ketoconazole has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 5 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Additionally, voriconazole could significantly increase Cmax of dasatinib by approximately 4." | 1.56 | Differential Impacts of Azole Antifungal Drugs on the Pharmacokinetic Profiles of Dasatinib in Rats by LC-MS-MS. ( Cheng, G; Huang, L; Li, T; Luo, X; Xue, X; Zhang, Y, 2020) |
| "Bosutinib is an orally available Src/Abl tyrosine kinase inhibitor indicated for the treatment of patients with Philadelphia chromosome-positive chronic myelogenous leukemia." | 1.46 | Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug-Drug and Drug-Disease Interactions. ( Abbas, R; Hsyu, PH; Loi, CM; Ono, C; Yamazaki, S, 2017) |
| "The hallmark of chronic myeloid leukemia (CML) is the presence of the bcr-abl oncogene, which is associated with transforming ability and an intrinsic resistance to induction of apoptosis by genotoxic agents." | 1.30 | Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells. ( Akard, L; Boswell, HS; Carlo-Stella, C; Dugan, M; Garau, D; Regazzi, E; Rizzo, MT; Rizzoli, V, 1999) |
| "The rhabdomyolysis was preceded by a grand mal seizure probably caused by a combination of cyclosporin A and corticosteroids given for the prevention and treatment of acute graft-versus-host disease." | 1.28 | Fatal rhabdomyolysis as a complication of bone marrow transplantation. ( Järventie, G; Ruutu, T; Volin, L, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prado-Carrillo, O | 1 |
| Arenas-Ramírez, A | 1 |
| Llaguno-Munive, M | 1 |
| Jurado, R | 1 |
| Pérez-Rojas, J | 1 |
| Cervera-Ceballos, E | 1 |
| Garcia-Lopez, P | 1 |
| Luo, X | 1 |
| Xue, X | 1 |
| Li, T | 1 |
| Zhang, Y | 1 |
| Huang, L | 1 |
| Cheng, G | 1 |
| Ono, C | 1 |
| Hsyu, PH | 1 |
| Abbas, R | 1 |
| Loi, CM | 1 |
| Yamazaki, S | 1 |
| Rizzo, MT | 1 |
| Regazzi, E | 1 |
| Garau, D | 1 |
| Akard, L | 1 |
| Dugan, M | 1 |
| Boswell, HS | 1 |
| Rizzoli, V | 1 |
| Carlo-Stella, C | 1 |
| Volin, L | 1 |
| Järventie, G | 1 |
| Ruutu, T | 1 |
5 other studies available for ketoconazole and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Ketoconazole Reverses Imatinib Resistance in Human Chronic Myelogenous Leukemia K562 Cells.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Doxorubicin; Drug R | 2022 |
Differential Impacts of Azole Antifungal Drugs on the Pharmacokinetic Profiles of Dasatinib in Rats by LC-MS-MS.
Topics: Administration, Oral; Animals; Antifungal Agents; Area Under Curve; Chromatography, High Pressure Li | 2020 |
Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug-Drug and Drug-Disease Interactions.
Topics: Administration, Oral; Aniline Compounds; Area Under Curve; Computer Simulation; Cytochrome P-450 CYP | 2017 |
Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Animals; Antioxidants; Apoptosis; Arachidonic Acid; Bone Mar | 1999 |
Fatal rhabdomyolysis as a complication of bone marrow transplantation.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Bone Marrow Transplantation; Cyclosporins; Graft vs H | 1990 |