ketoconazole has been researched along with Leukemia in 25 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a comparative study of infection prophylaxis, patients with acute leukemia receiving remission induction therapy were assigned either no prophylaxis, sulfamethoxazole and trimethoprim, ketoconazole, or the combination of sulfamethoxazole and trimethoprim and ketoconazole." | 9.05 | Infection prophylaxis in acute leukemia. Comparative effectiveness of sulfamethoxazole and trimethoprim, ketoconazole, and a combination of the two. ( Bodey, GP; Estey, E; Fainstein, V; Freireich, EJ; Keating, M; Maksymiuk, A; McCredie, KB; Smith, T, 1984) |
| "In a comparative study of infection prophylaxis, patients with acute leukemia receiving remission induction therapy were assigned either no prophylaxis, sulfamethoxazole and trimethoprim, ketoconazole, or the combination of sulfamethoxazole and trimethoprim and ketoconazole." | 5.05 | Infection prophylaxis in acute leukemia. Comparative effectiveness of sulfamethoxazole and trimethoprim, ketoconazole, and a combination of the two. ( Bodey, GP; Estey, E; Fainstein, V; Freireich, EJ; Keating, M; Maksymiuk, A; McCredie, KB; Smith, T, 1984) |
| "Deep fungal infections are an increasing problem in the treatment of acute leukemias and malignant lymphomas." | 2.66 | Prophylaxis of fungal infections with itraconazole during remission-induction therapy. ( Bradford, GR; Prentice, AG, 1989) |
| "Ketoconazole was administered in a 200 mg dose twice daily." | 2.66 | A randomized trial comparing ketoconazole and nystatin prophylactic therapy in neutropenic patients. ( Malcom, LG; Vogler, WR; Winton, EF, 1987) |
| " Liposomal Amphotericin B allowing higher dosage by lower toxicity appears effective as salvage treatment especially in aspergillosis which also responds to Itraconazole available as oral formulation so far." | 2.38 | Antifungal treatment strategy in leukemia patients. ( Büchner, T; Roos, N, 1992) |
| " The half-life of ketoconazole is dose-dependent, increases during long term treatment, suggesting auto-inhibition of metabolism." | 2.37 | Clinical pharmacokinetics of ketoconazole. ( Daneshmend, TK; Warnock, DW, 1988) |
| "Disseminated candidiasis is likely to become an increasing problem in cancer patients." | 1.27 | Candidiasis in cancer patients. ( Bodey, GP, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (80.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Looker, DN | 1 |
| Estey, E | 1 |
| Maksymiuk, A | 1 |
| Smith, T | 1 |
| Fainstein, V | 2 |
| Keating, M | 1 |
| McCredie, KB | 1 |
| Freireich, EJ | 1 |
| Bodey, GP | 3 |
| Maksymiuk, AW | 1 |
| Thongprasert, S | 1 |
| Hopfer, R | 1 |
| Luna, M | 1 |
| Hann, IM | 2 |
| Prentice, HG | 2 |
| Corringham, R | 2 |
| Blacklock, HA | 2 |
| Keaney, M | 2 |
| Shannon, M | 1 |
| Noone, P | 1 |
| Gascoigne, E | 2 |
| Fox, J | 2 |
| Boesen, E | 1 |
| Szawatkowski, M | 1 |
| Hoffbrand, AV | 1 |
| Pollock, AV | 1 |
| Evans, M | 1 |
| Van Cutsem, J | 1 |
| Brincker, H | 2 |
| Vu Van, H | 1 |
| Piens, MA | 2 |
| Archimbaud, E | 1 |
| Monier, MF | 1 |
| Guyotat, D | 2 |
| Mojon, M | 1 |
| Fiere, D | 1 |
| Kauffman, CA | 1 |
| Jones, PG | 1 |
| Bergman, AG | 1 |
| McAuliffe, LS | 1 |
| Liepman, MK | 1 |
| Persat, F | 1 |
| Marzullo, C | 1 |
| Rochet, MJ | 1 |
| Büchner, T | 1 |
| Roos, N | 1 |
| De Beule, F | 1 |
| Bercy, P | 1 |
| Ferrant, A | 1 |
| Wolf, HH | 1 |
| Scharf, RE | 1 |
| Arning, M | 1 |
| Schneider, W | 1 |
| Prentice, AG | 1 |
| Bradford, GR | 1 |
| Remmel, RP | 1 |
| Dombrovskis, D | 1 |
| Canafax, DM | 1 |
| Verhagen, C | 1 |
| Stalpers, LJ | 1 |
| de Pauw, BE | 1 |
| Haanen, C | 1 |
| Rodu, B | 1 |
| Carpenter, JT | 1 |
| Jones, MR | 1 |
| Daneshmend, TK | 1 |
| Warnock, DW | 1 |
| Schønheyder, H | 1 |
| Olsen, H | 1 |
| Stenderup, A | 1 |
| Vogler, WR | 1 |
| Malcom, LG | 1 |
| Winton, EF | 1 |
| Berkowitz, RJ | 1 |
| Hughes, C | 1 |
| Rudnick, M | 1 |
| Gordon, EM | 1 |
| Strandjord, S | 1 |
| Cheung, NK | 1 |
| Warkentin, P | 1 |
| Coccia, PF | 1 |
| Krcová, V | 1 |
| Krc, I | 1 |
| Kubis, M | 1 |
| Mlcochová, E | 1 |
| Podivínská, I | 1 |
| Mazzoni, A | 1 |
| Fiorentini, C | 1 |
| Cevenini, R | 1 |
| Nanetti, A | 1 |
2 reviews available for ketoconazole and Leukemia
| Article | Year |
|---|---|
Antifungal treatment strategy in leukemia patients.
