]2D) and whether ketoconazole administration may be useful in treating tuberculosis-associated hypercalcemia." | 4.78 | Ketoconazole decreases the serum ionized calcium and 1,25-dihydroxyvitamin D levels in tuberculosis-associated hypercalcemia. ( Baroncelli, GI; Bertelloni, S; Di Nero, G; Saggese, G, 1993) |
| "In a syndrome characterized by intermittent hypercalcemia, hypercalciuria, elevated 1,25-dihydroxyvitamin D, undetectable 24,25-dihydroxyvitamin D concentrations, splice junction mutations of the CYP24A1 gene, and autosomal dominant transmission of the trait, treatment with ketoconazole is useful in reducing urinary calcium." | 3.78 | Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: effects of ketoconazole therapy. ( Chelminski, PR; Foreman, JW; Harris, PC; Horst, RL; Kumar, R; Milliner, DS; Singh, RJ; Tebben, PJ; Wu, Y, 2012) |
| "To analyze vitamin D metabolism and response to ketoconazole, an imidazole derivative that inhibits the vitamin D-1-hydroxylase, in infants with idiopathic hypercalcemia, and hypercalciuria." | 3.76 | Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment. ( Boutignon, H; Garabedian, M; Guillozo, H; Jehan, F; Linglart, A; Mallet, E; Nguyen, M, 2010) |
| "Ketoconazole is an imidazole antifungal that inhibits macrophage 1 alpha-hydroxylation of 25-hydroxyvitamin D3 and has been used in paraneoplastic hypercalcemia." | 1.31 | Ketoconazole for the treatment of refractory hypercalcemic sarcoidosis. ( Beynon, HL; Conron, M, 2000) |
| " These data suggest that long-term use of ketoconazole may be a safe and effective alternative to corticosteroid treatment for sarcoid-associated hypercalcemia." | 1.28 | Treatment of sarcoidosis-associated hypercalcemia with ketoconazole. ( Bia, MJ; Insogna, K, 1991) |
| "Ketoconazole is an antifungal agent capable of inhibiting human steroid hormone synthesis, including renal 1,25-dihydroxyvitamin D [1,25-(OH)2D] synthesis." | 1.28 | Ketoconazole decreases the serum 1,25-dihydroxyvitamin D and calcium concentration in sarcoidosis-associated hypercalcemia. ( Adams, JS; Diz, MM; Endres, DB; Sharma, OP, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 9 (60.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Walters, S | 1 |
| Bhatt, N | 1 |
| Medford, AR | 1 |
| Nguyen, M | 1 |
| Boutignon, H | 1 |
| Mallet, E | 1 |
| Linglart, A | 1 |
| Guillozo, H | 1 |
| Jehan, F | 1 |
| Garabedian, M | 1 |
| Tebben, PJ | 1 |
| Milliner, DS | 1 |
| Horst, RL | 1 |
| Harris, PC | 1 |
| Singh, RJ | 1 |
| Wu, Y | 1 |
| Foreman, JW | 1 |
| Chelminski, PR | 1 |
| Kumar, R | 1 |
| Carpenter, TO | 1 |
| Solomon, CG | 1 |
| Dluhy, RG | 1 |
| Ejaz, AA | 1 |
| Zabaneh, RI | 1 |
| Tiwari, P | 1 |
| Nawab, ZM | 1 |
| Leehey, DJ | 1 |
| Ing, TS | 1 |
| BenÃtez, J | 1 |
| Muncio, MJ | 1 |
| Esbrit, P | 1 |
| Traba, ML | 1 |
| Saggese, G | 1 |
| Bertelloni, S | 1 |
| Baroncelli, GI | 1 |
| Di Nero, G | 1 |
| Yavuz, H | 1 |
| Young, C | 1 |
| Burrows, R | 1 |
| Katz, J | 1 |
| Beynon, H | 1 |
| Conron, M | 1 |
| Beynon, HL | 1 |
| Bia, MJ | 1 |
| Insogna, K | 1 |
| Glass, AR | 2 |
| Cerletty, JM | 1 |
| Elliott, W | 1 |
| Lemann, J | 1 |
| Gray, RW | 1 |
| Eil, C | 2 |
| Adams, JS | 1 |
| Sharma, OP | 1 |
| Diz, MM | 1 |
| Endres, DB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Rifampin to Reduce Elevated Levels of Blood and Urine Calcium in Patients With Idiopathic Infantile Hypercalcemia[NCT03384121] | Phase 1 | 5 participants (Anticipated) | Interventional | 2018-02-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketoconazole and Milk-Alkali Syndrome
| Article | Year |
|---|---|
Ketoconazole decreases the serum ionized calcium and 1,25-dihydroxyvitamin D levels in tuberculosis-associated hypercalcemia.
