ketoconazole has been researched along with Leishmaniasis in 32 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Leishmaniasis: A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen patients with cutaneous leishmaniasis were randomly selected for clinical trials with itraconazole." | 9.06 | Cutaneous leishmaniasis in India. Clinical experience with itraconazole (R51 211 Janssen). ( Aneja, N; Dogra, J; Lal, BB; Mishra, SN, 1990) |
| "A 17-year-old boy with an eight-month history of cutaneous leishmaniasis on the left earlobe was treated with ketoconazole for a period of four weeks." | 7.66 | Cutaneous leishmaniasis: treatment with ketoconazole. ( El-On, J; Livshin, R; Weinrauch, L, 1983) |
| "Both ketoconazole and Pentostam were more effective than placebo against L." | 6.67 | Efficacy of ketoconazole against Leishmania braziliensis panamensis cutaneous leishmaniasis. ( Berman, JD; Paz, H; Saenz, RE, 1990) |
| "Treatment with ketoconazole over 5 weeks resulted in major improvement of the lesions." | 5.28 | [An unusual case: cutaneous leishmaniasis with subcutaneous nodule--successfully treated with oral ketoconazole]. ( Ingber, A; Sandbank, M; Segal, B; Tratner, A; Wiesman-Katzenelson, W, 1990) |
| "The chemotherapy of leishmaniasis is still far from satisfactory." | 5.28 | Cutaneous leishmaniasis. Treatment with itraconazole. ( Albanese, G; Crippa, D; Giorgetti, P; Sala, G; Santagostino, L, 1989) |
| "Fifteen patients with cutaneous leishmaniasis were randomly selected for clinical trials with itraconazole." | 5.06 | Cutaneous leishmaniasis in India. Clinical experience with itraconazole (R51 211 Janssen). ( Aneja, N; Dogra, J; Lal, BB; Mishra, SN, 1990) |
| "Although oral miltefosine represented an important therapeutic advance in the treatment of leishmaniasis, the appearance of resistance remains a serious threat." | 3.77 | Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania. ( Bavchvarov, BI; Campillo, M; Castanys, S; Gamarro, F; López-Martín, C; Martínez-García, M; Pérez-Victoria, JM; Torrecillas, IR, 2011) |
| "The alkylphosphocholine class of drugs, including edelfosine and miltefosine, has recently shown promise in the treatment of protozoal and fungal diseases, most notably, leishmaniasis." | 3.72 | Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine. ( Birchmore, JL; Hanson, PK; Malone, L; Nichols, JW, 2003) |
| "A 17-year-old boy with an eight-month history of cutaneous leishmaniasis on the left earlobe was treated with ketoconazole for a period of four weeks." | 3.66 | Cutaneous leishmaniasis: treatment with ketoconazole. ( El-On, J; Livshin, R; Weinrauch, L, 1983) |
| "Both ketoconazole and Pentostam were more effective than placebo against L." | 2.67 | Efficacy of ketoconazole against Leishmania braziliensis panamensis cutaneous leishmaniasis. ( Berman, JD; Paz, H; Saenz, RE, 1990) |
| "Oral fluconazole has been shown to be more effective than placebo in one instance: for Leishmania major cutaneous disease from Saudi Arabia." | 2.43 | Clinical status of agents being developed for leishmaniasis. ( Berman, J, 2005) |
| "Cutaneous leishmaniasis is endemic in south central Texas." | 2.38 | Cutaneous leishmaniasis in Texas: report of a case and review of the literature. ( Furner, BB, 1990) |
| "Treatment with ketoconazole over 5 weeks resulted in major improvement of the lesions." | 1.28 | [An unusual case: cutaneous leishmaniasis with subcutaneous nodule--successfully treated with oral ketoconazole]. ( Ingber, A; Sandbank, M; Segal, B; Tratner, A; Wiesman-Katzenelson, W, 1990) |
| "The chemotherapy of leishmaniasis is still far from satisfactory." | 1.28 | Cutaneous leishmaniasis. Treatment with itraconazole. ( Albanese, G; Crippa, D; Giorgetti, P; Sala, G; Santagostino, L, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (50.00) | 18.7374 |
| 1990's | 11 (34.38) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 2 (6.25) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| dos Santos, MS | 1 |
| Oliveira, ML | 1 |
| Bernardino, AM | 1 |