Topics: Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Fluconazole; Flucytosine; Humans; Itra | 1992 |
Clinical pharmacokinetics of ketoconazole.
Topics: Administration, Intravaginal; Administration, Topical; Drug Interactions; Humans; Ketoconazole; Leuk | 1988 |
6 trials available for ketoconazole and Leukemia
| Article | Year |
|---|---|
Infection prophylaxis in acute leukemia. Comparative effectiveness of sulfamethoxazole and trimethoprim, ketoconazole, and a combination of the two.
Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Drug Combinations; Drug Therapy, Combi | 1984 |
Ketoconazole versus nystatin plus amphotericin B for fungal prophylaxis in severely immunocompromised patients.
Topics: Amphotericin B; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Imidazoles; Immunosuppr | 1982 |
The pharmacokinetics of ketoconazole in severely immunocompromised patients.
Topics: Adult; Antifungal Agents; Bone Marrow Transplantation; Female; Humans; Imidazoles; Immune Tolerance; | 1982 |
Effect of prophylactic ketoconazole and nystatin on fungal flora.
Topics: Adolescent; Adult; Clinical Trials as Topic; Humans; Ketoconazole; Leukemia; Lymphoma; Mycoses; Nyst | 1984 |
Prophylaxis of fungal infections with itraconazole during remission-induction therapy.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Double-Blind Method; Female; Humans; Itraconazole; Ketoc | 1989 |
A randomized trial comparing ketoconazole and nystatin prophylactic therapy in neutropenic patients.
Topics: Acute Disease; Adolescent; Adult; Aged; Agranulocytosis; Candidiasis, Oral; Female; Humans; Immune T | 1987 |
17 other studies available for ketoconazole and Leukemia
| Article | Year |
|---|---|
Oral ketoconazole and amphotericin B for the prevention of yeast colonization in patients with acute leukaemia.
Topics: Amphotericin B; Humans; Ketoconazole; Leukemia; Mycoses | 1984 |
Candidiasis in cancer patients.
Topics: Amphotericin B; Antibodies, Fungal; Candidiasis; Cephalosporins; Humans; Ketoconazole; Leukemia; Mic | 1984 |
Systemic candidiasis in cancer patients.
Topics: Acute Disease; Amphotericin B; Bacterial Infections; Bacteriological Techniques; Candida; Candidiasi | 1984 |
Oral ketoconazole and amphotericin B for the prevention of yeast colonization in patients with acute leukaemia.
Topics: Acute Disease; Amphotericin B; Humans; Ketoconazole; Leukemia; Mycoses | 1984 |
Prevention of mycosis in granulocytopenic patients with prophylactic ketoconazole treatment.
Topics: Acute Disease; Adult; Agranulocytosis; Antifungal Agents; Candidiasis, Cutaneous; Double-Blind Metho | 1983 |
Serum levels of ketoconazole in bone marrow transplanted patients.
Topics: Adult; Antifungal Agents; Biological Assay; Bone Marrow Transplantation; Candida albicans; Graft vs | 1983 |
Overcoming drug resistance: studies presented at ASCO.
Topics: Antigens, CD; Antigens, CD34; Cyclosporine; Drug Resistance; Humans; Ketoconazole; Leukemia; Tretino | 1992 |
Plasma itraconazole concentrations in neutropenic patients after repeated high-dose treatment.
Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Bone Marrow Transplantation; Combined Modality Th | 1992 |
The effectiveness of a preventive regimen on the periodontal health of patients undergoing chemotherapy for leukemia and lymphoma.
Topics: Acyclovir; Amphotericin B; Ceftazidime; Chlorhexidine; Dental Plaque Index; Fluconazole; Humans; Imm | 1991 |
Preliminary results of treatment with itraconazole in patients with systemic fungal infections.
Topics: Acute Disease; Adult; Agranulocytosis; Antifungal Agents; Antineoplastic Agents; Drug Evaluation; Dr | 1990 |
Assay of itraconazole in leukemic patient plasma by reversed-phase small-bore liquid chromatography.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Itraconazo | 1988 |
Drug-induced skin reactions in patients with acute non-lymphocytic leukaemia.
Topics: Acute Disease; Adult; Allopurinol; Cephalosporins; Drug Combinations; Drug Eruptions; Female; Humans | 1987 |
The pathogenesis and clinical significance of cytologically detectable oral Candida in acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Amphotericin B; Candida; Candidiasis, Oral; Female; Humans; | 1988 |
The serological response to Candida albicans in leukemic patients prophylactically treated with ketoconazole.
Topics: Adolescent; Adult; Aged; Antibodies, Fungal; Candida albicans; Candidiasis; Female; Humans; Immunogl | 1987 |
Oropharyngeal Candida prophylaxis in pediatric bone marrow transplant patients.
Topics: Adolescent; Anemia, Aplastic; Bone Marrow Transplantation; Burkitt Lymphoma; Candidiasis; Child; Chi | 1985 |
[Ketoconazole in the prevention of mycotic complications during cytostatic treatment of leukemias and lymphomas].
Topics: Female; Humans; Ketoconazole; Leukemia; Lymphoma; Male; Mycoses | 1985 |
Limits of antifungal prophylaxis by ketoconazole in leukemic patients.
Topics: Adult; Biological Assay; Female; Humans; Ketoconazole; Leukemia; Male; Mycoses | 1985 |