Topics: 25-Hydroxyvitamin D 2; Adolescent; Calcitriol; Calcium; Child; Creatinine; Humans; Hydrocortisone; H | 1993 |
14 other studies available for ketoconazole and Milk-Alkali Syndrome
| Article | Year |
|---|---|
Reversible cerebellar signs due to sarcoid-related severe hypercalcaemia.
Topics: Chloroquine; Dehydration; Glucocorticoids; Humans; Hypercalcemia; Ketoconazole; Male; Mental Disorde | 2013 |
Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment.
Topics: Calcium; Female; Fibroblast Growth Factor-23; Haplotypes; Humans; Hypercalcemia; Hypercalciuria; Inf | 2010 |
Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: effects of ketoconazole therapy.
Topics: 14-alpha Demethylase Inhibitors; Adult; Calcitriol; Genotype; Humans; Hypercalcemia; Hypercalciuria; | 2012 |
Take another CYP: confirming a novel mechanism for "idiopathic" hypercalcemia.
Topics: 14-alpha Demethylase Inhibitors; Calcitriol; Humans; Hypercalcemia; Hypercalciuria; Ketoconazole; Ma | 2012 |
Paraneoplastic endocrine syndromes.
Topics: Acromegaly; Adrenocorticotropic Hormone; Aminoglutethimide; Bromocriptine; Calcitonin; Cushing Syndr | 1994 |
Ketoconazole in the treatment of recurrent nephrolithiasis associated with sarcoidosis.
Topics: Adult; Humans; Hypercalcemia; Ketoconazole; Kidney Calculi; Lymphatic Diseases; Male; Recurrence; Sa | 1994 |
Role of parathormone-related protein and 1,25-dihydroxyvitamin D in the hypercalcemia of Walker 256 tumor-host rats.
Topics: Animals; Calcitriol; Carcinoma 256, Walker; Female; Hypercalcemia; Ketoconazole; Parathyroid Hormone | 1994 |
Familiar drugs for the treatment of hypercalcemia.
Topics: Antifungal Agents; Humans; Hypercalcemia; Ketoconazole | 1998 |
Hypercalcaemia in sarcoidosis.
Topics: Adult; Diabetes Mellitus, Type 2; Diagnosis, Differential; Female; Humans; Hypercalcemia; Hyperparat | 1999 |
Ketoconazole for the treatment of refractory hypercalcemic sarcoidosis.
Topics: Adrenal Cortex Hormones; Adult; Female; Follow-Up Studies; Humans; Hypercalcemia; Ketoconazole; Male | 2000 |
Treatment of sarcoidosis-associated hypercalcemia with ketoconazole.
Topics: Calcitriol; Calcium; Humans; Hypercalcemia; Ketoconazole; Kidney Failure, Chronic; Male; Middle Aged | 1991 |
Ketoconazole reduces elevated serum levels of 1,25-dihydroxyvitamin D in hypercalcemic sarcoidosis.
Topics: Adult; Calcifediol; Calcitriol; Calcium; Creatinine; Cyclic AMP; Humans; Hypercalcemia; Ketoconazole | 1990 |
Ketoconazole decreases the serum 1,25-dihydroxyvitamin D and calcium concentration in sarcoidosis-associated hypercalcemia.
Topics: Adult; Calcitriol; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Hypercalcemia | 1990 |
Ketoconazole-induced reduction in serum 1,25-dihydroxyvitamin D and total serum calcium in hypercalcemic patients.
Topics: Adult; Aged; Aged, 80 and over; Calcitriol; Calcium; Female; Humans; Hypercalcemia; Ketoconazole; Ma | 1988 |