| de Léo, RM | 1 |
| Amaral, VF | 1 |
| de Carvalho, FT | 1 |
| Leon, LL | 1 |
| Canto-Cavalheiro, MM | 1 |
| Nunes, DCOS | 1 |
| Costa, MS | 1 |
| Bispo-da-Silva, LB | 1 |
| Ferro, EAV | 1 |
| Zóia, MAP | 1 |
| Goulart, LR | 1 |
| Rodrigues, RS | 1 |
| Rodrigues, VM | 1 |
| Yoneyama, KAG | 1 |
| Pérez-Victoria, JM | 1 |
| Bavchvarov, BI | 1 |
| Torrecillas, IR | 1 |
| Martínez-García, M | 1 |
| López-Martín, C | 1 |
| Campillo, M | 1 |
| Castanys, S | 1 |
| Gamarro, F | 1 |
| Hanson, PK | 1 |
| Malone, L | 1 |
| Birchmore, JL | 1 |
| Nichols, JW | 1 |
| Berman, J | 1 |
| Weinrauch, L | 5 |
| El-On, J | 6 |
| Berman, JD | 3 |
| Urcuyo, FG | 1 |
| Zaias, N | 1 |
| Livshin, R | 4 |
| Even-Paz, Z | 1 |
| Jacobs, GP | 1 |
| Cook, GC | 1 |
| Balaña-Fouce, R | 1 |
| Reguera, RM | 1 |
| Cubría, JC | 1 |
| Ordóñez, D | 1 |
| Iyer, SR | 1 |
| Iyer, RR | 1 |
| Okelo, GB | 1 |
| Sang, D | 1 |
| Bhatt, KM | 1 |
| Saenz, RE | 1 |
| Paz, H | 1 |
| Pialoux, G | 1 |
| Hennequin, C | 1 |
| Dupont, B | 1 |
| Ravisse, P | 1 |
| Dogra, J | 1 |
| Aneja, N | 1 |
| Lal, BB | 1 |
| Mishra, SN | 1 |
| Furner, BB | 1 |
| Nicolas, JM | 1 |
| Pirson, P | 1 |
| Leclef, B | 1 |
| Trouet, A | 1 |
| Nakayama, J | 1 |
| Matsumoto, T | 1 |
| Asahi, M | 1 |
| Urabe, H | 1 |
| Tratner, A | 1 |
| Ingber, A | 1 |
| Segal, B | 1 |
| Wiesman-Katzenelson, W | 1 |
| Sandbank, M | 1 |
| Albanese, G | 1 |
| Giorgetti, P | 1 |
| Santagostino, L | 1 |
| Crippa, D | 1 |
| Sala, G | 1 |
| Kremsner, P | 1 |
| Lang, I | 1 |
| Kollaritsch, H | 1 |
| Chaniotis, BN | 1 |
| Johnson, CM | 1 |
| Christensen, HA | 1 |
| de Vasquez, AM | 1 |
| Dutz, W | 1 |
| Agarval, N | 1 |
| Bashardost, MZ | 1 |
| Bentley, G | 1 |
| Kindmark, CO | 1 |
| Viallet, J | 1 |
| MacLean, JD | 1 |
| Robson, H | 1 |
| Jolliffe, DS | 1 |
| Dedet, JP | 1 |
| Jamet, P | 1 |
| Esterre, P | 1 |
| Ghipponi, PM | 1 |
| Genin, C | 1 |
| Lalande, G | 1 |
| Dan, M | 1 |
| Verner, E | 1 |
| Zuckerman, F | 1 |
| Michaeli, D | 1 |
3 reviews available for ketoconazole and Leishmaniasis
| Article | Year |
|---|---|
Clinical status of agents being developed for leishmaniasis.
Topics: Aminoquinolines; Antiprotozoal Agents; Fluconazole; Humans; Imiquimod; Ketoconazole; Leishmaniasis; | 2005 |
The pharmacology of leishmaniasis.
Topics: Allopurinol; Amphotericin B; Animals; Antiprotozoal Agents; Drug Design; Humans; Itraconazole; Ketoc | 1998 |
Cutaneous leishmaniasis in Texas: report of a case and review of the literature.
Topics: Aged; Animals; Child; Child, Preschool; Female; Humans; Ketoconazole; Leishmania mexicana; Leishmani | 1990 |
3 trials available for ketoconazole and Leishmaniasis
| Article | Year |
|---|---|
Oral ketoconazole in the treatment of leishmaniasis.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Clinical Trials as Topic; Female; Humans | 1982 |
Efficacy of ketoconazole against Leishmania braziliensis panamensis cutaneous leishmaniasis.
Topics: Adolescent; Adult; Antimony Sodium Gluconate; Gluconates; Humans; Ketoconazole; Leishmaniasis; Male; | 1990 |
Cutaneous leishmaniasis in India. Clinical experience with itraconazole (R51 211 Janssen).
Topics: Adolescent; Adult; Animals; Female; Humans; India; Itraconazole; Ketoconazole; Leishmania tropica; L | 1990 |
26 other studies available for ketoconazole and Leishmaniasis
| Article | Year |
|---|---|
Synthesis and antileishmanial evaluation of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives.
Topics: Animals; Antiprotozoal Agents; Imidazoles; Leishmania; Leishmaniasis; Mice; Pyrazoles; Structure-Act | 2011 |
Mitochondrial dysfunction on Leishmania (Leishmania) amazonensis induced by ketoconazole: insights into drug mode of action.
Topics: Animals; Antiprotozoal Agents; Flow Cytometry; Humans; Ketoconazole; Leishmania; Leishmaniasis; Mice | 2022 |
Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania.
Topics: Aminoquinolines; Antimony; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Drug Resistance, | 2011 |
Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine.
Topics: Alleles; Antiprotozoal Agents; Biological Transport; Cell Division; Cell Membrane; Cycloheximide; Do | 2003 |
The effect of ketoconazole and a combination of rifampicin/amphotericin B on cutaneous leishmaniasis in laboratory mice.
Topics: Amphotericin B; Animals; Drug Therapy, Combination; Ketoconazole; Leishmaniasis; Male; Mice; Mice, I | 1984 |
Activity of imidazoles against Leishmania tropica in human macrophage cultures.
Topics: Clotrimazole; Humans; Imidazoles; In Vitro Techniques; Ketoconazole; Leishmania; Leishmaniasis; Macr | 1981 |
In vitro susceptibility of antimony-resistant Leishmania to alternative drugs.
Topics: Amphotericin B; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antimony; Formycins; Humans; Imi | 1982 |
Cutaneous leishmaniasis: treatment with ketoconazole.
Topics: Adolescent; Ear, External; Humans; Ketoconazole; Leishmaniasis; Male | 1983 |
Efficacy of ketoconazole in cutaneous leishmaniasis.
Topics: Adolescent; Adult; Female; Humans; Ketoconazole; Leishmaniasis; Male; Time Factors | 1983 |
Cutaneous leishmaniasis: failure of topical treatment with imidazole derivatives in laboratory animals and man.
Topics: Administration, Topical; Animals; Clotrimazole; Humans; Imidazoles; Ketoconazole; Leishmaniasis; Mic | 1984 |
Leishmaniasis: some recent developments in chemotherapy.
Topics: Allopurinol; Amphotericin B; Antiprotozoal Agents; Humans; Ketoconazole; Leishmaniasis; Paromomycin | 1993 |
Anti leishmanial therapy--the changing scene.
Topics: Antifungal Agents; Fluconazole; Humans; Ketoconazole; Leishmaniasis | 1995 |
The treatment of diffuse cutaneous leishmaniasis: a report of two cases.
Topics: Adolescent; Adult; Antimony Sodium Gluconate; Biopsy; Female; Humans; Isoniazid; Ketoconazole; Leish | 1991 |
Cutaneous leishmaniasis in an AIDS patient: cure with itraconazole.
Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Itraconazole; Ketoconazole; Leishmaniasis | 1990 |
Acetylated low-density lipoprotein as a vehicle for antiinfectious drugs: preparation and antileishmanial activity of Ac-LDL containing ketoconazole-oleate.
Topics: Animals; Antiprotozoal Agents; Cells, Cultured; Dose-Response Relationship, Drug; Drug Compounding; | 1990 |
Imported cutaneous leishmaniasis in Japan.
Topics: Adult; Humans; Japan; Ketoconazole; Leishmaniasis; Male; Saudi Arabia; Skin; Travel | 1990 |
[An unusual case: cutaneous leishmaniasis with subcutaneous nodule--successfully treated with oral ketoconazole].
Topics: Administration, Oral; Aged; Biopsy; Female; Humans; Ketoconazole; Leishmaniasis; Skin | 1990 |
Cutaneous leishmaniasis. Treatment with itraconazole.
Topics: Adult; Antiprotozoal Agents; Follow-Up Studies; Humans; Itraconazole; Ketoconazole; Leishmaniasis; M | 1989 |
[Successful treatment of antimony-resistant cutaneous leishmaniasis].
Topics: Aged; Animals; Antimony Sodium Gluconate; Drug Resistance; Gluconates; Humans; Ketoconazole; Leishma | 1987 |
Acquisition, development, and treatment of Panamanian cutaneous leishmaniasis: a case history.
Topics: Administration, Topical; Antimony; Antimony Potassium Tartrate; Drug Therapy, Combination; Ketoconaz | 1988 |
Topical therapy of cutaneous leishmaniasis with 2% ketoconazole ointment and DMSO.
Topics: Administration, Topical; Dimethyl Sulfoxide; Drug Therapy, Combination; Humans; Ketoconazole; Leishm | 1987 |
Ketoconazole in cutaneous leishmaniasis.
Topics: Humans; Ketoconazole; Leishmaniasis | 1987 |
Response to ketoconazole in two cases of longstanding cutaneous leishmaniasis.
Topics: Administration, Oral; Adult; Female; Humans; Ketoconazole; Leishmaniasis; Middle Aged; Time Factors | 1986 |
Cutaneous leishmaniasis from Belize--treatment with ketoconazole.
Topics: Adolescent; Adult; Humans; Ketoconazole; Leishmania braziliensis; Leishmania mexicana; Leishmaniasis | 1986 |
Failure to cure Leishmania braziliensis guyanensis cutaneous leishmaniasis with oral ketoconazole.
Topics: Administration, Oral; Adult; Female; Humans; Ketoconazole; Leishmaniasis; Male | 1986 |
Failure of oral ketoconazole to cure cutaneous ulcers caused by Leishmania braziliensis.
Topics: Administration, Oral; Adult; Female; Humans; Ketoconazole; Leishmania braziliensis; Leishmaniasis; M | 1986 |